The genetics of common variation affecting platelet development, function and pharmaceutical targeting

PRIMe: a method for characterization and evaluation of pleiotropic regions from multiple genome-wide association studies

(2011) Jie Huang et al.   BIOINFORMATICS

Novel loci involved in platelet function and platelet count identified by a genome-wide study performed in children

(2011) J. A. Guerrero et al.   HAEMATOLOGICA

Association of Hypertension Drug Target Genes With Blood Pressure and Hypertension in 86 588 Individuals

(2011) Andrew D. Johnson et al.   HYPERTENSION

CUBN Is a Gene Locus for Albuminuria

(2011) C. A. Boger et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A Follow-Up Study of a Genome-wide Association Scan Identifies a Susceptibility Locus for Venous Thrombosis on Chromosome 6p24.1

(2010) Pierre-Emmanuel Morange et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Clinical and hematologic findings in Noonan syndrome patients with PTPN11 gene mutations

(2010) Murat Derbent et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Genetic Regulation of Platelet Receptor Expression and Function

(2010) Marlene S. Williams et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The genetics of normal platelet reactivity

(2010) T. J. Kunicki et al.   BLOOD

Transcription profiling in human platelets reveals LRRFIP1 as a novel protein regulating platelet function

(2010) A. H. Goodall et al.   BLOOD

Detection of quantitative trait loci affecting haematological traits in swine via genome scanning

(2010) Yuan-Fang Gong et al.   BMC GENETICS

A combined genome-wide linkage and association approach to find susceptibility loci for platelet function phenotypes in European American and African American families with coronary artery disease

(2010) Rasika A Mathias et al.   BMC Medical Genomics

Epinephrine-induced platelet aggregation. A twin study**

(2010) Blanca Gaxiola et al.   CLINICAL GENETICS

Replication of past candidate loci for common diseases and phenotypes in 100 genome-wide association studies

(2010) Konstantinos C M Siontis et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Analysis of 12,517 inhabitants of a Sardinian geographic isolate reveals that predispositions to thrombocytopenia and thrombocytosis are inherited traits

(2010) G. Biino et al.   HAEMATOLOGICA

Large-scale genomic studies reveal central role of ABO in sP-selectin and sICAM-1 levels

(2010) M. Barbalic et al.   HUMAN MOLECULAR GENETICS

Reduced-Function CYP2C19 Genotype and Risk of Adverse Clinical Outcomes Among Patients Treated With Clopidogrel Predominantly for PCI

(2010) Jessica L. Mega et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Comparison of Platelet Function Tests in Predicting Clinical Outcome in Patients Undergoing Coronary Stent Implantation

(2010) Nicoline J. Breet   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

ACCF/AHA Clopidogrel Clinical Alert: Approaches to the FDA “Boxed Warning”

(2010) David R. Holmes et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

High platelet volume and increased risk of myocardial infarction: 39 531 participants from the general population

(2010) J. KLOVAITE et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Genetic variants in ABCB1 and CYP2C19 and cardiovascular outcomes after treatment with clopidogrel and prasugrel in the TRITON–TIMI 38 trial: a pharmacogenetic analysis

(2010) Jessica L Mega et al.   LANCET

Effect of CYP2C19 and ABCB1 single nucleotide polymorphisms on outcomes of treatment with ticagrelor versus clopidogrel for acute coronary syndromes: a genetic substudy of the PLATO trial

(2010) Lars Wallentin et al.   LANCET

Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists

(2010) Andrew D Johnson et al.   NATURE GENETICS

Genome-wide association study of hematological and biochemical traits in a Japanese population

(2010) Yoichiro Kamatani et al.   NATURE GENETICS

Effects ofCYP2C19Genotype on Outcomes of Clopidogrel Treatment

(2010) Guillaume Paré et al.   NEW ENGLAND JOURNAL OF MEDICINE

The PFA-100® cannot detect blood group-dependent inhibition of platelet function by eptifibatide or abciximab at therapeutic plasma concentrations

(2010) M. Feuring et al.   PLATELETS

Sequence Variants in Three Loci Influence Monocyte Counts and Erythrocyte Volume

(2009) Manuel A.R. Ferreira et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Quantitative trait loci for porcine white blood cells and platelet-related traits in a White Duroc × Erhualian F2resource population

(2009) S. Yang et al.   ANIMAL GENETICS

Mean platelet volume and the extent of coronary artery disease: Results from a large prospective study

(2009) Giuseppe De Luca et al.   ATHEROSCLEROSIS

Class prediction models of thrombocytosis using genetic biomarkers

(2009) D. V. Gnatenko et al.   BLOOD

A functional genomics approach reveals novel quantitative trait loci associated with platelet signaling pathways

