期刊
JOURNAL OF THORACIC ONCOLOGY
卷 3, 期 12, 页码 1379-1383出版社
ELSEVIER SCIENCE INC
DOI: 10.1097/JTO.0b013e31818dda9d
关键词
CXCR4; SDF-1; Non-small cell lung cancer; Chemokines; Metastasis; Migration
Chemokines are proinflammatory chemoattractant cytokines that regulate cell trafficking and adhesion. The CXCR4 chemokine receptor and its ligand, stromal cell derived factor (SDF-1) constitute a chemokine/receptor axis that has attracted great interest because of all increasing understanding of its role in cancer, including lung cancer. The CXCR4/SDF-1 complex activates several pathways that mediate chemotaxis, migration and secretion of angiopoietic factors. Neutralization of SDF-1 by anti-SDF-1 or anti-CXCR4 monoclonal antibody in preclinical in vivo studies results in a significant decrease of non-small cell lung cancer metastases. Since anti-SDF-1/CXCR4 strategies have already been developed for use in combating human immunodeficiency virus infections, it is likely that these approaches will be used in clinical trials in non-small cell lung cancer in the very near future.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据