Article
Thermodynamics
Widson M. Santos, Fernanda P. Nobrega, Jessica C. Andrade, Lucas F. Almeida, Marta M. Conceicao, Ana Claudia D. Medeiros, Francinalva D. Medeiros
Summary: This study aimed to assess the compatibility of dexamethasone with solid pharmaceutical excipients. The results showed slight anticipations of decomposition and interactions with certain excipients, indicating caution should be taken when using heat-based manufacturing processes with these excipients in solid dosage forms.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2021)
Article
Thermodynamics
Tadagbe Roger Sylvanus Gbenou, Kejian Wang
Summary: This research provides a comprehensive analysis of poly-aluminum sulfate (PAS) including its thermal properties, most stable form, and conditions for low-temperature thermochemical heat storage. The material undergoes four endothermic decomposition stages, three of which are dehydration reactions. The kinetics of dehydration for PAS are determined and various reaction models are evaluated. The overall kinetics modeling for aluminum sulfate hydrate is successful, indicating the potential substitution of aluminum sulfate with PAS in applications.
APPLIED THERMAL ENGINEERING
(2022)
Article
Chemistry, Physical
Krystyna Ciesla, Marcela Grabowska
Summary: This study investigated the influence of treatment with HEMA supported by gamma irradiation on the physicochemical properties of starch:PVA films. The results showed effective grafting of HEMA onto the polymer matrix and the differences in thermal degradation and structural changes between the treated and untreated samples.
RADIATION PHYSICS AND CHEMISTRY
(2022)
Article
Chemistry, Applied
Weronika Ruminska, Karolina H. Markiewicz, Agnieszka Z. Wilczewska, Agnieszka Nawrocka
Summary: Thermal analyses were used to investigate the effects of five oil pomaces on the thermal properties and transitions in model dough and gluten network. Results showed that there were differences in thermal behavior after supplementing with different pomaces, and the impact of various pomaces on model dough and gluten varied.
Article
Pharmacology & Pharmacy
Fernanda Cristina Stenger Moura, Nicola Pinna, Riccardo Vivani, Gisele Elias Nunes, Aurelie Schoubben, Tania Mari Belle Bresolin, Ivan Helmuth Bechold, Maurizio Ricci
Summary: The study identified six different crystalline phases of taxifolin prepared using crystallization in different solvents, with three of them having defined unit cell parameters and one fully structurally characterized by X-ray powder diffraction data. The hydrate and anhydrous forms showed remarkable stability in storage conditions, with the anhydrous form expected to solubilize more rapidly than the hydrate form.
Article
Engineering, Environmental
Hajo Bitter, Susanne Lackner
Summary: Differential scanning calorimetry (DSC) can be used to quantify microplastics, with improved detection accuracy and limits achieved through defined pre-heating and cooling steps. The method is shown to be feasible for environmental samples, with quantification limits and accuracy demonstrated for various polymers such as PE, PET, PP, and PA6.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Ewa Ostrowska-Ligeza, Karolina Dolatowska-Zebrowska, Rita Brzezinska, Magdalena Wirkowska-Wojdyla, Joanna Brys, Iga Piasecka, Agata Gorska
Summary: This study explored the thermal properties of ruby chocolate, which had been rarely studied in prior literature. Gas chromatography was used to determine the fatty acid composition of ruby chocolate fat. Differential scanning calorimetry (DSC) successfully determined the melting behavior and polymorphic forms of cocoa fat and milk fat in ruby chocolate. Pressurized differential scanning calorimetry (PDSC) was used to investigate the oxidative stability of the fat extracted from ruby chocolate. Thermogravimetry (TGA) was employed to study the thermal behavior of the chocolate and the fat. The results showed the thermal profile and characteristics of ruby chocolate in comparison to dark and milk chocolate. The melting temperature of ruby chocolate was found to be more similar to milk chocolate than dark chocolate. Regression analysis of PDSC data for the fat extracted from ruby chocolate exhibited a high correlation coefficient (>0.99). It was observed that there was no statistically significant difference in the activation energy (E-a) values for the oxidation process of the fat extracted from ruby chocolate obtained through maximum temperature (dynamic mode) and maximum induction time (isothermal mode).
APPLIED SCIENCES-BASEL
(2023)
Article
Environmental Sciences
Lucas Kurzweg, Sven Schirrmeister, Maurice Hauffe, Yasmin Adomat, Martin Socher, Kathrin Harre
Summary: This study presents a potential method for comprehensive microplastic monitoring in river sediments, combining electrostatic separation, density separation, and differential scanning calorimetry. The method allows for efficient processing of large sample masses and robust results, overcoming current limitations in microplastic analysis. It can be applied for monitoring microplastics in highly polluted sediments.
