Article
Cardiac & Cardiovascular Systems
Livia L. Camargo, Augusto C. Montezano, Misbah Hussain, Yu Wang, Zhiguo Zou, Francisco J. Rios, Karla B. Neves, Rheure Alves-Lopes, Fazli R. Awan, Tomasz J. Guzik, Thomas Jensen, Richard C. Hartley, Rhian M. Touyz
Summary: In this study, the role of NOX-induced oxidative stress in VSMCs in human hypertension was explored, with a focus on NOX5 and its connection to c-Src. The findings suggest that the NOX5/ROS/c-Src pathway plays a significant role in VSMC dysfunction in hypertension, and dampening this pathway may have therapeutic potential in reducing hypertension-associated vascular injury.
CARDIOVASCULAR RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Ye Liu, Yan Duan, Nan Zhao, Xinxin Zhu, Xiaoting Yu, Shiyu Jiao, Yanting Song, Li Shi, Yutao Ma, Xia Wang, Baoqi Yu, Aijuan Qu
Summary: The study reveals that PPAR alpha plays a critical protective role in Ang II-induced hypertension by attenuating ROS production in VSMCs, providing a potential therapeutic target for hypertensive diseases.
Article
Urology & Nephrology
Yuanzhi Ye, An Chen, Li Li, Qingchun Liang, Siyi Wang, Qianqian Dong, Mingwei Fu, Zirong Lan, Yining Li, Xiaoyu Liu, Jing-Song Ou, Lihe Lu, Jianyun Yan
Summary: Vascular calcification is regulated by ferroptosis of vascular smooth muscle cells (VSMCs) through the repression of the SLC7A11/GSH/GPX4 axis. Inhibition of ferroptosis reduces mineral deposition and osteogenic differentiation of VSMCs, providing a potential targeting strategy for vascular calcification in chronic kidney disease (CKD) patients.
KIDNEY INTERNATIONAL
(2022)
Article
Environmental Sciences
Li-Min Zhang, Shuai-Shuai Lv, Shi-Rui Fu, Jia-Qi Wang, Lu-Yao Liang, Rui-Qiang Li, Fan Zhang, Yu-Xia Ma
Summary: This study demonstrates that procyanidins (PC) can protect against PM2.5-induced vascular smooth muscle cells (VSMCs) apoptosis by activating the Nrf2 signal pathway, alleviating oxidative stress, and reducing apoptosis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Peripheral Vascular Disease
Jaime Ibarrola, Qing Lu, Maria-Christina Zennaro, Iris Z. Jaffe
Summary: This study investigated the regulatory mechanisms of MR gene transcription in aging human smooth muscle cells. The results revealed the involvement of the inflammatory transcription factor NF kappa B and the hypoxia-inducible factor HIF1 alpha in the regulation of SMC MR transcription, which contributes to aging-related vascular stiffness and cardiovascular disease.
Article
Multidisciplinary Sciences
Ewelina Wozniak, Marlena Broncel, Mateusz Niedzielski, Agnieszka Wozniak, Paulina Gorzelak-Pabis
Summary: The study compared the pleiotropic effects of two commonly-used statins (atorvastatin, rosuvastatin), ezetimibe, and their combinations, on the mRNA expression of pro-inflammatory and anti-inflammatory genes in endothelial cells damaged by 25-OHC. The results showed that rosuvastatin had the strongest anti-inflammatory effects and was most effective at reducing the effect of oxysterols. Both statins had stronger anti-inflammatory effects compared to ezetimibe. The combination therapies' anti-inflammatory effects seemed to be based on the statins alone, rather than their combination with ezetimibe.
