Review
Cell & Tissue Engineering
Hyun-Ji Park, Kenneth J. De Jesus Morales, Sruti Bheri, Brandon P. Kassouf, Michael E. Davis
Summary: This article summarizes the interactions between cardiac ECM and cells, focusing on their role in ischemic heart disease. It also highlights recent advances in native ECM-mimicking cardiac matrices as a platform for modulating cardiac cell behavior and inducing cardiac repair.
Article
Cardiac & Cardiovascular Systems
Andres Reyes-Valdivia, Theodoros Kratimenos, Marco Ferraresi, Simona Sica, Luigi Lovato, Giancarlo Accarino, Gabriele Pagliaricco, Yamume Tshomba, Giovanni Tinelli, Claudio Gandarias, Davide Pacini, Dimitrios Tomais, Emanuele Gatta, Sara Schiavon, Giulio Accarino, Fabrizio Minelli, Francesca De Nigris
Summary: The study evaluated the early outcomes of thoracic endovascular aortic repair (TEVAR) using the Valiant Navion (TM) stent graft, showing high technical success rate, low incidence rate, and safety especially in on-label procedures.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Cell Biology
Dong Mei Xie, Yang Chen, Yan Liao, Wanwen Lin, Gang Dai, Di Han Lu, Shuanghua Zhu, Ke Yang, Bingyuan Wu, Zhihong Chen, Chaoquan Peng, Mei Hua Jiang
Summary: The study found that CD51 can serve as a marker for resident cardiac MSCs, and CD51(+)cMSC therapy enhances cardiac repair through promoting angiogenesis and a mechanism mediated by SCF.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Xi Lou, Yawen Tang, Lei Ye, Danielle Pretorius, Vladimir G. Fast, Asher M. Kahn-Krell, Jue Zhang, Jianhua Zhang, Aijun Qiao, Gangjian Qin, Timothy Kamp, James A. Thomson, Jianyi Zhang
Summary: The study demonstrates that human cardiac muscle patches containing three types of cardiac cells derived from human pluripotent stem cells significantly improved cardiac function, reduced infarct size, and promoted cardiac maturation in a pig model of myocardial infarction. The inclusion of cardiac fibroblasts in the cardiac patches enhanced the maturity and function of cardiac muscle cells. Transplantation of cardiac patches with cardiac fibroblasts resulted in better cardiac recovery and engraftment compared to patches without fibroblasts.
CARDIOVASCULAR RESEARCH
(2023)
Editorial Material
Multidisciplinary Sciences
Paul S. Appelbaum
Summary: The constraints in clinical trials of psychedelic drugs make it challenging to assess their effectiveness in treating people.
Article
Robotics
Theophile Gervet, Soumith Chintala, Dhruv Batra, Jitendra Malik, Devendra Singh Chaplot
Summary: Semantic navigation is necessary for mobile robots in uncontrolled environments. Learning-based approaches have been proposed to enhance the classical pipeline for spatial navigation. A large-scale empirical study shows that modular learning achieves a 90% success rate in real-world environments, while end-to-end learning struggles due to a large image domain gap, resulting in a 23% success rate.
Review
Oncology
Azadeh Abravan, Gareth Price, Kathryn Banfill, Tom Marchant, Matthew Craddock, Joe Wood, Marianne C. Aznar, Alan McWilliam, Marcel van Herk, Corinne Faivre-Finn
Summary: This article is a narrative review of the literature using real-world data to study radiation-induced heart disease in lung cancer patients after radiotherapy. It summarizes the heart dosimetric factors associated with outcome, the strengths and limitations of real-world data studies, and how real-world data can be used to assess changes to cardiac dose constraints.
FRONTIERS IN ONCOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Giulia Campostrini, Laura M. Windt, Berend J. van Meer, Milena Bellin, Christine L. Mummery
Summary: Human pluripotent stem cells have the potential to differentiate into all cells of the body, but applications in cardiac research have been slower due to the complex 3-dimensional cues required for cardiomyocyte function. Recent tissue engineering approaches have addressed issues such as cardiomyocyte immaturity, leading to new possibilities in disease modeling, drug discovery, and heart repair through three-dimensional bioengineered heart tissues.
CIRCULATION RESEARCH
(2021)
Article
Engineering, Manufacturing
Seiji Harikae, James S. Dyer, Tianyang Wang
Summary: This study presents a framework for solving a multifactor real options problem by approximating the underlying stochastic process of project value with a generalized implied binomial tree, allowing for flexible structures for stochastic processes with fat tail distributions. The proposed approach provides a more accurate estimate of extreme downside risk by allowing negative values for the underlying project values, making it a more robust method for valuing complex real options under multiple sources of uncertainty in the volatile real world.
