Article
Oncology
Elizabeth G. Dunne, Cameron N. Fick, David R. Jones
Summary: This article discusses the importance of EBUS-FNA in the staging of non-small cell lung cancer and the use of EBUS alone or in combination with confirmatory mediastinoscopy. The study concludes that EBUS alone is noninferior to EBUS with confirmatory mediastinoscopy, supporting the current practice of forgoing confirmatory mediastinoscopy after negative EBUS findings.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Review
Respiratory System
Jose Sanz-Santos, Pere Almagro, Komal Malik, Pablo Martinez-Camblor, Conxi Caro, Ramon Rami-Porta
Summary: The current guidelines recommend invasive staging for non-small cell lung cancer (NSCLC) with endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA). However, the indication for confirming a negative EBUS-TBNA result with video-assisted mediastinoscopy (VAM) before resection varies in different guidelines. This study evaluates the evidence for the added value of confirmatory VAM after a negative EBUS-TBNA result in NSCLC mediastinal staging, and finds that confirmatory VAM can reduce the rate of unforeseen N2/3 disease, but with a high number needed to treat (NNT), and should be recommended only for specific cases yet to be defined.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)
Article
Critical Care Medicine
Hyun Sung Chung, Ho Il Yoon, Bin Hwangbo, Eun Young Park, Chang-Min Choi, Young Sik Park, Kyungjong Lee, Wonjun Ji, Sohee Park, Geon Kook Lee, Tae Sung Kim, Hyae Young Kim, Moon Soo Kim, Jong Mog Lee
Summary: This study developed prediction models for mediastinal metastasis and its detection in EBUS-TBNA for patients with non-small cell lung cancer (NSCLC). The validation results showed that these models can be effectively used for decision-making in invasive mediastinal staging in NSCLC.
Article
Oncology
Duilio Divisi, Gabriella Di Leonardo, Massimiliano Venturino, Elisa Scarnecchia, Alessandro Gonfiotti, Domenico Viggiano, Marco Lucchi, Alessandro Bertani, Maria Giovanna Mastromarino, Roberto Crisci
Summary: This study analyzed the role of endobronchial ultrasound (EBUS) in the preoperative staging of non-small cell lung cancer (NSCLC) and found that it has high sensitivity, specificity, and accuracy. EBUS is a minimally invasive and easy procedure that ensures patient safety.
Article
Critical Care Medicine
Bin Hwangbo, Eun Young Park, Bumhee Yang, Geon Kook Lee, Tae Sung Kim, Hyae Young Kim, Moon Soo Kim, Jong Mog Lee
Summary: This study retrospectively reviewed the medical records of 1,089 NSCLC patients who underwent EBUS-TBNA, revealing significant prognostic impact of eN stage and highlighting the importance of EBUS-TBNA in NSCLC staging. False-negative EBUS-TBNA cases had favorable survival rates similar to patients with pN1, suggesting a rationale for surgery after negative EBUS-TBNA results.
Article
Oncology
Clara So, Yuji Matsumoto, Tatsuya Imabayashi, Keigo Uchimura, Yuichiro Ohe, Hideaki Furuse, Takaaki Tsuchida
Summary: This study retrospectively investigated the factors causing failure of nodal staging by EBUS-TBNA in NSCLC. The results showed that false positives with ROSE and the involvement of driver oncogenes were associated with nodal staging failure, in addition to limitations of the procedure itself. Especially in adenocarcinoma patients with driver oncogenes, their nodal staging results should be interpreted cautiously.
TRANSLATIONAL LUNG CANCER RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Carmen M. Lucena, Roberto Martin-Deleon, Marc Boada, Ramon M. Marrades, David Sanchez, Marcelo Sanchez, Ivan Vollmer, Daniel Martinez, Ainhoa Fontana, Noemi Reguart, Laureano Molins, Carlos Agusti
Summary: This study investigates the diagnostic value of an integral mediastinal staging strategy combining EBUS-TBNA and VAM in NSCLC patients at risk of OMM. The results show that EBUS-TBNA has a sensitivity of 40%, a negative predictive value of 93.6%, and a negative likelihood ratio of 0.60. Overall, the prevalence of OMM is 10%. IMS does not seem to provide added diagnostic value to that of EBUS-TBNA in diagnosing OMM.
RESPIRATORY MEDICINE
(2023)
Review
Oncology
Joseph J. Zhao, Hiang Ping Chan, Yu Yang Soon, Yiqing Huang, Ross A. Soo, Adrian C. L. Kee
Summary: This study found a high yield for NGS using EBUS-TBNA samples, and the success of using EBUS-TBNA samples for NGS was proportional to the number of passes.
