Article
Pharmacology & Pharmacy
Changhong Cai, Yonghui Wu, Lebing Yang, Yijia Xiang, Ning Zhu, Huan Zhao, Wuming Hu, Lingchun Lv, Chunlai Zeng
Summary: Our study demonstrates that sodium selenite (SSE) attenuates vascular remodeling by improving characteristic features, inhibiting proliferation and enhancing apoptosis of VSMCs. SSE also inhibits AKT and ERK signaling pathways, preventing VSMCs dysfunction.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiong Chang Lim, Chenyuan Huang, Siti Maryam J. M. Yatim, Suet Yen Chong, Sock Hwee Tan, Xiaoxun Yang, Caryn L. Heldt, Jodi Pedersen, Michael Talanker, Harshvardhan Modh, Matthias G. Wacker, Giorgia Pastorin, Siew Pang Chan, A. Mark Richards, Chris J. Charles, Mark Y. Chan, Jiong-Wei Wang
Summary: The association between LDL-EV hemostatic/fibrinolysis protein ratios and post-acute myocardial infarction (post-AMI) left ventricular (LV) remodeling was investigated. It was found that higher levels of SerpinC1 and VWF but lower levels of plasminogen in LDL-EVs were associated with reverse LV remodeling. The ratios of VWF:Plasminogen and SerpinC1:Plasminogen showed better predictive power for reverse LV remodeling than current standard plasma biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemical Research Methods
Daishen Luo, Erika M. Chelales, Millicent M. Beard, Nithya Kasireddy, Damir B. Khismatullin
Summary: The study introduces a containerless drop-of-blood method for coagulation analysis, termed i-QATT (TM), which can rapidly detect hyper- and hypo-coagulable states and identify single deficiency in coagulation factors.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Review
Gastroenterology & Hepatology
Alberto Zanetto, Patrick Northup, Lara Roberts, Marco Senzolo
Summary: Hospitalised patients with decompensated cirrhosis experience a rebalanced haemostasis, but this balance can easily be disrupted, leading to bleeding. Acute kidney injury, bacterial infections/sepsis, and progression to acute-on-chronic liver failure further increase the risk of bleeding. Unfortunately, there is no single laboratory method to accurately assess bleeding risk and guide preventive measures. Understanding the haemostatic alterations during acute illness could improve the management of these patients.
JOURNAL OF HEPATOLOGY
(2023)
Article
Hematology
Johannes Thaler, Ton Lisman, Peter Quehenberger, Lena Hell, Philipp Schwabl, Bernhard Scheiner, Theresa Bucsics, Rienk Nieuwland, Cihan AY, Michael Trauner, Ingrid Pabinger, Thomas Reiberger, Mattias Mandorfer
Summary: This study investigated the coagulation system in ascites of patients with cirrhosis and found that ascitic fluid was procoagulant with high extracellular vesicle-associated tissue factor activity. Fibrinolytic enzymes were activated in ascitic fluid, potentially re-entering the systemic circulation and inducing systemic fibrinolysis. Plasma D-dimer levels were independently linked to ascites severity in a separate cohort of patients.
THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Biochemistry & Molecular Biology
Claire S. Whyte, Akriti Rastogi, Ellis Ferguson, Michela Donnarumma, Nicola J. Mutch
Summary: This study compared the efficacy of cryoprecipitate and two fibrinogen concentrates in restoring clot integrity in a trauma-induced coagulopathy (TIC) model. Results showed that FibCLOT(R) was superior in normalizing clot structure and stabilizing clots against mechanical and fibrinolytic degradation compared to the other treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Wenfeng Li, Wenjuan Chen, Hongyan Peng, Zhenghui Xiao, Jinqiao Liu, Yunhong Zeng, Ting Huang, Qingqing Song, Xun Wang, Yunbin Xiao
Summary: This study evaluated whether inhibiting the expression of pyruvate kinase M2 (PKM2) contributed to the improvement of pulmonary vascular remodeling in monocrotaline-induced pulmonary arterial hypertension (PAH) rats. Shikonin improved hemodynamics and pulmonary vascular remodeling in PAH rats, at least partly through the inhibition of PKM2 and the resultant suppression of aerobic glycolysis.
