Article
Cardiac & Cardiovascular Systems
Michael J. Hendrickson, Vardhmaan Jain, Kirtipal Bhatia, Christopher Chew, Sameer Arora, Joseph S. Rossi, Pedro Villablanca, Navin K. Kapur, Aditya A. Joshi, Arieh Fox, Kiran Mahmood, Edo Y. Birati, Mark J. Ricciardi, Arman Qamar
Summary: This study investigated the trends and impact of IABP and Impella use in patients with cardiogenic shock. The results showed an increase in the use of Impella and IABP, but the addition of these devices did not affect in-hospital mortality or length of stay.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Medicine, General & Internal
Nikolaos Patsalis, Julian Kreutz, Georgios Chatzis, Styliani Syntila, Sebastian Griewing, Carly Pirlet-Grant, Malte Schlegel, Bernhard Schieffer, Birgit Markus
Summary: Impella (R) support can improve hemodynamics and renal organ perfusion in patients with myocardial infarction complicating cardiogenic shock. Targeted control of the renal resistive index (RRI) by the Impella (R) pump may contribute to renal organ protection.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Critical Care Medicine
Mariusz Kowalewski, Kamil Zielinski, Giuseppe Maria Raffa, Paolo Meani, Valeria Lo Coco, Federica Jiritano, Dario Fina, Matteo Matteucci, Giovanni Chiarini, Anne Willers, Jorik Simons, Piotr Suwalski, Mario Gaudino, Michele Di Mauro, Jos Maessen, Roberto Lorusso
Summary: The study analyzed predictors of unfavorable outcomes in elderly patients (>= 70 yr) undergoing venoarterial extracorporeal membrane oxygenation for refractory cardiogenic shock. Despite high in-hospital mortality, the use of ECMO in elderly patients is still considered, as increasing age itself was not associated with higher mortality.
CRITICAL CARE MEDICINE
(2021)
Article
Medicine, General & Internal
Guillaume Schurtz, Natacha Rousse, Ouriel Saura, Vincent Balmette, Flavien Vincent, Nicolas Lamblin, Sina Porouchani, Basile Verdier, Etienne Puymirat, Emmanuel Robin, Eric Van Belle, Andre Vincentelli, Nadia Aissaoui, Cedric Delhaye, Clement Delmas, Alessandro Cosenza, Laurent Bonello, Francis Juthier, Mouhamed Djahoum Moussa, Gilles Lemesle
Summary: For patients with refractory left ventricle dominant cardiogenic shock, VA-ECMO was associated with improved survival rate and a lower need for escalation compared to IMPELLA(R) patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Styliani Syntila, Georgios Chatzis, Birgit Markus, Holger Ahrens, Christian Waechter, Ulrich Luesebrink, Dimitar Divchev, Harald Schuett, Panagiota-Eleni Tsalouchidou, Andreas Jerrentrup, Mariana Parahuleva, Bernhard Schieffer, Konstantinos Karatolios
Summary: This study compared the outcomes of Impella and extracorporeal life support (ECLS) in patients with post-cardiac arrest cardiogenic shock complicating acute myocardial infarction. Impella and ECLS patients had comparable hospital and 12-month survival rates, but Impella patients showed greater left ventricle ejection-fraction improvement and fewer device-related complications. Subgroup analyses indicated that Impella was associated with better survival in patients with lower-risk features.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Bernhard Wernly, Mina Karami, Annemarie E. Engstroem, Stephan Windecker, Lukas Hunziker, Thomas F. Luescher, Jose P. Henriques, Markus W. Ferrari, Stephan Binneboessel, Maryna Masyuk, David Niederseer, Peter Abel, Georg Fuernau, Marcus Franz, Malte Kelm, Mathias C. Busch, Stephan B. Felix, Holger Thiele, Alexander Lauten, Christian Jung
Summary: In patients with cardiogenic shock, the adjusted mortality rates were similar between Impella and ECLS. Baseline lactate level was identified as an independent predictor of mortality. The type of device used may be less important compared to other factors in patients with profound cardiogenic shock.
Review
Critical Care Medicine
Waiel Abusnina, Mahmoud Ismayl, Ahmad Al-abdouh, Vaishnavi Ganesan, Mostafa Reda Mostafa, Osama Hallak, Emily Peterson, Mahmoud Abdou, Andrew M. Goldsweig, Ahmed Aboeata, Khagendra Dahal
Summary: This study compared the clinical outcomes of Impella versus extracorporeal membrane oxygenation (ECMO) in patients with cardiogenic shock (CS). The results showed that the use of Impella was associated with lower rates of in-hospital mortality, bleeding, and stroke compared to ECMO.
