期刊
JOURNAL OF THEORETICAL BIOLOGY
卷 307, 期 -, 页码 205-210出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jtbi.2012.04.011
关键词
Negative feedback; Positive feedback; Oscillation; Noise; Circadian rhythm
资金
- Danish National Research Foundation
We analyze a class of network motifs in which a short, two-node positive feedback motif is inserted in a three-node negative feedback loop. We demonstrate that such networks can undergo a bifurcation to a state where a stable fixed point and a stable limit cycle coexist. At the bifurcation point the period of the oscillations diverges. Further, intrinsic noise can make the system switch between oscillatory state and the stationary state spontaneously. We find that this switching also occurs in previous models of circadian clocks that use this combination of positive and negative feedbacks. Our results suggest that real-life circadian systems may need specific regulation to prevent or minimize such switching reserved. (C) 2012 Elsevier Ltd. All rights reserved.
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