Article
Rheumatology
Matina Liapi, David Jayne, Peter A. Merkel, Marten Segelmark, Aladdin J. Mohammad
Summary: This study investigated the incidence rate and predictors of VTE in patients with ANCA-associated vasculitis. The results showed a high incidence rate of AAV-related VTE, especially early in the disease course. Vasculitis activity and age were positively associated with VTE.
Article
Medicine, General & Internal
Heena Tabassum, Sumit Aggarwal, Geetha R. Menon, Narendra Arora, Sagnik Chakraborty, M. Rao, Balram Bhargava, Nabendu S. Chatterjee
Summary: The Indian Council of Medical Research (ICMR) in New Delhi has established a nationwide registry called the 'Indian Registry for Venous Thromboembolism Disorder (i-RegVeD)' to analyze real-time sociodemographic profile, disease patterns, management strategies, treatment choices, and outcomes of patients with venous thromboembolism (VTE) in order to gather evidence and fill knowledge gaps about the disease across different demographic regions. This hospital-based registry will collect data on VTE occurrence and characteristics from 16 hospital sites throughout India and the results will be disseminated publicly on a study website as well as through scientific meetings and publications.
Article
Oncology
Hirotsugu Kenmotsu, Akifumi Notsu, Keita Mori, Shota Omori, Takahiro Tsushima, Yasuomi Satake, Yoshihiro Miki, Masakazu Abe, Masahito Ogiku, Toshio Nakamura, Masakazu Takagi, Hideto Ochiai, Hirofumi Yasui, Toshiaki Takahashi
Summary: This study revealed a high incidence of VTE in patients with advanced cancer, particularly in those with lung cancer. Although most VTE cases were asymptomatic, intensive screening may be necessary, especially for female patients with elevated D-dimer levels and decreased platelet counts.
Article
Cardiac & Cardiovascular Systems
Yingying Wu, Jingdi Liu, Wei Zeng, Bei Hu, Yu Hu, Liang V. Tang
Summary: The relationship between protein S deficiency and venous thromboembolism risk in the Han Chinese population was investigated through a case-control study. The study found a higher proportion of patients with protein S deficiency and disease-causing gene mutations among venous thromboembolism patients compared to healthy controls. The findings suggest the clinical application of protein S assays for the molecular diagnosis of thrombophilia.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Nutrition & Dietetics
Shuai Yuan, Jie Chen, Tian Fu, Xue Li, Maria Bruzelius, Agneta Akesson, Susanna C. Larsson
Summary: This study aimed to investigate the association between ultra-processed food (UPF) intake and the risk of venous thromboembolism (VTE). After adjusting for covariates, higher UPF intake was moderately associated with an increased risk of VTE compared to the lowest intake quintile.
CLINICAL NUTRITION
(2023)
Article
Oncology
Oded Icht, Avi Leader, Erez Batat, Lilach Yosef, Tzippy Shochat, Daniel A. Goldstein, Elizabeth Dudnik, Galia Spectre, Pia Raanani, Ariel Hammerman, Alona Zer
Summary: This study found that patients with ALK-positive NSCLC have a higher risk of VTE, but no significant difference in ATE risk. Prospective studies are needed to evaluate thromboprophylaxis in ALK-positive NSCLC.
Article
Cardiac & Cardiovascular Systems
Paul A. Kyrle, Lisbeth Eischer, Hana Sinkovec, Paul Gressenberger, Thomas Gary, Marianne Brodmann, Georg Heinze, Sabine Eichinger
Summary: This study evaluated the performance of the VPM in patients with unprovoked VTE, showing a 1-year recurrence rate of 5.2%. Recalibration improved the identification of patients at low recurrence risk and stratified them into distinct low-risk categories.
EUROPEAN HEART JOURNAL
(2023)
Article
Oncology
Oded Icht, Avi Leader, Erez Batat, Lilach Yosef, Tzippy Shochat, Daniel A. Goldstein, Elizabeth Dudnik, Galia Spectre, Pia Raanani, Ariel Hammerman, Alona Zer
Summary: This study found that patients with ALK-positive NSCLC had a higher risk of VTE compared to those without ALK rearrangement, but there was no association between ALK positivity and ATE incidence.
Article
Hematology
Helle Jorgensen, Erzsebet Horvath-Puho, Kristina Laugesen, Sigrid K. Braekkan, John-Bjarne Hansen, Henrik Toft Sorensen
Summary: This study examines the association between acute venous thromboembolism (VTE) and the risk of subsequent depression. Based on Danish nationwide registries, a population-based cohort of 64,596 individuals with incident VTE and a comparison cohort of 322,999 randomly selected individuals were established. The results show that VTE is associated with a 2.35-fold increased risk of depression compared to the comparison cohort, even after adjusting for socioeconomic status and comorbidities.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Hematology
Julie Riis, Borge G. Nordestgaard, Shoaib Afzal
Summary: The study revealed an association between the alpha(1)-antitrypsin Z genetic variant and an increased risk of venous thromboembolism, with hazard ratios of 2.2 for homozygotes and 1.1 for heterozygotes. The absolute risk of venous thromboembolism associated with alpha(1)-antitrypsin ZZ homozygosity was 7.8%.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Urology & Nephrology
Ayub Akbari, Elizabeth Kunkel, Sarah E. Bota, Ziv Harel, Gregoire Le Gal, Conor Cox, Gregory L. Hundemer, Mark Canney, Edward Clark, David Massicotte-Azarniouch, Anan Bader Eddeen, Greg Knoll, Manish M. Sood
Summary: In early pregnancy, the presence of proteinuria is significantly associated with a higher risk of VTE, especially in women with a history of kidney disease, gestational or non-gestational diabetes mellitus, and hypertension.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Medicine, General & Internal
Yanina Balabanova, Bahman Farahmand, Hans Garmo, Par Stattin, Gunnar Brobert
Summary: This nationwide cohort study in Sweden found that men with prostate cancer had a 50% increased risk of venous thromboembolism (VTE) compared with men without prostate cancer during a 5-year follow-up period.
Article
Environmental Sciences
Mehjar Azzouz, Yiyi Xu, Lars Barregard, Bengt Zoller, Peter Molnar, Anna Oudin, Marten Spanne, Gunnar Engstrom, Leo Stockfelt
Summary: Air pollution is a significant factor in global disease burden and is associated with various diseases, including cardiovascular disease. This study explores whether prolonged exposure to air pollution is linked to an increased incidence of venous thromboembolism (VTE). The study concludes that long-term exposure to PM2.5 may increase the risk of VTE in the general population in Sweden.
ENVIRONMENTAL POLLUTION
(2023)
Article
Medicine, General & Internal
Jin-Sung Yuk, Myounghwan Kim
Summary: This study aimed to calculate the mortality rate and incidence of venous thromboembolism during myomectomy in the Republic of Korea. The results showed that the current mortality rate after myomectomy is substantially lower than previous studies, and the incidence of venous thromboembolism is lower than the general population worldwide.
FRONTIERS IN MEDICINE
(2022)
Article
Hematology
Shuai Yuan, Olga E. Titova, Ke Zhang, Wanglong Gou, Tessa Schillemans, Pradeep Natarajan, Jie Chen, Xue Li, Agneta akesson, Maria Bruzelius, Derek Klarin, Scott M. Damrauer, Susanna C. Larsson
Summary: We conducted cohort and Mendelian randomisation analyses to explore the associations between circulating proteins and risk of venous thromboembolism (VTE), with the aim of providing evidence for disease prevention and drug development. The cohort analysis identified 21 proteins significantly associated with VTE risk, while the machine-learning model highlighted the importance of body mass index and von Willebrand factor (vWF) in predicting VTE risk. The Mendelian randomisation analysis revealed causal associations between genetically predicted levels of vWF, SERPINE1, EPHB4, TYRO3, TNFRSF11A, and BOC and VTE risk.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Marianne Benn, Sarah C. W. Marott, Anne Tybjaerg-Hansen, Borge G. Nordestgaard
Summary: High BMI causally increases the risk of both heart failure incidence and mortality.
