Article
Hematology
Yafei Yu, Yu Hou, Yajing Zhao, Hai Zhou, Fangmiao Jing, Yanfeng Liu, Jun Peng, Xinguang Liu, Ming Hou
Summary: In adult ITP patients who failed first-line treatments, the presence of anti-GPIb/IX autoantibodies was associated with poorer response to rhTPO treatment, while the presence of anti-GPIIb/IIIa autoantibodies did not significantly affect treatment response.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Hematology
Caroline Gabe, Emily Sirotich, Na Li, Nikola Ivetic, Ishac Nazy, James Smith, John G. Kelton, Donald M. Arnold
Summary: Misclassification of immune thrombocytopenia (ITP) is common and can undermine the value of platelet autoantibody testing. Sensitivity of platelet autoantibody testing is increased in patients with 'definite ITP', while specificity remains unchanged. High optical density values improve the specificity of platelet autoantibody testing but decrease sensitivity, suggesting that these antibodies may be most prevalent in certain patient subsets.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Medicine, General & Internal
Yan-Qiu Hou, Yan Wang, Chang-Xun Liu, Shu-Xia Li, Ya-Lan Peng, Wang Dong-Dong, Ru-La Sa
Summary: This study revealed that newly diagnosed adult patients with ITP who tested positive for platelet glycoprotein-specific antibodies were likely to achieve a better treatment response after receiving HD-DXM + prednisone maintenance.
ANNALS OF MEDICINE
(2022)
Review
Medicine, General & Internal
Maria Eva Mingot-Castellano, Mariana Canaro Hirnyk, Blanca Sanchez-Gonzalez, Maria Teresa Alvarez-Roman, Abelardo Barez-Garcia, Angel Bernardo-Gutierrez, Silvia Bernat-Pablo, Estefania Bolanos-Calderon, Nora Butta-Coll, Gonzalo Caballero-Navarro, Isabel Socorro Caparros-Miranda, Laura Entrena-Urena, Luis Fernando Fernandez-Fuertes, Luis Javier Garcia-Frade, Maria del Carmen Gomez del Castillo, Tomas Jose Gonzalez-Lopez, Carlos Grande-Garcia, Jose Maria Guinea de Castro, Isidro Jarque-Ramos, Reyes Jimenez-Barcenas, Elsa Lopez-Ansoar, Daniel Martinez-Carballeira, Violeta Martinez-Robles, Emilio Monteagudo-Montesinos, Jose Antonio Paramo-Fernandez, Maria del Mar Perera-alvarez, Inmaculada Soto-Ortega, David Valcarcel-Ferreiras, Cristina Pascual-Izquierdo
Summary: Primary immune thrombocytopenia (ITP) is a complex autoimmune disease characterized by dysregulation of the immune system, causing increased platelet destruction and reduced production. The diverse clinical manifestations make personalized diagnosis and management challenging. The Spanish ITP Group (GEPTI) of the Spanish Society of Hematology and Hemotherapy (SEHH) updated the guidelines in 2021 to provide a practical tool for comprehensive management of primary ITP.
JOURNAL OF CLINICAL MEDICINE
(2023)
Editorial Material
Hematology
Rick Kapur
Summary: Childhood immune thrombocytopenia (ITP) is a benign and self-limiting disorder, but a portion of patients develop chronic ITP with bleeding symptoms and impaired quality of life. Severe bleedings can be treated with corticosteroids, anti-D, or intravenous immunoglobulins (IVIg). A prospective study of 23 children with primary ITP suggests that IVIg may improve thrombin-induced platelet activation and enhance thrombin generation in addition to increasing platelet counts.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Medicine, General & Internal
Chong Chen, Sicheng Wu, Jia Chen, Jinghui Wu, Yabo Mei, Tao Han, Changshuan Yang, Xilin Ouyang, May Chun Mei Wong, Zhichun Feng
Summary: In preterm infants, platelet transfusion, PC, and MPV were associated with mortality, and PC was also associated with any grade IVH and severe IVH.
