Article
Thermodynamics
J. H. F. de Jesus, R. S. Medeiros, J. A. Ellena, E. T. G. Cavalheiro
Summary: The thermal behavior and polymorphism of tert-butylhydroquinone (TBHQ) were studied using differential scanning calorimetry, infrared spectroscopy, and hot stage microscopy. Two polymorphs of TBHQ were identified depending on the thermal treatment: a commercial form and a new form obtained from melt-crystallization.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2023)
Article
Materials Science, Ceramics
M. Kumar, H. Nagabhushana, Y. C. Ratnakaram
Summary: This study synthesized transparent glass ceramics doped with Sm3+ ions in BiPO4 nanocrystals, analyzing their thermal stability and crystalline phase. FTIR was used for structural unit validation, while Judd-Ofelt theory was applied to obtain spectral intensities and optical parameters, studying the influence of alkali and alkaline earths metals on Sm3+ excited levels. SrF2 glass ceramics showed promising properties in optical devices for visible laser applications compared to other glass networks and ceramics.
JOURNAL OF NON-CRYSTALLINE SOLIDS
(2021)
Article
Chemistry, Physical
Zijian Su, Shuo Liu, Benlai Han, Yuanbo Zhang, Tao Jiang
Summary: This study successfully developed a novel process for the preparation of sodium stannate from cassiterite concentrates, which is widely used in ceramics and electroplating industries. It was found that the main gangue of quartz in cassiterite concentrates easily formed sodium stannosilicate (Na8SnSi6O18), decreasing the quality of Na2SnO3. The study also determined the formation and transitions of Na8SnSi6O18 in the SnO2-SiO2-Na2CO3 system under a CO-CO2 atmosphere.
Article
Multidisciplinary Sciences
Guomin Zhu, Maria L. Sushko, John S. Loring, Benjamin A. Legg, Miao Song, Jennifer A. Soltis, Xiaopeng Huang, Kevin M. Rosso, James J. De Yoreo
Summary: Crystallization by particle attachment (CPA) is a common mechanism in colloidal crystallization that can produce nanomaterials with hierarchical morphologies. Oriented attachment, a form of CPA, results in mesocrystals that diffract as single crystals, although the constituent particles are still discernible.
Article
Pharmacology & Pharmacy
Monika Bhalodiya, Jayant Chavda, Dhaval Mori, Nilesh Patel, Ravi Manek, Kiran Dudhat
Summary: The study aimed to prepare an amorphous solid dispersion of methanolic extract of Boerhaavia diffusa root powder to improve its dissolution properties. The results showed significant improvement in the release of phytoconstituents from all prepared batches, and the stability studies indicated that the formulations were able to maintain the phytoconstituents in amorphous/molecularly dispersed form within the polymer matrix for 6 months.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Thermodynamics
Sandra Ramos-Inza, Eneko Almagro, Maria Font, Ignacio Encio, Daniel Plano, Carmen Sanmartin, Rafael Sirera, Elena Lizarraga
Summary: In this study, the stability, thermal characterization, and polymorphic forms of thirty new nonsteroidal anti-inflammatory drug derivatives containing selenium were analyzed. The compounds exhibited thermal stability and no significant differences were found among polymorphic forms, indicating their suitability for further drug development.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2023)
Article
Chemistry, Physical
P. Yogheshwari, B. Sridhar, K. Anitha
Summary: The study reveals the preparation of an organic co-crystal of 6-nitroquinoline fumaric acid and its characterization of structure and optical properties. The title compound shows 82% transparency in the visible region and exhibits high thermal stability. Furthermore, spectroscopic analysis reveals the molecular vibrations and chemical bonding properties of the compound.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Biochemistry & Molecular Biology
Shigesaburo Ogawa, Isao Takahashi
Summary: In this study, the crystal structures of short-chain n-alkyl beta-D-glucosides (CnG) were investigated. It was found that C4G and C5G formed cubic crystal phases, while C6G formed a modulated lamellar structure, demonstrating the concept of glycolipid motif with a cubic crystal structure.