MOLECULAR MEDICINE REPORTS
(2023)
Article
Pharmacology & Pharmacy
Telli Gokcen, Kazkayasi Inci, Ergonul E. Inci, Onder Sevgen, Uma Serdar
Summary: This study aimed to investigate the effects of allopurinol on the pathological changes in a rat model of pulmonary hypertension (PH) induced by monocrotaline (MCT). The results showed that allopurinol could reverse the pathological changes caused by oxidative stress and high uric acid levels, and improve pulmonary arterial relaxation and basal lung perfusion pressure.
PULMONARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Chemistry, Analytical
Jikang Wang, Cheol Ung Choi, Sehyun Shin
Summary: In this study, we propose an innovative method of microfluidic thromboelastography (mu-TEG) that rapidly measures the viscoelastic properties of blood coagulation in oscillating flow through circular tubes. The mu-TEG system showed good agreement with the TEG5000 and can be a useful tool for analyzing hemostasis and fibrinolysis in emergency and operating rooms.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Review
Biochemistry & Molecular Biology
Sabina Ugovsek, Miran Sebestjen
Summary: Increased levels of lipoprotein(a) are associated with coronary artery disease, degenerative aortic stenosis, and heart failure. These levels are determined by genetic variations of the LPA gene encoding the apolipoprotein(a) component of lipoprotein(a). Lipoprotein(a) increases cardiovascular risk through various mechanisms.
Article
Multidisciplinary Sciences
Ryogo Yoshii, Teiji Sawa, Hidetake Kawajiri, Fumimasa Amaya, Kenichi A. Tanaka, Satoru Ogawa
Summary: This study compared the ClotPro system with ROTEM and plasma coagulation assays in cardiac surgery patients. The results showed a strong correlation between ClotPro and ROTEM, with EX-test and IN-test parameters being interchangeable. ClotPro was capable of emulating well-established ROTEM thresholds, providing a new tool for assessing hemostasis.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Machteld Sillen, Paul J. Declerck
Summary: TAFI, a proenzyme, is converted to a potent attenuator of the fibrinolytic system upon activation by thrombin, plasmin, or the thrombin/thrombomodulin complex. The development of molecules antagonizing TAFI function has gained much interest in the field.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Hematology
Takumi Tsuchida, Mineji Hayakawa, Osamu Kumano
Summary: This study aimed to investigate the characteristics of clot-fibrinolysis waveform analysis (CFWA) using plasma samples from patients in the critical care unit. The results showed that there were significant differences in FMC, Fbg, and fibrinolysis-related markers (a(2)-PI and Plg) among the three groups. In conclusion, CFWA has the potential to reflect the fibrinolysis status in one global assay.
THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Cardiac & Cardiovascular Systems
C. Ibanez, J. Perdomo, A. Calvo, C. Ferrando, J. C. Reverter, D. Tassies, A. Blasi
Summary: In COVID-19 patients, a hypercoagulable state with decreased fibrinolytic capacity is observed in ROTEM profiles despite increased D-dimer levels, suggesting lungs may be the main source of D-dimer while a systemic hypofibrinolytic state coexists. Future studies should confirm this hypothesis.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2021)
Article
Cardiac & Cardiovascular Systems
Claire S. Whyte, Gael B. Morrow, Julia S. Gauer, Samantha J. Montague, Philip L. R. Nicolson
Summary: The 2023 annual meeting of the British Society for Haemostasis and Thrombosis (BSHT) was held in Birmingham, United Kingdom, focusing on novel therapeutics and emerging technology. This article discusses the exciting research presented at the meeting.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Letter
Critical Care Medicine
Taro Yasuma, Corina N. D'Alessandro-Gabazza, Hajime Fujimoto, Tetsu Kobayashi, Esteban C. Gabazza
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Cell Biology
Chisa Inoue, Taro Yasuma, Corina N. D'Alessandro-Gabazza, Masaaki Toda, Valeria Fridman D'Alessandro, Ryo Inoue, Hajime Fujimoto, Hajime Kobori, Suphachai Tharavecharak, Atsuro Takeshita, Kota Nishihama, Yuko Okano, Jing Wu, Tetsu Kobayashi, Yutaka Yano, Hirokazu Kawagishi, Esteban C. Gabazza
Summary: The chemical compound imidazole-4-carboxamide found in mushrooms shows potential as a coadjuvant therapy with cisplatin in cancer treatment, reducing tumor volume and improving immune response.