Article
Hematology
Prakash Vishnu, Joanne Duncan, Nathan Connell, Nichola Cooper, Wendy Lim, Francesco Rodeghiero, Yoshiaki Tomiyama, Rachael F. Grace, Tamam Bakchoul, Donald M. Arnold
Summary: The international survey showed that testing for H pylori was most common in Asia and among patients from Asia. Testing and treating practices varied across geographic regions.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Pharmacology & Pharmacy
Henk-Jan Boiten, Sufia Amini, Frank H. J. Wolfhagen, Peter E. Westerweel
Summary: The case study reports a 73-year-old male with Crohn's disease who developed severe thrombocytopenia while using the anti-TNF alpha agent adalimumab, which improved upon discontinuation of the medication. Regular monitoring of platelet levels after initiating anti-TNF alpha agents is recommended to prevent this potentially fatal complication.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Review
Cell Biology
Siyu Sun, Rolf T. Urbanus, Hugo ten Cate, Philip G. de Groot, Bas de Laat, Johan W. M. Heemskerk, Mark Roest
Summary: Autoimmune disorders often lead to low platelet count or thrombocytopenia, with mechanisms such as increased platelet activity, auto-antibodies suppressing platelet formation or increasing clearance, and interactions between platelets, coagulation, and complement activation processes being common factors in these conditions across various autoimmune disorders.
Article
Hematology
Guillaume Bonnard, Antoine Babuty, Romain Collot, Domitille Costes, Nicolas Drillaud, Marion Eveillard, Antoine Neel, Alexandra Espitia, Agathe Masseau, Anais Wahbi, Mohamed Hamidou, Marie C. Bene, Marc Fouassier
Summary: This study found that platelet sialylation and activation levels, as well as immature platelet counts, could help differentiate between ITP and IT, providing potential useful diagnostic tools for physicians in complex cases of thrombocytopenia.
ANNALS OF HEMATOLOGY
(2021)
Review
Medicine, General & Internal
Kerstin Jurk, Yavar Shiravand
Summary: Patients with inherited or acquired thrombocytopenia may also have platelet function defects, increasing the risk of severe bleeding complications. While there are numerous tests available for platelet phenotyping and function analysis, they are mostly time-consuming and require skilled personnel for handling, limiting their use to specialized laboratories.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Hematology
Ishac Nazy, Stefan D. Jevtic, Jane C. Moore, Angela Huynh, James W. Smith, John G. Kelton, Donald M. Arnold
Summary: Our study excludes heparin-induced thrombocytopenia in critically ill COVID-19 patients and identifies platelet-activating immune complexes as a novel mechanism contributing to the disease.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Review
Oncology
Yuwen Chen, Jianda Hu, Yingyu Chen
Summary: ITP is an autoimmune disease characterized by immune-mediated destruction of platelets, where an imbalance of platelet production and clearance is involved in its progression. Poor prognosis in patients may be associated with a novel Fc-independent platelet clearance pathway.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2021)
Editorial Material
Clinical Neurology
Andrea M. Gross, Scott R. Plotkin, Brigitte C. Widemann, REiNS Int Collaborat
Summary: Neurofibromatosis (NF) type 1 (NF1), NF type 2 (NF2), and schwannomatosis are genetic tumor predisposition syndromes with various clinical manifestations. Effective medical treatments for these conditions are limited, and the Response Evaluation in Neurofibromatosis and Schwannomatosis (REiNS) International Collaboration has been working since 2011 to develop standardized and clinically meaningful outcome measures for clinical trials in these conditions. Recommendations summarized in previous supplements published in Neurology in 2013 and 2016 provide guidelines for research in this field.
Article
Hematology
Ana Mendoza, Maria Teresa Alvarez-Roman, Elena Monzon-Manzano, Paula Acuna, Elena G. Arias-Salgado, Isabel Rivas-Pollmar, Monica Martin-Salces, Barbara Martinez de Miguel, Elena Montalban, Victor Jimenez-Yuste, Nora Butta
Summary: This study found that the splenic sequestration pattern is an independent predictor of splenectomy response and can predict the rate of complete response in ITP patients. The study also found that non-responding patients have a significant loss of sialic acid in their platelets.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