Review
Biotechnology & Applied Microbiology
Laura Locatelli, Sara Castiglioni, Jeanette A. M. Maier
Summary: This review article discusses the effects of space environment on the human vasculature and the adaptive responses activated in such conditions. The study suggests that oxidative stress and mitochondrial dysfunction might be mediators of vascular alterations in space. Understanding the cellular and molecular mechanisms involved in these adaptive processes could provide insights for designing proper countermeasures for space exploration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Critical Care Medicine
Geraldine Vitry, Roxane Paulin, Yann Grobs, Marie-Claude Lampron, Tsukasa Shimauchi, Sarah-Eve Lemay, Eve Tremblay, Karima Habbout, Charifa Awada, Alice Bourgeois, Valerie Nadeau, Renee Paradis, Sandra Breuils-Bonnet, Florence Roux-Dalvai, Mark Orcholski, Francois Potus, Steeve Provencher, Olivier Boucherat, Sebastien Bonnet
Summary: The study identified an increased expression of detoxifying DNA enzyme NUDT1 in patients with pulmonary arterial hypertension (PAH) and animal models, with its inhibition leading to improvements in DNA damage, cell death, and vascular remodeling, as well as hemodynamics and cardiac function in animal models of PAH. These findings suggest that NUDT1 inhibitors may represent a new therapeutic option for PAH patients.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Review
Developmental Biology
Arndt F. Siekmann
Summary: This review discusses the functions of vascular mural cells in blood vessel formation and diameter regulation, as well as their interactions with endothelial cells. It also introduces the signaling pathways controlling mural cell development and highlights distinguishing features of mural cells located on different types of blood vessels. Therapeutic strategies involving mural cells to improve tissue ischemia and vascular efficiency in various diseases are explored.
Review
Cardiac & Cardiovascular Systems
Mandy O. J. Grootaert, Martin R. Bennett
Summary: Vascular smooth muscle cells play a key role in atherosclerosis by forming a protective fibrous cap and exhibiting various phenotypes that can affect plaque formation and stability. They are a larger proportion of atherosclerotic plaques than previously thought and their plasticity is regulated by various mechanisms.
CARDIOVASCULAR RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Ocarol Lopez-Acosta, Magdalena Cristobal-Garcia, Guillermo Cardoso-Saldana, Karla Carvajal-Aguilera, Mohammed El-Hafidi
Summary: The aim of this study was to evaluate the effect of leptin on reactive oxygen species' (ROS) generation in smooth muscle cells (SMCs) from a rat model of obesity and hyperleptinemia. It was found that rats fed with a sucrose-based diet showed increased levels of plasma leptin and oxidative stress markers. The SMCs from sucrose-fed rats exhibited increased fluorescence intensity and levels of Nox subunits, indicating partial resistance to leptin-induced ROS generation.
Review
Pharmacology & Pharmacy
Tong Li, Baofu Wang, Hao Ding, Shiqi Chen, Weiting Cheng, Yang Li, Xiaoxiao Wu, Lei Wang, Yangyang Jiang, Ziwen Lu, Yu Teng, Sha Su, Xiaowan Han, Mingjing Zhao
Summary: Atherosclerosis (AS)-related diseases are the leading cause of death in clinical patients. Vascular smooth muscle cells (VSMCs) play a crucial role in AS, and intercellular communication through extracellular vesicles (EVs) is important in the pathophysiology of AS.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ying Tong, Mei-Hui Zhou, Sheng-Peng Li, Hui-Min Zhao, Ya-Ru Zhang, Dan Chen, Ya-Xian Wu, Qing-Feng Pang
Summary: The malfunction of vascular smooth muscle cells (VSMCs) is an initiating factor in the pathogenesis of pathological vascular remodeling, including hypertension-related vascular lesions. MicroRNAs (miRNAs) have been implicated in the development of VSMC proliferation and migration in cardiovascular remodeling. This study reveals that miR-155-5p attenuates VSMC migration and ameliorates vascular remodeling in spontaneously hypertensive rats (SHRs) by suppressing BACH1 expression.
Article
Biology
Guoqing Qian, Oluwaseun Adeyanju, Ayobami Olajuyin, Xia Guo
Summary: This article provides a summary of the risk factors, pathophysiology, and established animal models of abdominal aortic aneurysm (AAA). It focuses specifically on the vascular smooth muscle cell phenotypic switching and dysfunction in AAA formation, offering potential novel therapeutic targets for the treatment or prevention of the disease.
Article
Biochemistry & Molecular Biology
Bing Zhou, Lu-Lu Wu, Fen Zheng, Nan Wu, Ai-Dong Chen, Hong Zhou, Jing-Yu Chen, Qi Chen, Yue-Hua Li, Yu-Ming Kang, Guo-Qing Zhu
Summary: miR-31-5p plays a crucial role in oxidative stress and VSMC migration by inhibiting FNDC5 expression, leading to increased oxidative stress and cell migration in SHR. The imbalance of miR-31-5p and FNDC5 exacerbates oxidative stress and cell migration in vascular smooth muscle cells.
