Article
Veterinary Sciences
Fumi Yamaguchi, Hiroshi Nishi, Kazuhiro Misumi, Makoto Fujiki
Summary: The study revealed that NTx concentrations in dogs decrease with age, but bone metabolism is not affected after 2 years old. In the adult-to-geriatric cohort, intact males have the highest NTx concentrations, with neutering possibly not impacting bone metabolism in female dogs.
RESEARCH IN VETERINARY SCIENCE
(2021)
Article
Endocrinology & Metabolism
Sarah Seberg Diemar, Louise Lylloff, Maria Sode Ronne, Line Tang Mollehave, Malene Heidemann, Betina Heinsbaek Thuesen, Jesper Johannesen, Anders J. Schou, Steffen Husby, Niels Wedderkopp, Christian Molgaard, Niklas Rye Jorgensen
Summary: The study aimed to establish reference intervals for bone turnover markers in children and adolescents, showing that these markers vary with age and sex, with β-CTX and PINP being the most affected by these changes which reflect bone metabolism processes.
Article
Immunology
Yue Zheng, Pei-pei Wang, Yang Fu, Yue-yun Chen, Zhen-Yu Ding
Summary: The study demonstrates that zoledronic acid (ZA) can improve the therapeutic effects of immune checkpoint inhibitors (ICIs), possibly through the activation of immune cells and elevated cytokines.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Yan Wang, Hai-Nan Su, Hai-Yan Cao, Si-Min Liu, Shi-Cheng Liu, Xia Zhang, Peng Wang, Chun-Yang Li, Yu-Zhong Zhang, Xi-Ying Zhang, Xiu-Lan Chen
Summary: Collagenases produced by pathogenic Vibrio species are important virulence factors. This study characterizes the M9A collagenase VP397 from Marine Vibrio pomeroyi strain 12613 and reveals its degradation mechanism on type I collagen. VP397 first attacks the C-telopeptide region and then digests tropocollagen fragments at the Y-Gly bonds. This study provides new knowledge about the collagenolytic mechanism of Vibrio collagenase, which has implications for understanding Vibrio pathogenesis and developing industrial and medical applications of collagenase.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2022)
Article
Andrology
Stefan Aufderklamm, Joerg Hennenlotter, Steffen Rausch, Cornelia Bock, Eva Erne, Christian Schwentner, Arnulf Stenzl
Summary: The study confirms that increased levels of 1CTP and P1NP concentrations are associated with the presence of metastatic disease in the bone, and can predict the clinical course in PC patients with bone metastases. The potential use of these markers for treatment selection in advanced PC needs further investigation.
TRANSLATIONAL ANDROLOGY AND UROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chuan Niu, Ying Xiong, Liping Yang, Xiong Xiao, Shaojie Yang, Ziwei Huang, Yuchu Yang, Li Feng
Summary: The cellular microenvironment, specifically the level of CTX in collagen hydrogels, has significant effects on the fate and behavior of encapsulated cells. This study demonstrates the importance of CTX modulation in the hydrogel microenvironment for cell development and function.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Veterinary Sciences
Joze Staric, Jaka Jakob Hodnik
Summary: The study found that high dose vitamin D-3 supplementation did not statistically reduce the incidence of milk fever. Biochemical bone markers show promise in predicting milk fever, but further research is needed to confirm their clinical use.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Medical Laboratory Technology
Harjit P. Bhattoa, Etienne Cavalier, Richard Eastell, Annemieke C. Heijboer, Niklas R. Jorgensen, Konstantinos Makris, Candice Z. Ulmer, John A. Kanis, Cyrus Cooper, Stuart L. Silverman, Samuel D. Vasikaran
Summary: The International Osteoporosis Foundation and International Federation of Clinical Chemistry and Laboratory Medicine have designated PINP and beta-CTX as reference bone turnover markers. Efforts are being made to harmonize and standardize these markers, with the development of common calibrators and reference measurement procedures, in order to establish universally acceptable practice guidelines for the management of osteoporosis.
