Article
Hematology
Nadine Schwarz, Jens Mueller, Hamideh Yadegari, Hannah L. McRae, Sara Reda, Nasim Shahidi Hamedani, Johannes Oldenburg, Bernd Poetzsch, Heiko Ruehl
Summary: The formation rate of activated protein C (APC) is significantly higher in individuals with FVL mutation compared to those without, both in ex vivo and in vivo experiments.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Hematology
Jun Wan, Nadira Vadaq, Joke Konings, Martin Jaeger, Vinod Kumar, Bas de Laat, Leo Joosten, Mihai G. Netea, Andre J. van der Ven, Philip G. de Groot, Quirijn de Mast, Mark Roest
Summary: The KLKB1 gene was found to be associated with the protein C pathway function and thrombin generation. Kallikrein may play a role in regulating the anticoagulant protein C pathway during thrombin generation.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Review
Critical Care Medicine
Jessica C. Cardenas
Summary: Thrombin plays a central role in coagulation, essential for normal hemostasis. The generation of thrombin in severely injured patients is closely related to the risks of bleeding and thrombotic complications, and understanding the determinants of its production is clinically important.
Review
Pharmacology & Pharmacy
Sofia R. Bernstein, Caroline Kelleher, Raouf A. Khalil
Summary: Previous research has assumed that male and female biology is similar except for the reproductive system, leading to misconceptions in research interpretations and clinical applications. However, recent research has identified sex differences in various organs and systems, as well as differences in the prevalence and severity of certain disorders between males and females. This highlights the importance of studying gender differences in biology and disease.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Charlotte Xue Dong, Cassandra Malecki, Elizabeth Robertson, Brett Hambly, Richmond Jeremy
Summary: Thoracic aortic disease affects all ages, with a majority of cases having a genetic cause. Surgical intervention is currently the main treatment option. The mechanism of thoracic aneurysm is less understood compared to abdominal aortic aneurysm. This paper examines key cell signaling systems and explores potential novel therapeutic approaches for thoracic aortic aneurysm.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Hematology
Thomas Sinegre, Cedric Duron, Thomas Lecompte, Geraldine Lamblin, Laurie Talon, Leon Muti, Sylvie Massoulier, Bruno Pereira, Aurelien Lebreton, Armand Abergel
Summary: The aim of this study was to compare the intraindividual variability of thrombin generation over time between patients with cirrhosis and healthy controls. The results showed that patients with cirrhosis had higher endogenous thrombin potential when using the thrombin generation assay, and this increased with the severity of cirrhosis. The thrombin generation parameters were highly stable over time in healthy controls, moderately stable in Child-Turcotte-Pugh (CTP)-A patients, and poorly stable in CTP-B/C patients (severe cirrhosis), with one-third of patients transitioning to normal or hypercoagulable states during the 3-month follow-up.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Biochemistry & Molecular Biology
Chien-Chung Yang, I-Ta Lee, Yan-Jyun Lin, Wen-Bin Wu, Li-Der Hsiao, Chuen-Mao Yang
Summary: This study confirmed that thrombin induces the production of COX-2 and PGE(2) in human tracheal smooth muscle cells, leading to inflammation in the airways and lungs. The study identified specific signaling pathways involved, including the PKC delta/Pyk2/c-Src/EGFR/PI3K/Akt/AP-1 pathway. Resveratrol was also found to inhibit COX-2 and PGE(2) production by blocking the activation of these signaling molecules, suggesting its potential use in managing airway inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cardiac & Cardiovascular Systems
Helen Christou, Raouf A. Khalil
Summary: Pulmonary hypertension is a serious disease characterized by vasoconstriction and remodeling of the pulmonary arterioles, leading to increased pulmonary vascular resistance and right ventricular hypertrophy. Current pharmacological therapies focus on pulmonary vasodilation but are not universally successful. Therefore, researchers are exploring novel approaches to reverse pulmonary vascular pathology and structural remodeling.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Review
Hematology
Nikolaus B. Binder, Francois Depasse, Julia Mueller, Thomas Wissel, Stephan Schwers, Matthias Germer, Bjorn Hermes, Peter L. Turecek
Summary: TGA is a global assay that allows for the dynamic and continuous recording of both thrombin generation and inactivation effects. It is widely used in clinical medicine for the diagnosis, prognosis, prophylaxis, and treatment of inherited and acquired bleeding and thrombotic disorders.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Review
Pharmacology & Pharmacy
Joanne Ern Chi Soh, Akio Shimizu, Akira Sato, Hisakazu Ogita
Summary: This article outlines the functions of RhoA in the cardiovascular system and its corresponding cellular responses. RhoA plays a crucial role in cardiac remodeling through regulating actin stress fiber dynamics and cytoskeleton formation. However, its underlying mechanisms remain unclear and require further investigation.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Hematology
Claudia Khayat, Rita Marchi, Stephane Durual, Thomas Lecompte, Marguerite Neerman-Arbez, Alessandro Casini
Summary: This study investigated the impact of fibrinogen concentrate (FC) infusion on thrombin generation parameters and fibrin clot structure in patients with inherited afibrinogenemia. The results showed that FC infusion increased thrombin potential and peaks, but lag times and thrombin peaks were still lower than healthy controls. Fibrin clot structure formed after FC infusion was similar to patients with hypofibrinogenemia. These findings suggest that FC may not induce hypercoagulability in patients with afibrinogenemia.
THROMBOSIS AND HAEMOSTASIS
(2022)
Review
Cardiac & Cardiovascular Systems
Lars L. F. G. Valke, Sanna Rijpma, Danielle Meijer, Saskia E. M. Schols, Waander L. van Heerde
Summary: The treatment of bleeding and thrombotic disorders can be personalized through the use of global assays such as thrombin generation assays (TGAs). These assays can help identify patients with more severe bleeding phenotypes and guide non-replacement therapy and bypassing therapy. They also have a potential role in monitoring antithrombotic therapy.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Cell Biology
Diana Aboukhater, Bassel Morad, Nadim Nasrallah, Suzanne A. Nasser, Amirhossein Sahebkar, Firas Kobeissy, Ammar Boudaka, Ali H. Eid
Summary: Hypertension is a major contributor to cardiovascular disease and a leading cause of global death. Inflammation is one of the major factors driving increased blood pressure. This review highlights the causative relationship between inflammation and hypertension, focusing on the interplay between inflammation, reactive oxygen species, and endothelial damage. It also discusses the role of hyperhomocysteinemia and microRNA as links between inflammation and hypertension. The premises discussed in this review suggest that further research is needed to target the underlying mechanisms of hypertension.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Rebecca L. Shaw, Charles E. Norton, Steven S. Segal
Summary: Oxidative stress can lead to apoptosis of vascular cells, with smooth muscle cells (SMCs) showing greater susceptibility compared to endothelial cells (ECs). Further research is needed to validate these findings in intact resistance arteries.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Review
Hematology
Jun Wan, Joke Konings, Bas de Laat, Tilman M. Hackeng, Mark Roest
Summary: The study discusses plasma thrombin generation (TG) as a tool to assess blood coagulability, highlighting the importance of also considering the role of blood cells in coagulation. Platelets play a significant role in accelerating thrombin generation through various mechanisms, while erythrocytes and other blood cells also contribute to the coagulation process. Further research is needed to validate blood cell-dependent TG assays for clinical use.
THROMBOSIS AND HAEMOSTASIS
(2021)