Article
Hematology
Hisashi Sawada, Satoko Ohno-Urabe, Dien Ye, Michael K. Franklin, Jessica J. Moorleghen, Deborah A. Howatt, Adam E. Mullick, Alan Daugherty, Hong S. Lu
Summary: This study found that inhibition of angiotensin II action or production of the renin-angiotensin system does not attenuate BAPN-induced thoracic aortopathies in mice.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Review
Peripheral Vascular Disease
Edwyn O. Cruz-Lopez, Dien Ye, Congqing Wu, Hong S. Lu, Estrellita Uijl, Katrina M. Mirabito Colafella, A. H. Jan Danser
Summary: Multiple types of RAS blockers exist to treat hypertension, but patient noncompliance and RAS escape remain challenges. New approaches using antisense oligonucleotides and siRNA to target angiotensinogen show promise in circumventing RAS escape. However, limited clinical data is available to support these methods.
Article
Peripheral Vascular Disease
Cheol Ho Park, Hyung Woo Kim, Jung Tak Park, Tae Ik Chang, Tae-Hyun Yoo, Joongyub Lee, Suah Sung, Ji Yong Jung, Young Youl Hyun, Kook-Hwan Oh, Shin-Wook Kang, Seung Hyeok Han
Summary: This study found that higher systolic blood pressure (SBP) was associated with the progression of chronic kidney disease (CKD) when urinary angiotensinogen levels were low, but this association was not observed when urinary angiotensinogen levels were high. This finding suggests that intrarenal renin-angiotensin system activity may modify the relationship between SBP and adverse kidney outcome.
Article
Hematology
Jeff Z. Chen, Hisashi Sawada, Dien Ye, Yuriko Katsumata, Masayoshi Kukida, Satoko Ohno-Urabe, Jessica J. Moorleghen, Michael K. Franklin, Deborah A. Howatt, Mary B. Sheppard, Adam E. Mullick, Hong S. Lu, Alan Daugherty
Summary: Deletion of AT1aR and inhibition of Ang II production had similar effects in attenuating pathologies in the proximal thoracic aorta of male Fbn1(C1041G/+) mice. Inhibition of the renin-angiotensin system attenuated dysregulation of genes within the aorta related to pathology of Fbn1(C1041G/+) mice.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sam Siljee, Bridget Milne, Helen D. Brasch, Nicholas Bockett, Josie Patel, Paul F. Davis, Andrew Kennedy-Smith, Tinte Itinteang, Swee T. Tan
Summary: This study demonstrated the expression of PRR, ACE2, and AT(2)R by the CSCs within RCCC. Further studies may lead to novel therapeutic targeting of CSCs by manipulation of the RAS in the treatment of this aggressive cancer.
Article
Cardiac & Cardiovascular Systems
Patrick J. Trainor, Michela Brambatti, Samantha M. Carlisle, Adam E. Mullick, Sanjiv J. Shah, Tanvir Kahlon, Diana Otero Mostacero, Hossein Mousavi, Erin S. Morgan, Yvonne Tami, Erin D. Michos, Pamela Ouyang, Sotirios Tsimikas, Andrew P. DeFilippis
Summary: This study explores the relationship between circulating angiotensinogen levels and ethnicity, sex, blood pressure (BP), and hypertension. The results suggest significant differences in angiotensinogen levels between sexes and ethnicities, with a positive association between levels and prevalent hypertension and BP, which differs between sexes.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Review
Oncology
Huirong Jiang, Zongguang Tai, Zhongjian Chen, Quangang Zhu, Leilei Bao
Summary: The renin-angiotensin system plays a crucial role in the development of malignant tumors, and long-term use of RAS inhibitors can lower the risk of cancer. Blocking RAS has been shown to inhibit tumor growth, metastasis, and angiogenesis in malignant tumors.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Letter
Medicine, General & Internal
Robert C. Speth
Summary: The article does not differentiate between ACE inhibitor therapy and ARB therapy in advanced CKD. The mechanisms of action of ACE inhibitors and ARBs differ substantially, with varying effects on renal function.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Sebastian Andone, Zoltan Bajko, Anca Motataianu, Smaranda Maier, Laura Barcutean, Rodica Balasa
Summary: This article reviews the role of the renin-angiotensin system in stroke neuroprotection. The effects of the renin-angiotensin system on receptors were observed, and the neuroprotective properties seem to be independent of the blood pressure reduction mechanism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Peripheral Vascular Disease
Dominique M. Bovee, Liwei Ren, Estrellita Uijl, Marian C. Clahsen-van Groningen, Richard van Veghel, Ingrid M. Garrelds, Oliver Domenig, Marko Poglitsch, Ivan Zlatev, Jae B. Kim, Stephen Huang, Lauren Melton, Xifeng Lu, Ewout J. Hoorn, Don Foster, A. H. Jan Danser
Summary: AGT siRNA demonstrates blood pressure-lowering and renal protective effects in hypertensive chronic kidney disease, independently of blood pressure, mainly through suppression of renal Ang II formation from liver-derived AGT.
