Article
Biochemistry & Molecular Biology
Yu-si Chen, Yi-yang Sun, Zi-chen Qin, Sai-ya Zhang, Wen-bo Chen, Yan-qiang Liu
Summary: This study developed a sustained-release transdermal delivery system containing losartan potassium and verapamil hydrochloride, and evaluated its pharmacokinetics and skin irritation in vitro and in vivo. The results showed that the system continuously released the drugs for 24 hours and had good characteristics and pharmacokinetics, making it an ideal formulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Rui Li, Yue Pan, Di Chen, Xiangyu Xu, Guangrong Yan, Tianyuan Fan
Summary: This study aimed to investigate core-shell pulsatile tablets using FDM 3D printing and traditional pharmaceutical technology, achieving personalized medication and chronopathology treatment. The filament composition, geometric structure, and thickness of the shell affected the weight, hardness, and in vitro drug release of the tablets, achieving personalized lag time for drug release. The 3D-printed core-shell pulsatile tablets showed potential for personalized administration, improving therapeutic effects for circadian rhythm diseases.
Article
Pharmacology & Pharmacy
Hussein Allaboun, Khouloud A. Alkhamis, Suhair S. Al-Nimry
Summary: The study aimed to investigate the interaction between cation exchange resins and verapamil hydrochloride. Uptake studies showed that the resin with the lowest cross-linking had the highest uptake capacity. XRD, SEM, and particle size analysis confirmed the amorphous nature of the drug-resin complexes. Release studies demonstrated that conventional dissolution testing did not maintain sink conditions and that increasing the volume of samples withdrawn and fresh dissolution medium added significantly increased the drug release. The diffusion of exchanging cations through the liquid film was determined to be the rate-limiting step.
Article
Medicine, Research & Experimental
Yogeeta. O. Agrawal, Muzammil Husain, Kiran D. Patil, Vishal Sodgir, Tulshidas S. Patil, Vinit V. Agnihotri, Hitendra S. Mahajan, Charu Sharma, Shreesh Ojha, Sameer N. Goyal
Summary: This research aimed to improve the poor oral bioavailability of Verapamil by using Solid Lipid Nanoparticles (V-SLNs). The optimized V-SLN formulation showed promising results in terms of particle size, entrapment efficiency, and release behavior. In vivo studies demonstrated the cardioprotective effect of V-SLNs and improved pharmacokinetic parameters compared to free drugs.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Medicine, Research & Experimental
Yuan Chen, Jing Ling, Mingyue Li, Yongchao Su, Kinnari Santosh Arte, Tarun Tejasvi Mutukuri, Lynne S. Taylor, Eric J. Munson, Elizabeth M. Topp, Qi Tony Zhou
Summary: This study investigated the individual contribution of mannitol, leucine, and trehalose on protein physical stability in spray-dried solids. The results showed that trehalose had a positive impact on protein stability, while mannitol and leucine had different effects on protein stability. Advanced solid-state characterization techniques were pivotal in understanding the physical stability of spray-dried protein solids.
MOLECULAR PHARMACEUTICS
(2021)
Article
Chemistry, Analytical
Gugu Hao, Rong Hu, Xiaoqin Wang, Pan Gao, Lin Wang, Manhua Jiang, Libo Xin, Guoying Tan, Yanping Zhao, Fuzhou Sun, Dexin Chu, Jinqian Lv, Jinsong You, Fangfang Huang, Xuezhi Song
Summary: In recent years, the presence of nitrosamines in drug products has become a regulatory concern. This manuscript provides an industry perspective on nitrosamines research with a focus on Nnitrosodimethylamine (NDMA) in metformin hydrochloride sustained-release tablets (MET). The manuscript identifies the key factors contributing to NDMA formation in MET and proposes strategies to mitigate the risk of nitrosamine formation in finished drug products, such as avoiding excipients with nitrite, nitrate, and peroxide impurities, and maintaining appropriate formulation conditions.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Medicine, Research & Experimental
Chunting Zhang, Steven T. Gossert, Jonathan Williams, Michael Little, Marilia Barros, Barton Dear, Bradley Falk, Ankit D. Kanthe, Robert Garmise, Luciano Mueller, Andrew Ilott, Anuji Abraham
Summary: By conducting direct experimental evidence, we have elucidated the mechanism by which excipients enhance protein stability through their binding affinity to monoclonal antibodies.
Article
Thermodynamics
Dijana Jelic, Janja Todorovic, Mirzeta Saletovic, Aleksandra Smitran, Slavko Mentus
Summary: This study investigates the application of pyrophyllite as a substitute for talc in medicine. The thermal stability and antimicrobial properties of pyrophyllite and its modified form with nanodispersed silver (PYRO/Ag) were examined. The results show that pyrophyllite has good thermal stability and the modified PYRO/Ag exhibits excellent antimicrobial activity.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2023)
Article
Engineering, Chemical
Neetu Varun, Arnab Dutta, Chinmay Ghoroi
Summary: This study investigates the drug-excipient incompatibility in physical mixtures and its impact on properties of dry powder inhalers. The findings reveal the formation of condensed or addition compound due to interaction between drug and excipient in solid-state. The study also suggests that surface modification of excipient can improve the performance of the mixtures.
