Article
Cell & Tissue Engineering
Tayyebeh Vafaee, Fiona Walker, Dan Thomas, Joao Gabriel Roderjan, Sergio Veiga Lopes, Francisco D. A. da Costa, Amisha Desai, Paul Rooney, Louise M. Jennings, John Fisher, Helen E. Berry, Eileen Ingham
Summary: The study evaluated the performance of low concentration SDS decellularised porcine pulmonary roots in the right ventricular outflow tract of juvenile sheep and investigated the cellular population of the roots over time. The decellularised porcine pulmonary roots showed good functional performance and were repopulated with ovine cells of the appropriate phenotype, orchestrated by M2 macrophages. These findings highlight the importance of macrophages in the constructive tissue remodelling of cardiac root tissues.
JOURNAL OF TISSUE ENGINEERING
(2022)
Article
Cardiac & Cardiovascular Systems
Michael W. Kasten, Jeremy L. Herrmann, Morgan Cox, Chelsea McCurdy, Cody Tragesser, Mark W. Turrentine, Mark Rodefeld, John W. Brown
Summary: This study reviewed the outcomes of the Stentless Porcine Aortic Root Prosthesis (SPAR) in pulmonary position RVOTR surgeries conducted at Indiana University Methodist Hospital in Indianapolis. Results showed excellent medium to long-term durability, low rates of endocarditis, and high freedom from reintervention.
ANNALS OF THORACIC SURGERY
(2021)
Review
Biochemistry & Molecular Biology
Yen-Yu Lu, Yao-Chang Chen, Yung-Kuo Lin, Shih-Ann Chen, Yi-Jen Chen
Summary: The right ventricular outflow tract (RVOT) is a major source of ventricular arrhythmias. Various cellular and molecular mechanisms, including calcium handling protein modulation, enhanced CaMKII activity, ryanodine receptor phosphorylation, and elevated cAMP levels, contribute to arrhythmogenesis in RVOT. Decreased expression of Cx43 and Scn5a may also lead to electrical uncoupling. This review aims to provide an updated understanding of these mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Kei Kobayashi, Takeshi Shinkawa, Masaaki Yamagishi, Satoshi Saito, Yuki Nakayama, Ryogo Hoki, Hisashi Yoshida, Hiroshi Niinami
Summary: This study evaluated the outcomes of different material conduits with tricuspid ePTFE valves, finding that conduits with ePTFE valves in ePTFE tubes had better conduit function compared to those with autologous pericardial or xenograft roll, especially in terms of conduit regurgitation.
ANNALS OF THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Ming-Tai Lin, Chun-An Chen, Shyh-Jye Chen, Jou-Hsuan Huang, Yu-Hsuan Chang, Shuenn-Nan Chiu, Chun-Wei Lu, Mei-Hwan Wu, Jou-Kou Wang
Summary: This study aimed to evaluate the efficacy of percutaneous pulmonary valve implantation (PPVI) on right ventricular (RV) function and graft remodeling in patients with native repaired right ventricular outflow tracts. The results showed that within 6 months after PPVI, all patients exhibited resolution of paradoxical septal motion and a significant reduction in RV volume, N-terminal pro-B-type natriuretic peptide levels, and valve eccentricity indices. However, only 9 patients (17.3%) achieved normalization of the RV ejection fraction (> 50%).
CANADIAN JOURNAL OF CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Elijah R. Behr, Yael Ben-Haim, Michael J. Ackerman, Andrew D. Krahn, Arthur A. M. Wilde
Summary: Brugada syndrome is a primary electrical disorder associated with an increased risk of sudden cardiac death, with controversy over whether it is caused by cardiomyopathy or channelopathy. The final common pathway for BrS may be viewed as a disease of reduced RVOT conduction reserve.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Yen-Yu Lu, Shih-Yu Huang, Yung-Kuo Lin, Yao-Chang Chen, Yi-Ann Chen, Shih-Ann Chen, Yi-Jen Chen
Summary: This study found that the connection between epicardial adipose tissue and right ventricular outflow tract cardiomyocytes alters the electrophysiological characteristics of the heart muscle, leading to an increased susceptibility to arrhythmias.