Review
Immunology
Sizhu Gong, Fang Deng
Summary: Emotional disorders, such as depression and anxiety, have a significant impact on global morbidity. The renin-angiotensin system (RAS) plays a role in hypertension and emotional disorders, and elevated RAS activity is associated with depression and anxiety through neuroinflammation, stress, and oxidative stress. Blocking the RAS could potentially be a future treatment approach for anxiety and depression. The positive effects of RAS blockers on these disorders are reviewed, aiming to provide a promising target for novel medications and to improve the efficacy of current treatments independent of blood pressure management.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cell Biology
Maksymilian Ziaja, Kinga Anna Urbanek, Karolina Kowalska, Agnieszka Wanda Piastowska-Ciesielska
Summary: The renin-angiotensin system (RAS) is not only involved in regulating cardiovascular function, but also plays a complex role in various processes such as memory and cancer. Maintaining the balance between individual elements of the RAS system is crucial for achieving homeostasis, and any disturbance in their expression or activity can lead to pathological processes.
Review
Neurosciences
Naif H. Ali, Hayder M. Al-Kuraishy, Ali I. Al-Gareeb, Ali K. Albuhadily, Rabab S. Hamad, Athanasios Alexiou, Marios Papadakis, Hebatallah M. Saad, Gaber El-Saber Batiha
Summary: This article discusses the pathophysiology of depression and the role of the brain renin-angiotensin system (RAS) in it. It is found that angiotensin-converting enzyme inhibitors and angiotensin receptor blockers may be effective in the treatment of depression. By regulating serotonin, brain-derived neurotrophic factor, mitochondrial dysfunction, oxidative stress, and neuroinflammation, these drugs can ameliorate the pathophysiology of depression.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Lucas M. Kangussu, Natalia P. Rocha, Priscila A. C. Valadao, Thatiane C. G. Machado, Kivia B. Soares, Julliane V. Joviano-Santos, Leigh B. Latham, Gabriela D. Colpo, Ana Flavia Almeida-Santos, Erin Furr Stimming, Ana Cristina Silva, Antonio L. Teixeira, Aline Silva Miranda, Cristina Guatimosim
Summary: The imbalance of the Renin-Angiotensin System in the central nervous system may play a role in the pathophysiology of Huntington's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Driss Laghlam, Anis Chaba, Matthias Tarneaud, Julien Charpentier, Jean-Paul Mira, Frederic Pene, Clara Vigneron
Summary: This retrospective study aimed to assess the prognostic impact of renin-angiotensin system blockers (RABs) in critically ill cancer patients. The results showed that the use of angiotensin-receptor blockers (ARBs) and angiotensin-converting enzyme inhibitors (ACEis) was associated with improved in-ICU survival and one-year survival. Cellular evidence supports the beneficial impact of RABs on the survival rates of solid tumor patients.
Article
Biochemistry & Molecular Biology
Claudia M. Garcia-Cuellar, Yolanda I. Chirino, Rocio Morales-Barcenas, Ernesto Soto-Reyes, Raul Quintana-Belmares, Miguel Santibanez-Andrade, Yesennia Sanchez-Perez
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Cell Biology
Jose Alberto Carlos-Escalante, Liliana Gomez-Flores-Ramos, Xiaopeng Bian, Alexander Perdomo-Pantoja, Kelvin Cesar de Andrade, Sonia Liana Mejia-Perez, Bernardo Cacho-Diaz, Rodrigo Gonzalez-Barrios, Nancy Reynoso-Noveron, Ernesto Soto-Reyes, Thalia Estefania Sanchez-Correa, Lissania Guerra-Calderas, Chunhua Yan, Qingrong Chen, Clementina Castro-Hernandez, Silvia Vidal-Millan, Lucia Taja-Chayeb, Olga Gutierrez, Rosa Maria Alvarez-Gomez, Juan Luis Gomez-Amador, Patricia Ostrosky-Wegman, Alejandro Mohar-Betancourt, Luis Alonso Herrera-Montalvo, Teresa Corona, Daoud Meerzaman, Talia Wegman-Ostrosky
Summary: This study identified significant associations between variants in AGT, MGMT, and TP53 genes and the risk of astrocytoma, providing new genetic risk factors for the development of astrocytoma.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2021)
Article
Chemistry, Medicinal
Yerye Gibran Mayen-Lobo, Jose Jaime Martinez-Magana, Blanca Estela Perez-Aldana, Alberto Ortega-Vazquez, Alma Delia Genis-Mendoza, David Jose Davila-Ortiz De Montellano, Ernesto Soto-Reyes, Humberto Nicolini, Marisol Lopez-Lopez, Nancy Monroy-Jaramillo
Summary: This study investigated the mechanisms of action of Clozapine in patients with refractory psychosis, revealing an association between bipolar disorder risk score and Clozapine metabolic ratio, particularly in the GABAergic synapse pathway. The findings support the potential use of Clozapine as a mood stabilizer in addition to its antipsychotic effects, highlighting the need for further research with larger sample sizes to confirm these results.
