Article
Oncology
Zhenwen Chen, Fei Chai, Yanfeng Xi, Hongwei Zhang, Yirong Xu, Zhaoxia Zhang, Su Li, Xiaoai Tian
Summary: The study investigated the expression and genetic alterations of c-MYC in primary systemic ALCL and found that c-MYC protein expression and c-MYC aneuploidy could predict worse survival in patients with ALCL. The co-expression of c-MYC and ALK increased with ALCL clinical stages and the International Prognostic Index score. The study concluded that c-MYC was a significant independent prognostic factor for progression-free survival and overall survival in patients with ALCL.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Tongqing Li, Steven E. Stayrook, Yuko Tsutsui, Jianan Zhang, Yueyue Wang, Hengyi Li, Andrew Proffitt, Stefan G. Krimmer, Mansoor Ahmed, Olivia Belliveau, Ian X. Walker, Krishna C. Mudumbi, Yoshihisa Suzuki, Irit Lax, Diego Alvarado, Mark A. Lemmon, Joseph Schlessinger, Daryl E. Klein
Summary: The proto-oncogene ALK encodes anaplastic lymphoma kinase, which is primarily expressed in the developing nervous system. Its activity is associated with learning and memory, energy expenditure, and obesity prevention. Aberrant ALK signaling causes various cancers, including being a driver in pediatric neuroblastoma. The study reveals the crystal structures of ALK's extracellular glycine-rich domain (GRD) and how it regulates receptor activity, providing insights into potential therapeutics for ALK-expressing cancers.
Article
Multidisciplinary Sciences
Andrey V. Reshetnyak, Paolo Rossi, Alexander G. Myasnikov, Munia Sowaileh, Jyotidarsini Mohanty, Amanda Nourse, Darcie J. Miller, Irit Lax, Joseph Schlessinger, Charalampos G. Kalodimos
Summary: ALK is a receptor tyrosine kinase that regulates important functions in the central nervous system, and mutations in this gene may lead to neuroblastoma. Research has revealed a mechanism of RTK activation that allows dimerization by different ligands, with the complex architecture of the receptor-ligand complex playing a key role in this process.
Review
Immunology
Ye Guo, Hanfei Guo, Yongfei Zhang, Jiuwei Cui
Summary: Alterations in the ALK gene are crucial in the development of various tumors, and targeted therapy has transformed the treatment approach. However, resistance remains a challenge. ALK gene variants have a significant impact on the tumor immune microenvironment, suggesting potential clinical applications for immunotherapy targeting ALK-altered tumors.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Leora Horn, Ziping Wang, Gang Wu, Elena Poddubskaya, Tony Mok, Martin Reck, Heather Wakelee, Alberto A. Chiappori, Dae Ho Lee, Valeriy Breder, Sergey Orlov, Irfan Cicin, Ying Cheng, Yunpeng Liu, Yun Fan, Jennifer G. Whisenant, Yi Zhou, Vance Oertel, Kim Harrow, Chris Liang, Li Mao, Giovanni Selvaggi, Yi-Long Wu
Summary: Ensartinib demonstrated superior efficacy compared to crizotinib in both systemic and intracranial disease, making it a new first-line option for patients with ALK-positive NSCLC.
Article
Medicine, Research & Experimental
Junjiong Zheng, Sihong Lu, Yi Huang, Xu Chen, Jie Zhang, Yuhui Yao, Jinhua Cai, Jieying Wu, Jianqiu Kong, Tianxin Lin
Summary: This study confirms the prognostic value of preoperative FISH assay and proposes a FISH-clinical nomogram for predicting RFS in NMIBC patients.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Oncology
Qi Sun, Qi Li, Fuping Gao, Hongyan Wu, Yao Fu, Jun Yang, Xiangshan Fan, Xiaobin Cui, Xiaohong Pu
Summary: In this study, the HER2 scoring system in colorectal cancer (CRC) was evaluated using five immunohistochemical (IHC) scoring criteria and two fluorescence in situ hybridization (FISH) criteria. The study found that the IRS-p criterion was more suitable for assessing the HER2 status in CRC patients, while the FISH scoring system could identify subgroups with unique clinicopathological characteristics.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Nutrition & Dietetics
Simona Dedoni, Maria Scherma, Chiara Camoglio, Carlotta Siddi, Walter Fratta, Paola Fadda
Summary: The expression of ALK receptor is reduced in rats with activity-based anorexia, indicating a potential involvement of ALK receptor in the pathophysiology of anorexia nervosa.
