Article
Cardiac & Cardiovascular Systems
Hoorak Poorzand, Fatemeh Hamidi, Fereshte Sheybani, Fereshteh Ghaderi, Afsoon Fazlinezhad, Hedieh Alimi, Leila Bigdelu, Saeede Khosravi Bizhaem
Summary: The study aimed to determine the clinical characteristics and echocardiographic features of patients with IE. The short- and long-term prognosis for IE was poor, with heart failure and septic shock as predictors for in-hospital and 1-year mortality. Staphylococcus aureus was the most common causative pathogen.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Chemistry, Medicinal
Nidaa Mikail, Fabien Hyafil
Summary: Infective endocarditis (IE) is a life-threatening disease that remains prevalent despite advancements in prophylaxis, diagnosis, and treatment. With the increasing number of patients with cardiac devices, the occurrence of IE on prosthetic valves and cardiac implanted electronic devices (CIED) is rising rapidly. The diagnosis of IE is challenging, but nuclear imaging techniques such as F-18-fluorodeoxyglucose positron emission tomography with computed tomography (F-18-FDG-PET/CT) and white blood cells single photon emission tomography with computed tomography (WBC-SPECT) have emerged as valuable tools in managing prosthetic valve and CIED IE.
Review
Immunology
Katarzyna Holcman, Pawel Rubis, Andrzej Zabek, Krzysztof Boczar, Piotr Podolec, Magdalena Kostkiewicz
Summary: Infective endocarditis (IE) presents a significant epidemiological challenge, with diverse etiopathogenesis and clinical presentation making diagnosis difficult. Molecular imaging techniques, such as Tc-99m-HMPAO-SPECT/CT and F-18-FDG PET/CT, have shown promise in providing valuable diagnostic information. These techniques can offer insights into ongoing infection and aid in determining the optimal therapeutic strategies.
Article
Cardiac & Cardiovascular Systems
Victor Marcos-Garces, Ana Gabaldon-Perez, Hector Merenciano-Gonzalez, Meritxell Soler, Miguel Lorenzo-Hernandez, Gonzalo Nunez-Marin, Rafael de la Espriella, Clara Bonanad, Julio Nunez, Francisco Javier Chorro, Vicente Bodi, Enrique Santas
Summary: Echocardiography is crucial in diagnosing infective endocarditis but is often misused. Strict negative criteria help avoid unnecessary follow-up echocardiograms. A retrospective study found that only a minority of patients with suspected IE were definitively diagnosed, with initial TTE fulfilling strict negative criteria predicting low probability of follow-up studies and definitive diagnosis.
AMERICAN JOURNAL OF CARDIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Jeffrey J. Silbiger, Eman Rashed, Huazhen Chen, Elliot Wiesenfeld, Sam E. Robinson, Matthew Cagliostro
Summary: This article discusses the importance of cardiac imaging in the diagnosis, risk prediction, and surgical decision-making of infective endocarditis.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2022)
Review
Medicine, General & Internal
Ikram-Ul Haq, Iqraa Haq, Brian Griffin, Bo Xu
Summary: Although echocardiography is essential for diagnosing infective endocarditis, in cases where no evidence is found but clinical indicators are still consistent with the diagnosis, repeat imaging with proper timing and method such as TTE, TEE, or advanced imaging is crucial.
CLEVELAND CLINIC JOURNAL OF MEDICINE
(2021)
Article
Medicine, General & Internal
Enrico Cecchi, Silvia Corcione, Tommaso Lupia, Ilaria De Benedetto, Nour Shbaklo, Fabio Chirillo, Antonella Moreo, Mauro Rinaldi, Pompilio Faggiano, Moreno Cecconi, Olivia Bargiacchi, Alessandro Cialfi, Stefano Del Ponte, Angelo Squeri, Oscar Gaddi, Maria Gabriella Carmina, Alessandro Lazzaro, Giovannino Ciccone, Anna Castiglione, Francesco Giuseppe De Rosa
Summary: Intravenous drug use is a predisposing condition for infective endocarditis (IE). We reported the clinical features of IE in people who inject drugs (PWIDs), based on data from the Italian Registry of IE. The study found that PWIDs with IE were predominantly male and between the ages of 41 and 50. HIV and chronic liver disease were the most common comorbidities among PWIDs with IE. This study highlights the relatively high occurrence of IE in PWIDs.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biology
Abdullah M. K. Albloshi, Mohammed A. A. Alqumber
Summary: Infective endocarditis caused by bacteria like streptococci or staphylococci is difficult to manage despite broad-spectrum antimicrobial use. The study discusses the latest diagnostic modalities, suggesting that molecular techniques can aid in accurate and early diagnosis along with blood cultures and echocardiography.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Immunology
Matthaios Papadimitriou-Olivgeris, Benoit Guery, Nicoleta Ianculescu, Vincent Dunet, Yosra Messaoudi, Silvia Pistocchi, Piergiorgio Tozzi, Matthias Kirsch, Pierre Monney