Article
Mathematics
Rahmi Alkan, Beatrice De Lazzari, Massimo Capoccia, Claudio De Lazzari, Selim Bozkurt
Summary: Cardiogenic shock is a life-threatening condition characterized by low cardiac output resulting from acute ventricular failure or decompensation of chronic heart failure. There is a need for mechanical circulatory support when inotropic support fails. This study aims to compare the haemodynamic effects and left ventricular unloading of IABP, Impella 2.5, TandemHeart, and combined IABP and Impella 2.5 support in cardiogenic shock using cardiovascular system modelling and simulation. The results suggest that TandemHeart support may have a more beneficial effect on haemodynamics compared to IABP and Impella 2.5.
Review
Biochemistry & Molecular Biology
Federico Pappalardo, Giulia Malara, Andrea Montisci
Summary: Cardiogenic shock following acute myocardial infarction has a high mortality rate that has remained largely unchanged for the past 20 years. Various strategies, from myocardial revascularization to mechanical circulatory support, have been attempted without significant breakthrough. Systemic inflammation may play a key role in the condition, and a multitarget approach could potentially offer a solution.
Article
Cardiac & Cardiovascular Systems
Margriet Bogerd, Sanne ten Berg, Elma J. Peters, Alexander P. J. Vlaar, Annemarie E. Engstroem, Luuk C. Otterspoor, Christian Jung, Dirk Westermann, Janine Poess, Holger Thiele, Benedikt Schrage, Jose P. S. Henriques
Summary: This study aimed to investigate the use of Impella and VA-ECMO in acute myocardial infarction-related cardiogenic shock (AMICS) and their outcomes, adverse events, and resource demands. The results showed that Impella-supported patients had lower rates of adverse events and in-hospital mortality compared to VA-ECMO. They were also more likely to be discharged directly to home. The use of Impella was associated with shorter hospital stays and lower hospital costs.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Enzo Luesebrink, Antonia Kellnar, Kathrin Krieg, Leonhard Binzenhoefer, Clemens Scherer, Sebastian Zimmer, Benedikt Schrage, Stephanie Fichtner, Tobias Petzold, Daniel Braun, Sven Peterss, Stefan Brunner, Christian Hagl, Dirk Westermann, Joerg Hausleiter, Steffen Massberg, Holger Thiele, Andreas Schaefer, Martin Orban
Summary: The Impella device is a percutaneous transvalvular microaxial flow pump used for various cardiovascular conditions. However, there are risks of complications associated with its use and limited data from large randomized controlled trials to assess its efficacy and complications.
Article
Engineering, Biomedical
Ameesh Isath, Suguru Ohira, Avi Levine, Gregg M. Lanier, Stephen Pan, Chhaya Aggarwal-Gupta, Ian Mason, Vasiliki Gregory, David Spielvogel, Alan L. Gass, Masashi Kai
Summary: This study compared the safety and efficacy of Impella 5.5 with previous iterations in the setting of ECPELLA. The results showed that Impella 5.5 group had higher total ECPELLA flow and lower rates of total device complications and Impella-specific complications compared to the control group.
Article
Medicine, General & Internal
Anne Freund, Steffen Desch, Janine Poess, Dmitry Sulimov, Marcus Sandri, Nicolas Majunke, Holger Thiele
Summary: Mortality in infarct-related cardiogenic shock remains high, and active mechanical circulatory support devices such as VA-ECMO are rapidly evolving. However, supporting evidence of VA-ECMO therapy in this condition is lacking. Research on patient selection and potential complications is ongoing.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Konstantinos Karatolios, Georgios Chatzis, Birgit Markus, Ulrich Luesebrink, Holger Ahrens, Dimitar Divchev, Styliani Syntila, Andreas Jerrentrup, Bernhard Schieffer
Summary: This study compared outcomes of patients with cardiogenic shock supported by Impella or vaECMO, and found similar hospital and 6-month survival rates between the two groups. However, vaECMO group experienced more frequent vascular complications at access sites. A randomized trial is needed to further examine the effects and optimal device choice in these patients.
