Competitive mode and site of interaction of ticagrelor at the human platelet P2Y12-receptor

Agonist-bound structure of the human P2Y12 receptor

(2014) Jin Zhang et al.   NATURE

Structure of the human P2Y12 receptor in complex with an antithrombotic drug

(2014) Kaihua Zhang et al.   NATURE

Reduction in First and Recurrent Cardiovascular Events With Ticagrelor Compared With Clopidogrel in the PLATO Study

(2013) Payal Kohli et al.   CIRCULATION

Using ortholog sequence data to predict the functional relevance of mutations in G-protein-coupled receptors

(2012) Maxi Cöster et al.   FASEB JOURNAL

High-resolution crystal structure of human protease-activated receptor 1

(2012) Cheng Zhang et al.   NATURE

The platelet P2Y12 receptor under normal and pathological conditions. Assessment with the radiolabeled selective antagonist [3H]PSB-0413

(2012) Philippe Ohlmann et al.   Purinergic Signalling

Mutational analysis of residues important for ligand interaction with the human P2Y12 receptor

(2010) Yingying Mao et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Identification and characterization of a novel P2Y12 variant in a patient diagnosed with type 1 von Willebrand disease in the European MCMDM-1VWD study

(2009) M. E. Daly et al.   BLOOD

High-Affinity, Non-Nucleotide-Derived Competitive Antagonists of Platelet P2Y12Receptors

(2009) Younis Baqi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Interaction of New, Very Potent Non-Nucleotide Antagonists with Arg256 of the Human Platelet P2Y12 Receptor

(2009) K. Hoffmann et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Ticagrelor binds to human P2Y12independently from ADP but antagonizes ADP-induced receptor signaling and platelet aggregation

(2009) J. J. J. VAN GIEZEN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Involvement of basic amino acid residues in transmembrane regions 6 and 7 in agonist and antagonist recognition of the human platelet P2Y12-receptor

(2008) Kristina Hoffmann et al.   BIOCHEMICAL PHARMACOLOGY

Interaction of the active metabolite of prasugrel, R-138727, with cysteine 97 and cysteine 175 of the human P2Y12receptor

(2008) I. ALGAIER et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS