4.6 Editorial Material

Risk of recurrent venous thromboembolism after stopping treatment in cohort studies: recommendation for acceptable rates and standardized reporting

期刊

JOURNAL OF THROMBOSIS AND HAEMOSTASIS
卷 8, 期 10, 页码 2313-2315

出版社

WILEY
DOI: 10.1111/j.1538-7836.2010.03991.x

关键词

-

资金

  1. Canadian Institutes of Health Research [FRN 79846] Funding Source: Medline

向作者/读者索取更多资源

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

Article Health Care Sciences & Services

A taxonomy and framework for identifying and developing actionable statements in guidelines suggests avoiding informal recommendations

Tamara Lotfi, Anisa Hajizadeh, Lorenzo Moja, Elie A. Akl, Thomas Piggott, Tamara Kredo, Miranda W. Langendam, Alfonso Iorio, Miloslav Klugar, Jitka Klugarova, Ignacio Neumann, Wojtek Wiercioch, Grigorios Leontiadis, Lawrence Mbuagbaw, Alexis F. Turgeon, Joerg Meerpohl, Adrienne Stevens, Jan Brozek, Nancy Santesso, Kevin Pottie, Omar Dewidar, Signe A. Flottorp, Justine Karpusheff, Zuleika Saz-Parkinson, Maria X. Rojas, Elena Parmelli, Derek K. Chu, Peter Tugwell, Vivian Welch, Marc T. Avey, Romina Brignardello-Petersen, Joseph L. Mathew, Zachary Munn, Robby Nieuwlaat, Nathan Ford, Amir Qaseem, Lisa M. Askie, Holger J. Schunemann

Summary: This study proposes a taxonomy and framework to identify and present actionable statements in guidelines. By reviewing case studies and testing the framework using COVID-19 guidelines, the study distinguishes five types of actionable statements. The results suggest that the framework can help guideline developers create actionable statements with clear intent, avoid informal recommendations, and improve understanding and implementation by users.

JOURNAL OF CLINICAL EPIDEMIOLOGY (2022)

Article Hematology

Sexual issues in people with haemophilia: Awareness and strategies for overcoming communication barriers

Greig Blamey, Becky Van Tassel, Elizabeth Sagermann, Ann Marie Stain, Linda Waterhouse, Alfonso Iorio

Summary: The HERO Study identified sexual health as an important issue for people with hemophilia worldwide, but this issue is often inadequately addressed at treatment centers due to barriers in communication. The pilot program in Canada successfully demonstrated improvements in HCPs' knowledge, skills, and comfort levels in discussing sexual health, highlighting the effectiveness of educational programs in facilitating these conversations.

HAEMOPHILIA (2022)

Review Health Care Sciences & Services

Accuracy and Acceptability of Wrist-Wearable Activity-Tracking Devices: Systematic Review of the Literature

Federico Germini, Noella Noronha, Victoria Borg Debono, Binu Abraham Philip, Drashti Pete, Tamara Navarro, Arun Keepanasseril, Sameer Parpia, Kerstin de Wit, Alfonso Iorio

Summary: This study conducted a systematic review of the accuracy and acceptability of wrist-wearable activity trackers. The results showed that Fitbit Charge and Fitbit Charge HR had good accuracy in step counts, while Apple Watch was accurate in measuring heart rate. However, none of the tested devices proved to be accurate in measuring energy expenditure. Efforts should be made to reduce heterogeneity among studies.

JOURNAL OF MEDICAL INTERNET RESEARCH (2022)

Article Hematology

Emicizumab state-of-the-art update

Johnny Mahlangu, Alfonso Iorio, Gili Kenet

Summary: Emicizumab, a bispecific monoclonal antibody, has been widely used in the management of patients with haemophilia A with inhibitors. The global rollout of emicizumab has been successful, with diverse dosing regimens and pharmacokinetic tools contributing to its effectiveness and minimal drug wastage. Pediatric studies have confirmed the safety and efficacy of emicizumab.

HAEMOPHILIA (2022)

Article Hematology

von Willebrand factor propeptide variants lead to impaired storage and ER retention in patient-derived endothelial colony-forming cells

Mackenzie Bowman, Lara Casey, Soundarya N. Selvam, Patricia D. A. Lima, Orla Rawley, Megan Hinds, Angie Tuttle, Julie Grabell, Alfonso Iorio, Irwin Walker, David Lillicrap, Paula James

Summary: The study investigated VWF propeptide variants causing quantitative VWD using patient-derived endothelial colony-forming cells. The results further elucidated the importance of VWF propeptide in the VWD phenotype.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2022)

Article Hematology

Switching from standard to extended half-life FVIII prophylaxis in haemophilia A: Comparison of factor product use, bleed rates and pharmacokinetics

Vuokko Nummi, Anna-Elina Lehtinen, Alfonso Iorio, Timea Szanto, Riitta Lassila

Summary: This study compared the clinical and laboratory outcomes between SHL and EHL FVIII prophylaxis in haemophilia A patients. The results showed that switching to EHL led to decreased infusion frequency and factor consumption, and excellent clinical efficacy.

HAEMOPHILIA (2022)

Article Hematology

A personalized limited sampling approach to better estimate terminal half-life of FVIII concentrates

Pierre Chelle, Alfonso Iorio, Andrea N. Edginton

Summary: This study evaluates a personalized limited sampling approach (Personalized LSA) for more accurate estimation of the terminal half-life of FVIII concentrates in patients with hemophilia A using population PK modeling.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2022)

Review Hematology

Prophylaxis use of clotting factor replacement products in people with non-severe haemophilia: A review of the literature

Alfonso Iorio, Christoph Koenigs, Mark T. Reding, Dawn Rotellini, Mark W. Skinner, Maria Elisa Mancuso, Erik Berntorp

Summary: People with non-severe haemophilia are often under-treated, leading to joint damage and reduced quality of life. There is a need for further research to determine optimal treatment strategies. Early prophylaxis with clotting factor replacement may benefit individuals with frequent bleeding in moderate haemophilia.

