Fasxiator, a novel factor XIa inhibitor from snake venom, and its site-specific mutagenesis to improve potency and selectivity

Inhibition of Factor XI activity as a promising antithrombotic strategy

(2014) Zhu Chen et al.   DRUG DISCOVERY TODAY

Factor XI as a target for antithrombotic therapy

(2014) Charles E. Bane et al.   DRUG DISCOVERY TODAY

Antithrombotic Effect of Antisense Factor XI Oligonucleotide Treatment in Primates

(2013) Jeffrey R. Crosby et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Desmolaris, a novel factor XIa anticoagulant from the salivary gland of the vampire bat (Desmodus rotundus) inhibits inflammation and thrombosis in vivo

(2013) D. Ma et al.   BLOOD

Sulfated Pentagalloylglucoside Is a Potent, Allosteric, and Selective Inhibitor of Factor XIa

(2013) Rami A. Al-Horani et al.   JOURNAL OF MEDICINAL CHEMISTRY

Anticoagulation beyond direct thrombin and factor Xa inhibitors: indications for targeting the intrinsic pathway?

(2013) Maurits van Montfoort et al.   THROMBOSIS AND HAEMOSTASIS

The kunitz protease inhibitor domain of protease nexin-2 inhibits factor XIa and murine carotid artery and middle cerebral artery thrombosis

(2012) W. Wu et al.   BLOOD

Inhibitors of Serine Proteinases from Blood Coagulation Cascade - View on Current Developments

(2012) D. Danalev   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Factor XI and XII as antithrombotic targets

(2011) Felicitas Müller et al.   CURRENT OPINION IN HEMATOLOGY

Productive Recognition of Factor IX by Factor XIa Exosites Requires Disulfide Linkage between Heavy and Light Chains of Factor XIa

(2011) Mariola M. Marcinkiewicz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms underlying FeCl3-induced arterial thrombosis

(2011) A. ECKLY et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

A role for factor XIIa-mediated factor XI activation in thrombus formation in vivo

(2010) Q. Cheng et al.   BLOOD

Inhibition of the intrinsic coagulation pathway factor XI by antisense oligonucleotides: a novel antithrombotic strategy with lowered bleeding risk

(2010) H. Zhang et al.   BLOOD

Acute infusion reactions induced by monoclonal antibody therapy

(2010) Enrico Maggi et al.   Expert Review of Clinical Immunology

Thrombosis and cardiovascular disease: Exciting perspectives in cardiovascular prevention and therapy

(2010) Gregory Lip et al.   THROMBOSIS AND HAEMOSTASIS

Patients with severe factor XI deficiency have a reduced incidence of deep-vein thrombosis

(2010) Ophira Salomon et al.   THROMBOSIS AND HAEMOSTASIS

Therapeutic antibodies: successes, limitations and hopes for the future

(2009) Patrick Chames et al.   BRITISH JOURNAL OF PHARMACOLOGY

Glycolaldehyde induces fibrinogen post-translational modification, delay in clotting and resistance to enzymatic digestion

(2009) M.E. Andrades et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Crystal structure of textilinin-1, a Kunitz-type serine protease inhibitor from the venom of the Australian common brown snake (Pseudonaja textilis)

(2009) Emma-Karin I. Millers et al.   FEBS Journal

Dabigatran versus Warfarin in Patients with Atrial Fibrillation

(2009) Stuart J. Connolly et al.   NEW ENGLAND JOURNAL OF MEDICINE

Prevention of vascular graft occlusion and thrombus-associated thrombin generation by inhibition of factor XI

(2008) E. I. Tucker et al.   BLOOD

Reduced incidence of ischemic stroke in patients with severe factor XI deficiency

(2008) O. Salomon et al.   BLOOD

Clavatadine A, A Natural Product with Selective Recognition and Irreversible Inhibition of Factor XIa†

(2008) Malcolm S. Buchanan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Distinct Functions of Activated Protein C Differentially Attenuate Acute Kidney Injury

(2008) A. Gupta et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY