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Cell Biology
Tzu-Cheng Sung, Yi-Peng Jiang, Jhe-Yu Hsu, Qing-Dong Ling, Hao Chen, Suresh S. Kumar, Yung Chang, Shih-Tien Hsu, Qingsong Ye, Akon Higuchi
Summary: This study successfully generated universal hiPSCs without gene editing and evaluated their resistance to immune reactions, demonstrating that the cells maintained stable characteristics even after continuous passages.
CELL PROLIFERATION
(2021)
Review
Biochemistry & Molecular Biology
Aline Yen Ling Wang
Summary: Induced pluripotent stem cells (iPSCs) and iPSC-derived exosomes demonstrate therapeutic effects through paracrine mechanisms, with potential applications in various disease models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Lu Zhang, Xiao-Jing-Nan Ma, Yuan-Yuan Fei, Heng-Tong Han, Jun Xu, Lu Cheng, Xun Li
Summary: The liver has the ability to repair itself, but pathological changes can impair its regenerative capacity and lead to liver failure. Mesenchymal stem cells (MSCs) have shown promise in liver regeneration, and induced pluripotent stem cells have made progress in organoid establishment and drug screening.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Biophysics
M. R. Poorna, R. Jayakumar, Jyh-Ping Chen, Ullas Mony
Summary: Induced pluripotent stem cells (iPSCs) have great potential in regenerative medicine, and improving culture methods, such as using hydrogels as substrates, can support iPSC adhesion, proliferation, and differentiation. Using hydrogels may help generate large numbers of clinical-grade cells for potential clinical applications.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Review
Biochemistry & Molecular Biology
Matin Chehelgerdi, Fereshteh Behdarvand Dehkordi, Mohammad Chehelgerdi, Hamidreza Kabiri, Hosein Salehian-Dehkordi, Mohammad Abdolvand, Sharareh Salmanizadeh, Mohsen Rashidi, Anoosha Niazmand, Saba Ahmadi, Sara Feizbakhshan, Saber Kabiri, Nasimeh Vatandoost, Tayebeh Ranjbarnejad
Summary: The emergence of iPSCs has revolutionized stem cell research and opened up new avenues for cancer treatment. iPSCs provide a unique platform for investigating the origin of cancer and can be used for personalized treatment and drug testing. This review article discusses the science behind iPSCs, the limitations and challenges in iPSC-based cancer therapy, ethical and social implications, and a comparative analysis with other stem cell types for cancer treatment. It also explores the applications of iPSCs in tumorigenesis and the future of iPSC research in this field.
Review
Biochemistry & Molecular Biology
Giuliana Minani Bertolino, Marie Maumus, Christian Jorgensen, Daniele Noel
Summary: Extracellular vesicles (EVs) isolated from induced pluripotent stem cells (iMSCs) show promise in regenerative medicine for the treatment of various diseases. However, the heterogeneity between MSC donors may lead to batch-to-batch variability in the use of EVs as cell-free therapeutic agents.
Review
Cardiac & Cardiovascular Systems
Parisa K. Kargaran, Diogo Mosqueira, Tamas Kozicz
Summary: Mitochondrial medicine is a rapidly evolving field with implications in neurodegenerative diseases, type 2 diabetes, aging, and cardiovascular disorders. Effective treatments for mitochondrial diseases are currently lacking, highlighting the need for developing platforms to target the mitochondrial genome. iPSC-CM models and cellular models offer promising avenues for discovering and testing new therapies for mitochondrial diseases.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Jessica C. Garbern, Gabriela O. Escalante, Richard T. Lee
Summary: Cell replacement therapy using pluripotent stem cell-derived cardiomyocytes (PSC-CMs) is still in the research phase, with various challenges that need to be addressed before successful clinical translation can be achieved.
TRENDS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cell Biology
Glyn Nigel Stacey, Jie Hao
Summary: In recent years, significant progress has been made in China in establishing hPSCs for the manufacture of cell therapies. The National Stem Cell Resource Center and its partner organizations have over 600 hPSC lines formally recorded, with 47 of them also registered for European Commission funded research projects. This national and international coordination aims to promote the translation of Chinese hPSC-based products into clinical use according to established standards.