Letter
Critical Care Medicine
Hajime Fujimoto, Corina N. D'Alessandro-Gabazza, Taro Yasuma, Tetsu Kobayashi, Esteban C. Gabazza
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Microbiology
Ahmed M. Abdel-Hamid, Corina N. D'Alessandro-Gabazza, Taro Yasuma, Kimberly K. O. Walden, Christopher J. Fields, Esteban C. Gabazza, Isaac Cann
Summary: We report the complete genome sequences of three Staphylococcus haemolyticus strains isolated from a mouse fibrotic lung tissue, which exhibit proapoptotic activity on human lung alveolar epithelial cells. The genomes were obtained using a combination of Illumina MiSeq and Oxford Nanopore MinION sequencing.
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2022)
Article
Chemistry, Medicinal
Yoichi Nishii, Kazuki Furuhashi, Kentaro Ito, Tadashi Sakaguchi, Yuta Suzuki, Kentaro Fujiwara, Taro Yasuma, Tetsu Kobayashi, Corina N. D'Alessandro-Gabazza, Esteban C. Gabazza, Osamu Taguchi, Osamu Hataji
Summary: This article reports a rare case of advanced thymic carcinoma that showed successful maintenance therapy with pembrolizumab after effective first-line treatment with carboplatin-based chemotherapy plus pembrolizumab. This provides a new approach for the treatment of thymic carcinoma.
Letter
Allergy
Taro Yasuma, Corina N. D'Alessandro-Gabazza, Hajime Fujimoto, Tetsu Kobayashi, Ichiro Imoto, Esteban C. Gabazza
Article
Environmental Sciences
Takumi Kitajima, Joachim Schuz, Akemi Morita, Wakaha Ikeda, Hirokazu Tanaka, Kayo Togawa, Esteban C. Gabazza, Masao Taki, Kuniaki Toriyabe, Tomoaki Ikeda, Shigeru Sokejima
Summary: This study estimated the exposure of pregnant women to intermediate frequency electromagnetic fields (IF-EMFs) generated by induction cookers in households using a questionnaire. The validity of different estimation models was compared, and it was found that using three variables (distance, wattage, and cookware diameter) provided the best estimation. This study contributes to understanding the dose-response relationship in epidemiological studies of IF-EMF exposure.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Letter
Critical Care Medicine
Taro Yasuma, Corina N. D'Alessandro-Gabazza, Tetsu Kobayashi, Esteban C. Gabazza, Hajime Fujimoto
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Mihaya Kotajima, Jae-Hoon Choi, Mitsuru Kondo, Corina N. D'Alessandro-Gabazza, Masaaki Toda, Taro Yasuma, Esteban C. Gabazza, Yukihiro Miwa, Chiho Shoda, Deokho Lee, Ayaka Nakai, Toshihide Kurihara, Jing Wu, Hirofumi Hirai, Hirokazu Kawagishi
Summary: Two compounds (1 and 2) were isolated from the culture broth of Lepista luscina, and the structure of compound 1 was identified for the first time in a natural source. These compounds showed inhibitory effects on the expression of Axl and immune checkpoint molecules in A549 lung cancer cells. Moreover, they also exhibited HIF inhibitory activities in different cell lines.