HAEMOPHILIA (2022)

Review Hematology

Prevalence of selected bleeding and thrombotic events in persons with hemophilia versus the general population: A scoping review

Amy D. Shapiro, Brandon M. Hardesty, Flora Peyvandi, Alfonso Iorio

Summary: Life expectancy for persons with hemophilia has increased due to advances in treatment, but they are now more likely to be affected by conditions associated with aging. This study analyzed the prevalence of bleeding and thrombotic events in hemophilia populations compared to the general population. The results showed consistently higher rates of bleeding events in hemophilia populations, while the prevalence of arterial thrombosis varied.

RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS (2023)

Article Hematology

Von Willebrand disease: Gaining a global perspective

Jamie M. M. O'Sullivan, Ellia Tootoonchian, Baiba Ziemele, Michael Makris, Augusto B. B. Federici, Claudia Khayat Djambas, Magdy El Ekiaby, Dawn Rotellini, Robert F. F. Sidonio, Alfonso Iorio, Donna Coffin, Glenn F. F. Pierce, Jeffrey Stonebraker, Paula D. D. James, Michelle Lavin

Summary: Recent guidelines for von Willebrand Disease (VWD) highlighted the challenges in diagnosis and management. Identifying the number of persons with VWD (PwVWD) internationally will help target support to aid diagnosis of PwVWD. Registration rates of PwVWD vary internationally and are influenced by national income status.

HAEMOPHILIA (2023)

Review Hematology

Reported prevalence of von Willebrand disease worldwide in relation to income classification

Jeffrey S. Stonebraker, Alfonso Iorio, Michelle Lavin, Suely M. Rezende, Alok Srivastava, Glenn F. Pierce, Donna Coffin, Ellia Tootoonchian, Michael Makris

Summary: This study analyzed the reported prevalence of von Willebrand disease (VWD) worldwide in relation to income classification. The results showed that the prevalence of VWD was significantly higher in high-income countries compared to other income classifications, and the prevalence was higher in females than males. The detection and diagnosis of type 1 VWD presented challenges in forming a consistent prevalence value across countries and income classifications.

HAEMOPHILIA (2023)

Review Hematology

Bleeding events in people with congenital haemophilia A without factor VIII inhibitors receiving prophylactic factor VIII treatment: A systematic literature review

Pier Mannuccio Mannucci, Craig M. Kessler, Federico Germini, Francis Nissen, Richard Ofori-Asenso, Cristian Brocchieri, Sara Bendinelli, Alfonso Iorio

Summary: This systematic literature review assessed bleeding outcomes in people with congenital haemophilia A (PwcHA) using FVIII-containing products as prophylactic treatment. The results showed that PwcHA without inhibitors still experience bleeding despite FVIII prophylaxis. Therefore, improved standardization on capturing and reporting bleeding outcomes is needed for effective treatment comparisons.

HAEMOPHILIA (2023)

Article Hematology

Treatment switch to nonacog beta pegol factor IX in hemophilia B: A Canadian cost-consequence analysis based on real-world factor IX consumption and clinical outcomes

Alfonso Iorio, Vance Macdonald, Alexandre Caillaud, Maria D. Luckevich, Pia Christoffersen, Davide Matino, Arun Keepanasseril, Emma Iserman, Federico Germini, Anthony Bentley, Man-Chiu Poon

Summary: This study evaluates the impact of switching to N9-GP on treatment costs for patients with hemophilia. The results show that the switch to N9-GP leads to improvements in bleed rates and factor consumption, resulting in a decrease in treatment costs by 9.4% to 10.5%.

RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS (2023)

Article Health Care Sciences & Services

User-Centered Development and Testing of the Online Patient-Reported Outcomes, Burdens, and Experiences (PROBE) Survey and the myPROBE App and Integration With the Canadian Bleeding Disorder Registry: Mixed Methods Study

Federico Germini, Victoria Borg Debono, David Page, Victoria Zuk, Alexandra Kucher, Chris Cotoi, Nicholas Hobson, Michael Sevestre, Mark W. Skinner, Alfonso Iorio

Summary: This study aimed to assess the needs of stakeholders involved in the use of the PROBE questionnaire, develop the necessary software infrastructure, and test the usability of the final product. Through interviews and user evaluations, an updated online survey and a mobile app were successfully developed with a high user satisfaction score. This will facilitate data collection for research and advocacy purposes in clinical practice.

JMIR HUMAN FACTORS (2022)

Article Hematology

Switching to nonacog beta pegol in hemophilia B: Outcomes from a Canadian real-world, multicenter, retrospective study

Davide Matino, Alfonso Iorio, Arun Keepanasseril, Federico Germini, Alexandre Caillaud, Manuel Carcao, Julia Hews-Girard, Emma Iserman, Paula James, Adrienne Lee, Chai W. Phua, Haowei (Linda) Sun, Jerome Teitel, Man-Chiu Poon

Summary: This study assessed the treatment outcomes of using Nonacog beta pegol (N9-GP) in a real-world setting for patients with hemophilia B. The results showed that switching to N9-GP resulted in optimal bleeding control and lower factor consumption, regardless of the previous product used.

RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS (2022)

暂无数据