Article
Medicine, General & Internal
Jingsheng Cai, Fan Yang, Xun Wang
Summary: This study aims to investigate occult non-small cell lung cancer (NSCLC), an underappreciated tumor, and found that it is an aggressive tumor with poor prognosis. Surgery is the preferred treatment. More attention should be paid to this overlooked disease due to no evidence of tumor imaging.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Shawn J. Rice, Chandra P. Belani
Summary: Blood-based biomarkers, including systemic inflammation indicators and circulating factors, are associated with poor prognosis in lung cancer patients. Elevated levels of inflammation markers were found in non-small cell lung cancer (NSCLC) patients compared to small cell lung cancer (SCLC) and disease-free (DF) patients. Specific markers were identified as predictors of progression and overall survival in NSCLC patients, highlighting the potential for personalized treatment strategies.
Article
Multidisciplinary Sciences
Qing Li, Zhen Lin, Ye Hong, Yang Fu, Yueyun Chen, Ting Liu, Yue Zheng, Jiangfang Tian, Chunhua Liu, Wei Pu, Zhenyu Ding, Chun Wang
Summary: Patients with advanced non-small cell lung cancer are susceptible to brain metastases, including brain parenchymal metastases and leptomeningeal metastases. Patients with leptomeningeal metastases have a higher proportion of EGFR exon 21 point mutations and shorter survival compared to patients without brain metastases or with brain parenchymal metastases. Two prediction models were developed to predict the development of brain parenchymal metastases and leptomeningeal metastases in advanced non-small cell lung cancer patients.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Nasser Altorki, Xiaofei Wang, David Kozono, Colleen Watt, Rodney Landrenau, Dennis Wigle, Jeffrey Port, David R. Jones, Massimo Conti, Ahmad S. Ashrafi, Moishe Liberman, Kazuhiro Yasufuku, Stephen Yang, John D. Mitchell, Harvey Pass, Robert Keenan, Thomas Bauer, Daniel Miller, Leslie J. Kohman, Thomas E. Stinchcombe, Everett Vokes
Summary: This study compared lobectomy and sublobar resection in lung cancer patients. The results showed that in patients with tumors sized 2 cm or less and negative lymph nodes, sublobar resection was not inferior to lobectomy in terms of disease-free survival, and overall survival was similar between the two procedures.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Medicine, Research & Experimental
Yuan Gu, Gianni Pais, Vivien Becker, Christina Korbel, Emmanuel Ampofo, Elke Ebert, Johannes Hohneck, Nicole Ludwig, Eckart Meese, Rainer M. Bohle, Yingjun Zhao, Michael D. Menger, Matthias W. Laschke
Summary: The research demonstrates that miR-22 is highly expressed in ECs and significantly downregulated in NSCLC tissues. Endothelial miR-22 acts as an angiogenesis inhibitor by targeting sirtuin 1 and FGFR1 to inhibit ECs' angiogenic activities, thus suppressing NSCLC growth.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Biochemistry & Molecular Biology
Qing Ye, Nancy Lan Guo
Summary: Currently, there are no accurate biomarkers for optimal treatment selection in early-stage non-small cell lung cancer (NSCLC). This study demonstrates that hub genes in genome-scale regulatory networks are associated with NSCLC tumorigenesis, proliferation, and survival. These findings have implications for prioritizing therapeutic targets to improve patient survival outcomes.
Article
Oncology
Pietro Rosellini, Samuel Amintas, Charline Caumont, Remi Veillon, Sigolene Galland-Girodet, Alain Cuguilliere, Laurent Nguyen, Charlotte Domblides, Amandine Gouverneur, Jean-Philippe Merlio, Julien Bezin, Pierre-Olivier Girodet
Summary: STK11 mutation is associated with poor prognosis in non-small cell lung cancer (NSCLC), leading to decreased response to immunotherapy treatment.
EUROPEAN JOURNAL OF CANCER
(2022)
Letter
Medicine, General & Internal
Hollis Viray, Deepa Rangachari, Daniel B. Costa
Summary: The study reported initial data of trastuzumab deruxtecan in the treatment of lung cancers with ERBB2 mutations, including patients who had previously received ineffective ERBB2 tyrosine kinase inhibitors.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Oncology
Ambika S. Bhatt, Matthew B. Schabath, Aasha I. Hoogland, Heather S. L. Jim, Renee Brady-Nicholls
Summary: This study analyzed the dynamics of patient-reported outcomes (PROs) to predict tumor volume changes in non-small cell lung cancer patients undergoing immunotherapy. The study found significant correlations between changes in tumor volume over time and dizziness, insomnia, and fatigue. Cumulative changes in insomnia were able to predict progressive disease with 77% accuracy, an average of 45 days prior to the next imaging scan.
