Article
Education, Scientific Disciplines
Karen A. Moser, Kristi J. Smock
Summary: Direct oral anticoagulants (DOACs) can interfere with hemostasis assays, leading to inaccurate results. Preanalytic strategies, educational materials, testing algorithms, DOAC-neutralizing agents, and interpretive comments can help in correctly interpreting laboratory tests in the presence of DOACs.
HEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM
(2021)
Article
Hematology
Chiara Ambaglio, Federica Zane, Maria Concetta Russo, Paola Stefania Preti, Luigia Scudeller, Catherine Klersy, Gabriella Gamba, Alessandro Squizzato
Summary: The study aimed to assess the usefulness of ISTH-BAT and laboratory screening tests in identifying mild undiagnosed bleeding disorders and predicting bleeding complications in selected surgical patients.
Article
Medicine, Research & Experimental
Junko Ichikawa, Ryouta Okazaki, Tomoki Fukuda, Daejoon Yoon, Makiko Komori
Summary: In a dilutional model study, the effects of hemodilution on clot wave analysis parameters, clotting factors, and thrombin generation assays were evaluated. Correlations were observed between aPTT and clotting factors, while rate/acceleration parameters and delta changed with variation in thrombin and fibrinogen generation. These findings can potentially aid in assessing coagulability.
MEDICAL SCIENCE MONITOR
(2022)
Article
Medicine, General & Internal
Eugenio Pagnussatt Neto, Paula Daniele Lopes da Costa, Sanderland J. Tavares Gurgel, Paula Schmidt Azevedo, Norma S. Pinheiro Modolo, Paulo do Nascimento Junior
Summary: This study aimed to assess the association between preoperative fibrinogen levels and perioperative blood-product transfusion in patients undergoing hip arthroplasty. The results showed that there was no association between preoperative fibrinogen levels and the need for blood transfusion.
Article
Medical Laboratory Technology
Silje Hovden Christensen, Peter Henrik Nissen, Niels Eykens Hjornet, Jacob Raben Greisen, Anne-Mette Hvas
Summary: This study found that arterial and venous blood samples have no significant differences in most coagulation parameters, except for two parameters which had very small differences that are clinically insignificant. In conclusion, both arterial and venous blood samples can be used for coagulation and fibrinolysis analysis.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2022)
Article
Medicine, General & Internal
Jennifer A. Rymer, Karen Chiswell, Lauren Young, Andy Chiu, Li Liu, Laura Webb, Matthew Carlisle, Daniel Friedman, Tracy Y. Wang
Summary: This study aimed to determine whether underdosing of DOACs is associated with longitudinal adherence to anticoagulation. The study found that a significant number of patients with nonvalvular atrial fibrillation received DOACs with doses that did not follow FDA labeling recommendations. This improper dosing was associated with worse renal function and less consistent long-term anticoagulation.
Article
Materials Science, Biomaterials
Xiao Fu, Ting Lei, Yuan Xiao, Ci Tang
Summary: Blood purification therapy is commonly used in the treatment of critically ill patients. However, most dialysis membranes are prone to thrombosis. In this study, a modified polyethersulfone membrane with an FXa inhibitor was developed. The modified membrane exhibited good hydrophilicity and dialysis performance, and effectively inhibited the activation of intrinsic, extrinsic, and common coagulation pathways. It also demonstrated excellent anticoagulant and antiplatelet activities.
BIOMATERIALS ADVANCES
(2022)
Review
Anesthesiology
Patricia Guilabert, Lars Asmis, Vicente Cortina, Joan P. Barret, Maria J. Colomina
Summary: Factor XIII (FXIII) is the final factor in the coagulation cascade and its deficiency can lead to surgical bleeding. Congenital FXIII deficiency is rare, while acquired FXIII deficiency is more common. This review provides guidance on the diagnosis and treatment of FXIII deficiency in preoperative consultation and surgical settings.