ADVANCED POWDER TECHNOLOGY
(2022)
Article
Environmental Sciences
Narasamma Nippatlapalli, Kamaraj Ramakrishnan, Ligy Philip
Summary: This study focuses on the degradation of pharmaceutically active compounds in water bodies using pulsed corona plasma technology. Three different plasma reactors were designed and experimented, showing that continuous flow reactors achieved higher degradation efficiency, shorter treatment time, and lower energy consumption.
ENVIRONMENTAL RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Lijuan Wang, Lei Zhao, Wenmei Zhang, Yuanyuan Wu, Yingqi Liang, Guangsheng Guo, Xiayan Wang
Summary: A narrow-bore capillary zone electrophoresis method was developed to study the interaction between metformin hydrochloride and bovine serum albumin. The method successfully separated the free components and their complex, allowing the determination of the association constant and the number of binding sites.
CHEMICAL COMMUNICATIONS
(2022)
Article
Thermodynamics
Widson M. Santos, Fernanda P. Nobrega, Jessica C. Andrade, Lucas F. Almeida, Marta M. Conceicao, Ana Claudia D. Medeiros, Francinalva D. Medeiros
Summary: This study aimed to assess the compatibility of dexamethasone with solid pharmaceutical excipients. The results showed slight anticipations of decomposition and interactions with certain excipients, indicating caution should be taken when using heat-based manufacturing processes with these excipients in solid dosage forms.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2021)
Article
Biochemistry & Molecular Biology
Yuxuan Xiao, Haiyu Zheng, Meng Du, Zhe Zhang
Summary: Na-attapulgite was successfully used as an excipient to prepare domperidone sustained-release tablets in this study. The compatibility between Na-attapulgite and domperidone was investigated, and it was found that there was no interaction between the two. The tablets met the requirements of the United States Pharmacopoeia and showed improved release performance when Na-attapulgite was used as an excipient. Additionally, the doping of Na-attapulgite enhanced cell compatibility and cell activity.
Article
Multidisciplinary Sciences
E. Sabine M. Schleker, Sabine Buschmann, Hao Xie, Sonja Welsch, Hartmut Michel, Christoph Reinhart
Summary: Adenosine triphosphate (ATP)-binding cassette (ABC) transporters are important transmembrane proteins that facilitate the transport of substances across cell membranes. In this study, the role and function of the ABC-B transporter STE6-2p in the methylotrophic yeast Pichia pastoris were investigated. The findings suggest that STE6-2p can transport rhodamines in vivo and remain active in the presence of verapamil and triazoles in vitro. Additionally, the high-resolution structures of an ABC transporter from P. pastoris in the apo conformation and in complex with verapamil and adenylyl imidodiphosphate (AMP-PNP) provide insights into a potential sterol-binding site of unknown function.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Chemistry, Medicinal
Ryoma Tanaka, Sae Ishihara, Tetsuo Sasaki, Yusuke Hattori, Makoto Otsuka
Summary: This research focused on a single-step preparation of coamorphous tablet during injection molding and mechanistic characterization. The results showed that coamorphous tablet had enhanced dissolution compared to pure loratadine amorphous, and the physical stability was correlated with the interaction strength between loratadine and acids. Terahertz spectra played an important role in detecting molecular mobility and crystallization propensity in the coamorphous system.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Chemistry, Physical
Ana Luisa Silva, Matheus Millen Correa, Grasielli Correa de Oliveira, Pedro Pablo Florez-Rodriguez, Carlos Alberto Rodrigues Costa, Felipe Silva Semaan, Eduardo Ariel Ponzio
JOURNAL OF ALLOYS AND COMPOUNDS
(2017)
Article
Electrochemistry
Grasielli C. de Oliveira, Lucas C. Pereira, Ana L. Silva, Felipe S. Semaan, Marilza Castilho, Eduardo A. Ponzio
JOURNAL OF SOLID STATE ELECTROCHEMISTRY
(2018)
Article
Thermodynamics
Marcos Vinicius Dobies Navia, Diogo Alves Galico, Flavio Junior Caires, Jose Marques Luiz, Ronaldo Spezia Nunes
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2018)
Article
Engineering, Multidisciplinary
Leonardo de Almeida Furtado, Izylla Oliveira de Lucena, Julia de Oliveira Fernandes, Fabio Grandis Lepri, Daniela de Luna Martins, Felipe Silva Semaan
Article
Chemistry, Physical
E. G. Ciapina, L. B. Viana, R. M. I. S. Santos, M. S. M. Nogueira, O. P. Almeida-Junior, R. S. Nunes, S. F. Santos, R. Z. Nakazato
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2018)
Article
Materials Science, Multidisciplinary
