Article
Environmental Sciences
Jinyao Yin, Qian Zhou, Jingwen Tan, Wangjun Che, Yuefeng He
Summary: Arsenic, a human carcinogen, poses a threat to global environmental health. This study investigated the effect of arsenic on MDM2, p53, and their phosphorylation. The findings suggest that arsenic and its methylated metabolites can modulate the expression and phosphorylation of MDM2 and p53, as well as the interaction between MDM2 and p53.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Hyun-Young Lee, Seon-Hee Oh
Summary: In cadmium-induced kidney injury, autophagy modulates apoptosis process by regulating the p53-mediated DRAM-BAX signaling pathway.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Cell Biology
Muhammad Ali Khan, Purba Nag, Anca Grivei, Kurt T. K. Giuliani, Xiangju Wang, Vishal Diwan, Wendy Hoy, Helen Healy, Glenda Gobe, Andrew J. Kassianos
Summary: The pathogenesis of crystal nephropathy involves deposition of intratubular crystals, tubular obstruction and cell death. This study investigated the modes of adenine-induced tubular cell death and found that baicalein can act as a novel cell death inhibitor. Baicalein inhibits cell death by modulating the mitochondrial antioxidant enzyme SOD2.
CELL DEATH & DISEASE
(2022)
Article
Multidisciplinary Sciences
Kunihiro Nakai, Minato Umehara, Atsushi Minamida, Hiroko Yamauchi-Sawada, Yasuto Sunahara, Yayoi Matoba, Natsuko Okuno-Ozeki, Itaru Nakamura, Tomohiro Nakata, Aya Yagi-Tomita, Noriko Uehara-Watanabe, Tomoharu Ida, Noriyuki Yamashita, Michitsugu Kamezaki, Yuhei Kirita, Eiichi Konishi, Hiroaki Yasuda, Satoaki Matoba, Keiichi Tamagaki, Tetsuro Kusaba
Summary: Streptozotocin (STZ) is an anti-cancer drug used to treat neuroendocrine tumors (NETs). It enters pancreatic beta-cells or proximal tubular epithelial cells through GLUT2. This study demonstrated the cytotoxic effects of STZ on kidney cells and identified DNA damage and p53 signaling as underlying mechanisms. Inhibition of p53 and SGLT2 mitigated kidney injury caused by STZ, but the cytotoxic effects on pancreatic beta-cells were not affected. These findings suggest the potential use of SGLT2 inhibitors as preventive treatments for kidney injury in NET patients treated with STZ.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
Joana D'Arc Campeiro, Wendy A. Dam, Mirian A. F. Hayashi, Jacob van den Born
Summary: Proteinuria promotes progressive tubulointerstitial fibrosis in kidneys, and this process is mainly driven by the activation of proximal tubular epithelial cells (PTECs). PTEC syndecan-1 serves as a docking platform for properdin-mediated alternative complement activation during proteinuria. The use of a non-viral gene delivery vector targeting PTEC syndecan-1 could be beneficial for reducing alternative complement activation.
Article
Environmental Sciences
Wenxuan Dong, Gang Liu, Kanglei Zhang, Yun Tan, Hui Zou, Yan Yuan, Jianhong Gu, Ruilong Song, Jiaqiao Zhu, Zongping Liu
Summary: Cd exposure induces kidney cell injury by inhibiting autophagic flux leading to p62 accumulation and Nrf2 nucleus translocation. Nrf2 nucleus translocation inhibits AMPK phosphorylation, activates the AKT/mTOR signaling, and ultimately results in rPT cell injury.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Oncology
Yousef Salama, Satoshi Takahashi, Yuko Tsuda, Yoshio Okada, Koichi Hattori, Beate Heissig
Summary: We discovered that induction of tumor suppressor p53 in melanoma cells inhibits tumor growth by targeting LRP1 expression, which is achieved through microRNAs miR103/107. We identified the small molecule YO-2 as an inducer of p53 and proposed its combination with doxorubicin as a novel treatment option. These findings highlight the importance of p53 and LRP1 in melanoma growth and suggest potential therapeutic strategies.