Article
Oncology
Dinora Polanco, Lucia Pinilla, Esther Gracia-Lavedan, Sonia Gatius, Maria Zuil, Marina Pardina, Silvia Gomez, Ferran Barbe
Summary: This study aimed to analyze the diagnostic performance of EBUS-TBNA as the first-choice nodal staging procedure for determining PD-L1 expression in NSCLC patients. The results showed that EBUS-TBNA as the first procedure provides reliable specimens for detecting PD-L1 expression in advanced NSCLC patients and can guide immunotherapy.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Pieter W. J. Lozekoot, Jean H. T. Daemen, Robert R. van den Broek, Jos G. Maessen, Michiel H. M. Gronenschild, Yvonne L. J. Vissers, Karel W. E. Hulsewe, Erik R. de Loos
Summary: VAMLA demonstrates superior sensitivity and negative predictive value in detecting N2 disease, offering a significant decrease in risk of unforeseen pN2, but is also associated with a higher risk of complications.
TRANSLATIONAL LUNG CANCER RESEARCH
(2021)
Review
Oncology
Virginia Leiro-Fernandez, Alberto Fernandez-Villar
Summary: Accurate staging of mediastinal lymph nodes is crucial for planning treatments for lung cancer patients. While computed tomography and positron emission tomography are commonly used for mediastinal staging, surgical techniques provide higher accuracy, especially in cases where further confirmation is needed for negative results.
TRANSLATIONAL LUNG CANCER RESEARCH
(2021)
Article
Multidisciplinary Sciences
Naoko Katsurada, Motoko Tachihara, Naoe Jimbo, Masatsugu Yamamoto, Junya Yoshioka, Chihiro Mimura, Hiroki Satoh, Koichi Furukawa, Takehiro Otoshi, Tatsunori Kiriu, Yuichiro Yasuda, Tomonori Tanaka, Tatsuya Nagano, Yoshihiro Nishimura
Summary: This study found that using a large guide sheath for biopsy significantly increased the sample size obtained, especially for lesions involving a third or less bronchus generation. However, there was no significant difference in tumor cell number between the large guide sheath and small guide sheath groups.
Article
Oncology
Atsushi Ito, Daisuke Yamaguchi, Shinji Kaneda, Koji Kawaguchi, Akira Shimamoto, Makiko Kubooka, Yoshihito Nomoto, Motoshi Takao
Summary: Endobronchial metastasis after surgery of NSCLC is a rare type of recurrence. EBBT may be a promising treatment with curative intent in these cases, offering both palliative and definitive benefits. The use of EBBT in combination with EBRT can achieve local control without severe adverse events for patients.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Letter
Medicine, General & Internal
Hollis Viray, Deepa Rangachari, Daniel B. Costa
Summary: The study reported initial data of trastuzumab deruxtecan in the treatment of lung cancers with ERBB2 mutations, including patients who had previously received ineffective ERBB2 tyrosine kinase inhibitors.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Multidisciplinary Sciences
Yoonki Hong, Sunmin Park, Myoung Kyu Lee
Summary: The presence of endobronchial metastatic lesion (EML) is associated with a poorer prognosis in patients with non-small cell lung cancer (NSCLC), particularly in those without detectable lesions on PET or CT scans. This study evaluated the progression-free survival (PFS) and overall survival (OS) in NSCLC patients with or without EML. The results showed that patients with EML had shorter median PFS and OS compared to those without EML. Additionally, EGFR mutation status, performance status, and pleural effusion were also significant factors affecting PFS in NSCLC patients.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Tatsuro Okamoto, Kazuki Takada, Seijiro Sato, Gouji Toyokawa, Tetsuzo Tagawa, Fumihiro Shoji, Ryota Nakanishi, Eiji Oki, Terumoto Koike, Masayuki Nagahashi, Hiroshi Ichikawa, Yoshifumi Shimada, Satoshi Watanabe, Toshiaki Kikuchi, Kouhei Akazawa, Stephen Lyle, Kazuaki Takabe, Shujiro Okuda, Kenji Sugio, Toshifumi Wakai, Masanori Tsuchida, Yoshihiko Maehara
ANNALS OF SURGICAL ONCOLOGY
(2018)
Letter
Cardiac & Cardiovascular Systems
Shoichi Inagawa, Tatsuhiko Sato, Terumoto Koike, Hajime Umezu
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
(2018)
Article
Multidisciplinary Sciences
