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Endocrinology & Metabolism
Sai Wang, Xuelun Zou, Leiyun Wang, Huifang Zhou, Lianxu Wu, Yupeng Zhang, Tian-Xing Yao, Lei Chen, Ye Li, Yi- Zeng, Le Zhang
Summary: Hypertensive cerebral microbleeds (HCMB) may be an early stage of hypertensive intracerebral hemorrhage (HICH) and pose a serious threat to health. Early clinical symptoms of HCMB may go unnoticed, and achieving early diagnosis and intervention for targeted prevention of HICH is challenging. This study used liquid chromatography-mass spectrometry to identify potential early biomarkers for HCMB in hypertensive mice, aiming to lay the foundation for early prevention of HICH in hypertensive patients.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Dapeng Chen, Noella A. Bryden, Wayne A. Bryden, Michael McLoughlin, Dexter Smith, Alese P. Devin, Emily R. Caton, Caroline R. Haddaway, Michele Tameris, Thomas J. Scriba, Mark Hatherill, Sophia Gessner, Digby F. Warner, Robin Wood
Summary: Human breath contains trace amounts of non-volatile organic compounds (NOCs) which could be used as markers of individual health. In this study, metabolites and lipids in exhaled breath aerosol (EBA) samples were analyzed to identify molecular signatures of active tuberculosis (TB). Thirteen metabolite and nine lipid markers were identified with statistically different values between individuals with active TB and healthy controls. Importantly, EBA lipid profiles can effectively distinguish the two sample types, indicating the diagnostic potential of the identified molecules.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Haoyue Wang, Yanbo Luo, Huan Chen, Hongwei Hou, Qingyuan Hu, Min Ji
Summary: In this study, non-targeted lipidomics was used to investigate the differential lipid metabolites in the serum of laryngeal cancer patients, laryngeal benign tumor patients, and healthy individuals. The results revealed that the regulation of lipid metabolism network mainly occurred in phosphatidylcholine, lysophosphatidylcholine, and sphingomyelin metabolism. Sphingolipids 42:2 and sphingolipids 42:3 were found to be potential biomarkers for diagnosis and progression monitoring of laryngeal cancer. This study not only provided insights into the changes in lipid metabolism network, but also offered new possibilities for screening biomarkers in laryngeal cancer.
Review
Chemistry, Analytical
A. Fernez Asensio, E. Alvarez-Gonzalez, A. Rodriguez, L. M. Sierra, E. Blanco-Gonzalez
Summary: Dysregulation of TCA cycle enzymes leads to abnormal accumulation of oncometabolites, which contribute to cancer formation and progression. GC-MS and LC-MS are powerful analytical tools for accurate identification and determination of these metabolites.
ANALYTICA CHIMICA ACTA
(2021)
Article
Endocrinology & Metabolism
Cora M. Best, Leila R. Zelnick, Kenneth E. Thummel, Simon Hsu, Christine Limonte, Ravi Thadhani, Howard D. Sesso, JoAnn E. Manson, Julie E. Buring, Samia Mora, I-Min Lee, Nancy R. Cook, Georgina Friedenberg, Heike Luttmann-Gibson, Ian H. de Boer, Andrew N. Hoofnagle
Summary: Vitamin D-3 supplementation increases total serum vitamin D and 25(OH) D concentrations with variation according to baseline 25(OH)D, which suggests that 25-hydroxylation of vitamin D-3 is more efficient when serum 25(OH)D concentration is low.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Genetics & Heredity
Jinliang Peng, Chongrong Qiu, Jun Zhang, Xiaoliu Xiao
Summary: By using serum metabolomics, this study identified differential expression of metabolites in sepsis patients, which could potentially serve as diagnostic markers for sepsis. The pathogenesis of sepsis was found to be associated with mTOR signaling, NF-κB signaling pathway, calcium signaling, calcium transport, and tRNA charging pathway.
BMC MEDICAL GENOMICS
(2023)
Article
Immunology
Sora Mun, Seungyeon Lee, Yeeun Yun, Eun-Jeong Joo, Hee-Gyoo Kang, Jiyeong Lee
Summary: The discovery of biomarkers reflecting changes in serum protein metabolism can help evaluate the severity of depressive mood. In this study, lower levels of apolipoprotein A-IV and fibronectin were found in individuals with current episodes of depression, suggesting their potential as novel biomarkers for detecting depression.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Oncology
Xin Chen, Bo-lun Shi, Run-zhi Qi, Xing Chang, Hong-gang Zheng
Summary: This study investigated the therapeutic effects and molecular mechanisms of Honokiol (HNK) on colorectal cancer through metabolomics analysis. Results showed potential urine biomarkers related to purines, tyrosines, tryptophans metabolism, and indicated that HNK modulated the citrate cycle to exert its efficacy against intestinal tumors.