PRODUCTION AND OPERATIONS MANAGEMENT
(2021)
Review
Chemistry, Analytical
David Duncker, Wern Yew Ding, Susan Etheridge, Peter A. Noseworth, Christian Veltmann, Xiaoxi Yao, T. Jared Bunch, Dhiraj Gupta
Summary: This review focuses on the real-world use and evolution of wearable cardiac monitoring devices for other arrhythmias, cardiovascular diseases and some risk factors beyond atrial fibrillation. Wearable technologies such as Holter, event recorder, ECG patches have a broad application in cardiology. Implementation in other patient cohorts, such as STEMI, heart failure or sleep apnea, is feasible and expanding, with the need for clinical studies to address validation of clinical pathways and appropriate device usage leading to clinical decisions.
Review
Cell Biology
Yuchang Liu, Minrui Wang, Yang Yu, Chunhong Li, Chunxiang Zhang
Summary: Acute myocardial infarction, characterized by irreversible cardiomyocyte death and restricted blood supply, is the leading cause of death in coronary heart disease. Conventional reperfusion therapy can worsen myocardial injury. Stem cell therapy using mesenchymal stem cells (MSCs) has emerged as a promising approach for cardiac repair and function improvement. MSCs may exert their effects by secreting exosomes containing therapeutically active RNA, proteins, and lipids. Analyzing these vesicles can provide valuable insights into myocardial infarction pathology and guide the development of new treatments.
CELL COMMUNICATION AND SIGNALING
(2023)
Review
Medicine, Research & Experimental
Robin Augustine, Pan Dan, Anwarul Hasan, Israa Magdi Khalaf, Parvathy Prasad, Kajal Ghosal, Carmine Gentile, Lana McClements, Pablo Maureira
Summary: Cardiovascular disease is a major cause of death globally, with promising cardiac tissue engineering strategies using biomaterial scaffolds and stem cells. Differentiated stem cells from various sources have the potential to repair damaged heart tissue. The stem cell microenvironment plays a crucial role in maintaining stemness and directing differentiation into cardiac-specific cell lineages within tissue engineering platforms.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Biochemistry & Molecular Biology
Diego Herrero, Guillermo Albericio, Marina Higuera, Maria Herranz-Lopez, Miguel A. Garcia-Brenes, Alejandra Cordero, Enrique Roche, Pilar Sepulveda, Carmen Mora, Antonio Bernad
Summary: Research on the interaction of adult cardiac progenitor cells with other cardiac cell populations can define the vascular cardiac stem cell niche, which is associated with low oxidative stress domains in vasculature, and manipulating this niche may offer new hope in the cardiac regeneration field.
Article
Oncology
Sofia Chatzileontiadou, Thomas Zegkos, Christina Frouzaki, Athanasia Apsemidou, Georgios Efthimiadis, Despoina Parcharidou, Maria Papaioannou
Summary: Cardiac amyloidosis is a rare myocardial disorder characterized by fibril deposition of misfolding proteins. Early and accurate diagnosis is crucial for prompt treatment initiation, as the severity of cardiac involvement is strongly associated with morbidity and mortality. Light chain amyloidosis is a life-threatening disease caused by clonal plasma cells producing amyloidogenic light chain fragments.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Anthony Soonseng Yee-Goh, Atsushi Yamauchi, Isabelle van Hout, Jayanthi Bellae Papannarao, Ramanen Sugunesegran, Dominic Parry, Philip Davis, Rajesh Katare
Summary: Cardiac progenitor cells (CPCs) and adipocyte stem cells (ASCs) have potential in treating heart diseases. A study found that CPCs and ASCs from the same patient have different characteristics, with CPCs showing slightly superior functional efficacy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
L. Karygianni, S. Proksch, S. Schneider, K. Vach, E. Hellwig, T. Steinberg, S. D. Schulz, J. P. Tchorz, M. J. Altenburger
INTERNATIONAL ENDODONTIC JOURNAL
(2016)
Article
Cell & Tissue Engineering
