Article
Endocrinology & Metabolism
Mengying Wang, Jie Huang, Tao Wu, Lu Qi
Summary: The study found that pulse wave arterial stiffness index (ASI) is positively associated with the risk of type 2 diabetes (T2D), while the association between pulse pressure (PP) and T2D shows a nonlinear J-shaped relationship. Additionally, the association between ASI and T2D is more pronounced among individuals with higher genetic susceptibility to T2D.
Article
Endocrinology & Metabolism
Ayaka Kobayashi, Hiroshi Okada, Masahide Hamaguchi, Kazushiro Kurogi, Hiroaki Murata, Masato Ito, Michiaki Fukui
Summary: This study found that the stable, metabolically healthy nonobesity group had a lower risk of incident type 2 diabetes compared to the stable, metabolically healthy obesity group. When metabolically healthy obese individuals changed to metabolically healthy nonobese status, their risk of developing type 2 diabetes was similar to that of participants in the stable metabolically healthy nonobesity group. These findings suggest the importance of paying attention to changes in metabolic phenotypes to prevent incident type 2 diabetes in the Japanese population.
Article
Endocrinology & Metabolism
Mengying Wang, Jie Huang, Tao Wu, Lu Qi
Summary: Pulse wave arterial stiffness index (ASI) showed a dose-response association with type 2 diabetes (T2D), while pulse pressure (PP) displayed a nonlinear J-shaped association with T2D. Additionally, the association between ASI and T2D was partially strengthened by higher genetic susceptibility to T2D.
Article
Multidisciplinary Sciences
Hsin-Hui Lin, Hsin-Yin Hsu, Ming-Chieh Tsai, Le-Yin Hsu, Kuo-Liong Chien, Tzu-Lin Yeh
Summary: This retrospective cohort study in Taiwan found that patients with type 2 diabetes had a higher risk of osteoporosis, especially among younger participants. There was no significant difference in risk based on sex, but age did have a marginal effect on the relationship between type 2 diabetes and osteoporosis risk.
Article
Medicine, Research & Experimental
Jimin Jeon, Jinkwon Kim
Summary: Proteinuria is significantly associated with an increased risk of new-onset type 2 diabetes mellitus, with a positive dose-response relationship between the degree of dipstick proteinuria and the risk of the disease.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Qiannan Chen, Yaohan Zhou, Chen Dai, Gang Zhao, Yimin Zhu, Xuhui Zhang
Summary: The study revealed that individuals with metabolically abnormal but normal weight have a higher risk of type 2 diabetes mellitus, indicating the need for increased attention in prevention and management of common chronic diseases.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Obstetrics & Gynecology
Kristina Mattsson, Emma Nilsson-Condori, Eva Elmerstig, Ditte Vassard, Lone Schmidt, Soren Ziebe, Anna Joud
Summary: Women diagnosed with type 2 diabetes before their reproductive journey had lower birth rates, higher risk of miscarriage, and increased risk of infertility.
FERTILITY AND STERILITY
(2021)
Article
Endocrinology & Metabolism
Jiho Park, Ji Hyun Yoon, Hyun Kyun Ki, Kyungdo Han, Hyungjin Kim
Summary: This study found that lifestyle changes, including smoking, alcohol intake, and exercise, were associated with the development of tuberculosis in patients with type 2 diabetes mellitus, highlighting the potential importance of lifestyle management in controlling tuberculosis in Korea.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Wei Fang, Xiaojie Yuan, Weijian Li, Samuel Seery, Guanzhi Chen, Zefeng Cai, Zegui Huang, Xianxuan Wang, Weiqiang Wu, Zhichao Chen, Yan Li, Shouling Wu, Youren Chen
Summary: This study aimed to investigate the association between the onset-age of overweight/obesity and the risk of developing diabetes mellitus in China. The study found that individuals who experienced early onset of excessive weight gain were at a significantly higher risk of developing diabetes mellitus compared to those who maintained a normal weight.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Valentin Maisons, Jean-Michel Halimi, Gregoire Fauchier, Jean-Baptiste de Freminville, Nicolas Goin, Juliette Gueguen, Philippe Gatault, Benedicte Sautenet, Denis Angoulvant, Julien Herbert, Arnaud Bisson, Pierre-Henri Ducluzeau, Laurent Fauchier
Summary: This study aimed to examine the effect of type 2 diabetes mellitus on cardiorenal syndrome. It found that type 2 diabetes mellitus patients accounted for nearly half of the patients with cardiorenal syndrome and were younger than non-diabetic counterparts. Type 2 diabetes mellitus doubled the risk of cardiorenal syndrome and increased the risk of death, cardiovascular events, and end-stage kidney disease, but not ischemic stroke.