MINERVA ANESTESIOLOGICA
(2022)
Review
Medicine, General & Internal
Rahul Chaudhary, Amteshwar Singh, Rohit Chaudhary, Michael Bashline, Damon E. Houghton, Alejandro Rabinstein, Jill Adamski, Richard Arndt, Narith N. Ou, Maria Rudis, Caitlin S. Brown, Erin D. Wieruszewski, Matthew Wanek, Nathan J. Brinkman, Jane A. Linderbaum, Melissa A. Sorenson, John L. Atkinson, Kristine M. Thompson, Aryan N. Aiyer, Robert D. McBane
Summary: The study evaluated the safety and outcomes of different DOAC reversal agents among patients with ICH, and found that the anticoagulation reversal rates and safety profiles of different reversal agents were similar. Additionally, there were no significant differences between 4F-PCC and AA in terms of anticoagulation reversal, mortality, or thromboembolic events.
Article
Hematology
Pauline Vermeiren, Arne Vandevelde, Harlinde Peperstraete, Katrien M. J. Devreese
Summary: This study compared the effectiveness of global coagulation assays, including thrombin generation assay (TGA), with the anti-Xa assay for monitoring heparin therapy. The results showed that the TGA may not be sensitive enough for low concentrations of low molecular weight heparin (LMWH), but it could be a useful additional tool for monitoring heparin therapy in heparin-resistant patients.
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2022)
Article
Hematology
Anke Adenaeuer, Eyiuche D. Ezigbo, Hanan Fawzy Nazir, Stefano Barco, Alice Trinchero, Dagmar Laubert-Reh, Konstantin Strauch, Philipp S. Wild, Karl J. Lackner, Bernhard Laemmle, Heidi Rossmann
Summary: Severe prekallikrein deficiency is a rare autosomal-recessive condition. A variant in the KLKB1 gene causing PK deficiency was found to be common in Africans (allele frequency 1.43%) but absent in Europeans. This highlights the higher prevalence of PK deficiency among people of African descent compared to Europeans.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Multidisciplinary Sciences
Arman Jahangiri, Sara Ahmadi, Hassan Rafieemehr
Summary: This study aimed to assess the survival of patients with rare bleeding disorders (RBDs) in a five-year follow-up. The results showed that patients with RBDs had different rates of survival, and timely therapeutic interventions may improve their survival time.
Article
Cardiac & Cardiovascular Systems
Cornelius Keyl, Albina Bashota, Friedhelm Beyersdorf, Dietmar Trenk
Summary: The linear association between ROTEM and conventional laboratory tests is significant, but the predictability of ROTEM within clinically useful ranges is limited. The frequencies of exceeding intervention thresholds differ markedly between ROTEM and conventional tests, impacting treatment decisions significantly.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2022)
Article
Hematology
Nuanrat Tangcheewinsirikul, Chatphatai Moonla, Noppacharn Uaprasert, Rapat Pittayanon, Ponlapat Rojnuckarin
Summary: Compared with conventional SCT-guided transfusion, VET-guided strategy decreases periprocedural plasma and platelet transfusions and transfusion-related adverse events (TRAEs), without increasing hemorrhagic complications, length of stay (LOS) or mortality in cirrhosis.
Article
Biochemistry & Molecular Biology
Xiuxiu Wang, Juan Zhao, Shengli Ding, Hongyan Zhang
Summary: Nanoplastics are a type of emerging environmental contaminant that can enter the bloodstream and pose a risk to human health. This study found that polystyrene (PS), PS-NH2, and PS-COOH nanoparticles disrupt the structure of human fibrinogen (HF) in a dose-dependent manner, potentially affecting protein structure and function and inducing biological effects.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Hematology
Barbara Faganel Kotnik, Karin Strandberg, Marusa Debeljak, Lidija Kitanovski, Janez Jazbec, Majda Benedik-Dolnicar, Alenka Trampus Bakija
BLOOD COAGULATION & FIBRINOLYSIS
(2020)
Review
Hematology
Richard A. Marlar, Karin Strandberg, Midori Shima, Dorothy M. Adcock
EUROPEAN JOURNAL OF HAEMATOLOGY
(2020)
Article
Nutrition & Dietetics
Urban Alehagen, J. Alexander, J. Aaseth, A. Larsson, T. L. Lindahl
EUROPEAN JOURNAL OF NUTRITION
(2020)
Article
Biotechnology & Applied Microbiology
Jonas Holm, Ingemar Cederholm, Urban Alehagen, Tomas L. Lindahl, Zoltan Szabo
Article
Hematology
Andreas Hillarp, Karin Strandberg, Kerstin M. Gustafsson, Tomas L. Lindahl
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2020)
Article
Cell Biology
Anna Holm, Eva Swahn, Sofia Sederholm Lawesson, Kerstin M. Gustafsson, Magnus Janzon, Lena Jonasson, Tomas L. Lindahl, Joakim Alfredsson
Summary: In patients with myocardial infarction, women have a significantly higher rate of in-hospital bleeding events compared to men, although there were no significant differences in platelet aggregation between the sexes. The results do not support excess dosing of anti-platelet drugs as a major explanation for the increased bleeding risk in women.
