Article
Nanoscience & Nanotechnology
Melissa Chernick, Alan Kennedy, Treye Thomas, Keana C. K. Scott, Christine Ogilvie Hendren, Mark R. Wiesner, David E. Hinton
Summary: Polymer nanocomposites combine the characteristics of polymers and nanomaterials, but ingestion of these materials may pose health risks. Particularly, multi-walled carbon nanotubes (MWCNTs) may contribute to toxicity and unique effects.
Article
Marine & Freshwater Biology
Abraham J. Fischer, Leslie Kerr, Tamanna Sultana, Chris D. Metcalfe
Summary: The study found that exposure to codeine reduced reproductive capacity and altered hormone levels in fish. However, exposure to fentanyl did not affect fish reproduction or hormone levels. Monitoring in southern Ontario, Canada showed that concentrations of fentanyl and codeine in surface waters were environmentally relevant. These findings contribute to understanding the impacts of opioids and other drugs released into surface waters.
AQUATIC TOXICOLOGY
(2021)
Article
Environmental Sciences
Elizabeth DiBona, Carol Haley, Simon Geist, Frauke Seemann
Summary: Microplastic pollution is a potential threat to environmental and human health. This study reveals that microplastics are present in all ecosystems and can contaminate food and water sources. Exposure to polyethylene fibers during the development stage of Japanese medaka fish results in delayed hatching and adverse effects at the molecular and organismal levels. These findings suggest a potential risk of polyethylene fiber exposure for wild fish during reproductive development.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2022)
Article
Marine & Freshwater Biology
Kun Chen, Naoto Iwasaki, Xuchun Qiu, Hai Xu, Yuki Takai, Kosuke Tashiro, Yohei Shimasaki, Yuji Oshima
Summary: The widely used antifoulant tributyltin chloride (TBT) was found to have significant effects on bone morphology and adipogenic processes in juvenile Japanese medaka, possibly induced through metabolic processes and oxidative phosphorylation pathways.
AQUATIC TOXICOLOGY
(2021)
Article
Environmental Sciences
Ruichao Chen, Jianwu He, Yu Li, Lihui An, Jianying Hu
Summary: Tricresyl phosphate (TCrP), a commonly found compound in global water sources, has been found to have potential reproductive toxicity to fish. Exposure to TCrP resulted in significant fertilization inhibition and induced intersex in Japanese medaka larvae. The compound also caused dilation of the efferent duct in the testes. Metabolites of TCrP exhibited higher androgen receptor antagonistic activity and anti-estrogenic activities, which may contribute to the observed adverse outcomes. These adverse effects occurred at environmentally relevant concentrations, indicating considerable ecological risk to wild fish.
ENVIRONMENTAL POLLUTION
(2022)
Article
Environmental Sciences
Asok K. Dasmahapatra, Paul B. Tchounwou
Summary: In this study, the effects of graphene oxide (GO) as an endocrine disrupting chemical (EDC) on the endocrine pancreas of Japanese medaka adults were investigated. It was found that GO exposure enhanced immunoreactivity in the islet organs, and the impairments in the pancreas were inconsistent and influenced by exposure routes and sex of the fish.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Immunology
Yoshie Takahashi, Yo Okamura, Nanaki Harada, Mika Watanabe, Hiroshi Miyanishi, Tomoya Kono, Masahiro Sakai, Jun-ichi Hikima
Summary: This study on Japanese medaka revealed that IL-22 is crucial for maintaining intestinal homeostasis and plays a significant role in promoting intestinal healing and preventing exacerbation of inflammatory pathology.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Fisheries
Muhammad Fariz Zahir Ali, Kenta Kameda, Fumitaka Kondo, Toshiharu Iwai, Rio Aditya Kurniawan, Takashi Ohta, Atsushi Ido, Takayuki Takahashi, Chiemi Miura, Takeshi Miura