Article
Cardiac & Cardiovascular Systems
Bo Chen, Ting Fan, Yong Cao, Lian Hu, Guanshui Yu
Summary: Cardiac masses can be primary tumors, metastatic diseases, nonbacterial thrombotic, or infective endocarditis. Myxomas are the most common primary tumors, accounting for 75%. Hemolymphangiomas are a rare type of tumor originating from mesenchyme and have not been reported in the ventricular outflow tract of the heart before. We report a case of hemolymphangioma tumor in the right ventricular outflow tract, which was successfully removed, and the patient remained tumor-free after 18 months of follow-up.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Shengyuan Huang, Shiye Wang, Zhixiang Tang, Yinghuan Dai, Long Song
Summary: This article presents a rare case of palpitations caused by right ventricular outflow tract obstruction (RVOTO) caused by a cardiac multicomponent mesenchymal tumor. Surgical resection successfully stabilized the patient's condition, and there was no tumor recurrence during a 7-year follow-up.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Valentin Sans-Coma, Barbara Pozo-Vilumbrales, Maria Carmen Fernandez, Miguel A. Lopez-Unzu, Maria Teresa Soto-Navarrete, Ana Carmen Duran, Josep M. Arque, Borja Fernandez
Summary: This article compares the gross anatomy of the outflow tract valvular system among several groups of vertebrates, aiming to understand the conceptual and nomenclature controversies in the field and the discrepancies between physicians and zoologists in defining what a cardiac outflow tract valve is.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2022)
Review
Biotechnology & Applied Microbiology
Chenggang Li, Bo Xie, Ruizhe Tan, Lijin Liang, Zhaoxiang Peng, Qi Chen
Summary: This review discusses the complications associated with bovine jugular vein conduit (BJVC) in right ventricular outflow tract (RVOT) reconstruction surgery and summarizes the current technological advancements. Novel crosslinking agents, decellularization techniques, conduit coatings, and physical reinforcement materials have improved the performance of BJVCs. The authors believe that breakthroughs in BJVC's clinical application may come from new genetic research findings and advanced characterization apparatuses and bioreactors, and they are optimistic about BJVC's potential in providing sophisticated therapies for next-generation RVOT reconstruction.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Pediatrics
Guan-Xi Wang, Feng-Qun Mao, Kai Ma, Rui Liu, Kun-Jing Pang, Sen Zhang, Yang Yang, Ben-Qing Zhang, Shou-Jun Li
Summary: This study aimed to investigate the performance of handmade tri-leaflet ePTFE conduits in the absence of a suitable homograft. The results showed that the ePTFE conduits had acceptable early and midterm outcomes, but longer follow-up is needed to assess their long-term effects.
WORLD JOURNAL OF PEDIATRICS
(2022)
Article
Biochemistry & Molecular Biology
Ching-Han Liu, Yao-Chang Chen, Yen-Yu Lu, Yung-Kuo Lin, Satoshi Higa, Shih-Ann Chen, Yi-Jen Chen
Summary: This study investigated the mechanisms of gender difference in lithium-induced arrhythmogenesis and found that male rabbits were more prone to developing Brugada-pattern ECG changes and fatal arrhythmia compared to female rabbits. The study also showed that lithium reduced sodium current to a greater extent and increased late sodium current in male cardiomyocytes. Inhibition of late sodium current with ranolazine prevented Brugada-pattern ECG changes induced by lithium. Targeting late sodium current may be a potential therapeutic strategy for Brugada syndrome-related ventricular tachyarrhythmia.
