Article
Hematology
Jieru Shen, Satish Casie Chetty, Sepideh Shokouhi, Jenish Maharjan, Yevheniy Chuba, Jacob Calvert, Qingqing Mao
Summary: This study conducted a large-scale external validation of a machine learning-based PE prediction model. The results showed that the model performed well across different patient populations, demonstrating its generalizability and potential as a clinical decision support tool to aid PE detection and improve patient outcomes.
THROMBOSIS RESEARCH
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sadjad Riyahi, Hreedi Dev, Ashkan Behzadi, Jinhye Kim, Hanieh Attari, Syed Raza, Daniel J. Margolis, Ari Jonisch, Ayah Megahed, Anas Bamashmos, Kareem Elfatairy, Martin R. Prince
Summary: This study aimed to determine the incidence of PE in patients with COVID-19, revealing that 25% of COVID-19 patients were diagnosed with PE. The study also found that PE was associated with male sex, smoking, as well as increased levels of d-dimer, lactate dehydrogenase, ferritin, and interleukin-6. Additionally, d-dimer levels greater than 1600 ng/mL showed high sensitivity in identifying patients who required CT pulmonary angiography.
Article
Medicine, General & Internal
Paul D. Stein, Fadi Matta, Patrick G. Hughes, Mary J. Hughes
Summary: The study assessed the 19-year national trend in mortality of high-risk patients with pulmonary embolism from 1999 to 2017, finding a decrease in mortality in all high-risk patients, which was attributed to improved treatment of patients, rather than advances in therapy for pulmonary embolism.
AMERICAN JOURNAL OF MEDICINE
(2021)
Article
Health Care Sciences & Services
Nikolaos Pagkratis, Miltiadis Matsagas, Foteini Malli, Konstantinos Gourgoulianis, Ourania S. Kotsiou
Summary: This study evaluated the prevalence and clinical characteristics of hemorrhages in hospitalized patients with pulmonary embolism. The results showed that approximately one-fifth of the patients experienced hemorrhagic complications, with the majority being minor and of short duration. Nadroparin was the medication most commonly associated with major bleeding events.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Respiratory System
Khalid Shalaby, Adriana Kahn, Elizabeth S. Silver, Min Jung Kim, Kathir Balakumaran, Agnes S. Kim
Summary: Cancer-associated PE imposes a significant burden on patients and healthcare systems. Analysis of the data revealed noticeable differences in clinical outcomes and healthcare utilization between patients with and without cancer.
BMC PULMONARY MEDICINE
(2022)
Article
Medicine, General & Internal
Valerie M. Vaughn, Monica Yost, Chelsea Abshire, Scott A. Flanders, David Paje, Paul Grant, Scott Kaatz, Tae Kim, Geoffrey D. Barnes
Summary: This study analyzed a large, multicenter cohort of patients hospitalized with COVID-19 and found that only a small number of patients had confirmed VTE, with varying use of treatment-dose anticoagulation across hospitals. Nonadherence to VTE prevention and anticoagulation strategies were associated with 60-day mortality, while receiving any dose of anticoagulation (compared to no anticoagulation) was associated with lower in-hospital mortality.
Article
Infectious Diseases
Alberto Garcia-Ortega, Grace Oscullo, Pilar Calvillo, Raquel Lopez-Reyes, Raul Mendez, Jose Daniel Gomez-Olivas, Amina Bekki, Carles Fonfria, Laura Trilles-Olaso, Enrique Zaldivar, Ana Ferrando, Gabriel Anguera, Andres Briones-Gomez, Juan Pablo Reig-Mezquida, Laura Feced, Paula Gonzalez-Jimenez, Soledad Reyes, Carlos F. Munoz-Nunez, Ainhoa Carreres, Ricardo Gil, Carmen Morata, Nuria Toledo-Pons, Luis Marti-Bonmati, Rosario Menendez, Miguel Angel Martinez-Garcia
Summary: The study revealed a high incidence of pulmonary embolism in hospitalized COVID-19 patients, with heart rate, spO2, D-dimer, and CRP levels at admission serving as predictors of PE during hospitalization.
JOURNAL OF INFECTION
(2021)
Article
Hematology
Douglas Buckheit, Amanda Lefemine, Diana M. Sobieraj, Laura Hobbs
Summary: The study found that reducing anticoagulant doses for VTE prophylaxis in underweight medical patients is a common practice and is associated with less major bleeding. However, the incidence of clinically relevant non-major bleeding and VTE was similar between the two groups.