Article
Immunology
Wen Dong, Pengfei Lei, Xin Liu, Qin Li, Xiangyang Cheng
Summary: The case report presented a rare PD-L1-overexpressing lung adenocarcinoma patient who harbored both EML4-ALK gene rearrangement and BRAF mutation. Molecular analysis after resistance to ALK-TKIs revealed high PD-L1 expression and tumor mutation burden, leading to successful treatment with the anti-PD-1 inhibitor nivolumab. This suggests that PD-1 inhibitors may be effective for patients with multiple gene-driven PD-L1-expressing NSCLC with ALK gene rearrangement.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Yushi Wang, Yingying Chen, Yeqing Wan, Chen Hong, Jinhua Shang, Fengzhe Li, Xiaoqing Liu, Fuan Wang
Summary: This study proposes an autocatalytic hybridization system that combines hybridization chain assembly and catalytic DNA assembly for highly efficient positive feedback amplification. The system allows sensitive detection of polynucleotide kinase and has the potential for accurate monitoring and screening in vitro and in biological samples.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Pharmacology & Pharmacy
Kajetan Kielbowski, Justyna Zychowska, Rafal Becht
Summary: This review summarizes the efficacy and safety profile of ALK inhibitors, describes off-target anticancer effects, and discusses resistance mechanisms in the context of personalized oncology.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Yihan Liu, Chen Chen, Chencheng Rong, Xucheng He, Li Chen
Summary: This study analyzed real-world data from the FAERS to investigate cardiac disorders associated with ALK-TKIs. The results showed that cardiac adverse events were more prevalent in patients aged 45 or older, with a higher proportion among women. Cardiac arrhythmia, especially bradycardia, was a common adverse event, and certain drugs like crizotinib and lorlatinib showed positive signals in cardiac disorders. The study also identified potential new adverse drug reactions, such as myocarditis caused by ceritinib and cardiomyopathy caused by lorlatinib. The findings highlight the importance of monitoring and further research on the cardiac safety of ALK-TKIs.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Keshav Patil, Earl Joseph Jordan, Jin H. Park, Krishna Suresh, Courtney M. Smith, Abigail A. Lemmon, Yael P. Mosse, Mark A. Lemmon, Ravi Radhakrishnan
Summary: Kinases are crucial in various cellular processes and commonly mutated in cancer, their activation status can be effectively predicted through computational studies despite mutations occurring throughout the kinase domain. The results provide insights into convergent activation mechanisms in majority of studied mutations.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
I. Garces de los Fayos Alonso, L. Zujo, I Wiest, P. Kodajova, G. Timelthaler, S. Edtmayer, M. Zrimsek, S. Kollmann, C. Giordano, M. Kothmayer, H. A. Neubauer, S. Dey, M. Schlederer, B. S. Schmalzbauer, T. Limberger, C. Probst, O. Pusch, S. Hogler, S. Tangermann, O. Merkel, A. Schiefer, C. Kornauth, N. Prutsch, M. Zimmerman, B. Abraham, J. Anagnostopoulos, L. Quintanilla-Martinez, S. Mathas, P. Wolf, D. Stoiber, P. B. Staber, G. Egger, W. Klapper, W. Woessmann, T. A. Look, P. Gunning, S. D. Turner, R. Moriggl, S. Lagger, L. Kenner
Summary: This study reveals the important role of PDGFRβ in aggressive ALCL and its activation of STAT5 in inducing cell growth and survival-related gene expression. Simultaneous deletion of STAT5 gene products significantly impairs cell viability. Additionally, blockade of PDGFRβ and STAT3/5 activity effectively obstructs tumor development. Thus, PDGFRβ and PDGFRβ-STAT3/5 signaling may serve as novel targets for the treatment of aggressive ALCL.