CLINICAL CANCER RESEARCH
(2023)
Review
Oncology
Jessica Donington, Lana Schumacher, Jane Yanagawa
Summary: Surgical care for early stage non-small-cell lung cancer is constantly improving with new procedures and techniques, particularly a shift towards minimally invasive surgery. These advancements in care are crucial as there is an increase in early detection through screening and a greater need for adjuvant and neoadjuvant strategies.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Bor-Shiuan Shyr, Chien-Sheng Huang, Hui-Shan Chen, Po-Kuei Hsu, Chao-Hua Chiu, Han-Shui Hsu, Chun-Ming Tsai, Yuh-Min Chen
Summary: This study aimed to investigate the impact of primary lung resection and systemic treatment on disease progression and survival in patients with oligometastatic NSCLC. The results showed no significant differences in perioperative complications, hospital length of stay, disease progression, overall death, median PFS, and OS between patients who received primary lung resection and systemic treatment. It was also found that patients with single-organ metastasis had significantly longer PFS and OS than those with oligometastases. Nonsolitary metastasis was identified as the only independent predictor of PFS.
ANNALS OF THORACIC SURGERY
(2022)
Article
Medicine, Research & Experimental
Dan Yan, Justus M. Huelse, Dmitri Kireev, Zikang Tan, Luxiao Chen, Subir Goyal, Xiaodong Wang, Stephen Frye, Madhusmita Behera, Frank Schneider, Suresh S. Ramalingam, Taofeek Owonikoko, H. Shelton Earp, Deborah DeRyckere, Douglas K. Graham
Summary: Acquired resistance is inevitable in non-small cell lung cancers (NSCLCs) treated with osimertinib (OSI). Activation of MERTK is associated with OSI resistance and inhibition of MERTK kinase can resensitize resistant cells to OSI.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Oncology
Haiying Ding, Jiao Sun, Yu Song, Wenxiu Xin, Junfeng Zhu, Like Zhong, Yinbo Chen, Yiwen Zhang, Yinghui Tong, Luo Fang
Summary: The prognosis of NSCLC patients is closely related to the distance between tumor microvessels and cancer cells, with longer distances associated with poorer survival rates.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Ditte Sloth Moller, Christina Maria Lutz, Azza Ahmed Khalil, Markus Alber, Marianne Ingerslev Holt, Maria Kandi, Hjordis Hjalting Schmidt, Marie Tvilum, Ane Appelt, Marianne Marquard Knap, Lone Hoffmann
Summary: This study investigated the clinical benefits of tumor match and adaptive radiotherapy for non-small cell lung cancer patients. The results showed that tumor match and adaptive radiotherapy significantly reduced the incidence of radiation pneumonitis and improved progression-free and overall survival.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Biology
Qingzhu Jia, Qian Chu, Anmei Zhang, Jing Yu, Fangfang Liu, Kaiyu Qian, Yu Xiao, Xue Wang, Ying Yang, Yi Zhao, Ji He, Guanghui Li, Yisong Y. Wan, Conghua Xie, Bo Zhu
Summary: The study used whole exome sequencing to investigate the impact of tumor mutational burden (TMB) and chromosomal aneuploidy (ANE) on the survival outcomes of non-small cell lung cancer patients undergoing radiotherapy. Higher TMB and lower ANE were associated with better survival outcomes, and these factors were found to interact synergistically.
COMMUNICATIONS BIOLOGY
(2021)
Article
Oncology
Karen Kelly, Jeffrey R. Infante, Matthew H. Taylor, Manish R. Patel, Deborah J. Wong, Nicholas Iannotti, Janice M. Mehnert, Anja H. Loos, Helga Koch, Isabell Speit, James L. Gulley
Review
Oncology
Navika D. Shukla, Ameen A. Salahudeen, Gregory A. Taylor, Suresh S. Ramalingam, Everett E. Vokes, Glenwood D. Goss, Roy H. Decker, Karen Kelly, Giorgio V. Scagliotti, Tony S. Mok, Heather A. Wakelee
CLINICAL LUNG CANCER
(2018)
Article
Oncology
