Article
Environmental Sciences
Jing Leng, Hongyi Li, Yuequn Niu, Kelie Chen, Xiaoyu Yuan, Hanwen Chen, Zhiqin Fu, Lihuan Zhang, Fang Wang, Chaoyi Chen, Paul Heroux, Jun Yang, Xinqiang Zhu, Weiguo Lu, Dajing Xia, Yihua Wu
Summary: Low-dose MEHP promotes ovarian cancer progression through activating the PI3K/Akt/NF-kappa B pathway in a PPAR alpha-dependent manner.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Chemistry, Multidisciplinary
Kuo-Cheng Lan, Te- Weng, Wei-Che Chiang, Chen-Yuan Chiu, Ding-Cheng Chan, Rong-Sen Yang, Shing-Hwa Liu
Summary: DEHP and its metabolite MEHP have been found to inhibit myogenesis in vitro, suggesting their potential role as environmental risk factors affecting muscle differentiation.
APPLIED SCIENCES-BASEL
(2022)
Article
Environmental Sciences
Qi Xu, Liting Zhou, Hyonju Ri, Xu Li, Xueting Zhang, Wen Qi, Lin Ye
Summary: This study found that MEHP can induce thyroid damage by upregulating the expression of ERs and further activating endoplasmic reticulum stress, leading to a decrease in cell viability and an increase in cell apoptosis.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2022)
Article
Toxicology
Zeze Wang, Yi Liu, Xuehui Liu, Lixiao Zhou, Xindi Ma, Junyao Liu, Lei Wang, Huicai Guo
Summary: The cardiotoxicity of MEHP is mediated by reduced cell viability, mitochondrial dysfunction, oxidative stress, and apoptosis in cardiomyocytes. FOXO3a plays a critical role in defending against MEHP-induced oxidative stress and apoptosis by upregulating the expression of Mn-SOD and ARC.
JOURNAL OF APPLIED TOXICOLOGY
(2021)
Article
Environmental Sciences
Wen Qi, Qi Xu, Yixuan Xu, Zheng Wang, Liwei Yang, Shuangyu Guo, Yanbin Shi, Tianyang Zhao, Liting Zhou, Lin Ye
Summary: Exposure to MEHP can increase intracellular TG content in 3T3-L1 cells, leading to abnormal expression of Notch pathway genes and lipid metabolic related genes, with Notch-1 and Jagged-2 playing critical roles in this process.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Toxicology
Samantha Lapehn, Scott Houghtaling, Kylia Ahuna, Leena Kadam, James W. MacDonald, Theo K. Bammler, Kaja Z. LeWinn, Leslie Myatt, Sheela Sathyanarayana, Alison G. Paquette
Summary: This study investigated changes in placental gene expression in response to exposure to the phthalate metabolite MEHP. The researchers found that MEHP affected gene expression in the placenta, with male placentas being more responsive to exposure. Pathway analysis identified several key metabolic pathways and transcription factors associated with MEHP exposure. This study provides new insights into the toxic effects of phthalates on placental gene expression and generates new hypotheses for further research.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jian Xu, Liming Wang, Lihuan Zhang, Fang Zheng, Fang Wang, Jianhang Leng, Keyi Wang, Paul Heroux, Han-Ming Shen, Yihua Wu, Dajing Xia
Summary: MEHP exacerbates cytotoxicity by amplifying the PINK1-Parkin-mediated mitophagy pathway, leading to increased mitochondrial damage and robust mitophagy. Co-treatment with N-acetyl cysteine (NAC) counteracted the effects of MEHP-CCCP, suggesting that mitochondrial ROS played a vital role in this process. The findings provide insights into the potential roles of endocrine disrupting chemicals (EDCs) in human diseases such as Parkinson's disease.
Article
Environmental Sciences
Bo Zhang, Xu Li, Xueting Zhang, Jiaming Ye, Weisen Zhao, Meng Zhang, Jiqiang Xing, Wen Qi, Lin Ye
Summary: MEHP exposure can promote neuroblastoma cell proliferation, alter the cell cycle, and affect cell apoptosis. The Notch pathway plays a critical role in this process.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiuzhen Liu, Ana M. Adamo, Patricia I. Oteiza
Summary: The study found that gestational exposure to DEHP could cause secondary zinc deficiency and impaired neurogenesis, which may have long-term consequences on the brain structure and function of adult offspring.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Toxicology
Yifan Hong, Xiazhu Zhou, Qi Li, Jing Chen, Yuexin Wei, Lianju Shen, Chunlan Long, Shengde Wu, Guanghui Wei
Summary: This study demonstrated that epigallocatechin gallate (EGCG) from green tea can protect germ cells from severe injury induced by mono-2-ethylhexyl phthalate (MEHP). It does so by reducing reactive oxygen species (ROS) generation, suppressing the mTOR pathway, and inhibiting pyroptosis. EGCG may serve as a potential treatment for MEHP-related spermatogenic dysfunction.
TOXICOLOGY IN VITRO
(2023)
Article
Pharmacology & Pharmacy
Yu-Ting Zhu, Yi-Zhen Yuan, Qiu-Ping Feng, Meng-Yuan Hu, Wen-Jie Li, Xiu Wu, Su-Yun Xiang, Shu-Qin Yu
Summary: The study found that polysorbate 80 (P80) promotes the oral absorption of Di-2-ethylhexyl phosphate (DEHP) mainly by altering the mucus barrier and mucosal barrier of the small intestine, increasing the permeability of intestinal epithelial cells.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Environmental Sciences
Gizem Ozkemahli, Pinar Erkekoglu, Ayse Ercan, Naciye Dilara Zeybek, Nilgun Yersal, Belma Kocer-Gumusel
Summary: This study investigates the toxic effects of BPA and/or MEHP on the HepG2 cell line. The results suggest that combined exposure to these chemicals may cause serious toxicological outcomes.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Chien-Yu Lin, Ching-Way Chen, Hui-Ling Lee, Charlene Wu, Chikang Wang, Fung-Chang Sung, Ta-Chen Su
Summary: Global DNA methylation plays a mediating role in the relationship between DEHP exposure and endothelial cell function. These findings suggest that DNA methylation may be involved in the pathogenesis of DEHP-induced endothelial cell apoptosis. Further studies are needed to confirm the causal relationship.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Environmental Sciences
Luis Daniel Martinez-Razo, Alejandra Martinez-Ibarra, Edgar Ricardo Vazquez-Martinez, Marco Cerbon
Summary: DEHP, considered an endocrine disruptor chemical (EDC), is widely used in the plastic industry and can have negative effects on placental development and function, potentially impacting fetal growth. Research indicates that DEHP and MEHP can impair key processes in placental development and affect various placental functions. Clinical evidence also supports the connection between DEHP exposure and adverse pregnancy outcomes and pathologies.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Food Science & Technology
Donghyun Kim, Eujin Oh, Haram Kim, Seung Mi Baek, Junho Cho, Eun-Hye Kim, Sungbin Choi, Yiying Bian, Wondong Kim, Ok-Nam Bae
Summary: Phthalates in contaminated foods and personal care products are commonly exposed chemicals with potential health concerns. The mechanism behind the relationship between phthalate exposure and cardiovascular diseases, such as diabetic vascular complications and cerebrovascular diseases, is still unclear. This study investigated the damage to the blood-brain barrier by di-(2-ethylhexyl) phthalate (DEHP) or its metabolite mono-(2-ethylhexyl) phthalate (MEHP), and found that MEHP, especially in the presence of methylglyoxal (MG), significantly increased the damage. This research provides new insights into the enhanced toxicity of phthalates in susceptible populations, such as diabetic patients.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