FRONTIERS IN ENVIRONMENTAL SCIENCE
(2022)
Article
Oncology
Gabriela Schneider, Alagammai Kaliappan, Taylor Q. Nguyen, Robert Buscaglia, Guy N. Brock, Melissa Barousse Hall, Crissie DeSpirito, Daniel W. Wilkey, Michael L. Merchant, Jon B. Klein, Tanya A. Wiese, Hiram L. Rivas-Perez, Goetz H. Kloecker, Nichola C. Garbett
Summary: Lung cancer is the most common malignancy worldwide and improving screening strategies is crucial due to limitations of current methods. Differential scanning calorimetry (DSC) shows promise in diagnosing lung cancer patients and correlating with survival rates, suggesting it as a potentially accurate, non-invasive, radiation-free screening tool.
Article
Polymer Science
Yong-xuan Chen, Dong-shan Zhou, Wen-bing Hu
Summary: Differential scanning calorimetry (DSC) is an efficient tool for characterizing thermal properties and investigating thermal reactions of materials. Recent developments in DSC technique have greatly expanded the measurement range for polymer characterization. Temperature-modulated DSC (TMDSC) and fast scanning chip-calorimetry (FSC) are significant advances in DSC technology, introducing scanning rate perturbation and ultra-fast heating and cooling rates for measurements on micro- and nanogram scale samples.
ACTA POLYMERICA SINICA
(2021)
Article
Chemistry, Physical
Galina Sadovska, Pavla Honcova, Jaroslava Moravkova, Ivan Jirka, Maryna Vorokhta, Radim Pilar, Jiri Rathousky, Dalibor Kaucky, Eliska Mikyskova, Petr Sazama
Summary: This work examines how the nanostructure affects the thermal stability of graphene-based materials in air. The results show that the stacking of graphene layers and the presence of oxygen-containing functional groups are the key factors influencing stability.
Article
Polymer Science
Miao Huo, Mingchao Ma, Yinuo Teng, Yuhan Xiao, Yunlong Guo
Summary: This study investigates the effect of particle alignment on the physical aging process of PMMA-TiO2 nanocomposites. The alignment of TiO2 particles was controlled using an external electric field, resulting in a transition from a uniform distribution to a pillar structure. The aging behavior was measured using differential scanning calorimetry, showing that randomly distributed nanoparticles accelerate aging, while aligned nanoparticles decrease the aging rate. The study also observed a dual-relaxation mechanism in the aging process. This research highlights the significance of particle alignment and structure in the aging behavior of polymer nanocomposites, which has implications for designing materials with improved stability in applications that require slow aging.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Thermodynamics
Matteo Pecchi, Jillian L. Goldfarb, Marco Baratieri
Summary: High pressure differential scanning calorimetry is suitable for studying hydrothermal carbonization. A method using an already reacted sample as the blank assumes equilibrium in the blank system throughout the run. However, this assumption affects the final enthalpy results, as shown in our study.
THERMOCHIMICA ACTA
(2022)
Article
Biochemistry & Molecular Biology
Anna Czerniecka-Kubicka, Marcin Skotnicki, Weronika Gonciarz, Iwona Zarzyka, Barbara Jadach, Lenka Lovecka, Karolina Maternia-Dudzik, Miroslava Kovarova, Marek Pyda, Piotr Tutka, Vladimir Sedlarik
Summary: Polymeric cytisine-enriched fibers were prepared using electrospinning method based on poly(3-hydroxybutyrate). The biocompatibility, thermal analysis, and cytisine release from the fibers were examined. The morphology of the nanofibers was evaluated using scanning electron microscopy. Advanced thermal analysis was conducted to study the phases and thermal processes of the fibers. Quantitative thermal analysis revealed the heat capacities and allowed for the study of the glass transition and melting/crystallization process of the polymeric fibers. The dissolution behavior of cytisine was also investigated, showing delayed release from the polymeric nanofibers compared to the marketed product. The immunosafety of the tested polymeric nanofibers with cytisine was confirmed by regulatory agencies. The polymeric matrix with cytisine holds promise as a prolonged release formulation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Thermodynamics
Hui-Fei Lu, Jun Deng, Da-Jiang Li, Fan Xu, Yang Xiao, Chi-Min Shu
Summary: Pre-oxidised coal has poorer ignition performance and burnout capacity compared to raw coal. However, its combustion rate and short-term combustion intensity are higher than raw coal. The temperature at which thermal release occurs rapidly for pre-oxidised coal lags behind raw coal, and its maximum thermal release power is less than that of raw coal.