CLINICAL RESEARCH IN CARDIOLOGY
(2021)
Review
Medicine, General & Internal
Riley J. Batchelor, Andrew Wheelahan, Wayne C. Zheng, Dion Stub, Yang Yang, William Chan
Summary: Despite the increased use of mechanical circulatory support (MCS) devices in acute myocardial infarction cardiogenic shock (AMI-CS), there is a lack of randomized data directly comparing Impella and veno-arterial extra-corporeal membrane oxygenation (VA-ECMO). This study conducted a systematic review and meta-analysis of existing studies and found that Impella use in AMI-CS was associated with reduced in-hospital and medium-term mortality compared to VA-ECMO.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Emergency Medicine
Barret Rush, Andrew Wormsbecker, Landon Berger, Katie Wiskar, Mypinder S. Sekhon, Donald E. Griesdale
CANADIAN JOURNAL OF EMERGENCY MEDICINE
(2017)
Article
Emergency Medicine
Robert S. Green, Dean A. Fergusson, Alexis F. Turgeon, Lauralyn A. McIntyre, George J. Kovacs, Donald E. Griesdale, Ryan Zarychanski, Michael B. Butler, Nelofar Kureshi, Mete Erdogan
CANADIAN JOURNAL OF EMERGENCY MEDICINE
(2017)
Review
Critical Care Medicine
Barret Rush, Katie Wiskar, Landon Berger, Donald Griesdale
JOURNAL OF INTENSIVE CARE MEDICINE
(2017)
Article
Emergency Medicine
Barret Rush, Katie Wiskar, Landon Berger, Donald E. Griesdale
JOURNAL OF EMERGENCY MEDICINE
(2017)
Article
Anesthesiology
Nicholas West, Paul B. McBeth, Sonia M. Brodie, Klaske van Heusden, Sarah Sunderland, Guy A. Dumont, Donald E. G. Griesdale, J. Mark Ansermino, Matthias Gorges
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2018)
Article
Anesthesiology
Nicholas A. Fergusson, Steve Ahkioon, Mahesh Nagarajan, Eric Park, Yichuan Ding, Najib Ayas, Vinay K. Dhingra, Dean R. Chittock, Donald E. G. Griesdale
CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE
(2020)
Article
Critical Care Medicine
Ryan L. Hoiland, Mypinder S. Sekhon, Danilo Cardim, Michael D. Wood, Peter Gooderham, Denise Foster, Donald E. Griesdale
Article
Anesthesiology
Nicholas A. Fergusson, Steve Ahkioon, Najib Ayas, Vinay K. Dhingra, Dean R. Chittock, Mypinder S. Sekhon, Anish R. Mitra, Donald E. G. Griesdale
CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE
(2020)
Article
Hematology
Ryan L. Hoiland, Nicholas A. Fergusson, Anish R. Mitra, Donald E. G. Griesdale, Dana Devine, Sophie Stukas, Jennifer Cooper, Sonny Thiara, Denise Foster, Luke Y. C. Chen, Agnes Y. Y. Lee, Edward M. Conway, Cheryl L. Wellington, Mypinder S. Sekhon
Editorial Material
Anesthesiology
Sonny Thiara, Donald E. G. Griesdale
CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE
(2021)
Editorial Material
Critical Care Medicine
Mypinder S. Sekhon, Ryan L. Hoiland, Donald E. Griesdale
Article
Critical Care Medicine
Carleen Batson, Logan Froese, Mypinder Sekhon, Donald Griesdale, Alwyn Gomez, Eric P. Thelin, Rahul Raj, Marcel Aries, Clare Gallagher, Francis Bernard, Andreas H. Kramer, Frederick A. Zeiler
Summary: This study investigates the impact of age and biological sex on cerebral physiology and finds a positive linear correlation between PAx, RAC, and age, but no relationship between PRx and age.
JOURNAL OF NEUROTRAUMA
(2023)
Article
Medicine, General & Internal
Eleen Yang, Mypinder Sekhon, Donald Griesdale
Summary: This case report describes a previously healthy early adolescent female who developed severe neurological deterioration due to meningococcal meningitis. Monitoring of intracranial pressure and brain tissue oxygen revealed a complete absence of autoregulation in the patient, emphasizing the importance of maintaining adequate cerebral oxygenation while avoiding increased intracranial pressure. Despite initial complications, the patient made a full neurologic recovery.
Article
Anesthesiology
Alana M. Flexman, Peter A. Gooderham, Donald E. Griesdale, Ruth Argue, Brian Toyota
CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE
(2017)
Review
Critical Care Medicine
Mypinder S. Sekhon, Philip N. Ainslie, Donald E. Griesdale