Article
Physiology
Jianwei Zheng, Guohua Fu, Islam Abudayyeh, Magdi Yacoub, Anthony Chang, William W. Feaster, Louis Ehwerhemuepha, Hesham El-Askary, Xianfeng Du, Bin He, Mingjun Feng, Yibo Yu, Binhao Wang, Jing Liu, Hai Yao, Huimin Chu, Cyril Rakovski
Summary: The proposed multistage diagnostic scheme achieved clinical-grade precision in predicting the LVOT and RVOT locations of VT origin with fewer applicability restrictions than previous studies.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Kang Li, Pinchao Lv, Yuchuan Wang, Fangfang Fan, Yansheng Ding, Jianping Li, Jing Zhou
Summary: This study aimed to identify electrocardiographic (ECG) characteristics that predict the site for successful ablation of premature ventricular complexes (PVCs) originating in the inferior right ventricular outflow tract (RVOT). The ECG features of the inferior RVOT group were found to be helpful in diagnosing and determining the possibility of PVCs originating from the RVOT.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Bardia Arabkhani, Robert J. M. Klautz, Frederiek de Heer, Laurent De Kerchove, Gebrine El Khoury, Emmanuel Lansac, Hans-Joachim Schaefers, Ismail El-Hamamsy, Marien Lenoir, Jose Aramendi, Bart Meuris, Peter Verbrugghe, Jolanda Kluin, Dave R. Koolbergen, Olivier Bouchot, Igor Rudez, Adrian Kolesar, Thomas J. van Brakel
Summary: This study compared the outcomes of valve-sparing surgery and valve replacement surgery in patients with aortic root aneurysm and valve insufficiency. The results showed that valve-sparing surgery had higher survival rates and fewer valve-related events, indicating that it should be considered as the preferred surgical method.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Francesco Pollari, Paolo Berretta, Alberto Albertini, Thierry Carrel, Kevin Teoh, Bart Meuris, Emmanuel Villa, Utz Kappert, Martin Andreas, Marco Solinas, Martin Misfeld, Carlo Savini, Antonio Fiore, Malakh Shrestha, Giuseppe Santarpino, Gian Luca Martinelli, Carmelo Mignosa, Mattia Glauber, Tristan Yan, Theodor Fischlein, Marco Di Eusanio
Summary: The objective of this study was to investigate the need for postoperative permanent pacemaker implantation (PPI) following sutureless and rapid-deployment aortic valve replacement (SuRD-AVR). The study retrospectively analyzed a large multicenter international registry (SURD-IR) from 2008 to 2019. The results showed a significant decrease in the PPI rate over time in the Su cohort, while the RD cohort showed no significant differences in PPI rate between the two time periods.
THORACIC AND CARDIOVASCULAR SURGEON
(2023)
Review
Cell Biology
Ramadan Jashari, Vanessa Bouzet, Maria-Josee Alcaraz Blanco, Alison Oleffe, Emilie Lecocq, Stefano Mastrobuoni
Summary: Vascular tissue banking has been conducted in Brussels for over 30 years in compliance with EU and Swiss regulations. The number of vascular tissue donations significantly increased during the second and third decades, with a total of 2,765 donations performed in multiple transplant centres. Approximately 65.9% of the evaluated tissues were accepted for transplantation, with a majority of allografts used for infection treatment, critical limb ischaemia, and congenital cardiac surgery. Complications, including acute rejection, were reported after transplantation.
CELL AND TISSUE BANKING
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
B. Meuris, M. Lamberigts
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Lucas Van Hoof, Marie Lamberigts, Dries Noe, Ismail El-Hamamsy, Emmanuel Lansac, Jolanda Kluin, Laurent de Kerchove, John Pepper, Tom Treasure, Bart Meuris, Filip Rega, Peter Verbrugghe
Summary: This study compared the efficacy of PEARS and VSRR in treating syndromic root aneurysms using propensity score analysis. The results showed that both methods have favorable mid-term survival, freedom from reintervention, and preservation of valve function.
Article
Cardiac & Cardiovascular Systems
Masafumi Ono, Shigetaka Kageyama, Neil O'Leary, Mohammed S. El-Kurdi, Jochen Reinoehl, Eric Solien, Richard W. Bianco, Mirko Doss, Bart Meuris, Renu Virmani, Martijn Cox, Yoshinobu Onuma, Patrick W. Serruys
Summary: This study demonstrates the feasibility and effectiveness of a novel biorestorative graft in an ovine coronary artery bypass graft model, suggesting its potential as an alternative to saphenous vein grafts. These findings could pave the way for the first-in-man trial of using this new material for coronary artery bypass graft patients who struggle with harvesting SVGs.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2023)
Correction
Surgery
Hozan Mufty, Jef Van Den Eynde, Bart Meuris, Willem-Jan Metsemakers, Eric Van Wijngaerden, Thomas Vandendriessche, Hans P. Steenackers, Inge Fourneau
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Serban Stoica, Chloe Beard, Johanna J. M. Takkenberg, Mostafa M. Mokhles, Mark Turner, John Pepper, Noreen Hopewell-Kelly, Umberto Benedetto, Samer A. M. Nashef, Ismail El-Hamamsy, Peter Skillington, Mattia Glauber, Ruggero De Paulis, Elaine Tseng, Bart Meuris, Marta Sitges, Victoria Delgado, Markus Krane, Martin Kostolny, Maria Pufulete
Summary: This study used a formal consensus method to evaluate surgical procedures for adult patients undergoing aortic valve replacement. The results showed that conventional AVR, Ross procedure, and Ozaki procedure were appropriate for clinical scenarios, while transcatheter aortic valve implantation was suitable for selected cases.