Article
Hematology
Cecilia Augustsson, Eva Norstrom, Vivian Lind, Myriam Martin, Jan Astermark, Karin Strandberg
Summary: The study validated the monitoring of different FVIII products on Atellica Coag, showing good correlation and acceptable bias between CSA-1 and OSA. There was a clear dose-response relationship between thrombin generation parameters and products.
Article
Nutrition & Dietetics
Urban Alehagen, Jan Aaseth, Tomas L. Lindahl, Anders Larsson, Jan Alexander
Summary: Supplementation with selenium and coenzyme Q(10) can reduce D-dimer levels and the risk of cardiovascular mortality. The study results demonstrate that supplementation can prevent an increase in D-dimer, lower cardiovascular mortality, and reveal important associations between inflammation, endothelial function, and cardiovascular risk.
Article
Medical Laboratory Technology
Karin Strandberg, Cecilia Augustsson
Summary: This study evaluated the analytical performance of the Atellica COAG 360 analyzer in diagnosing bleeding disorders in a specialized coagulation laboratory. The results showed that the analyzer performed as expected and was equivalent to the BCS-XP in determining coagulation parameters, making it suitable for accurate diagnosis of bleeding disorders.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Cardiac & Cardiovascular Systems
Mikael Lund, Ankit S. Macwan, Kjersti Tunstromer, Tomas L. Lindahl, Niklas Boknas
Summary: The study found that heparin and bivalirudin have different and complementary inhibitory effects on the activation of PAR1 and PAR4 by thrombin. Heparin inhibits PAR4-mediated platelet activation, while bivalirudin inhibits signaling from both receptors but leads to delayed PAR4-mediated platelet activation, resulting in a strong prothrombotic response.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Hematology
Niklas Boknas, Cia Laine, Andreas Hillarp, Ankit S. Macwan, Kerstin M. Gustafsson, Tomas L. Lindahl, Margareta Holmstrom
Summary: In this study, laboratory markers were used to characterize hemostatic function in COVID-19 patients. The incidence of death and venous thromboembolism in COVID-19 positive patients was significantly higher compared to COVID-19 negative patients. Elevated levels of von Willebrand factor and fibrinogen were observed in COVID-19 positive patients. In addition, abnormalities in specific hemostatic markers were associated with increased mortality in COVID-19 positive patients, particularly in cases with combined defects in markers of fibrinolysis and coagulation.
THROMBOSIS RESEARCH
(2022)
Article
Hematology
Myriam Martin, Cecilia Augustsson, Vivian Lind, Riam Al-Sabti, My Chi Lam, Nadine G. Andersson, Karin Strandberg
Summary: The xFLI method, based on Luminex xMAP fluorescence-immunoassay, is more sensitive and reproducible than ELISA and CBA for detecting anti-FVIII antibodies in patients with haemophilia A. It can detect both functional inhibitors and non-neutralising antibodies accurately. The overall concordance between xFLI and ELISA was 82.1% and xFLI and CBA was 77.9%.
Article
Cell Biology
Kjersti Tunstromer, Lars Faxalv, Pia Larsson, Tomas L. Lindahl, Niklas Boknas
Summary: Pharmacological inhibition of the platelet ADP-receptor P2Y(12) is important in preventing atherothrombotic events. Our study compared the effects of two different P2Y(12) inhibitors and found that one had a slower but significant platelet inhibitory effect. Additionally, we observed that inhibited platelets gradually accumulated at the periphery of the thrombus.
Article
Hematology
Cecilia Augustsson, Eva Norstrom, Nadine Gretenkort Andersson, Eva Zetterberg, Jan Astermark, Karin Strandberg
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
(2020)