Summary: This study demonstrates that dietary silkrose-AY from the Japanese oak silkmoth can enhance the survival of medaka fish infected with Edwardsiella tarda, while decreasing bacterial load in their kidneys. Microarray analysis revealed differential expression of 2930 genes in the intestine of fish fed with silkrose-AY, highlighting the involvement of various genes related to pathogen recognition, complement cascade, antimicrobial peptides/enzymes, opsonization/phagocytosis, and epithelial junctional modification in the immune response to bacterial infection.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Environmental Sciences
Shinichi Chisada, Masao Yoshida, Kanae Karita
Summary: This study evaluated the adverse effects of polyethylene microplastic beads on the growth, reproduction, eyes, and kidneys of medaka under breeding conditions. Although histologic analyses showed an absence of microplastics in the tissues, adverse effects were still observed in the eyes, kidneys, and reproduction, with increased microplastic concentrations. The data suggested that microplastics were more toxic to the eyes and reproduction than the kidneys or growth.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Marilyn W. Mason, Emily M. Bertucci, Faith M. Leri, Benjamin B. Parrott
Summary: Combination of environmental stressors, such as CuSO4 exposure and high temperature, can affect the development and survival of organisms. In addition to impacting survival rates, CuSO4 exposure during development may lead to changes in sex and fin regenerative capabilities in fish. These findings suggest that developmental Cu exposure can have long-lasting effects on organismal growth and function.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2022)
Article
Fisheries
Natsuki Morimoto, Yo Okamura, Tomoya Kono, Masahiro Sakai, Jun-ichi Hikima
Summary: ASC genes in Japanese medaka show different expression patterns, with asc1 having higher expression levels in multiple organs, suggesting a possible dominant role in inflammation. The expression of asc genes is regulated differently under infection and stimulation conditions, with asc2 and asc3 showing significantly higher expression levels during A. hydrophila infection.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Engineering, Environmental
Chenyang Ji, Philip Tanabe, Qingyang Shi, Le Qian, Victoria McGruer, Jason T. Magnuson, Xinru Wang, Jay Gan, Rama S. Gadepalli, John Rimoldi, Daniel Schlenk
Summary: The study found enantioselective oxidation of BF to an estrogenic metabolite in zebrafish embryos, with increased formation after liver development. However, this metabolism was not observed in medaka embryos. These results indicate species-specific effects in BF metabolism.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Fisheries
Mika Watanabe, Yo Okamura, Tomoya Kono, Masahiro Sakai, Jun-ichi Hikima
Summary: This study analyzed the functional significance of IL-22 in fish gills and found that IL-22 may be involved in immune responses through the production of inflammatory cytokines and antimicrobial peptides in fish gills.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2023)
Article
Cell Biology
Ke Lu, Xiaodan Jia, Jiaqi Wu, Qiuling Wang, Xu-Fang Liang
Summary: In this study, a npy2r-deficient medaka model was established using the CRISPR/Cas9 system. The deletion of npy2r resulted in an all-male medaka population and increased food intake. It also led to significant changes in the expression levels of appetite stimulating and anorexia factors. Moreover, npy2r deletion improved sociability and reduced anxiety-like behavior in medaka, accompanied by decreased expression levels of anxiety-related genes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Toxicology
Kaori Miyaoku, Yukiko Ogino, Anke Lange, Ayaka Ono, Tohru Kobayashi, Masaru Ihara, Hiroaki Tanaka, Kenji Toyota, Hiroshi Akashi, Genki Yamagishi, Tomomi Sato, Charles R. Tyler, Taisen Iguchi, Shinichi Miyagawa
Summary: The study cloned and characterized two genes encoding medaka Gper1, Gper1a and Gper1b, showing that Gper1a can mediate estrogen effects on oocytes through the activation of the MAPK pathway. 17α-ethinylestradiol and bisphenol A enhanced MAPK phosphorylation through medaka Gper1, but did not affect oocyte maturation.
JOURNAL OF APPLIED TOXICOLOGY
(2021)