Mariane Brandao da Silva Assis, Izabella Helena Soares Rezende Werneck, Gabriela Nestal de Moraes, Felipe Silva Semaan, Robson Pacheco Pereira
MATERIALS RESEARCH EXPRESS
(2019)
Article
Chemistry, Analytical
Leonardo de A. Furtado, Mariana C. de O. Goncalves, Carlos V. M. Inocencio, Edilson M. Pinto, Daniela de L. Martins, Felipe S. Semaan
JOURNAL OF ANALYTICAL METHODS IN CHEMISTRY
(2019)
Article
Electrochemistry
Rafaella Silva Aredes, Matheus Moreira, Pedro Henrique Oliveira Amorim, Rafael Machado Dornellas, Felipe Silva Semaan
Summary: A composite electrode was developed for quantifying saccharin in commercial sweeteners using cyclic voltammetry, and its accuracy was evaluated using other techniques, showing satisfactory and comparable results.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2022)
Article
Electrochemistry
Gabriel. M. M. Alvarenga, Julio Palombarini, Rosana. A. A. Goncalves, Olivia. M. M. Berengue, Ronaldo. S. S. Nunes, Sydney. F. F. Santos, Hebe. M. M. Villullas, Eduardo. G. G. Ciapina
Summary: The aim of this study was to investigate the influence of a RuO2 support on the activity of Pd nanoparticles during formic acid oxidation, comparing it with Pd/C. Contrary to previous reports on enhancing effects of RuO2, our findings reveal a negative impact of the RuO2 support on the activity of Pd nanoparticles for formic acid oxidation. The formation of CO2 at low potentials and the absence of adsorbed CO signals suggest that the oxidation of formic acid on Pd/RuO2 and Pd/C occurs through a direct pathway without significant contribution from a bifunctional mechanism involving OH species on the oxide support surface. The detrimental effect of the RuO2 support on activity is likely a result of metal-support interactions altering the electronic properties of Pd.
JOURNAL OF SOLID STATE ELECTROCHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Taissa S. Cabral, Suellen F. L. do Nascimento, Lucas V. de Faria, Thalles P. Lisboa, Pedro H. S. Borges, Edson Nossol, Felipe S. Semaan, Rafael M. Dornellas, Wagner F. Pacheco
Summary: Silver nanoparticles (AgNPs) obtained from photographic waste were synthesized and electrodeposited onto an epoxy-graphite composite substrate. The modified electrode showed improved electrochemical properties compared to the unmodified electrode, with lower charge transfer resistance, more kinetically favored electron transfer, and increased active area. The presence of AgNPs on the carbonaceous surface was confirmed by SEM and Raman spectroscopy. The modified electrode demonstrated enhanced analytical performance for Pb2+ detection, with a wider linear range, lower detection limit, and increased sensitivity compared to the unmodified electrode. The method was successfully applied to real water samples with varying levels of Pb2+. The reuse of silver waste provides an effective and low-infrastructure solution for electrochemical sensing applications.
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
(2023)
Proceedings Paper
Computer Science, Artificial Intelligence
Pedro Henrique Oliveira Amorim, Fernando Quirino Oliveira, Henrique Cardoso dos Santos, Robson Pacheco Pereira, Rafael Machado Dornellas, Felipe Silva Semaan
Summary: This study evaluates the use of cellulose acetate as a modifier in acrylonitrile-butadiene-styrene/graphite composite electrodes, showing that it can improve surface smoothness and enhance load transfer kinetics.
DEVELOPMENTS AND ADVANCES IN DEFENSE AND SECURITY, MICRADS 2021
(2022)
Proceedings Paper
Computer Science, Artificial Intelligence
Izabella Helena Werneck Soares Rezende, Felipe Silva Semaan, Luiz Eduardo Pizarro Borges, Robson Pacheco Pereira
Summary: This study examines the use of nanomaterials and energy storage and conversion devices, mainly supercapacitors, in the Defense area. It focuses on the concepts, tools, and methods of nanotechnology related to these devices, as well as their application. The development of nanomaterials, especially metal oxides and their nanocomposites, is highlighted as a promising tool for improving energy devices, specifically in the area of Defense.
DEVELOPMENTS AND ADVANCES IN DEFENSE AND SECURITY, MICRADS 2021
(2022)
Proceedings Paper
Computer Science, Artificial Intelligence
Joseane R. Barbosa, Pedro H. O. Amorim, Mariana C. de O. Goncalves, Rafael M. Dornellas, Robson P. Pereira, Felipe S. Semaan
DEVELOPMENTS AND ADVANCES IN DEFENSE AND SECURITY
(2020)
Review
Chemistry, Multidisciplinary
Igor A. Fioravante, Ronaldo S. Nunes, Heloisa A. Acciari, Eduardo N. Codaro
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
(2019)
Article
Chemistry, Multidisciplinary
Ana Luisa Silva, Matheus Millen Correa, Grasielli Correa de Oliveira, Ricardo Cunha Michel, Felipe Silva Semaan, Eduardo Ariel Ponzio
NEW JOURNAL OF CHEMISTRY
(2018)