CLINICA CHIMICA ACTA
(2021)
Article
Endocrinology & Metabolism
Pattara Wiromrat, Phanpaphorn Namphaisan, Nantaporn Wongsurawat, Ouyporn Panamonta, Nat Nasomyont
Summary: This study evaluated the associations between prognostic biomarkers and bone mineral density changes in adolescents with 21-hydroxylase deficiency. The results showed that higher glucocorticoid dose and the use of prednisolone were associated with decreased bone mineral density accrual. Additionally, CTX z-score independently associated with bone mineral density accrual.
CLINICAL ENDOCRINOLOGY
(2023)
Article
Orthopedics
Gao-Xiang Wang, Jun-Tong Li, Fang-ying Cai, Bao-Li Huang, Ze-Bin Fang, Heng-Xia Zhao, Shu-Fang Chu, De-Liang Liu, Hui-Lin Li
Summary: This study explored the correlation between bone turnover markers (BTMs) and lumbar bone mineral density (BMD) in middle-aged populations. Data from NHANES were analyzed in a cross-sectional analysis. Serum bone alkaline phosphatase (sBAP) and urinary N-telopeptide (uNTx) levels were used as representatives of bone turnover. Multivariable linear regression models were used to detect the correlation of sBAP and uNTx with lumbar BMD.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yang Ni, Guanghui Huang, Xia Yang, Xin Ye, Xiaoguang Li, Qingliang Feng, Yongjie Li, Wenhong Li, Jiao Wang, Xiaoying Han, Min Meng, Zhigeng Zou, Zhigang Wei
Summary: This study demonstrates that microwave ablation is a safe, effective, and potentially curative therapy for medically inoperable stage I non-small cell lung cancer patients. The five-year follow-up shows high disease-free survival and overall survival rates.
EUROPEAN RADIOLOGY
(2022)
Article
Medicine, General & Internal
Berrin Papila Kundaktepe, Volkan Sozer, Fatih Orkun Kundaktepe, Sinem Durmus, Cigdem Papila, Hafize Uzun, Gonul Simsek, Remise Gelisgen
Summary: The study identifies that bone turnover markers NTx and alpha-CTx can help detect bone metastasis in breast cancer patients, especially in those with elevated levels of urine alpha-CTx. While bone mineral density is generally lower in BC patients, there was no significant difference observed in BC patients with metastasis.
MEDICINA-LITHUANIA
(2021)
Article
Oncology
Young-Jen Lin, Xu-Heng Chiang, Tzu-Pin Lu, Min-Shu Hsieh, Mong-Wei Lin, Hsao-Hsun Hsu, Jin-Shing Chen
Summary: This study aimed to evaluate the survival and perioperative outcomes of thoracoscopic lobectomy resection (LR) or sublobar resection (SR) in geriatric patients with early-stage non-small cell lung cancer (NSCLC). The study found that thoracoscopic SR may provide similar oncological outcomes to LR, but may be a safer and more feasible surgical method in terms of perioperative outcomes for geriatric patients with early-stage NSCLC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Cong Zhao, Zhiyun Zhang, Xingsheng Hu, Lina Zhang, Yanxia Liu, Ying Wang, Yi Guo, Tongmei Zhang, Weiying Li, Baolan Li
Summary: This study investigated the role of hyaluronan (HA) in predicting metastasis and survival rate in patients with small-cell lung cancer (SCLC). The results showed that baseline plasma HA was associated with bone metastasis, and the dynamic detection of HA could predict prognosis in SCLC patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Sunyi Zheng, Jiapan Guo, Johannes A. Langendijk, Stefan Both, Raymond N. J. Veldhuis, Matthijs Oudkerk, Peter M. A. van Ooijen, Robin Wijsman, Nanna M. Sijtsema
Summary: This study aimed to develop and evaluate a prediction model for 2-year overall survival (OS) in stage I-IIIA non-small cell lung cancer (NSCLC) patients who received definitive radiotherapy. The hybrid model, which integrated clinical variables and image features from pre-treatment CT scans, achieved reasonable performance and has the potential to identify high mortality risk patients and guide clinical decision making.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Mathematical & Computational Biology
Ying Wu, Richard J. Cook
Summary: This paper develops methods for assessing the predictive accuracy of a given event time model when the validation sample is comprised of interval-censored data, and empirically investigates their performance in the context of a rheumatology study.
