Fluctuation effects in metapopulation models Percolation and pandemic threshold

Metapopulation models provide the theoretical framework for describing disease spread between different populations connected by a network In particular these models are at the basis of most simulations of pandemic spread They are usually studied at the mean-field level by neglecting fluctuations Here we include fluctuations in the models by adopting fully stochastic descriptions of the corresponding processes This level of description allows to address analytically in the SIS and SIR cases problems such as the existence and the calculation of an effective threshold for the spread of a disease at a global level We show that the possibility of the spread at the global level is described in terms of (bond) percolation on the network This mapping enables us to give an estimate (lower bound) for the pandemic threshold in the SIR case for all values of the model parameters and for all possible networks (C) 2010 Elsevier Ltd All rights reserved