FRONTIERS IN ONCOLOGY
(2021)
Article
Endocrinology & Metabolism
Jun Kou, Chunyang He, Lin Cui, Zhengping Zhang, Wei Wang, Li Tan, Da Liu, Wei Zheng, Wei Gu, Ning Xia
Summary: The study on Chinese postmenopausal women with osteoporosis identified potential biomarkers related to metabolic pathway disorders, providing new insights for early diagnosis. The findings suggest that metabonomic analysis has great potential for application in postmenopausal women with osteoporosis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemical Research Methods
Shaobo Yang, Hong Yang, Yanlei Huang, Gong Chen, Chun Shen, Shan Zheng
Summary: Hirschsprung's disease (HSCR) is a congenital digestive tract malformation characterized by the absence of intramural ganglion cells in the myenteric and submucosal plexuses along variable lengths of the gastrointestinal tract. This study used metabolomic profiling to analyze HSCR serum samples and identified 21 biomarkers related to HSCR. It revealed that tryptophan metabolism was a crucial disordered pathway in HSCR. This is the first serum metabolomics study focusing on HSCR and provides a new perspective for explaining its mechanism.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Zhanxuan E. Wu, Marlena C. Kruger, Garth J. S. Cooper, Ivana R. Sequeira, Anne-Thea McGill, Sally D. Poppitt, Karl Fraser
Summary: Untargeted metabolomics of blood samples has been widely used to study metabolic alterations in diseases and identify biomarkers. This study found that the concentration of metabolites in plasma was more reflective of the liver profile than muscle or adipose tissue, highlighting the importance of considering the metabolomic relationship between different tissues and plasma.
Article
Oncology
Yanan Yi, Jianjian Wang, Chengtong Liang, Chuanli Ren, Xu Lian, Chongxu Han, Wei Sun
Summary: Background: Colorectal cancer (CRC) is a common digestive system tumor with high mortality and recurrence rates. Methods: Serum metabolites of healthy controls and CRC patients were analyzed using UPLC-MS. Results: The analysis showed a clear distinction in the serum metabolic profile between CRC patients and healthy controls. Pathway analysis revealed significant associations with arginine biosynthesis, pyrimidine metabolism, pantothenate, and CoA biosynthesis. Conclusion: Serum metabolomics may be a valuable tool for the screening and monitoring of CRC patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Chemistry, Analytical
Yuting Wang, Yisheng Wang, Chen Chen, Fang Ren, Rui Cao, Yuefei Wang, Pin Han, Xiaoyan Zhang, Congjian Xu, Xinyu Liu, Guowang Xu
Summary: The study identified lipid disturbances in the serum of patients with epithelial ovarian cancer (EOC) and established 4 lipids as potential markers for aiding EOC diagnosis. These markers showed high accuracy in distinguishing EOC and early EOC from non-cancer, with good specificity and sensitivity. The research not only revealed the characteristics of lipid metabolism in EOC, but also provided a potential marker pattern for aiding EOC diagnosis.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Article
Biochemistry & Molecular Biology
Claudiu Rachieriu, Dan Tudor Eniu, Emil Mois, Florin Graur, Carmen Socaciu, Mihai Adrian Socaciu, Nadim Al Hajjar
Summary: Metabolomics combined with bioinformatics can identify relevant biomolecules and potential biomarkers related to specific metabolic pathways in colorectal cancer. This study utilized metabolomic profiling to identify over 400 metabolites in blood serum samples from CRC cases, confirming a specific lipid phenotype and upregulated lipogenesis associated with tumor progression. Both multivariate and univariate bioinformatics analyses supported the importance of putative lipid biomarkers in altered metabolic pathways of colorectal cancer.
Article
Multidisciplinary Sciences
Mateusz Maciejewski, Caroline Sands, Nisha Nair, Stephanie Ling, Suzanne Verstappen, Kimme Hyrich, Anne Barton, Daniel Ziemek, Matthew Lewis, Darren Plant
Summary: Methotrexate is a common first-line treatment for rheumatoid arthritis, but it is ineffective for a significant portion of patients, with no reliable way to predict individual responses. Statistical models based on serum lipid levels were explored for predicting methotrexate response in patients, but clinical covariates alone outperformed lipid-based models in predicting response. Serum lipid profiles at pre-treatment or early-treatment time points are unlikely to be predictive of methotrexate response by 6 months in a way that would be useful for clinical management of rheumatoid arthritis.