Summary: Cerebral imaging did not significantly change patient classification according to Duke criteria among those suspected of infective endocarditis. However, it did lead to the establishment of a new surgical indication for preventing embolic events in 20% of patients.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Cardiac & Cardiovascular Systems
Rossella Maria Benvenga, Christophe Tribouilloy, Hector I. Michelena, Angelo Silverio, Florent Arregle, Helene Martel, Seyhan Denev, Yohann Bohbot, Sandrine Hubert, Sebastien Renard, Laurence Camoin, Anne Claire Casalta, Jean Paul Casalta, Frederic Gouyier, Alberto Riberi, Hubert Lepidi, Frederic Collart, Didier Raoult, Michel Drancourt, Gennaro Galasso, Daniel C. DeSimone, Rodolfo Citro, Gilbert Habb
Summary: This study aimed to investigate the clinical characteristics of different bicuspid aortic valve (BAV) morphology in infective endocarditis (IE). Patients were divided into two groups based on echocardiographic definition: right-left coronary (RL type) and right noncoronary or left noncoronary (non-RL type) cusp fusion. The study found that patients with BAV and IE may have different clinical and echocardiographic features according to valve morphology, and they tend to be referred late, even with pre-existing BAV disease.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2023)
Article
Infectious Diseases
Elisavet Stavropoulou, Benoit Guery, Nicoleta Ianculescu, Piergiorgio Tozzi, Matthias Kirsch, Pierre Monney, Matthaios Papadimitriou-Olivgeris
Summary: This study evaluated the role of defervescence within 4 days from antibiotic treatment initiation in ruling out suspected infective endocarditis (IE). The results showed that defervescence within 4 days cannot rule out the diagnosis of IE.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Review
Biochemistry & Molecular Biology
Mustapha Abdeljalil Brai, Nadji Hannachi, Nabila El Gueddari, Jean-Pierre Baudoin, Abderrhamane Dahmani, Hubert Lepidi, Gilbert Habib, Laurence Camoin-Jau
Summary: The incidence of infective endocarditis (IE) has increased in the past decade, with changes in the causative bacteria. The role of bacterial interaction with human platelets in the pathogenesis of IE is crucial but not yet fully understood. This review explores the involvement of platelets in endocarditis, their role in vegetation formation depending on bacterial species, and investigates platelet therapy advancements and future research avenues to understand the mechanistic enigma of bacteria-platelet interaction for preventive and curative medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Yolanda Carrascal, Barbara Segura, Eduardo Velasco, Angel L. Guerrero
Summary: Patients with active left-sided infective endocarditis who require early surgery are at higher risk of preoperative symptomatic neurological complications (SNC). Postoperative SNC does not significantly affect postoperative mortality. Mortality is increased in patients who undergo surgery within the first week after SNC, with a higher risk of mortality or postoperative hemorrhagic transformation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Immunology
Norman Mangner, Vassili Panagides, David del Val, Mohamed Abdel-Wahab, Lisa Crusius, Eric Durand, Nikolaj Ihlemann, Marina Urena, Costanza Pellegrini, Francesco Giannini, Tomasz Gasior, Wojtek Wojakowski, Martin Landt, Vincent Auffret, Jan-Malte Sinning, Asim N. Cheema, Luis Nombela-Franco, Chekrallah Chamandi, Francisco Campelo-Parada, Erika Munoz-Garcia, Howard C. Herrmann, Luca Testa, Won-Keun Kim, Helene Eltchaninoff, Lars Sondergaard, Dominique Himbert, Oliver Husser, Azeem Latib, Herve Le Breton, Clement Servoz, Philippe Gervais, Melanie Cote, Holger Thiele, David Holzhey, Axel Linke, Josep Rodes-Cabau
Summary: In transcatheter aortic valve related infective endocarditis (IE), absent echocardiographic signs of IE were associated with the same prognosis as evident echocardiographic signs, highlighting the need for early treatment initiation in high-risk patients presenting with positive blood cultures and symptoms of infection after TAVI.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Cardiac & Cardiovascular Systems
Xin Tao Ye, Edward Buratto, Jim Dimitriou, Nima Yaftian, Andrew Wilson, Jonathan Darby, Andrew Newcomb
Summary: In right-sided infective endocarditis, vegetation size >2cm, chronic kidney disease, and Pitt bacteraemia score are independent predictors of late mortality, while vegetation >2.5cm, prisoner status, and multivalvular IE involvement increase the risk of recurrence. Patients with small vegetations do well with medical management, but those with large vegetations may require more aggressive treatment and follow-up.
HEART LUNG AND CIRCULATION
(2021)