DIABETES & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Andrea J. Glenn, Jie Li, Kenneth Lo, David J. A. Jenkins, Beatrice A. Boucher, Anthony J. Hanley, Cyril W. C. Kendall, Aladdin H. Shadyab, Lesley F. Tinker, Steven D. Chessler, Barbara V. Howard, Simin Liu, John L. Sievenpiper
Summary: This study analyzed the relationship between diet patterns and incident type 2 diabetes in 145,299 postmenopausal women without diabetes. The findings showed that greater adherence to the Portfolio, DASH, and Mediterranean diets was associated with a lower risk of type 2 diabetes in postmenopausal women.
Article
Endocrinology & Metabolism
Sudan Wang, Xiaoyan Qian, Chao Shen, Qian Sun, Yang Jing, Bingyue Liu, Kexin Zhang, Mengyuan Li, Junrong Wang, Hui Zhou, Chen Dong
Summary: This study examined the association between lipoxin A4 (LXA4) and type 2 diabetes mellitus (T2DM) in a Chinese cohort study. Higher levels of LXA4 were found to be significantly associated with a lower risk of T2DM development. Gender and family history of diabetes modified this association, and several serum lipids also partially suppressed the association.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Edouard L. Fu, Elisabetta Patorno, Brendan M. Everett, Muthiah Vaduganathan, Scott D. Solomon, Raisa Levin, Sebastian Schneeweiss, Rishi J. Desai
Summary: This study aimed to evaluate the comparative effectiveness of SGLT2i vs. sitagliptin in older adults with HF and type 2 diabetes and found that initiating SGLT2i was associated with a lower risk of the primary composite outcome compared to sitagliptin.
EUROPEAN HEART JOURNAL
(2023)
Article
Endocrinology & Metabolism
Min-Kyung Lee, Bongsung Kim, Kyungdo Han, Jae-Hyuk Lee, Minhee Kim, Mee Kyoung Kim, Ki-Hyun Baek, Ki-Ho Song, Hyuk-Sang Kwon, Young-Jung Roh
Summary: The study discovered a significant association between the use of SGLT2 inhibitors and retinal vein occlusion, finding that new users of SGLT2 inhibitors were more likely to develop RVO compared to users of other glucose-lowering drugs. Additionally, older patients and those with chronic kidney disease were at a higher risk of developing RVO.
Article
Multidisciplinary Sciences
Giovanni De Pergola, Fabio Castellana, Roberta Zupo, Sara De Nucci, Francesco Panza, Marco Castellana, Luisa Lampignano, Martina Di Chito, Vincenzo Triggiani, Rodolfo Sardone, Gianluigi Giannelli
Summary: Family history of type 2 diabetes (FHT2D) was found to be an independent determinant of NAFLD, regardless of age group, in overweight individuals. The presence of FHT2D led to a twofold higher probability of NAFLD, even after adjusting for major confounders.
