Article
Multidisciplinary Sciences
Naoko Yamagishi, Yuta Yamamoto, Toshio Nishi, Takao Ito, Yoshimitsu Kanai
Summary: Lansoprazole exerts antioxidant effects by activating the Nrf2 pathway and provides hepatoprotection in a drug-induced hepatitis animal model. The cytoprotective effect of lansoprazole on liver epithelial cells against cisplatin-induced cytotoxicity is mediated through the p38 MAPK signaling pathway. This study suggests the potential application of lansoprazole in preventing and treating oxidative liver injury.
Article
Cell Biology
Simeng He, Jia Shi, Wenming Liu, Shihan Du, Yuan Zhang, Lirong Gong, Shuan Dong, Xiangyun Li, Qiaoying Gao, Jing Yang, Jianbo Yu
Summary: The present study found that heme oxygenase-1 (HO-1) can attenuate endotoxin-induced acute lung injury (ALI) by regulating nicotinamide adenine dinucleotide (NAD(+)) and NAD(+)-mediated mitonuclear communication through the PGC1 alpha/PPAR gamma pathway. The study observed that NAD(+) affected mitonuclear communication and imbalance, and that the inhibition of the PGC1 alpha/PPAR gamma signaling exacerbated septic lung injury by reducing NAD(+) levels.
INFLAMMATION RESEARCH
(2022)
Article
Cell Biology
Jia Shi, Shi-Han Du, Jian-Bo Yu, Yan-Fang Zhang, Si-Meng He, Shu-An Dong, Yuan Zhang, Li-Li Wu, Cui Li, Hai-Bo Li
Summary: The study demonstrated that pretreatment with hydromorphone could alleviate pneumoperitoneum-induced lung injury in mice by enhancing HO-1-regulated mitochondrial dynamics. In clinical patients, hydromorphone pretreatment resulted in lower levels of CC-16 and ICAM-1 compared to morphine pretreatment.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Biochemistry & Molecular Biology
Seong Hoon Kim, Hye-Won Yum, Seung Hyeon Kim, Su-Jung Kim, Kyeojin Kim, Chaekyun Kim, Young-Ger Suh, Young-Joon Surh
Summary: Taurine chloramine (TauCl) can effectively protect the skin from photodamage by reducing oxidative damage, apoptotic cell death, and inflammation. This protective effect is associated with inhibition of STAT3 activation and induction of antioxidant enzymes.
Article
Gastroenterology & Hepatology
Shao-Wei Li, Terumi Takahara, Weitao Que, Masayuki Fujino, Wen-Zhi Guo, Shin-Ichi Hirano, Li-Ping Ye, Xiao-Kang Li
Summary: Hydrogen-rich water (HRW) protects mice with nonalcoholic fatty liver disease by increasing the expression of Sirt1 in hepatocytes, which leads to the suppression of abnormal fat metabolism. In a NASH mouse model, HRW reduces the expression of inflammatory cytokines, alleviates tissue damage, and reverses preexisting hepatic fibrosis.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2021)
Article
Immunology
Bitna Kweon, Dong-Uk Kim, Jin-Young Oh, Gi-Sang Bae, Sung-Joo Park
Summary: Guggulsterone (GS) exerts anti-inflammatory effects by inducing heme oxygenase-1 (HO-1) expression through reactive oxygen species (ROS) production. GS inhibits the expression of inflammatory mediators and prolongs survival in an endotoxemia model.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Kelly J. Peyton, Ghazaleh Behnammanesh, Giovanna L. Durante, William Durante
Summary: Research shows that canagliflozin can act as a novel inducer of HO-1 in human ECs. While HO-1 contributes to the anti-inflammatory action, it does not affect the anti-proliferative and antimigratory effects of the drug.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Virginia Athanassiadou, Stella Plavoukou, Eirini Grapsa, Maria G. Detsika
Summary: The protein heme oxygenase-1 plays a key role in kidney disease and affects immune pathways and responses, as demonstrated by animal models and patient studies.
Article
Medicine, Research & Experimental
Xiao Liu, Ling Wang, Qunzhi Xing, Kehan Li, Jianluo Si, Xiaowu Ma, Lianjing Mao
Summary: Sevoflurane exerts a protective effect on lipopolysaccharide-induced acute lung injury by regulating ferroptosis through up-regulating HO-1 expression, which may provide a possible mechanism for its application in clinical anesthesia.
Article
Plant Sciences
Jing Ni, Yuanmin Li, Yawei Xu, Rong Guo
Summary: Salidroside has been found to significantly improve diabetes-induced cardiac dysfunction, hypertrophy, and fibrosis by up-regulating HO-1 expression through activation of the AKT signaling pathway. This demonstrates the cardio-protective effect of salidroside in diabetic mice, which is dependent on AKT signaling activation.
Article
Immunology
Ziheng Yang, Jie Zhang, Yan Wang, Jing Lu, Quan Sun
Summary: This study reveals that Cav1 deficiency in mice provides protection against acute liver injury, reducing hepatocyte degeneration, necrosis, and apoptosis as well as lowering ALT levels. Cav1 is also crucial for the polarization of hepatic macrophages, with its deficiency inhibiting the polarization towards the M1 phenotype. These findings suggest that Cav1 expressed in macrophages could be a potential therapeutic target for acute liver injury.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Wei -Chun Chen, Chung-Hao Huang, Wangta Liu, Jin-Ching Lee
Summary: Dengue virus (DENV) infection is a life-threatening disease with no effective treatment options. However, a study found that sulforaphane (SFN) has significant antiviral activity against DENV by inducing heme oxygenase-1 (HO-1) expression and inhibiting viral protease activity. This suggests that SFN could be a promising candidate for treating DENV.
ANTIVIRAL RESEARCH
(2022)
Article
Hematology
Louise L. Dunn, Stephanie M. Y. Kong, Sergey Tumanov, Weiyu Chen, James Cantley, Anita Ayer, Ghassan J. Maghzal, Robyn G. Midwinter, Kim H. Chan, Martin K. C. Ng, Roland Stocker
Summary: The stress-induced enzyme Hmox1 plays a protective role against cardiovascular diseases and ischemic injury by interacting with HIF-1 alpha and regulating cellular metabolism. Lack of Hmox1 leads to impaired blood flow recovery, tissue necrosis, and autoamputation, highlighting its crucial role in ischemic injury protection.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Yan Hao, Jie Miao, Wenjia Liu, Li Peng, Yue Chen, Qing Zhong
Summary: This study demonstrated that FOR protects against CIS-induced AKI through activation of the PPAR alpha/Nrf2/HO-1/NQO1 pathway. Additionally, FOR and eupatilin promote cell viability and antioxidant enzyme activity, while showing significant inhibitory effects on apoptosis and inflammatory factors in HK-2 cells.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Bo Yoon Chang, Hyung Joong Kim, Tae Young Kim, Sung Yeon Kim
Summary: The study indicates that pre-treatment with ETZL can effectively reduce alcohol-induced liver injury, decrease oxidative stress, and enhance antioxidant defense mechanisms.