Article
Rheumatology
Sahil Koppikar, Keith Colaco, Paula Harvey, Shadi Akhtari, Vinod Chandran, Dafna D. Gladman, Richard Cook, Lihi Eder
Summary: This study aimed to assess the incidence and risk factors for heart failure in patients with psoriatic disease and describe their electrocardiographic and echocardiographic findings. The results showed that heart failure was associated with a combination of known cardiovascular risk factors and measures of disease activity, particularly in nonischemic heart failure.
ARTHRITIS CARE & RESEARCH
(2022)
Article
Rheumatology
Samantha Sarabia, Chandra Farrer, Jensen Yeung, Dana Jerome, Richard J. Cook, Lihi Eder
Summary: Combining MSK-US with a screening questionnaire improves the triage of patients with suspected PsA.
ARTHRITIS CARE & RESEARCH
(2022)
Article
Rheumatology
Antonio Wong, Justine Y. Ye, Richard J. Cook, Dafna D. Gladman, Vinod Chandran
Summary: This study found that symptoms of anxiety/depression reduce the probability of achieving sustained MDA in PsA patients. Comprehensive management of PsA should include measures to address these comorbidities.
ARTHRITIS CARE & RESEARCH
(2022)
Article
Statistics & Probability
Liqun Diao, Richard J. Cook
Summary: In this study, inference regarding exposure effects within subgroups of individuals and the effect-modifying role of certain covariates in stratified medicine research was discussed. The use of doubly inverse probability-weighted estimating equations and nested doubly robust estimating functions proved to yield efficient and robust estimators, especially in cases where auxiliary models are misspecified.
CANADIAN JOURNAL OF STATISTICS-REVUE CANADIENNE DE STATISTIQUE
(2022)
Article
Rheumatology
Lihi Eder, Ruth Croxford, Aaron M. Drucker, Arielle Mendel, Bindee Kuriya, Zahi Touma, Sindhu R. Johnson, Richard Cook, Sasha Bernatsky, Nigil Haroon, Jessica Widdifield
Summary: Compared with the general population, patients with immune-mediated inflammatory diseases (IMIDs) were more likely to be tested for SARS-CoV-2, but the infection rate was similar. The odds of SARS-CoV-2 infection varied across different IMID subgroups.
ARTHRITIS CARE & RESEARCH
(2023)
Review
Statistics & Probability
Richard J. Cook, Jerald F. Lawless
Summary: Life history analysis has evolved as a methodology for analyzing processes related to human health, education, employment, and other areas. The complexity of processes, difficulty of obtaining accurate data, and increased use of observational data have posed challenges. This review discusses recent work and emphasizes the use of expanded models.
CANADIAN JOURNAL OF STATISTICS-REVUE CANADIENNE DE STATISTIQUE
(2022)
Article
Mathematics, Interdisciplinary Applications
Richard J. Cook, Jerald F. Lawless, Bingfeng Xie
Summary: Studies on chronic diseases often utilize the Cox regression model to analyze the relationship between marker processes and disease onset or progression. However, in cohort studies where biomarker values are only intermittently measured, Cox models treat biomarker values as fixed at their most recently observed values. This study investigates the implications of this convention and proposes a joint multistate model to mitigate bias caused by the impact of marker values on clinic visit intensity.