CARDIOVASCULAR RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Mie Balling, Shoaib Afzal, George Davey Smith, Anette Varbo, Anne Langsted, Pia R. Kamstrup, Borge G. Nordestgaard
Summary: Elevated LDL triglycerides are associated with an increased risk of ASCVD and its individual components, as shown in two prospective cohort studies and meta-analyses.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Respiratory System
Josefine Freyberg, Eskild M. Landt, Shoaib Afzal, Borge G. Nordestgaard, Morten Dahl
Summary: This study found that statins, which lower low-density lipoprotein (LDL) cholesterol, can improve lung function and possibly decrease the rate of exacerbations in individuals with chronic obstructive pulmonary disease (COPD). However, it is still unknown whether high levels of LDL cholesterol are associated with increased susceptibility to COPD.
Article
Medicine, General & Internal
Andreas Fuchs, Jorgen Tobias Kuhl, Per Ejlstrup Sigvardsen, Shoaib Afzal, Andreas Dehlbaek Knudsen, Mathias Bech Moller, Martina Chantal de Knegt, Mathias Holm Sorgaard, Borge Gronne Nordestgaard, Lars Valeur Kober, Klaus Fuglsang Kofoed
Summary: This study found that subclinical obstructive coronary atherosclerosis in asymptomatic individuals is associated with a more than 8-fold increased risk for myocardial infarction.
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Helene Gellert-Kristensen, Anne Tybjaerg-Hansen, Borge G. Nordestgaard, Jonas Ghouse, Andreas Fuchs, Jorgen T. Kuhl, Per E. Sigvardsen, Klaus F. Kofoed, Stefan Stender
Summary: Observational epidemiological studies have shown that fatty liver disease is associated with higher all-cause mortality, liver-related mortality, ischemic heart disease-related mortality, and extrahepatic cancer-related mortality. In this genetic study, we found that seven genetic variants associated with fatty liver disease were significantly correlated with liver-related mortality. Using a Mendelian randomization framework, we further demonstrated that hepatic steatosis and elevated plasma ALT, as genetically determined factors, are associated with liver-related mortality.
LIVER INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Jacob Louis Marott, Magnus T. Jensen, Marianne Benn, Martina Chantal de Knegt, James H. O'Keefe, Carl J. Lavie, Peter Schnohr, Berge Gronne Nordestgaard, Gorm Boje Jensen
Summary: This study aimed to test the hypothesis that the increased risk of atrial fibrillation in men compared with women is explained by height. The results showed that the higher risk of atrial fibrillation in men can indeed be explained by differences in height. The study also suggested that height is one of the most important risk factors for atrial fibrillation in both men and women.