Article
Surgery
Michael Ho-Yan Lee, Ben Li, Tiam Feridooni, Pei Ye Li, Audrey Shakespeare, Yasith Samarasinghe, Cesar Cuen-Ojeda, Raj Verma, Teruko Kishibe, Mohammed Al-Omran
Summary: This study evaluated the effect of race and ethnicity on the severity and postoperative outcomes of vascular diseases. The results showed that Black, Hispanic, and Indigenous patients had higher disease severity and mortality rates after vascular surgery. This highlights the significant impact of race and ethnicity on vascular surgical outcomes.
JOURNAL OF VASCULAR SURGERY
(2023)
Article
Clinical Neurology
Chih-Hao Chen, Mark D. Peterson, C. David Mazer, Makoto Hibino, Andrew E. Beaudin, Michael W. A. Chu, Francois Dagenais, Hwee Teoh, Adrian Quan, Jeffrey Dickson, Subodh Verma, Eric E. Smith
Summary: This study investigated the frequency and distribution of new ischemic brain lesions detected by diffusion-weighted imaging after aortic arch surgery. Results showed that 70% of the participants had 391 new lesions, with half of them in the middle cerebral artery territory. Factors such as preoperative white matter hyperintensity, lower intraoperative temperature, and older age were associated with the occurrence of new ischemic lesions.
Article
Cardiac & Cardiovascular Systems
Kim A. Connelly, C. David Mazer, Pankaj Puar, Hwee Teoh, Chao-Hung Wang, Tamique Mason, Farhad Akhavein, Ching-Wen Chang, Min-Hui Liu, Ning- Yang, Wei-Siang Chen, Yu-Hsiang Juan, Erika Opingari, Yaseen Salyani, William Barbour, Aryan Pasricha, Shamon Ahmed, Andrew Kosmopoulos, Raj Verma, Michael Moroney, Ehab Bakbak, Aishwarya Krishnaraj, Deepak L. Bhatt, Javed Butler, Mikhail N. Kosiborod, Carolyn S. P. Lam, David A. Hess, Otavio Rizzi Coelho-Filho, Myriam Lafreniere-Roula, Kevin E. Thorpe, Adrian Quan, Lawrence A. Leiter, Andrew T. Yan, Subodh Verma
Summary: This study aimed to evaluate the effect of sodium-glucose cotransporter 2 inhibition with empagliflozin on left ventricular mass in individuals without diabetes or significant heart failure. The results showed that after 6 months of treatment with empagliflozin, there was no significant reduction in left ventricular mass index. The findings suggest that empagliflozin may not have meaningful benefits on cardiac remodeling in this population.
Article
Endocrinology & Metabolism
Jean Jacob-Brassard, Mohammed Al-Omran, Therese A. Stukel, Muhammad Mamdani, Douglas S. Lee, Giuseppe Papia, Charles de Mestral
Summary: This study aimed to describe the impact of diabetes on rates of lower extremity revascularization and amputation for peripheral artery disease (PAD) in Ontario, Canada. The study found that the increasing prevalence of diabetes contributed to the increase in rates of PAD-related revascularization and amputation.
Article
Surgery
Jean Jacob-Brassard, Mohammed Al-Omran, Therese A. Stukel, Muhammad Mamdani, Douglas S. Lee, Charles de Mestral
Summary: The study aimed to quantify the regional variation in revascularization and amputation rates for peripheral artery disease (PAD). A repeated cross-sectional analysis of Ontarians aged 40 years and older between 2002 and 2019 was conducted. The results showed significant regional differences in demographics, comorbidities, and rates of revascularization and amputation for PAD.
JOURNAL OF VASCULAR SURGERY
(2023)
Article
Surgery
Patrick Heindel, James J. Fitzgibbon, Jessica D. Feliz, Dirk M. Hentschel, Steven K. Burke, Mohammed Al-Omran, Deepak L. Bhatt, Michael Belkin, C. Keith Ozaki, Mohamad A. Hussain
Summary: This study aims to evaluate whether radiocephalic arteriovenous fistulas meet the guidelines from the National Kidney Foundation, and to elucidate the clinical and anatomic characteristics associated with interventions following fistula creation. The results of the study demonstrate that creation of radiocephalic arteriovenous fistula is a guideline-concordant strategy for appropriately selected patients.