(2009) C. I. Jones et al.   BLOOD

Role of sialic acid for platelet life span: exposure of  -galactose results in the rapid clearance of platelets from the circulation by asialoglycoprotein receptor-expressing liver macrophages and hepatocytes

(2009) A. L. Sorensen et al.   BLOOD

Common susceptibility alleles are unlikely to contribute as strongly as the FV and ABO loci to VTE risk: results from a GWAS approach

(2009) D.-A. Tregouet et al.   BLOOD

The low-frequency isoform of platelet glycoprotein VIb attenuates ligand-mediated signal transduction but not receptor expression or ligand binding

(2009) E. Trifiro et al.   BLOOD

A HaemAtlas: characterizing gene expression in differentiated human blood cells

(2009) Nicholas A. Watkins et al.   BLOOD

Genetic evidence for a predominant role of PI3K  catalytic activity in ITAM- and integrin-mediated signaling in platelets

(2009) I. Canobbio et al.   BLOOD

A novel variant on chromosome 7q22.3 associated with mean platelet volume, counts, and function

(2009) N. Soranzo et al.   BLOOD

An Open Access Database of Genome-wide Association Results

(2009) Andrew D Johnson et al.   BMC Medical Genetics

The genetics of antiplatelet drug resistance

(2009) G Feher et al.   CLINICAL GENETICS

Association of Cytochrome P450 2C19 Genotype With the Antiplatelet Effect and Clinical Efficacy of Clopidogrel Therapy

(2009) Alan R. Shuldiner   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Prognostic Role of Mean Platelet Volume and Platelet Count in Ischemic and Hemorrhagic Stroke

(2009) Füsun Mayda-Domaç et al.   Journal of Stroke & Cerebrovascular Diseases

Rap1b is critical for glycoprotein VI-mediated but not ADP receptor-mediated α2β1activation

(2009) Z. WANG et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

VAMP8/endobrevin is overexpressed in hyperreactive human platelets: suggested role for platelet microRNA

(2009) A. A. KONDKAR et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-analysis

(2009) S. G. CHU et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Junctional Adhesion Molecule A Interacts with Afadin and PDZ-GEF2 to Activate Rap1A, Regulate β1 Integrin Levels, and Enhance Cell Migration

(2009) Eric A. Severson et al.   MOLECULAR BIOLOGY OF THE CELL

Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction

(2009) Daniel F Gudbjartsson et al.   NATURE GENETICS

A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium

(2009) Nicole Soranzo et al.   NATURE GENETICS

Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants

(2009) Sekar Kathiresan et al.   NATURE GENETICS

Heritability and Demographic Analyses in the Large Isolated Population of Val Borbera Suggest Advantages in Mapping Complex Traits Genes

(2009) Michela Traglia et al.   PLoS One

ABO-identical versus nonidentical platelet transfusion: a systematic review

(2009) Nadine Shehata et al.   TRANSFUSION

Human platelets as a substrate source for the in vitro amplification of the abnormal prion protein (PrPSc) associated with variant Creutzfeldt-Jakob disease

(2009) Michael Jones et al.   TRANSFUSION

A Genome-wide Association Study Identifies Three Loci Associated with Mean Platelet Volume

(2008) Christa Meisinger et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A Novel Variant in the Platelet Endothelial Aggregation Receptor-1 Gene Is Associated With Increased Platelet Aggregability

(2008) J. Enrique Herrera-Galeano et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Downregulation of Platelet Responsiveness Upon Contact With LDL by the Protein-Tyrosine Phosphatases SHP-1 and SHP-2

(2008) Suzanne J.A. Korporaal et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

PKC-  selectively controls the adhesion-stimulating molecule Rap1

(2008) T. Letschka et al.   BLOOD

Inherited traits affecting platelet function

(2008) Isabelle I. Salles et al.   BLOOD REVIEWS

Pharmacogenetics of aspirin resistance: a comprehensive systematic review

(2008) Timothy Goodman et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Dynamin 3 participates in the growth and development of megakaryocytes

(2008) Jo–Anna Reems et al.   EXPERIMENTAL HEMATOLOGY

Gene Variants Associated With Deep Vein Thrombosis

(2008) Irene D. Bezemer   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The Gi-coupled P2Y12 Receptor Regulates Diacylglycerol-mediated Signaling in Human Platelets

(2008) Gianni F. Guidetti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Ashwell receptor mitigates the lethal coagulopathy of sepsis

(2008) Prabhjit K Grewal et al.   NATURE MEDICINE

Estimates of Genetic and Environmental Contribution to 43 Quantitative Traits Support Sharing of a Homogeneous Environment in an Isolated Population from South Tyrol, Italy

(2007) Fabio Marroni et al.   HUMAN HEREDITY