Article
Chemistry, Physical
Raju Ram Puniya, Priyanka Takhar, Tanmoy Kalita, Dhruba Jyoti Kalita, Devendra Singh
Summary: Hydrogen bonded multi-component crystalline solids with diverse potential applications have attracted research attention due to their desired physicochemical properties. This study focuses on the formation of different hydrogen bond patterns between isomeric host molecules and identical guest solvent molecules. Structural analysis reveals the various types of interactions between the host-host, host-guest, and guest-guest molecules, leading to the formation of 3D supramolecular architectures. Thorough understanding of these hydrogen bond motifs provides insight into the influence of steric orientations and other weak interactions.
MOLECULAR SYSTEMS DESIGN & ENGINEERING
(2023)
Article
Pharmacology & Pharmacy
Mansour Latreche, Jean-Francois Willart
Summary: This paper investigates the dissolution mechanism of crystalline sulindac into amorphous Polyvinylpyrrolidone (PVP) through heating and annealing at high temperatures. The diffusion mechanism of drug molecules in the polymer is given special attention, leading to a homogeneous amorphous solid dispersion of the two components. The study also highlights the exceptional ability of temperature Modulated Differential Scanning Calorimetry (MDSC) in identifying the equilibrium and out of equilibrium stages of dissolution.
Article
Chemistry, Multidisciplinary
Jia-Yuan Zhao, Ning Ren, Ying-Ying Zhang, Kun Tang, Jian-Jun Zhang
Summary: This article presents a series of newly synthesized complexes and their characterization studies. Single crystal data revealed that these complexes are binuclear and possess different crystal structures. The thermal decomposition mechanism of these complexes was investigated using TG/DSC-FTIR technology.
FRONTIERS IN CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Artem O. Surov, Ksenia V. Drozd, Anna G. Ramazanova, Andrei V. Churakov, Anna V. Vologzhanina, Elizaveta S. Kulikova, German L. Perlovich
Summary: Polymorphism is a common phenomenon in molecular crystals and has a significant impact on drug development. This study obtained and characterized a new polymorphic form of the drug carbamazepine (CBZ) cocrystal with methylparaben (MePRB), as well as a channel-like cocrystal with highly disordered coformer molecules, using various analytical methods. The structural analysis revealed a close resemblance between the novel form II and previously reported form I of the [CBZ + MePRB] cocrystal. The discovered form II showed superior thermodynamic stability and dissolution performance, making it a more promising solid form for pharmaceutical development.
Article
Chemistry, Physical
S. Nishanth, S. Nivithaa, C. Sridhar, K. S. Nagaraja, C. Karnan
Summary: Methylhydroxy(diphenyl)ethanoate was synthesized through a facile reaction of benzilic acid and methanol using FeCl3 as a catalyst. The compound was characterized by various techniques and was found to exhibit potential applications for OLED due to its blue and green emissions. The presence of Fe3+ in the crystal lattice was confirmed through EPR analysis. Published by Elsevier B.V. in 2023.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Polymer Science
Zhenkang Zhang, Yanhu Xue, Rui Li, Wei Liu, Peng Liu, Xiangling Ji
Summary: In this study, the influence of temperature, time, and molecular weight on the crystal transformation of PB-1 was investigated using differential scanning calorimetry. The step-by-step annealing process was found to significantly accelerate the rate of transformation from crystal form II to I. The results provide an effective method for accelerating the crystal transformation of PB-1, which has both academic significance and industrial application.
Article
Pharmacology & Pharmacy
Katarzyna Trzeciak, Ewelina Wielgus, Slawomir Kazmierski, Tomasz Pawlak, Marek J. Potrzebowski
Summary: The applicability of different solvent-free approaches leading to the amorphization of active pharmaceutical ingredients (APIs) was tested. Ethenzamide (ET) and two ethenzamide cocrystals were used as pharmaceutical models. Three methods (manual physical mixing, melting, and grinding) were used to prepare the samples. The amorphization process was determined using instrumental techniques, and the dissolution profiles showed significant differences for each sample. The nature and mechanism of this distinction were discussed.