CELL PROLIFERATION
(2022)
Review
Biochemistry & Molecular Biology
Agnieszka Fus-Kujawa, Barbara Mendrek, Anna Trybus, Karolina Bajdak-Rusinek, Karolina L. Stepien, Aleksander L. Sieron
Summary: Induced pluripotent stem cells (iPSCs) show potential in gene therapy and disease modeling. To safely apply this technology in clinical settings, optimal reprogramming factors and vectors must be considered to reduce the risk of insertional tumorigenesis.
Review
Cell Biology
Mingyang Chang, Mariia S. Bogacheva, Yan-Ru Lou
Summary: Bioengineering technologies have been applied to develop and optimize liver organoids, which can be used for disease modeling, drug discovery, and the generation of cell therapy products.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Andre Cronemberger Andrade, Martin Wolf, Heide-Marie Binder, Fausto Gueths Gomes, Felix Manstein, Patricia Ebner-Peking, Rodolphe Poupardin, Robert Zweigerdt, Katharina Schallmoser, Dirk Strunk
Summary: The study found that the quantity of iPSC-EVs is influenced by oxygen conditions and the method of EV preparation, with the best recovery observed at 1% oxygen and significantly elevated angiogenic potential.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Rie Ouchi, Hiroyuki Koike
Summary: The discovery of human pluripotent stem cells (PSCs), including embryonic stem cells and induced pluripotent stem cells (iPSCs), has greatly advanced our understanding of human developmental biology and has been used in drug discovery and disease treatments. PSC-derived organoids, which replicate the complex structures of living organs, have been created and used in various fields. iPSC-derived organoids, with their genetic background matching the donor, are useful for disease modeling, pathophysiology elucidation, and drug screening. They are also promising in regenerative medicine as a low-risk alternative to organ transplantation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Linda Krisch, Gabriele Brachtl, Sarah Hochmann, Andre Cronemberger Andrade, Michaela Oeller, Patricia Ebner-Peking, Katharina Schallmoser, Dirk Strunk
Summary: By modifying the protocol prior to hemogenic endothelial cell (HEC) differentiation, more MK progenitors (MKPs) were produced and platelet output was increased. The modified protocol resulted in five times more platelets per hiPSC and showed similar or higher expression of angiogenesis-related proteins compared to adult donor-derived platelets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Computer Science, Interdisciplinary Applications
Yusuke Hayashi, Ikki Horiguchi, Masahiro Kino-oka, Hirokazu Sugiyama
Summary: This study presents a model-based assessment of temperature profiles in slow freezing for human induced pluripotent stem cells, which can estimate cell survival rate and required freezing time based on given freezing temperature profiles to achieve quality and productivity objectives. Simulation results indicate different cooling rates in dehydration, nucleation-promoting, and further cooling zones.
