期刊
JOURNAL OF THERMAL BIOLOGY
卷 44, 期 -, 页码 1-4出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jtherbio.2014.06.003
关键词
Rats; Body temperature; Biotelemetry; Polysaccharide peptide; Anapyrexia; Tumor necrosis factor-alpha
资金
- Nicolaus Copernicus University [1527-B]
Polysaccharide peptide (PSP) extracted from the Coriolus versicolor mushroom is frequently suggested as an adjunct to the chemo- or radiotherapy in cancer patients. It improves quality of the patients' life by decreasing pain, fatigue, loss of appetite, nausea, and vomiting. However, the effect of PSP on body temperature has not thus far been studied, although it is well known that treatment with other polysaccharide adjuvants, such as lipopolysaccharides, may induce fever. The aim of the present study, therefore, was to investigate the influence of PSP on temperature regulation in rats. We report that intraperitoneal injection of PSP provoked a dose-dependent decrease of temperature in male Wistar rats equipped with biotelemetry devices to monitor deep body temperature (T-b). The response was rapid (i.e., with latency of 15-20 min), transient (lasting up to 5 h post-injection), and accompanied by a significant elevation of the blood tumor necrosis factor-alpha (TNF-alpha) level. Pretreatment of the rats with anti-TNF-alpha antibody prevented the PSP-induced drop in T-b. Based on these data, we conclude that rats may develop an anapyrexia-like response to the injection of peptidopolysaccharide rather than fever, and the response was TNF-alpha-dependent. (C) 2014 Elsevier Ltd. All rights reserved.
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