MAYO CLINIC PROCEEDINGS
(2023)
Correction
Multidisciplinary Sciences
Itziar de Rojas, Sonia Moreno-Grau, Niccolo Tesi, Benjamin Grenier-Boley, Victor Andrade, Iris Jansen, Nancy L. Pedersen, Najada Stringa, Anna Zettergren, Isabel Hernandez, Laura Montrreal, Carmen Antunez, Anna Antonell, Rick M. Tankard, Joshua Bis, Rebecca Sims, Celine Bellenguez, Ines Quintela, Antonio Gonzalez-Perez, Miguel Calero, Emilio Franco-Macias, Juan Macias, Rafael Blesa, Laura Cervera-Carles, Manuel Menendez-Gonzalez, Ana C. Frank-Garcia, Jose Luis W. Royo, Fermin Moreno, Raquel Huerto Vilas, Miquel Baquero, Monica Diez-Fairen, Carmen Lage, Sebastian Garcia-Madrona, Pablo Garcia-Gonzalez, Emilio Alarcon-Martin, Sergi Valero, Oscar Sotolongo-Grau, Abbe Ullgren, Adam C. Naj, Afina W. Lemstra, Alba Benaque, Alba Perez-Cordon, Alberto L. Benussi, Alberto Rabano, Alessandro Padovani, Alessio Squassina, Alexandre de Mendonca, Alfonso M. Arias Pastor, Almar A. L. Kok, Alun Meggy, Ana Belen Pastor, Ana Espinosa, Anais Corma-Gomez, Angel Martin Montes, Angela Sanabria, Anita W. DeStefano, Anja Schneider, Annakaisa Haapasalo, Anne Kinhult Stahlbom, Anne Tybjaerg-Hansen, Annette M. Hartmann, Annika Spottke, Arturo Corbaton-Anchuelo, Arvid B. Rongve, Barbara Borroni, Beatrice Arosio, Benedetta Nacmias, Borge G. Nordestgaard, Brian W. Kunkle, Camille Charbonnier, Carla Abdelnour, Carlo Masullo, Carmen Martinez Rodriguez, Carmen Munoz-Fernandez, Carole Dufouil, Caroline Graff, Catarina Ferreira, Caterina Chillotti, Chandra A. Reynolds, Chiara Fenoglio, Christine Van Broeckhoven, Christopher Clark, Claudia Pisanu, Claudia L. Satizabal, Clive Holmes, Dolores Buiza-Rueda, Dag Aarsland, Dan Rujescu, Daniel Alcolea, Daniela Galimberti, David Wallon, Davide Seripa, Edna Grunblatt, Efthimios Dardiotis, Emrah Duezel, Elio Scarpini, Elisa Conti, Elisa Rubino, Ellen Gelpi, Eloy Rodriguez-Rodriguez, Emmanuelle Duron, Eric Boerwinkle, Evelyn Ferri, Fabrizio Tagliavini, Fahri Kuecuekali, Florence Pasquier, Florentino Sanchez-Garcia, Francesca Mangialasche, Frank Jessen, Gael Nicolas, Geir Selbaek, Gemma K. Ortega, Genevieve Chene, Georgios Hadjigeorgiou, Giacomina Rossi, Gianfranco Spalletta, Giorgio Giaccone, Giulia Grande, Giuliano Binetti, Goran Papenberg, Harald Hampel, Henri Bailly, Henrik Zetterberg, Hilkka Soininen, Ida Karlsson, Ignacio Alvarez, Ildebrando Appollonio, Ina Giegling, Ingmar Skoog, Ingvild Saltvedt, Innocenzo Rainero, Irene Rosas Allende, Jakub Hort, Janine Diehl-Schmid, Jasper Van Dongen, Jean-Sebastien Vidal, Jenni Lehtisalo, Jens Wiltfang, Jesper Qvist Thomassen, Johannes Kornhuber, Jonathan A. Haines, Jonathan Vogelgsang, Juan Pineda, Juan Fortea, Julius Popp, Juergen Deckert, Katharina Buerger, Kevin Morgan, Klaus Fliessbach, Kristel Sleegers, Laura Molina-Porcel, Lena Kilander, Leonie Weinhold, Lindsay Farrer, Li-San Wang, Luca Kleineidam, Lucia A. Farotti, Lucilla Parnetti, Lucio Tremolizzo, Lucrezia Hausner, Luisa Benussi, Lutz Froelich, M. Arfan Ikram, M. Candida Deniz-Naranjo, Magda Tsolaki, Maitee