4.4 Article

A compact result for the time-dependent probability of fixation at a neutral locus

期刊

JOURNAL OF THEORETICAL BIOLOGY
卷 274, 期 1, 页码 131-135

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ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jtbi.2011.01.019

关键词

Gene fixation; Random genetic drift; Diffusion approximation; Neutral theory; Wright-Fisher model

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A result is derived, in the form of a sum, for the time-dependent probability of fixation of an unlinked neutral locus. The result captures many of the key features of the probability of fixation in a highly compact form. For 'small' times (t less than or similar to 4N(e)) a single term of the sum accurately determines the time-dependent probability of fixation. This is in contrast to the well-known result of Kimura, which requires the contribution of many terms in a different sum, for 'small' times. Going beyond small times, an approximation is derived for the time-dependent probability of fixation which applies for all times when the initial relative allele frequency is small. (C) 2011 Elsevier Ltd. All rights reserved.

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