Howard L. West, James Moon, Antoinette J. Wozniak, Philip Mack, Fred R. Hirsch, Martin J. Bury, Myron Kwong, Dorothy D. Nguyen, Dennis F. Moore, Jieling Miao, Mary Redman, Karen Kelly, David R. Gandara
CLINICAL LUNG CANCER
(2018)
Article
Oncology
Heather M. McGee, Megan E. Daly, Sohelia Azghadi, Susan L. Stewart, Leslie Oesterich, Jeffrey Schlom, Renee Donahue, Jonathan D. Schoenfeld, Qian Chen, Shyam Rao, Ruben C. Fragoso, Richard K. Valicenti, Robert J. Canter, Emmanual M. Maverakis, William J. Murphy, Karen Kelly, Arta M. Monjazeb
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2018)
Article
Cardiac & Cardiovascular Systems
Elizabeth A. David, Stina W. Andersen, Laurel A. Beckett, Joy Melnikow, James M. Clark, Lisa M. Brown, David T. Cooke, Karen Kelly, Robert J. Canter
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2019)
Article
Biochemistry & Molecular Biology
Ziming Wang, Ethan G. Aguilar, Jesus I. Luna, Cordelia Dunai, Lam T. Khuat, Catherine T. Le, Annie Mirsoian, Christine M. Minnar, Kevin M. Stoffel, Ian R. Sturgill, Steven K. Grossenbacher, Sita S. Withers, Robert B. Rebhun, Dennis J. Hartigan-O'Connor, Gema Mendez-Lagares, Alice F. Tarantal, R. Rivkah Isseroff, Thomas S. Griffith, Kurt A. Schalper, Alexander Merleev, Asim Saha, Emanual Maverakis, Karen Kelly, Raid Aljumaily, Sami Ibrahimi, Sarbajit Mukherjee, Michael Machiorlatti, Sara K. Vesely, Dan L. Longo, Bruce R. Blazar, Robert J. Canter, William J. Murphy, Arta M. Monjazeb
Article
Multidisciplinary Sciences
Michael E. Goldberg, Meagan Montesion, Lauren Young, James Suh, Joel Greenbowe, Mark Kennedy, Giuseppe Giaccone, Wallace L. Akerley, Afshin Dowlati, Benjamin C. Creelan, James K. Hicks, Paul J. Hesketh, Karen L. Kelly, Jonathan W. Riess, Vincent A. Miller, Philip J. Stephens, Garrett M. Frampton, Siraj Ali, Jeffrey P. Gregg, Lee A. Albacker
Article
Oncology
Steven E. Schild, Wen Fan, Thomas E. Stinchcombe, Everett E. Vokes, Suresh S. Ramalingam, Jeffrey D. Bradley, Karen Kelly, Herbert H. Pang, Xiaofei Wang
JOURNAL OF THORACIC ONCOLOGY
(2019)
Review
Oncology
Nagla Abdel Karim, Karen Kelly
Article
Oncology
Apar Kishor Ganti, Xiaofei Wang, Thomas E. Stinchcombe, Yinpeng Wang, Jeffrey Bradley, Harvey J. Cohen, Karen Kelly, Rebecca Paulus, Suresh S. Ramalingam, Everett E. Vokes, Herbert Pang
JOURNAL OF GERIATRIC ONCOLOGY
(2019)
Article
Oncology
Mary L. Disis, Matthew H. Taylor, Karen Kelly, J. Thaddeus Beck, Michael Gordon, Kathleen M. Moore, Manish R. Patel, Jorge Chaves, Haeseong Park, Alain C. Mita, Erika P. Hamilton, Christina M. Annunziata, Hans Juergen Grote, Anja von Heydebreck, Jaspreet Grewal, Vikram Chand, James L. Gulley
Article
Oncology
Charu Aggarwal, Mary W. Redman, Primo N. Lara, Hossein Borghaei, Philip Hoffman, Jeffrey D. Bradley, Alfred J. Newman, Marvin J. Feldman, Katherine Minichiello, Jieling Miao, Philip C. Mack, Vassiliki A. Papadimitrakopoulou, Roy S. Herbst, Karen Kelly, David R. Gandara
JOURNAL OF THORACIC ONCOLOGY
(2019)
Article
Oncology
Corey J. Langer, Mary W. Redman, James L. Wade, Charu Aggarwal, Jeffrey D. Bradley, Jeffrey Crawford, Philip J. Stella, Mark H. Knapp, Jieling Miao, Katherine Minichiello, Roy S. Herbst, Karen Kelly, David R. Gandara, Vassiliki A. Papadimitrakopoulou
JOURNAL OF THORACIC ONCOLOGY
(2019)
Article
Respiratory System
Michael K. Gould, Rebecca Smith-Bindman, Karen Kelly, Danielle E. Altman, Igor Barjaktarevic, Beth Creekmur, Evan De Bie, Debra S. Dyer, Eduardo J. Mortani Barbosa, Richard A. Mularski, Lihong Qi, Laszlo T. Vaszar, Sophronia Yu, Diana L. Miglioretti
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2019)
Article
Oncology
Edward S. Kim, Karen Kelly, Luis G. Paz-Ares, Pilar Garrido, Shadia Jalal, Daruka Mahadevan, Martin Gutierrez, Mariano Provencio, Eric Schaefer, Monte Shaheen, Erica L. Johnston, P. Kellie Turner, Siva Rama Prasad Kambhampati, Richard Beckmann, Anwar Hossain, William J. John, Jonathan W. Goldman
CLINICAL CANCER RESEARCH
(2018)