Rosende-Roca, Malin Lowenmark, Marc Hulsman, Marco Spallazzi, Margaret H. Pericak-Vance, Margaret Esiri, Maria Bernal Sanchez-Arjona, Maria Carolina Dalmasso, Maria Teresa T. Martinez-Larrad, Marina Arcaro, Markus Noethen, Marta Fernandez-Fuertes, Martin Dichgans, Martin Ingelsson, Martin Herrmann, Martin Scherer, Martin Vyhnalek, Mary M. Kosmidis, Mary M. Yannakoulia, Matthias Schmid, Michael J. Ewers, Michael T. Heneka, Michael Wagner, Michela Scamosci, Miia Kivipelto, Mikko Hiltunen, Miren Zulaica, Montserrat Alegret, Myriam Fornage, Natalia Roberto, Natasja van Schoor, Nazib Seidu, Nerisa Banaj, Nicola Armstrong, Nikolaos Scarmeas, Norbert A. Scherbaum, Oliver Goldhardt, Oliver Hanon, Oliver Peters, Olivia Anna Skrobot, Olivier Quenez, Ondrej Lerch, Paola Bossu, Paolo Caffarra, Paolo Dionigi Rossi, Paraskevi Sakka, Patrizia Mecocci, Per Hoffmann, Peter Holmans, Peter A. Fischer, Peter Riederer, Qiong Yang, Rachel Marshall, Rajesh N. Kalaria, Richard Mayeux, Rik Vandenberghe, Roberta Cecchetti, Roberta Ghidoni, Ruth Frikke-Schmidt, Sandro Sorbi, Sara Haegg, Sebastiaan Engelborghs, Seppo Helisalmi, Sigrid Botne Sando, Silke Kern, Silvana Archetti, Silvia Boschi, Silvia Fostinelli, Silvia Gil, Silvia Mendoza, Simon Mead, Simona Ciccone, Srdjan Djurovic, Stefanie Heilmann-Heimbach, Steffi Riedel-Heller, Teemu Kuulasmaa, Teodoro del Ser, Thibaud Lebouvier, Thomas Polak, Tiia Ngandu, Timo Grimmer, Valentina Bessi, Valentina Escott-Price, Vilmantas Giedraitis, Vincent Deramecourt, Wolfgang Maier, Xueqiu Jian, Yolande A. L. Pijnenburg, Patrick Gavin Kehoe, Guillermo Garcia-Ribas, Pascual Sanchez-Juan, Pau Pastor, Jordi Perez-Tur, Gerard Pinol-Ripoll, Adolfo Lopez De Munain, Jose Maria Garcia-Alberca, Maria J. Bullido, Victoria Alvarez, Alberto Lleo, Luis M. Real, Pablo Mir Miguel Medina, Philip Scheltens, Henne Holstege, Marta Marquie, Maria Eugenia Saez, Angel Carracedo, Philippe Amouyel, Gerard D. Schellenberg, Julie Williams, Sudha Seshadri, CorneliaM. Van Duijn, Karen A. Mather, Raquel Sanchez-Valle, Manuel Serrano-Rios, Adelina Orellana, Lluis Tarraga, Kaj Blennow, Ole A. Andreassen, Danielle Posthuma, Jordi Clarimon, Merce Boada, Wiesje M. Van der Flier, Alfredo Ramirez, Jean-Charles Lambert, Sven J. Van der Lee, Agustin Ruiz
NATURE COMMUNICATIONS
(2023)
Review
Public, Environmental & Occupational Health
Kristina Laugesen, Jonas Mengel-From, Kaare Christensen, Jorn Olsen, David M. Hougaard, Lasse Boding, Anja Olsen, Christian Erikstrup, Merete Lund Hetland, Estrid Hogdall, Alisa Kjaergaard, Erik Sorensen, Anja Brugmann, Eva Rabing Brix Petersen, Ivan Brandslund, Borge Nordestgaard, Gorm B. Jensen, Nils Skajaa, Frederikke Schonfeldt Troelsen, Cecilia Hvitfeldt Fuglsang, Lise Skovgaard Svingel, Henrik T. Sorensen
Summary: Denmark has a rich source of biobanks and a comprehensive healthcare system, which allows for the integration of biological specimens with clinical and demographic data for biobank research. This can contribute to a better understanding of disease etiology and personalized medicine.