SCIENTIFIC REPORTS
(2021)
Article
Public, Environmental & Occupational Health
Maki Inoue-Choi, Neal D. Freedman, Eiko Saito, Shiori Tanaka, Mayo Hirabayashi, Norie Sawada, Shoichiro Tsugane, Yoshiaki Usui, Hidemi Ito, Chaochen Wang, Akiko Tamakoshi, Taro Takeuchi, Yuri Kitamura, Mai Utada, Kotaro Ozasa, Yumi Sugawara, Ichiro Tsuji, Keiko Wada, Chisato Nagata, Taichi Shimazu, Tetsuya Mizoue, Keitaro Matsuo, Mariko Naito, Keitaro Tanaka, Kota Katanoda, Manami Inoue
Summary: A study in Japan found that even smoking a small number of cigarettes per day is associated with increased mortality risks. Both male and female low-intensity smokers had higher all-cause mortality risks compared to non-smokers, and the risk further increased with higher cigarette consumption.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Surgery
Taihei Ito, Takashi Kenmochi, Atsuhiko Ota, Kaori Kuramitsu, Akihiko Soyama, Osamu Kinoshita, Susumu Eguchi, Kenji Yuzawa, Hiroto Egawa
Summary: In 2020, the number of brain-dead donors decreased to 68 (69% of the year-on-year average) and the number of donors after cardiac death decreased to 9 (32% of the year-on-year average). 85 transplant centers suspended transplant surgeries in response to the COVID-19 pandemic, significantly impacting organ transplantation activities in Japan.
Review
Environmental Sciences
Yasuhiro Yamaguchi, K. M. Saif-Ur-Rahman, Motoko Nomura, Hiromitsu Ohta, Yoshihisa Hirakawa, Takashi Yamanaka, Satoshi Hirahara, Hisayuki Miura
Summary: Opioids can alleviate breathlessness and improve the quality of life in patients with chronic obstructive pulmonary disease. Recent studies suggest that regular oral opioid use can decrease the severity of breathlessness, and morphine or codeine show significant acute effects. Further research is needed to optimize prescription methods and minimize adverse effects.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Fangfang Hou, Xiao Han, Qiong Wang, Shuai Zhou, Jingya Zhang, Guodong Shen, Yan Zhang
Summary: This study explores the relationship between living and built environments and depression among older Chinese adults. The findings suggest that living in a non-dusty environment with proximity to green spaces reduces the risk of depression, while the absence of barrier-free facilities and proximity to hospitals increase the risk. Dusty environments, lack of accessibility, and close proximity to hospitals and green spaces are associated with depression symptoms among older Chinese adults.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Yoshinobu Kondo, Hiroshi Yatsuya, Atsuhiko Ota, Shoji Matsumoto, Akihiro Ueda, Hirohisa Watanabe, Hideaki Toyoshima
Summary: This study examined the associations between adult height and ischemic stroke subtypes for the first time. The results showed that these associations varied according to sex and age group.
JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Masako Shimoda, Kayo Kaneko, Takeshi Nakagawa, Naoko Kawano, Rei Otsuka, Atsuhiko Ota, Hisao Naito, Masaaki Matsunaga, Naohiro Ichino, Hiroya Yamada, Chifa Chiang, Yoshihisa Hirakawa, Koji Tamakoshi, Atsuko Aoyama, Hiroshi Yatsuya
Summary: There is limited evidence on the relationship between DM in middle age and mild cognitive impairment. This study investigated the relationship between fasting blood glucose levels in middle age and cognitive function in later life. The results suggest that FBG level in middle age is negatively associated with cognitive function assessed later in life.
JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Dermatology
Chaochen Wang, Toshihiko Aranishi, Catherine Reed, Peter Anderson, Jenny Austin, Victoria A. A. Davis, Emily Quinones, James Piercy
Summary: This study investigated the disconnect between patients and physicians in terms of treatment satisfaction in atopic dermatitis (AD) in Japan. It found that the main reasons for dissatisfaction were treatment efficacy and usability. Inconsistent treatment satisfaction influenced treatment patterns, clinical characteristics, and patient-reported outcomes.
DERMATOLOGY AND THERAPY
(2023)
Article
Oncology
Yuriko Koyanagi, Keitaro Matsuo, Hidemi Ito, Chaochen Wang, Akiko Tamakoshi, Yumi Sugawara, Ichiro Tsuji, Ayami Ono, Shoichiro Tsugane, Norie Sawada, Keiko Wada, Chisato Nagata, Taro Takeuchi, Tetsuhisa Kitamura, Mai Utada, Ritsu Sakata, Tetsuya Mizoue, Sarah Krull Abe, Manami Inoue
Summary: The effect of body mass index (BMI) on esophageal and gastric carcinogenesis varies depending on subtype or subsite. In this study, a pooled analysis of 10 population-based cohort studies in Japan, we observed an inverse association between BMI and esophageal squamous cell carcinoma, but a positive association with gastric cardia cancer. Additionally, a positive association was found for overweight or obese individuals with esophageal adenocarcinoma and gastric cardia cancer. The study highlights the subtype- or subsite-specific impact of BMI on upper gastrointestinal cancer in the Japanese population.