Seijiro Sato, Masayuki Nagahashi, Terumoto Koike, Hiroshi Ichikawa, Yoshifumi Shimada, Satoshi Watanabe, Toshiaki Kikuchi, Kazuki Takada, Ryota Nakanishi, Eiji Oki, Tatsuro Okamoto, Kouhei Akazawa, Stephen Lyle, Yiwei Ling, Kazuaki Takabe, Shujiro Okuda, Toshifumi Wakai, Masanori Tsuchida
SCIENTIFIC REPORTS
(2018)
Article
Respiratory System
Seijiro Sato, Masaya Nakamura, Yuki Shimizu, Tatsuya Goto, Terumoto Koike, Hiroyuki Ishikawa, Masanori Tsuchida
BMC PULMONARY MEDICINE
(2019)
Article
Oncology
Bin Zheng, Guobing Xu, Xiayu Fu, Weidong Wu, Mingqiang Liang, Taidui Zeng, Shuliang Zhang, Yong Zhu, Wei Zheng, Chun Chen, Benoit Bedat, Scott J. Swanson, Terumoto Koike, Hisashi Iwata, Benedetta Bedetti, Masaaki Sato
TRANSLATIONAL LUNG CANCER RESEARCH
(2019)
Article
Surgery
Seijiro Sato, Masaya Nakamura, Yuki Shimizu, Tatsuya Goto, Akihiko Kitahara, Terumoto Koike, Masanori Tsuchida
Editorial Material
Oncology
Terumoto Koike, Seijiro Sato, Masanori Tsuchida
ANNALS OF TRANSLATIONAL MEDICINE
(2020)
Article
Cardiac & Cardiovascular Systems
Terumoto Koike, Akihiro Nakamura, Yuki Shimizu, Tatsuya Goto, Seijiro Sato, Shin-ichi Toyabe, Masanori Tsuchida
GENERAL THORACIC AND CARDIOVASCULAR SURGERY
(2020)
Article
Cardiac & Cardiovascular Systems
Seijiro Sato, Yuki Shimizu, Tatsuya Goto, Terumoto Koike, Takahisa Koizumi, Takehiro Watanabe, Hirohiko Shinohara, Yasushi Yamato, Masanori Tsuchida
Summary: This study retrospectively reviewed clinical data from 61 patients who underwent pulmonary resection for ipsilateral MSPLC and found that postoperative complications existed, but did not differ significantly based on the combination of surgeries. There were no differences in the 5-year survival and recurrence rates between patients who underwent anatomic resection and wedge resection.
INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Terumoto Koike, Noriaki Sato, Yuta Hosoda, Masayuki Tazawa, Tatsuya Goto, Seijiro Sato, Motohiko Yamazaki, Shin-ichi Toyabe, Masanori Tsuchida
SEMINARS IN THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Hirokazu Yamaguchi, Masaaki Sato, Kazumichi Yamamoto, Keiko Ueda, Hiroshi Date, Toyofumi Chen-Yoshikawa, Yoshito Yamada, Junko Tokuno, Masahiro Yanagiya, Fumitsugu Kojima, Nobuyuki Yoshiyasu, Masashi Kobayashi, Yasuhiro Nakashima, Terumoto Koike, Jin Sakamoto, Shinji Kosaka, Ryuta Fukai, Tomoki Nishida, Hiroaki Sakai, Shinji Shinohara, Masaru Takenaka, Fumihiro Tanaka, Kenji Misawa, Jun Nakajima
Summary: With the advancement of high-resolution computed tomography (CT), suspicious small pulmonary nodules are being detected more frequently. The preoperative bronchoscopic multi-spot lung-marking technique, VAL-MAP, has been proven effective in two prospective multicentre studies and showed promising long-term outcomes in local recurrence and survival of patients.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Bin Qiu, Ying Ji, Fan Zhang, Guangyu Bai, Qi Xue, Mateusz Polaczek, Davide Tosi, Terumoto Koike, Shugeng Gao, Jie He
Summary: This study retrospectively evaluated the outcomes of anatomic partial lobectomy (APL) in early-stage lung cancer patients in China. The results showed that APL procedures were safe and feasible, with a low overall complication rate, especially when performed by experienced surgeons in specialized centers.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Editorial Material
Surgery
Terumoto Koike, Mika Miyajima, Masaya Nakamura, Yuki Shimizu, Tatsuya Goto, Masanori Tsuchida
VIDEO-ASSISTED THORACIC SURGERY
(2022)
Article
Oncology
Yuki Shimizu, Terumoto Koike, Toshiki Hasebe, Masaya Nakamura, Tatsuya Goto, Shin-ichi Toyabe, Masanori Tsuchida
Summary: This study aimed to investigate the risk factors for poor postoperative survival and recurrence in patients with NSCLC and nodal metastasis who were surgically treated and did not receive any induction treatments. Multiple-node metastases are risk factors for both poor survival and recurrence. Additional perioperative therapies may be required, especially in patients with squamous cell carcinoma.
Article
Cardiac & Cardiovascular Systems
Seijiro Sato, Atsuhiro Nakamura, Yuki Shimizu, Tatsuya Goto, Akihiko Kitahara, Terumoto Koike, Takeshi Okamoto, Masanori Tsuchida
GENERAL THORACIC AND CARDIOVASCULAR SURGERY
(2019)