CLINICAL EPIDEMIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Katrine L. Rasmussen, Jiao Luo, Borge G. Nordestgaard, Anne Tybjaerg-Hansen, Ruth Frikke-Schmidt
Summary: The structural genetic variations in the APOE gene are associated with vascular diseases. APOE variants with high apoE, triglycerides, and remnant cholesterol are associated with peripheral arterial disease (PAD), while common APOE variants with high LDL cholesterol, triglycerides, and remnant cholesterol are associated with ischemic heart disease (IHD). APOE variants with low apoE are associated with increased risk of ischemic cerebrovascular disease (ICVD).
Article
Cardiac & Cardiovascular Systems
Nawar Dalila, Ruth Frikke-Schmidt, Borge G. Nordestgaard, Anne Tybjaerg-Hansen
Summary: This study found that low levels of thyroid stimulating hormone (TSH) are associated with increased risk of cardiovascular diseases (such as atrial fibrillation, myocardial infarction, stroke) both observationally and genetically. These findings suggest a potential causal relationship.
Article
Cardiac & Cardiovascular Systems
Laerke Kristine Kyhl, Borge Gronne Nordestgaard, Anne Tybjaerg-Hansen, Sune Fallgaard Nielsen
Summary: High levels of plasma triglycerides, BMI, and waist circumference, individually and combined, are associated with an increased risk of clinically diagnosed non-alcoholic fatty liver disease. This study found that the risk of non-alcoholic fatty liver disease increased in individuals with higher plasma triglycerides, BMI, and waist circumference over a 9.2-year follow-up period.
Article
Cardiac & Cardiovascular Systems
Louise E. Bechmann, Frida Emanuelsson, Borge G. Nordestgaard, Marianne Benn
Summary: A functional genetic variant in SLC5A2, mimicking SGLT2-inhibition, was associated with a lower risk of heart failure, myocardial infarction, ischaemic heart disease, and all-cause mortality. However, the effects were minimally mediated through lower plasma glucose.
CARDIOVASCULAR RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Maria Booth Nielsen, Yunus Colak, Marianne Benn, Amy Mason, Stephen Burgess, Borge Gronne Nordestgaard
Summary: Observational findings indicate that elevated plasma adiponectin levels are associated with an increased risk of heart failure, atrial fibrillation, aortic valve stenosis, and myocardial infarction. However, genetic evidence does not support the causality of these associations.
CARDIOVASCULAR RESEARCH
(2023)
Article
Multidisciplinary Sciences
Yann Le Guen, Guo Luo, Aditya Ambati, Vincent Damotte, Iris Jansen, Eric Yu, Aude Nicolas, Itziar de Rojasj, Thiago Peixoto Leal, Akinori Miyashita, Celine Bellenguez, Michelle Mulan Lian, Kayenat Parveen, Takashi Morizono, Hyeonseul Park, Benjamin Grenier-Boley, Tatsuhiko Naito, Fahri Kucukali, Seth D. Talyansky, Selina Maria Yogeshwar, Vicente Sempere, Wataru Satake, Victoria Alvarez, Beatrice Arosio, Michael E. Belloy, Luisa Benussi, Anne Boland, Barbara Borroni, Maria J. Bullido, Paolo Caffarra, Jordi Clarimon, Antonio Daniele, Daniel Darling, Stephanie Debette, Jean-Francois Deleuze, Martin Dichgans, Carole Dufouil, Emmanuel During, Emrah Duzel, Daniela Galimberti, Guillermo Garcia-Ribas, Jose Maria Garcia-Alberca, Pablo Garcia-Gonzalez, Vilmantas Giedraitis, Oliver Goldhardt, Caroline Graff, Edna Grunblatt, Olivier