Correction
Polymer Science
Sajan Jose, Thomas A. A. Cinu, Rosmy Sebastian, M. H. Shoja, N. A. Aleykutty, Alessandra Durazzo, Massimo Lucarini, Antonello Santini, Eliana B. B. Souto
Article
Pharmacology & Pharmacy
Ruth M. Galindo-Camacho, Isabel Haro, Maria J. Gomara, Marta Espina, Joel Fonseca, Carlos Martins-Gomes, Antoni Camins, Amelia M. Silva, Maria L. Garcia, Eliana B. Souto
Summary: The biocompatibility of cell penetrating peptides-functionalized Licochalcone-A-loaded PLGA nanoparticles was evaluated in Caco-2 cell lines, demonstrating non-cytotoxicity, while the anti-inflammatory activity of the nanoparticles was tested in RAW 264.7 cell lines. Freeze-drying with different cryoprotectants was performed to prevent particle aggregation and physical stress. An in-situ forming gel based on poloxamer 407 containing Licochalcone-A-loaded PLGA nanoparticles functionalized with B6 and Tet-1 was developed for ocular administration, providing viscoelasticity, suitable mechanical properties, and mucoadhesive performance.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Ian M. R. Blanco, Raquel de Melo Barbosa, Julita M. P. Borges, Silvio A. B. Vieira de Melo, Ramon dos Santos El-Bacha, Cesar Viseras, Patricia Severino, Elena Sanchez-Lopez, Eliana B. B. Souto, Elaine Cabral-Albuquerque
Summary: Traditional medicine uses resin oils from plants for medicinal purposes, and this study focuses on understanding their pharmacological properties. Liposomes containing resin oils or extracts from Copaifera sabulicola leaves were prepared and characterized. The liposomes showed cytotoxic effects against cancer cells and have potential applications in chemotherapy.
Review
Health Care Sciences & Services
Raquel da Ana, Anna Gliszczynska, Elena Sanchez-Lopez, Maria L. Garcia, Karolline Krambeck, Andjelka Kovacevic, Eliana B. Souto
Summary: Oxidation of lipids and lipoproteins contributes to inflammation processes that promote the development of eye diseases. Targeting lipid metabolism to treat ocular diseases is an interesting and effective approach.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Environmental Sciences
Sara A. Santos, Ricardo G. Amaral, Ariel S. Graca, Silvana V. F. Gomes, Fabricio P. Santana, Iza B. de Oliveira, Luciana N. Andrade, Patricia Severino, Ricardo L. C. de Albuquerque-Junior, Sandra L. Santos, Eliana B. Souto, Adriana A. Carvalho
Summary: The objective of this study was to evaluate the effects of combining the antineoplastic drug 5-fluorouracil (5-FU) with Matricaria recutita flowers extract (MRFE) to treat mice transplanted with sarcoma 180. The results showed that the combination of 5-FU and MRFE 200 mg/kg/day had a more significant tumor reduction compared to 5-FU alone. However, using MRFE 200 mg/kg/day may cause intense weight loss and splenic atrophy, but has minimal effects on cardiac and renal function. Therefore, the combination of 5-FU and MRFE 200 mg/kg/day may positively interfere with antitumor activity and reduce chemotherapy toxicity.
Article
Biochemistry & Molecular Biology
Andrea V. Machado, Luana R. O. Menezes, Adilson A. M. Santana, Maria N. Marques, Adriana K. de Lima, Amanda Cano, Patricia Severino, Eliana B. Souto, Juliana C. Cardoso
Summary: This work describes a new hair dyeing method using geniposide to react with the amino group in hair keratin. The study evaluated the effects of reaction conditions on color change, hair morphology, and mechanical properties. The results showed that geniposide treatment can significantly change hair color and affect its mechanical properties and morphology.
CHEMISTRY & BIODIVERSITY
(2023)
Review
Pharmacology & Pharmacy
Camilla A. S. Valenca, Ana A. T. Barbosa, Silvio S. Dolabella, Patricia Severino, Carla Matos, Karolline Krambeck, Eliana B. Souto, Sona Jain
Summary: The global problem of antibiotic resistance is a serious threat to the treatment of infectious diseases. New antimicrobials and improved delivery systems are needed. Bacterial secondary metabolites have potential as antimicrobial agents, but few molecules make it to the clinical phase.