SCIENTIFIC REPORTS
(2021)
Article
Engineering, Biomedical
Vanathi Gopalakrishnan, Prahlad G. Menon, Shobhit Madan
BIOMEDICAL ENGINEERING ONLINE
(2015)
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Biochemical Research Methods
Henry A. Ogoe, Shyam Visweswaran, Xinghua Lu, Vanathi Gopalakrishnan
BMC BIOINFORMATICS
(2015)
Article
Oncology
Arturo Lopez Pineda, Henry Ato Ogoe, Jeya Balaji Balasubramanian, Claudia Rangel Escareno, Shyam Visweswaran, James Gordon Herman, Vanathi Gopalakrishnan
Article
Clinical Neurology
Caitlin M. Kirkwood, Matthew L. MacDonald, Tadhg A. Schempf, Anil V. Vatsavayi, Milos D. Ikonomovic, Jeremy L. Koppel, Ying Ding, Mai Sun, Julia K. Kofler, Oscar L. Lopez, Nathan A. Yates, Robert A. Sweet
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2016)
Article
Neurosciences
Rafael Ceschin, Alexandria Zahner, William Reynolds, Jenna Gaesser, Giulio Zuccoli, Cecilia W. Lo, Vanathi Gopalakrishnan, Ashok Panigrahy
Article
Cell Biology
Yang Li, Chelsea D. Merkel, Xuemei Zeng, Jonathon A. Heier, Pamela S. Cantrell, Mai Sun, Donna B. Stolz, Simon C. Watkins, Nathan A. Yates, Adam V. Kwiatkowski
JOURNAL OF CELL SCIENCE
(2019)
Article
Multidisciplinary Sciences
Yuzhe Liu, Jody Manners, Yazan Bittar, Sherry H-Y Chou, Vanathi Gopalakrishnan
Article
Computer Science, Interdisciplinary Applications
Jeya Balaji Balasubramanian, Rebecca D. Boes, Vanathi Gopalakrishnan
JOURNAL OF BIOMEDICAL INFORMATICS
(2020)
Article
Medicine, Research & Experimental
Tuna Toptan, Pamela S. Cantrell, Xuemei Zeng, Yang Liu, Mai Sun, Nathan A. Yates, Yuan Chang, Patrick S. Moore
Article
Multidisciplinary Sciences
Matthew L. Blank, Jing Xia, Mary M. Morcos, Mai Sun, Pamela S. Cantrell, Yang Liu, Xuemei Zeng, Cameron J. Powell, Nathan Yates, Martin J. Boulanger, Jon P. Boyle
Summary: Research identified interactions between a single parasite effector and multiple target host proteins at the interface between the Toxoplasma gondii vacuole and the host mitochondria, some of which are critical for the HMA phenotype itself.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Public, Environmental & Occupational Health
Raju S. R. Adduri, Ravikiran Vasireddy, Margaret M. Mroz, Anisha Bhakta, Yang Li, Zhe Chen, Jeffrey W. Miller, Karen Y. Velasco-Alzate, Vanathi Gopalakrishnan, Lisa A. Maier, Li Li, Nagarjun Konduru
Summary: This study identified novel biomarkers associated with beryllium exposure using extracellular vesicles derived from blood plasma. The biomarkers successfully differentiated between exposed and unexposed subjects, with high predictive accuracy. These biomarkers could be used for beryllium exposure assessment in resource-limited settings.
INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH
(2022)
Article
Clinical Neurology
Ayesha Firdous, Vanathi Gopalakrishnan, Nam Vo, Gwendolyn Sowa
Summary: Chronic low back pain is a common health condition with limited treatment success. This study examines the application of omics technologies in the diagnosis and classification of chronic low back pain. The results show associations between inflammatory and pain pathways, but challenges remain.
EUROPEAN SPINE JOURNAL
(2022)
Article
Oncology
Jeya Balaji Balasubramanian, Vanathi Gopalakrishnan
WORLD JOURNAL OF CLINICAL ONCOLOGY
(2018)
Article
Computer Science, Information Systems
Jonathan Lyle Lustgarten, Jeya Balaji Balasubramanian, Shyam Visweswaran, Vanathi Gopalakrishnan
Article
Computer Science, Information Systems
Yuzhe Liu, Vanathi Gopalakrishnan