Susanne Proksch, Gido Bittermann, Kirstin Vach, Roland Nitschke, Pascal Tomakidi, Elmar Hellwig
Article
Oncology
Diana Huelter-Hassler, Martin Wein, Simon D. Schulz, Susanne Proksch, Thorsten Steinberg, Britta A. Jung, Pascal Tomakidi
EXPERIMENTAL CELL RESEARCH
(2017)
Article
Dentistry, Oral Surgery & Medicine
S. Proksch, K. Kirsch, K. Vach, E. Hellwig, P. Tomakidi
CLINICAL ORAL INVESTIGATIONS
(2019)
Article
Dentistry, Oral Surgery & Medicine
S. Proksch, J. Brossart, K. Vach, E. Hellwig, M. J. Altenburger, L. Karygianni
INTERNATIONAL ENDODONTIC JOURNAL
(2018)
Article
Cell Biology
Susanne Proksch, Thorsten Steinberg, Kirstin Vach, Elmar Hellwig, Pascal Tomakidi
CELL AND TISSUE RESEARCH
(2014)
Review
Cell Biology
Pascal Tomakidi, Simon Schulz, Susanne Proksch, Wilfried Weber, Thorsten Steinberg
CELL AND TISSUE RESEARCH
(2014)
Article
Dentistry, Oral Surgery & Medicine
Susanne Proksch, Sabrina Lydia Strobel, Kirstin Vach, Thaer Abouassi, Pascal Tomakidi, Petra Ratka-Krueger, Elmar Hellwig
JOURNAL OF PERIODONTOLOGY
(2014)
Article
Dentistry, Oral Surgery & Medicine
Liza L. Ramenzoni, Adrian Bosch, Susanne Proksch, Thomas Attin, Patrick R. Schmidlin
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
(2020)
Article
Cardiac & Cardiovascular Systems
Dorothee Jakob, Alexander Klesen, Benoit Allegrini, Elisa Darkow, Diana Aria, Ramona Emig, Ana Simon Chica, Eva A. Rog-Zielinska, Tim Guth, Friedhelm Beyersdorf, Fabian A. Kari, Susanne Proksch, Stephane N. Hatem, Matthias Karck, Stephan R. Kunzel, Helene Guizouarn, Constanze Schmidt, Peter Kohl, Ursula Ravens, Remi Peyronnet
Summary: The study found that human atrial fibroblasts contain at least two types of ion channels activated during stretch: Piezol and BKca. Sustained atrial fibrillation is associated with increased Piezol and decreased BKca activity, indicating differential regulation of these channels.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Martin Philipp Dieterle, Thorsten Steinberg, Pascal Tomakidi, Jiri Nohava, Kirstin Vach, Simon Daniel Schulz, Elmar Hellwig, Susanne Proksch
Summary: This study developed a new nonwoven scaffold for periodontal tissue engineering. Nonwovens of 16% gelatin/5% hydroxyapatite with additional porosity were produced by electrospinning and in situ cross-linking. The results showed that the scaffold efficiently supported the adhesion and survival of human mesenchymal stem cells (hMSCs) and periodontal ligament fibroblasts (PDLFs), indicating its potential applications.
Article
Cell Biology
Martin Philipp Dieterle, Tara Gross, Thorsten Steinberg, Pascal Tomakidi, Kathrin Becker, Kirstin Vach, Katrin Kremer, Susanne Proksch
Summary: This study analyzes human dental pulp stem cells (hDPSCs) using different purification methods and finds that STRO-1-positive cell enrichment is the optimal choice for maintaining stemness. Additionally, (immuno)phenotypic characterization is the minimum requirement for quality control in hDPSCs studies.
Article
Biotechnology & Applied Microbiology
Tara Gross, Martin Philipp Dieterle, Kirstin Vach, Markus Joerg Altenburger, Elmar Hellwig, Susanne Proksch
Summary: This study investigated the differentiation of dental pulp stem cells (DPSCs) towards soft tissue using extracellular elasticity. DPSCs cultured on substrates with a low elasticity of 1.5 kPa showed a soft tissue-like phenotype and gene expression, while cells cultured on substrates with a higher elasticity of 28 kPa exhibited a differentiation signature resembling hard tissues. Cells cultured on substrates with an intermediate elasticity of 15 kPa showed the highest cytokine expression, suggesting their potential role as trophic mediators.
BIOENGINEERING-BASEL
(2023)
Article
Dentistry, Oral Surgery & Medicine
Brigitte Altmann, Kerstin Rabel, Ralf J. Kohal, Susanne Proksch, Pascal Tomakidi, Erik Adolfsson, Falk Bernsmann, Paola Palmero, Tobias Fuerderer, Thorsten Steinberg
Meeting Abstract
Cell & Tissue Engineering
C. Hege, S. Proksch, D. Siegel-Axel, S. Schiller
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2014)