JOURNAL OF VASCULAR SURGERY
(2023)
Review
Gastroenterology & Hepatology
Nasruddin Sabrie, Rishad Khan, Samir Seleq, Hoomam Homsi, Nikko Gimpaya, Rishi Bansal, Michael A. Scaffidi, David Lightfoot, Samir C. Grover
Summary: This study aimed to systematically characterize the credentialing recommendations and requirements worldwide. The analysis of 20 credentialing documents from 12 societies revealed substantial variation among societies in terms of procedural volume and key performance indicator statements.
ENDOSCOPY INTERNATIONAL OPEN
(2023)
Article
Cardiac & Cardiovascular Systems
Rawan K. Rumman, Subodh Verma, Vincent Chan, David Mazer, Adrian Quan, Makoto Hibino, Benoit De Varennes, Michael W. A. Chu, David Latter, Hwee Teoh, Bobby Yanagawa, Howard Leong-Poi, Kim A. Connelly
Summary: This study evaluated the effect of annuloplasty size on postoperative mitral valve hemodynamics during exercise and examined predictors of mitral valve hemodynamics. Intraoperative mean and peak mitral valve gradients by transesophageal echocardiography independently predicted mean and peak resting and exercise gradients at follow-up.
Article
Dermatology
Abdelrahman Zamzam, Ann-Marie McLaren, Emily Ram, Muzammil H. Syed, Sreenath Rave, Suzanne H. Lu, Mohammed Al-Omran, Charles de Mestral
Summary: This manuscript discusses the implementation and initial evaluation of a novel acute care pathway for Canadian patients with diabetic foot ulcers (DFU). A multidisciplinary team developed and implemented the pathway for DFU patients who visited the emergency department and needed hospitalization. The study analyzed processes of care, length of stay, and hospitalization costs, showing favorable results compared to historical data.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Michael Moroney, Raj Verma, Makoto Hibino, C. David Mazer, Kim A. Connelly, Andrew T. Yan, Adrian Quan, Hwee Teoh, Subodh Verma, Pankaj Puar
Summary: The study found that the drug empagliflozin can reduce cardiac burden in patients with type 2 diabetes (T2DM), regardless of the duration of diabetes being less than 10 years or more than 10 years.
Article
Cardiac & Cardiovascular Systems
Pankaj Puar, Nikhil Mistry, Kim A. Connelly, Andrew T. Yan, Adrian Quan, Hwee Teoh, Yi Pan, Raj Verma, David A. Hess, Subodh Verma, C. David Mazer
Summary: This study investigated the association between serum levels of insulin-like growth factor-binding protein 7 (IGFBP7) and empagliflozin-mediated left ventricular mass regression. The results showed no significant association between IGFBP7 levels and left ventricular mass. It suggests that SGLT2i-mediated cardiac remodeling may be independent of IGFBP7 levels.
Article
Cardiac & Cardiovascular Systems
Raj Verma, Michael Moroney, Makoto Hibino, Cyril David Mazer, Kim A. Connelly, Andrew T. Yan, Adrian Quan, Hwee Teoh, Subodh Verma, Pankaj Puar
Summary: This study aimed to evaluate the relationship between neutrophil-to-lymphocyte ratio (NLR) and cardiac reverse remodeling in patients with heart failure. By studying 97 patients with type 2 diabetes and coronary artery disease treated with empagliflozin, it was found that patients with higher NLR levels had higher left ventricular mass index (LVMi) and left ventricular end-diastolic volume index. Regardless of baseline NLR levels, empagliflozin treatment consistently reduced LVMi in patients.
Meeting Abstract
Cardiac & Cardiovascular Systems
Aishwarya Krishnaraj, Ehab Bakbak, Irene Firoz, Yi Pan, Adrian Quan, Hwee Teoh, David Hess, Subodh Verma
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Michael Moroney, Raj Verma, Makoto Hibino, C. David Mazer, Kim Connelly, Andrew T. Yan, Adrian Quan, Hwee Teoh, Subodh Verma, Pankaj Puar
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Ehab Bakbak, Pankaj Puar, Aishwarya Krishnaraj, Daniella Terenzi, Tamique Mason, Adrian Quan, Hwee Teoh, Andrew T. Yan, Kim A. Connelly, C. David Mazer, David Hess, Subodh Verma
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)