Article
Medicine, Research & Experimental
Bayan Maraqa, Maxim Al-Ashhab, Maher A. Sughayer
Summary: This study examined the prevalence of ALK rearrangement in Jordanian patients with NSCLC and compared the results of IHC and FISH for detecting ALK rearrangement. The sensitivity and specificity of ALK immunostaining compared with FISH were calculated. ALK rearrangement was significantly associated with age, gender, and smoking history.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2022)
Review
Medical Laboratory Technology
Jennifer M. Boland, Bobbi S. Pritt
SEMINARS IN DIAGNOSTIC PATHOLOGY
(2017)
Article
Pathology
Cory J. Broehm, Carrie Y. Inwards, Alyaa Al-Ibraheemi, Doris E. Wenger, Sarah M. Jenkins, Long Jin, Andre M. Oliveira, Riyam T. Zreik, Jodi M. Carter, Jennifer M. Boland, Karen J. Fritchie
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2018)
Article
Pathology
Raghavendra Pillappa, Joseph J. Maleszewski, William R. Sukov, Patrick P. Bedroske, Patricia T. Greipp, Jennifer M. Boland, Eunhee S. Yi, Tobias Peikert, Marie Christine Aubry, Anja C. Roden
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2018)
Article
Pathology
Simone B. S. P. Terra, Scott W. Aesif, Joseph J. Maleszewski, Andrew L. Folpe, Jennifer M. Boland
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2018)
Article
Oncology
Kunlatida Maneenil, Zhiqiang Xue, Ming Liu, Jennifer Boland, Fengying Wu, Shawn M. Stoddard, Julian Molina, Ping Yang
CLINICAL LUNG CANCER
(2018)
Article
Pathology
Jennifer M. Boland, Joseph J. Maleszewski, Jason A. Wampfler, Jesse S. Voss, Benjamin R. Kipp, Ping Yang, Eunhee S. Yi
Article
Pathology
Andrew L. Folpe, Rondell P. Graham, Anthony Martinez, David Schembri-Wismayer, Jennifer Boland, Karen J. Fritchie
Article
Oncology
Janani S. Reisenauer, Wadad Mneimneh, Sarah Jenkins, Aaron S. Mansfield, Marie Christine Aubry, Karen J. Fritchie, Mark S. Allen, Shanda H. Blackmon, Stephen D. Cassivi, Francis C. Nichols, Dennis A. Wigle, K. Robert Shen, Jennifer M. Boland
JOURNAL OF THORACIC ONCOLOGY
(2018)
Review
Endocrinology & Metabolism
J. M. Boland, P. J. Tebben, A. L. Folpe
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2018)
Editorial Material
Microbiology
Poornima Ramanan, Abinash Virk, Jennifer M. Boland, Bobbi Pritt, Marco Rizzo, Nancy L. Wengenack
JOURNAL OF CLINICAL MICROBIOLOGY
(2018)
Article
Clinical Neurology
Jonathan J. Stone, Jennifer M. Boland, Robert J. Spinner
WORLD NEUROSURGERY
(2018)
Article
Oncology
Cyril Varghese, Srinivasan Rajagopalan, Ronald A. Karwoski, Brian J. Bartholmai, Fabien Maldonado, Jennifer M. Boland, Tobias Peikert
JOURNAL OF THORACIC ONCOLOGY
(2019)
Article
Clinical Neurology
J. C. Benson, J. Trejo-Lopez, J. Boland-Froemming, B. Pollock, C. H. Hunt, J. T. Wald
Summary: Calcified pseudoneoplasms of the neuraxis are extremely rare non-neoplastic lesions that can cause neurological symptoms and mimic other entities such as calcified oligodendrogliomas and meningiomas. These lesions can be distinguished at imaging due to their unique characteristics, aiding in diagnosis.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2021)
Article
Pathology
Nooshin Karamzadeh Dashti, Armita Bahrami, Seung J. Lee, Sarah M. Jenkins, Fausto J. Rodriguez, Andrew L. Folpe, Jennifer M. Boland
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2017)
Review
Pathology
Jennifer M. Boland, Andrew L. Folpe
ADVANCES IN ANATOMIC PATHOLOGY
(2017)