Article
Cardiac & Cardiovascular Systems
Bart Meuris, Serdar Gunaydin, Patrizio Lancellotti, Luigi Badano, Gabriel Aldea, Rita Herrenknecht, Elisa Cerutti, Sara Gaggianesi, Silvia Dipinto, Paola Morando, Joerg Kempfert
Summary: This study introduces the umbrella concept to the medical device area, aiming to collect safety and device performance data for the treatment of aortic, mitral, and tricuspid valve diseases. The study uses a master protocol with three substudies to address specific research questions. The study started in June 2021 and enrollment is ongoing.
JOURNAL OF CARDIOTHORACIC SURGERY
(2023)
Article
Surgery
Manon Van Hecke, Lucas Van Hoof, Magdalena Sikole, Hozan Mufty, Piet Claus, Peter Verbrugghe, John Ely, Geoffrey A. Berg, Tania Roskams, Bart Meuris
Summary: This study assessed the safety and efficacy of an experimental large-diameter vascular graft externally sealed with an elastomeric polymer when used as an interposition graft in the descending aorta of sheep. The results showed that the experimental graft had a similar safety and performance profile compared to a commonly used prosthetic vascular graft, with no significant difference in surgical handling, hemostasis time, hematologic and radiologic results between the study groups.
JOURNAL OF SURGICAL RESEARCH
(2023)
Letter
Cardiac & Cardiovascular Systems
Lennert Minten, Michiel Algoet, Johan Bennett, Wouter Oosterlinck, Bart Meuris, Tom Langenaeken, Stephanie Bezy, Laurine Wouters, Juergen Duchenne, Alexis Puvrez, Senne De Groote, Pierluigi Lesizza, Pascal Frederiks, Laurens De Vos, Tom Adriaenssens, Peter Sinnaeve, Walter Desmet, Keir McCutcheon, Christophe Dubois
CIRCULATION RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Lise Geuens, Lucas Van Hoof, Alexander Van De Bruaene, Filip Rega, Bart Meuris, Peter Verbrugghe
Summary: The preferred surgical treatment for non-elderly patients in need of AVR varies widely. There is a need for increased collaboration between cardiac departments and for education and scientific research on patient-centered outcomes of different AVR techniques.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Review
Medicine, General & Internal
Tom Langenaeken, Arnaud Vanoppen, Fien Janssens, Loes Tanghe, Peter Verbrugghe, Filip Rega, Bart Meuris
Summary: Valvular heart disease often requires valve replacement surgery, with mechanical heart valves being commonly used in younger patients. The main drawback of mechanical valves is the lifelong need for anticoagulation. Direct oral anticoagulants (DOACs) offer a patient-friendly alternative to warfarin, but their use in mechanical valves has not been approved yet.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Tom Langenaeken, Pieter De Meester, Peter Verbrugghe, Filip Rega, Marie Lamberigts, Manon Van Hecke, Lucas Van Hoof, Bart Meuris
Summary: This study presents the long-term results of Triflo versus On-X mechanical valves in both aortic and pulmonary positions in a sheep model. The Triflo valve showed lower mean and peak gradients, excellent hemodynamics, stable long-term function, and low valve noise. These results lay the foundation for future clinical trials.
INTERDISCIPLINARY CARDIOVASCULAR AND THORACIC SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Bart Meuris, Jean-Christian Roussel, Michael A. Borger, Matthias Siepe, Pierluigi Stefano, Guenther Laufer, Thierry Langanay, Alexis Theron, Martin Grabenwoeger, Konrad Binder, Philippe Demers, Renzo Pessotto, Wouter van Leeuwen, Thierry Bourguignon, Sergio Canovas, Giovanni Mariscalco, Enrico Coscioni, Francois Dagenais, Olaf Wendler, Gianluca Polvani, Matthias Eden, Beate Botta, Peter Bramlage, Ruggero De Paulis
Summary: This study reports the 1-year safety and clinical outcomes of patients under 60 years old who underwent bioprosthetic surgical aortic valve intervention. The results showed good safety, excellent haemodynamic performance, and improved quality of life after the surgery.
INTERDISCIPLINARY CARDIOVASCULAR AND THORACIC SURGERY
(2023)