CURRENT PHARMACEUTICAL DESIGN
(2023)
Review
Food Science & Technology
Beatriz N. Guedes, Faezeh Fathi, Amelia M. Silva, Antonello Santini, M. Beatriz P. P. Oliveira, Eliana B. Souto
Summary: Prickly pear, also known as Opuntia ficus-indica (OFI), is a beneficial plant with dietary fibers, vitamins and various bioactive compounds. This article reviews its nutritional composition, biological activities, and extraction techniques commonly used for different parts of the plant.
EUROPEAN FOOD RESEARCH AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Cristina Galocha-Leon, Cristina Antich, Ana Voltes-Martinez, Juan A. Marchal, Mireia Mallandrich, Lyda Halbaut, Maria J. Rodriguez-Lagunas, Eliana B. Souto, Beatriz Clares-Naveros, Patricia Galvez-Martin
Summary: This study developed a hydrogel loaded with human mesenchymal stromal cells (hMSCs) for the treatment of superficial skin injuries. The hydrogel, using poloxamer 407 as a biomaterial, showed excellent physical, mechanical, morphological, and biological properties. It demonstrated high swelling capacity and did not affect the viability and healing capacity of keratinocytes.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Chemistry, Multidisciplinary
Aleksandra Zielinska, Jacek Karczewski, Piotr Eder, Tomasz Kolanowski, Milena Szalata, Karolina Wielgus, Marlena Szalata, Dohun Kim, Su Ryon Shin, Ryszard Slomski, Eliana B. Souto
Summary: Scaffolds are commonly used implants for delivering cells, drugs, and genes, with their porous structure providing support for cell attachment, proliferation, differentiation, and migration. Various techniques are used to fabricate scaffolds, and they have applications in tissue engineering and multiple medical fields.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Pharmacology & Pharmacy
Venancio A. Amaral, Juliana Ferreira de Souza, Thais F. R. Alves, Fernando Batain, Denicezar A. Baldo, Patricia Severino, Norberto Aranha, Eliana B. Souto, Marco V. Chaud
Summary: The aim of this study was to develop a dense lamellar scaffolding composed of collagen, silk fibroin, and polyethylene glycol 400, and to evaluate the influence of freezing parameters on its structure. The results showed that freezing rate could modulate the pore size, connectivity, and anisotropy of the scaffolds. This study provides important insights for potential tissue engineering applications.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Instruments & Instrumentation
Marismar F. do Nascimento, Clauberto R. de Oliveira, Juliana C. Cardoso, Natalia C. T. Bordignon, Rogerio Gondak, Patricia Severino, Eliana B. Souto, Ricardo L. C. de Albuquerque Jr
Summary: This study aimed to develop and analyze the healing properties of GelMA containing AEPG, gallic acid, or ellagic acid. The results showed that GPG and GGA significantly accelerated wound closure, improved collagenization, increased histological grading, and hastened myofibroblast differentiation.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Instruments & Instrumentation
Venancio A. Amaral, Juliana Ferreira de Souza, Thais F. R. Alves, Jose M. de Oliveira Junior, Patricia Severino, Norberto Aranha, Eliana B. Souto, Marco V. Chaud
Summary: The aim of this work was to develop a dense lamellar scaffold for tracheal tissue regeneration using phenolic compounds from Psidium guajava Linn. Fourier transform infrared spectroscopy and differential scanning calorimetry confirmed chemical interactions between the polymers and cross-linking of phenolic compounds. Morphological analyses showed scaffolds with porosity and a porous surface structure. The addition of phenolic compounds modulated the morphological and mechanical properties of the scaffolds.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Green & Sustainable Science & Technology
Faezeh Fathi, Reza M. Kouchaksaraee, Samad N. Ebrahimi, Anabela S. G. Costa, Eliana B. Souto, Joao A. Prior, M. Beatriz P. P. Oliveira, Rita C. Alves
Summary: This study aimed to develop an antioxidant-rich grape seed (GS) fraction and formulate appropriate delivery systems for oral administration. Phenolic compounds were enriched in a hydroethanolic extract of GS using adsorbent resin column chromatography, resulting in a 4-fold increase in phenolic content compared to the crude extract. The enriched fraction was loaded into cholesterol-incorporated phytosomes to improve stability, gut absorption, and oral bioavailability. Different polysaccharide-based polymers were tested as natural-based coatings to improve stability and protection against gastrointestinal degradation, while providing a modified-release profile. The phytosomes showed potential as smart nutraceuticals for dietary supplements.
SUSTAINABLE MATERIALS AND TECHNOLOGIES
(2023)