LIFETIME DATA ANALYSIS
(2022)
Article
Mathematical & Computational Biology
Ce Yang, Liqun Diao, Richard J. Cook
Summary: This article introduces the methods of using biobanks and two-phase response-dependent sampling designs in large cohort studies. The optimal subsampling scheme in adaptive two-phase designs is refined, and the analysis based on likelihood or conditional likelihood is discussed. Furthermore, the efficiency and robustness issues in the context of continuous biomarkers are investigated, along with the application of these methods to the surrogate variable problem and multiple stages of subsampling.
STATISTICS IN MEDICINE
(2022)
Article
Biology
Fangya Mao, Richard J. Cook
Summary: Modeling the spatial dependence of damage progression in chronic diseases can provide important scientific insights into their effects on multiple organ systems. This study focuses on modeling the spatial dependence of joint damage in psoriatic arthritis (PsA) and proposes new models and methods. By incorporating latent joint-specific indicators of susceptibility and adopting a Gaussian copula for dependence modeling, the authors develop likelihood and composite likelihoods for analyzing progression times subject to interval censoring. Simulation studies confirm the validity of the proposed methods, and the application to real data provides important insights for distinguishing PsA from other arthritic conditions.
Article
Statistics & Probability
Meaghan S. Cuerden, Liqun Diao, Cecilia A. Cotton, Richard J. Cook
Summary: We investigate causal inference for the effect modification of a biomarker in an observational study where the biomarker is only available for some individuals. We propose inverse probability weighted mean score estimating functions with two weights to account for confounding and missing data. An iterative approach is used to solve the equations and the large sample properties of the estimator are developed. Simulation studies compare the proposed method with other approaches, and an application to a rheumatology cohort illustrates the effect of a biologic therapy on inflammation.
COMMUNICATIONS IN STATISTICS-THEORY AND METHODS
(2023)
Article
Public, Environmental & Occupational Health
Mahmood R. Gohari, Marsha Taylor, Melissa C. MacKinnon, Dimitra Panagiotoglou, Eleni Galanis, Gilaad G. Kaplan, Richard J. Cook, David M. Patrick, Steen Ethelberg, Shannon E. Majowicz
Summary: This study assessed the patterns and impacts of enteric infections in British Columbia, Canada from 2005 to 2014. The majority of individuals experienced only one infection, but some had multiple concurrent infections or unreported infections. The study highlights the need to consider the impacts of multiple infections and to estimate the risk for individuals with potentially unreported infections in sequelae risk analysis.
EPIDEMIOLOGY AND INFECTION
(2022)
Article
Rheumatology
Timothy S. H. Kwok, Mitchell Sutton, Richard J. Cook, Daniel Pereira, Vinod Chandran, Dafna D. Gladman
Summary: This study aimed to describe musculoskeletal (MSK) surgery in patients with psoriatic arthritis (PsA) and identify risk factors for undergoing first MSK surgery attributable to PsA. The results showed that markers of cumulative disease activity and damage were associated with a greater risk of needing surgery, while the effect of biologics did not reach statistical significance.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Mathematical & Computational Biology
Mao Fangya, Richard J. Cook
Summary: In this study, we focus on the design and analysis of two-phase studies to assess the relationship between a fixed marker (e.g., genetic) and event time under current status observation. We propose a design challenge of selecting a phase II sub-sample to maximize the precision of the marker effect, considering likelihood and weighted estimating functions for inference. Different design strategies are explored using registry data of patients with psoriatic arthritis to study the risk of diabetes as a comorbidity.
STATISTICS IN MEDICINE
(2023)
Article
Rheumatology
Stefan Perera, Richard Cook, Ker-Ai Lee, Patti Katz, Zahi Touma
Summary: Cognitive impairment is prevalent in SLE patients. This study examined cognitive changes in SLE patients over a 7-year period and found that most patients had relatively stable cognition. Older age and higher education levels were associated with improved cognition, while self-reported disease severity and depression were associated with cognitive decline.
ACR OPEN RHEUMATOLOGY
(2023)