Article
Peripheral Vascular Disease
Abubakr Ahmed Abdullah Al-Shoaibi, Yuanying Li, Zean Song, Chifa Chiang, Yoshihisa Hirakawa, K. M. Saif-Ur-Rahman, Masako Shimoda, Yoshihisa Nakano, Masaaki Matsunaga, Atsuko Aoyama, Koji Tamakoshi, Atsuhiko Ota, Hiroshi Yatsuya
Summary: This study examined the association between LDL-C levels and the risk of coronary heart disease (CHD) and stroke subtypes among the Japanese population. The results showed that LDL-C was positively associated with CHD, but not with ischemic stroke. LDL-C was inversely associated with intracerebral hemorrhage.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2023)
Article
Public, Environmental & Occupational Health
Qiong Wang, Shuai Zhou, Jingya Zhang, Qing Wang, Fangfang Hou, Xiao Han, Guodong Shen, Yan Zhang
Summary: A risk assessment tool for mild cognitive impairment (MCI) was developed and validated in this study, focusing on modifiable factors and risk stratification. Nine modifiable risk factors were selected and the tool's performance was verified using cross-sectional and longitudinal datasets from a Chinese elderly cohort. The tool has significant public health implications for the primary prevention of MCI in elderly individuals in China.
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
(2023)
Article
Dermatology
Chaochen Wang, Hitoe Torisu-Itakura, Takao Hanada, Takashi Matsuo, Zhihong Cai, Satoshi Osaga, Toshihiko Aranishi
Summary: Real-world evidence on the persistence of IL-17 inhibitors (IL-17i) among Japanese patients with psoriasis, including its subtypes, is lacking. This study found that the persistence rates of IL-17is were over 50% in patients with psoriasis and its subtypes (PsO, PsA, GPP or EP) in Japan for up to 36 months.
JOURNAL OF DERMATOLOGICAL TREATMENT
(2023)
Article
Health Care Sciences & Services
Han Xiao, Hou Fangfang, Wang Qiong, Zhou Shuai, Zhang Jingya, Lou Xu, Shen Guodong, Zhang Yan
Summary: Early identification of individuals with mild cognitive impairment (MCI) is crucial, and physical function indicators can serve as low-cost early markers for cognitive decline. This study aimed to establish an early identification tool for MCI by combining upper and lower limb function indicators. Three models were developed and all showed good discrimination performance, with the model combining both upper and lower limb function performing the best. The final prediction model can assist health workers in early identification of MCI and support early interventions to reduce the future risk of Alzheimer's disease.
INQUIRY-THE JOURNAL OF HEALTH CARE ORGANIZATION PROVISION AND FINANCING
(2023)
Meeting Abstract
Peripheral Vascular Disease
Zean Song, Yupeng He, Chifa Chiang, Abubakr A. Alshoaibi, K. M. Saif Ur Rahman, Md Razib Mamun, Atsuko Aoyama, Yoshihisa Hirakawa, Masaaki Matsunaga, Atsuhiko Ota, Koji Tamakoshi, Yuanying Li, Hiroshi Yatsuya
JOURNAL OF HYPERTENSION
(2023)
Article
Medicine, Research & Experimental
Chaochen Wang, Tomoko Ishizuka, Masaru Tanaka, Koji Matsuo, Hannah Knight, Niamh Harvey, Liane Gillespie-Akar, Theresa Hunter Gibble
Summary: This study investigated the prevalence of bowel urgency (BU) in Japanese patients with inflammatory bowel disease (IBD) and compared the clinical outcomes and health-related quality of life (HRQoL) between patients with and without BU. The results showed that patients with BU had worse clinical outcomes and HRQoL compared to patients without BU.
ADVANCES IN THERAPY
(2023)