COMPUTERS & CHEMICAL ENGINEERING
(2021)
Article
Obstetrics & Gynecology
Pascale V. Guillot
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2016)
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Cell & Tissue Engineering
Dafni Moschidou, Michelangelo Corcelli, Kwan-Leong Hau, Victoria J. Ekwalla, Jacques V. Behmoaras, Paolo De Coppi, Anna L. David, George Bou-Gharios, H. Terence Cook, Charles D. Pusey, Nicholas M. Fisk, Pascale V. Guillot
STEM CELLS AND DEVELOPMENT
(2016)
Article
Biotechnology & Applied Microbiology
Kate E. Hawkins, Dafni Moschidou, Danilo Faccenda, Wasco Wruck, Alex Martin-Trujillo, Kwan-Leong Hau, Anna Maria Ranzoni, Veronica Sanchez-Freire, Fabio Tommasini, Simon Eaton, Paolo De Coppi, David Monk, Michelangelo Campanella, Adrian J. Thrasher, James Adjaye, Pascale V. Guillot
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Multidisciplinary Sciences
Kwan-Leong Hau, Anna Maria Ranzoni, Filipa Vlahova, Kate Hawkins, Paolo De Coppi, Anna L. David, Pascale V. Guillot
SCIENTIFIC REPORTS
(2017)
Article
Multidisciplinary Sciences
Michelangelo Corcelli, Kate Hawkins, Filipa Vlahova, Avina Hunjan, Kate Dowding, Paolo De Coppi, Anna L. David, Donald Peebles, Pierre Gressens, Henrik Hagberg, Mariya Hristova, Pascale V. Guillot
SCIENTIFIC REPORTS
(2018)
Article
Cell & Tissue Engineering
Md Shaifur Rahman, Lucas-Sebastian Spitzhorn, Wasco Wruck, Carsten Hagenbeck, Percy Balan, Nina Graffmann, Martina Bohndorf, Audrey Ncube, Pascale V. Guillot, Tanja Fehm, James Adjaye
STEM CELL RESEARCH & THERAPY
(2018)
Article
Cell & Tissue Engineering
Kate E. Hawkins, Michelangelo Corcelli, Kate Dowding, Anna M. Ranzoni, Filipa Vlahova, Kwan-Leong Hau, Avina Hunjan, Donald Peebles, Pierre Gressens, Henrik Hagberg, Paolo de Coppi, Mariya Hristova, Pascale V. Guillot
STEM CELLS TRANSLATIONAL MEDICINE
(2018)
Article
Multidisciplinary Sciences
Anna M. Ranzoni, Michelangelo Corcelli, Timothy R. Arnett, Pascale V. Guillot
Article
Multidisciplinary Sciences
Anna M. Ranzoni, Michelangelo Corcelli, Kwan-Leong Hau, Jemma G. Kerns, Maximilien Vanleene, Sandra Shefelbine, Gemma N. Jones, Dafni Moschidou, Benan Dala-Ali, Allen E. Goodship, Paolo De Coppi, Timothy R. Arnett, Pascale V. Guillot
SCIENTIFIC REPORTS
(2016)
Article
Multidisciplinary Sciences
Filipa Vlahova, Kate E. Hawkins, Anna Maria Ranzoni, Kwan-Leong Hau, Rachel Sagar, Paolo De Coppi, Anna L. David, James Adjaye, Pascale Guillot
SCIENTIFIC REPORTS
(2019)
Correction
Multidisciplinary Sciences
Filipa Vlahova, Kate E. Hawkins, Anna Maria Ranzoni, Kwan-Leong Hau, Rachel Sagar, Paolo De Coppi, Anna L. David, James Adjaye, Pascale V. Guillot
SCIENTIFIC REPORTS
(2020)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Alexandre Lugat, Delphine Drui, Kalyane Bach-Ngohou, Pascale Guillot, Emmanuelle Mourrain-Langlois, Francoise Kraeber-Bodere, Catherine Ansquer
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Nutrition & Dietetics
Marie Mathieu, Pascale Guillot, Typhaine Riaudel, Anne-Sophie Boureau, Guillaume Chapelet, Celine Brouessard, Laure de Decker, Gilles Berrut
Summary: This study aimed to explore the relationship between osteoporosis and sarcopenia in women aged 75 or older, revealing a significant association between fat mass and bone density, with osteosarcopenic patients having lower fat mass and body mass index.
Article
Nutrition & Dietetics
Marc Dauty, Pierre Menu, Baptiste Jolly, Sylvain Lambert, Bruno Rocher, Maelle Le Bras, Adam Jirka, Pascale Guillot, Stephane Pretagut, Alban Fouasson-Chailloux
Summary: This study examines the effectiveness of controlled physical activities in early refeeding for patients with severe anorexia nervosa and finds that engaging in physical activities during hospitalization in a Physical Medicine and Rehabilitation (PMR) department does not compromise the efficiency of intensive refeeding.
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Cardiac & Cardiovascular Systems
Kaloyan Takov, Zhenhe He, Harvey E. Johnston, John F. Timms, Pascale V. Guillot, Derek M. Yellon, Sean M. Davidson
BASIC RESEARCH IN CARDIOLOGY
(2020)