Article
Cardiac & Cardiovascular Systems
Raihan Kabir, Prithvi Sinha, Sumita Mishra, Obialunanma Ebenebe, Nicole Taube, Chistian U. Oeing, Gizem Keceli, Rui Chen, Nazareno Paolocci, Ana Rule, Mark J. Kohr
Summary: This study establishes a mechanistic link between environmentally relevant doses of inorganic arsenic (iAS) and pathological hypertrophy in the heart. Results show that iAS exposure may induce pathological cardiac hypertrophy not only by increasing systolic blood pressure, but also by potentially activating calcineurin-nuclear factor of activated T cells and inducing fetal gene expression. These findings provide new mechanistic insights into the threat of iAS exposure to the heart, necessary for identifying targets for medical and public health interventions.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Biology
Shintaro Ide, Yoshihiko Kobayashi, Kana Ide, Sarah A. Strausser, Koki Abe, Savannah Herbek, Lori L. O'Brien, Steven D. Crowley, Laura Barisoni, Aleksandra Tata, Purushothama Rao Tata, Tomokazu Souma
Summary: The study reveals that proximal tubular cells develop a pro-inflammatory state following injury, which can lead to persistent inflammation and fibrosis. After mild injury, these inflammatory PT cells transiently appear and make the cells vulnerable to ferroptotic stress; while after severe injury, they accumulate and enhance inflammation and fibrosis.
Article
Nutrition & Dietetics
Shisheng Jiang, Chaoming Huang, Guodong Zheng, Wei Yi, Bo Wu, Junyuan Tang, Xiawen Liu, Biyun Huang, Dan Wu, Tingdong Yan, Mingxi Li, Chunpeng Wan, Yi Cai
Summary: Epigallocatechin-3-gallate (EGCG), a catechin in green tea, inhibits cell proliferation and promotes apoptosis in human nasopharyngeal carcinoma (NPC) cells. It down-regulates SIRT1 and involves the SIRT1-p53 signaling pathway in this process.
FRONTIERS IN NUTRITION
(2022)
Article
Engineering, Environmental
Zhi-Hua Dai, You-Jing Peng, Song Ding, Jia-Yi Chen, Si-Xue He, Chun-Yan Hu, Yue Cao, Dong-Xing Guan, Lena Q. Ma
Summary: Selenate treatment can enhance arsenic (As) accumulation in the hyperaccumulator plant Pteris vittata, mainly by promoting reduction of AsV to AsIII, translocation of AsIII from roots to fronds, and sequestration of AsIII into vacuoles in the fronds. This finding suggests that selenate may be used to enhance phytoremediation of As-contaminated soils using P. vittata.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Engineering, Environmental
Jun-Xiu Chen, Yue Cao, Xiangjuan Yan, Yanshan Chen, Lena Q. Ma
Summary: The ACR3 genes in arsenic hyperaccumulator Pteris vittata were studied in yeast and tobacco, showing their roles in regulating arsenic translocation and sequestration. PvACR3;2 facilitated AsIII translocation to the shoots and efflux from the roots in tobacco, while PvACR3;3 sequestered AsIII in tobacco root vacuoles.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Chi Zhang, Zhihuang Zheng, Kexin Xu, Guozhe Cheng, Huijuan Wu, Jun Liu
Summary: This study reveals that LATS2 deficiency exacerbates maladaptive repair after acute kidney injury and contributes to the progression of kidney disease. LATS2 deficiency activates p53 and increases the level of apoptotic molecules while decreasing the level of anti-apoptotic molecules. Inhibiting p53 effectively attenuates the damage caused by LATS2 deficiency. Additionally, overexpression of LATS2 decreases the expression of p53. In conclusion, LATS2 deficiency aggravates maladaptive repair through the regulation of the MDM2-p53 axis in acute kidney injury-induced damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Toxicology
Momoka Ota, Takeshi Funakoshi, Toshihiko Aki, Kana Unuma, Koichi Uemura
Summary: Oxcarbazepine, a derivative of carbamazepine, induces G2/M cell cycle arrest in renal proximal tubular cells by inhibiting centrosome separation, leading to mitotic catastrophe and apoptosis.
TOXICOLOGY LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Samuel Shin, Cliff-Lawrence Ibeh, Eugenia Awuah Boadi, Bok-Eum Choi, Sanjit K. Roy, Bidhan C. Bandyopadhyay
Summary: A regulated Ca2+ entry pathway through the transient receptor potential canonical 3 (TRPC3) channel was found in proximal tubule (PT) cells, initiating transcellular Ca2+ transport. Knockout of TRPC3 gene in mice resulted in hypercalciuria and the formation of calcium phosphate (CaP) crystals, causing PT cell damage and mixed stone formation.