Article
Biochemistry & Molecular Biology
Ryo Inoue, Taro Yasuma, Valeria Fridman D'Alessandro, Masaaki Toda, Toshiyuki Ito, Atsushi Tomaru, Corina N. N. D'Alessandro-Gabazza, Tatsuki Tsuruga, Tomohito Okano, Atsuro Takeshita, Kota Nishihama, Hajime Fujimoto, Tetsu Kobayashi, Esteban C. C. Gabazza
Summary: This study evaluated the role of matrix metalloproteinase-2 (MMP-2) in the development of pulmonary fibrosis. Transgenic mice overexpressing human MMP-2 showed decreased lung inflammation and fibrosis compared to wild-type mice, following bleomycin-induced lung injury. MMP-2 appears to protect against pulmonary fibrosis by inhibiting apoptosis of lung epithelial cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agronomy
Suphachai Tharavecharak, Corina N. D'Alessandro-Gabazza, Masaaki Toda, Taro Yasuma, Taku Tsuyama, Ichiro Kamei, Esteban C. Gabazza
Summary: The study evaluated the optimal conditions for the artificial culture of Termitomyces and their inhibitory activity on AXL and immune checkpoint molecules in lung adenocarcinoma and melanoma cell lines. The results showed that one selected strain of Termitomyces inhibited the mRNA relative expression of AXL receptor tyrosine kinase and immune checkpoint molecules in cancer cell lines, suggesting its potential usefulness as a co-adjuvant therapy in malignant diseases.
Review
Microbiology
Ichiro Imoto, Taro Yasuma, Corina N. D'Alessandro-Gabazza, Satoko Oka, Moriharu Misaki, Noriyuki Horiki, Esteban C. Gabazza
Summary: Helicobacter pylori is the main causative agent of gastroduodenal diseases, and its eradication has become challenging due to the emergence of antibiotic-resistant strains. Lactoferrin, an iron-binding protein, has shown antimicrobial properties and its concentrations increase during H. pylori infection. Although lactoferrin alone cannot eradicate H. pylori, recent studies have explored the potential of oral lactoferrin supplementation as a part of eradication therapy.
Article
Infectious Diseases
Jing Wu, Takeru Ohura, Ryuhei Ogura, Junhong Wang, Jae-Hoon Choi, Hajime Kobori, Corina N. D'Alessandro-Gabazza, Masaaki Toda, Taro Yasuma, Esteban C. Gabazza, Yuichi Takikawa, Hirofumi Hirai, Hirokazu Kawagishi
Summary: A novel compound (1) and two known compounds (2 and 3) were isolated from the culture broth of Chlorophyllum molybdites, while three known compounds (4-6) were isolated from its fruiting bodies. The planar structure of 1 was determined by spectroscopic data interpretation. Compound 2 exhibited significant inhibition activity against Axl and immune checkpoints (PD-L1, PD-L2), and compounds 2 and 3 inhibited the growth of P. carotovorum and C. michiganensis phytopathogenic bacteria. Compounds 1-4 showed significant regulatory activity on lettuce growth.
Letter
Critical Care Medicine
Taro Yasuma, Corina N. D'Alessandro-Gabazza, Tetsu Kobayashi, Esteban C. Gabazza, Hajime Fujimoto
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Oncology
Tadashi Nishimura, Hajime Fujimoto, Tomohito Okano, Masahiro Naito, Chikashi Tsuji, Soichi Iwanaka, Yasumasa Sakakura, Taro Yasuma, Corina N. D'Alessandro-Gabazza, Yasuhiro Oomoto, Esteban C. Gabazza, Tetsu Kobayashi, Hidenori Ibata
Summary: This study retrospectively evaluated patients with non-small cell lung cancer and found that the combination therapy of docetaxel plus ramucirumab was superior to docetaxel monotherapy for improving time-to-treatment failure and overall survival, irrespective of previous treatment with immune checkpoint inhibitors.