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
(2021)
Article
Cardiac & Cardiovascular Systems
Aaron Shengting Mai, Andrija Matetic, Islam Y. Elgendy, Juan Lopez-Mattei, Rafail A. Kotronias, Louise Y. Sun, Jung Hahn Yong, Rodrigo Bagur, Harriette G. C. Van Spall, Mamas A. Mamas
Summary: This study evaluated the clinical care provided to cancer patients hospitalized for acute pulmonary embolism and assessed the association between type of cancer, in-hospital care, and clinical outcomes. The results showed that cancer patients were less likely to receive invasive management compared to non-cancer patients. Cancer patients had higher odds of mortality, with lung cancer patients having the highest mortality and hemorrhagic stroke risk, while colorectal cancer patients had the highest bleeding risk.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Surgery
Emad A. Hussein, Dana B. Semaan, Amanda R. Phillips, Elizabeth A. Andraska, Belinda N. Rivera-Lebron, Rabih A. Chaer, Mohammad H. Eslami, Natalie Sridharan
Summary: This study describes the experience of a large multihospital single-network institution with multidisciplinary pulmonary embolism (PE) response teams (PERT). The results show that PERT improves the management of acute PE by increasing the number of patients receiving a full PE workup and specialty consultations, as well as utilizing advanced therapies. However, implementation of PERT did not significantly change the mortality rate. Further research is needed to assess the long-term survival of patients with massive PE after PERT implementation.
JOURNAL OF VASCULAR SURGERY-VENOUS AND LYMPHATIC DISORDERS
(2023)
Article
Hematology
Jeeyune Bahk, Abdul Rehman, Kam Sing Ho, Bharat Narasimhan, Hafiza Noor Ul, Ain Baloch, Jiafang Zhang, Rowena Yip, Robert Lookstein, David J. Steiger
Summary: A retrospective case-control study found that 40.8% of COVID-19 patients had a pulmonary embolism (PE), and the presence of PE was associated with certain clinical characteristics and biomarkers. These findings can aid in the early identification and reduction of PE-related mortality in COVID-19 patients.
THROMBOSIS JOURNAL
(2023)
Article
Medicine, General & Internal
Orly Efros, Tal Beit Halevi, Eshcar Meisel, Shelly Soffer, Noam Barda, Omri Cohen, Gili Kenet, Aharon Lubetsky
Summary: An elevated NLR in patients hospitalized with acute PE is associated with increased short-term and long-term mortality risk, longer hospital stays, and higher in-hospital mortality rates.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Joseph G. Noto, Parth Rali
Summary: This study examined the role and potential benefits of dedicated pulmonary follow-up after hospital discharge for patients with pulmonary embolism (PE).
PULMONARY CIRCULATION
(2022)
Article
Multidisciplinary Sciences
Lujuan Ye, Hailiang Xie, Minggui Lai, Guofu Zheng, Yuancai Xie, Xiaochun Liu
Summary: This study aimed to determine the independent risk factors for acute hospital-acquired symptomatic pulmonary embolism (HA-SPE) by comparing clinical data with acute nonhospital-acquired symptomatic pulmonary embolism (NHA-SPE). The analysis included 292 patients, of whom 191 had acute NHA-SPE and 101 had acute HA-SPE. The multivariate analysis identified malignant tumor, recent surgery, previous VTE, and length of stay as independent risk factors for acute HA-AEP. Strengthening prevention and control measures for patients with these risk factors may reduce the incidence of acute HA-SPE.
SCIENTIFIC REPORTS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Davide Ippolito, Teresa Giandola, Cesare Maino, Anna Pecorelli, Carlo Capodaglio, Maria Ragusi, Marco Porta, Davide Gandola, Alessandro Masetto, Silvia Drago, Pietro Allegranza, Rocco Corso, Cammillo Talei Franzesi, Sandro Sironi
Summary: This study analyzed pulmonary embolism (PE) in hospitalized patients affected by SARS-CoV-2 through chest CTPA, finding that PE-positive patients had slightly longer hospitalization time and majority were hospitalized in non-intensive wards. Overall, 85.9% of patients were discharged in three months, with a 14.1% mortality rate, among which 54.2% were PE-positive.