Hanon, Lucrezia Hausner, Stefanie Heilmann-Heimbach, Henne Holstege, Jakub Hort, Yoo Jin Jung, Deckert Jurgen, Silke Kern, Teemu Kuulasmaa, Kun Ho Lee, Ling Lin, Carlo Masullo, Patrizia Mecocci, Shima Mehrabian, Alexandre de Mendonca, Merce Boada, Pablo Mir, Susanne Moebus, Fermin Moreno, Benedetta Nacmias, Gael Nicolas, Shumpei Niida, Borge G. Nordestgaard, Goran Papenberg, Janne Papma, Lucilla Parnetti, Florence Pasquier, Pau Pastor, Oliver Peters, Yolande A. L. Pijnenburg, Gerard Pinol-Ripoll, Julius Popp, Laura Molina Porcel, Raquel Puertaj Jordi Perez-Tur, Innocenzo Rainero, Inez Ramakers, Luis M. Real, Steffi Riedel-Heller, Eloy Rodriguez-Rodriguez, Owen A. Ross, Jose Luis Royo, Dan Rujescu, Nikolaos Scarmeas, Philip Scheltens, Norbert Scherbaum, Anja Schneider, Davide Seripa, Ingmar Skoog, Vincenzo Solfrizzi, Gianfranco Spalletta, Alessio Squassina, John van Swieten, Raquel Sanchez-Valle, Eng-King Tan, Thomas Tegos, Charlotte Teunissen, Jesper Qvist Thomassen, Lucio Tremolizzo, Martin Vyhnalek, Frans Verhey, Margda Waern, Jens Wiltfang, Jing Zhangc, Henrik Zetterberg, Kaj Blennow, Zihuai He, Julie Williams, Philippe Amouyel, Frank Jessen, Patrick G. Kehoe, Ole A. Andreassen, Cornelia Van Duin, Magda Tsolaki, Pascual Sanchez-Juan, Ruth Frikke-Schmidt, Kristel Sleegers, Tatsushi Todau, Anna Zettergren, Martin Ingelsson, Yukinori Okada, Giacomina Rossi, Mikko Hiltunen, Jungsoo Gim, Kouichi Ozaki, Rebecca Sims, Jia Nee Foo, Wiesje van der Fliere, Takeshi Ikeuchi, Alfredo Ramirez, Ignacio Mata, Agustin Ruiz, Ziv Gan-Or, Jean-Charles Lambert, Michael D. Greicius, Emmanuel Mignot
Summary: We analyzed the HLA associations in individuals with Parkinson's disease and Alzheimer's disease across different ancestry groups and found that these two diseases share a common protective association at the HLA locus. Fine-mapping showed that specific subtypes of HLA-DRB1*04 were responsible for this association, with HLA-DRB1*04:04 and HLA-DRB1*04:07 showing the strongest association. This protective effect was also associated with decreased neurofibrillary tangles in the brain and reduced levels of tau protein in cerebrospinal fluid.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Cardiac & Cardiovascular Systems
Jeanine E. Roeters van Lennep, Lale S. Tokgozoglu, Lina Badimon, Sandra M. Dumanski, Martha Gulati, Connie N. Hess, Kirsten B. Holven, Maryam Kavousi, Meral Kayikcioglu, Esther Lutgens, Erin D. Michos, Eva Prescott, Jane K. Stock, Anne Tybjaerg-Hansen, Marieke J. H. Wermer, Marianne Benn
Summary: Cardiovascular disease is the leading cause of death globally, with women experiencing the fastest relative increase in middle-aged mortality. In addition to missed or delayed diagnosis and undertreatment, sex-specific factors contribute to increased cardiovascular risk in women. The European Atherosclerosis Society's position statement focuses on the impact of gender-specific factors and the effects of these factors on women's lifelong lipid profiles, including lipoprotein(a). Sociocultural components further compound these effects. Early identification and treatment of modifiable cardiovascular risk factors in women, especially those related to sex-specific conditions, are necessary to reduce the high burden of cardiovascular disease in women.
EUROPEAN HEART JOURNAL
(2023)