Article
Neurosciences
Gerardo Ramirez-Mejia, Elvi Gil-Lievana, Oscar Urrego-Morales, Ernesto Soto-Reyes, Federico Bermudez-Rattoni
Summary: The research demonstrates that inhibiting class I HDAC enhances long-term object recognition memory consolidation, coinciding with a peak of BDNF expression 4 hours after acquisition. Blocking the tyrosine kinase B (TrkB) receptor at 4 hours, but not at 8 hours, impairs ORM consolidation.
Article
Multidisciplinary Sciences
Cesar Melendez-Ramirez, Raquel Cuevas-Diaz Duran, Tonatiuh Barrios-Garcia, Mayela Giacoman-Lozano, Adolfo Lopez-Ornelas, Jessica Herrera-Gamboa, Enrique Estudillo, Ernesto Soto-Reyes, Ivan Velasco, Victor Trevino
Summary: Chromatin architecture plays a key role in influencing transcription during dopaminergic neuron differentiation, with a high abundance of long non-coding RNAs in the most downregulated transcripts. Open chromatin regions decrease during differentiation and are associated with specific functional pathways and gene-sets. The study also identifies potential transcription factors and structural nuclear proteins involved in regulating dopaminergic differentiation.
SCIENTIFIC REPORTS
(2021)
Article
Mathematical & Computational Biology
Marisol Salgado-Albarran, Erick I. Navarro-Delgado, Aylin Del Moral-Morales, Nicolas Alcaraz, Jan Baumbach, Rodrigo Gonzalez-Barrios, Ernesto Soto-Reyes
Summary: COVID-19 is caused by SARS-CoV-2 and has led to a global outbreak. Research efforts are focused on understanding the molecular mechanisms of SARS-CoV-2 infection for potential drug-based therapies. This study identified key host cell responses and potential therapeutic targets by analyzing transcriptomes from MERS-CoV, SARS-CoV, SARS-CoV-2 infected cells, and COVID-19 patient-derived samples.
NPJ SYSTEMS BIOLOGY AND APPLICATIONS
(2021)
Article
Oncology
Laura Itzel Quintas-Granados, Hernan Cortes, Manuel Gonzalez-Del Carmen, Gerardo Leyva-Gomez, Lilia Patricia Bustamante-Montes, Miguel Rodriguez-Morales, Edgar Yebran Villegas-Vazquez, Israel Lopez-Reyes, Sofia Lizeth Alcaraz-Estrada, Jorge Sandoval-Basilio, Ernesto Soto-Reyes, Javad Sharifi-Rad, Gabriela Figueroa-Gonzalez, Octavio Daniel Reyes-Hernandez
Summary: The study found methylation changes in the ESR1 gene in breast cancer patients, particularly lower levels in ER alpha positive tumors, and an association with menopausal status. Triple-negative cancer subtypes showed higher levels of ESR1 methylation.
CANCER CELL INTERNATIONAL
(2021)
Article
Mathematical & Computational Biology
Marisol Salgado-Albarran, Julian Spath, Rodrigo Gonzalez-Barrios, Jan Baumbach, Ernesto Soto-Reyes
Summary: In this study, the researchers aimed to understand the regulatory functions of CTCFL in high-grade serous ovarian carcinoma (HGSC) and identify potential target genes. Through in vitro models and network analysis, they identified CTCFL-driven genes and mechanistic biomarkers associated with survival in HGSC. Additionally, they discovered potential drug targets that could aid in the development of therapies for HGSC.
NPJ SYSTEMS BIOLOGY AND APPLICATIONS
(2022)
Article
Genetics & Heredity
Aylin del Moral-Morales, Marisol Salgado-Albarran, Elizabeth Ortiz-Gutierrez, Gerardo Perez-Hernandez, Ernesto Soto-Reyes
Summary: KDM4 proteins are involved in cancer development and their deregulation is associated with poor prognosis. Natural compounds have shown potential as inhibitors of KDM4 enzymes and could be used as novel therapies in cancer treatment.
FRONTIERS IN GENETICS
(2022)
Article
Psychiatry
Blanca Estela Perez-Aldana, Jose Jaime Martinez-Magana, Yerye Gibran Mayen-Lobo, David Jose Davila-Ortiz de Montellano, Carlos Luis Avina-Cervantes, Alberto Ortega-Vazquez, Alma Delia Genis-Mendoza, Emmanuel Sarmiento, Ernesto Soto-Reyes, Isela Esther Juarez-Rojop, Carlos Alfonso Tovilla-Zarate, Thelma Beatriz Gonzalez-Castro, Humberto Nicolini, Marisol Lopez-Lopez, Nancy Monroy-Jaramillo
Summary: Long-term studies have shown that continuous clozapine (CLZ) treatment leads to significantly lower mortality rates compared to other antipsychotics. This study aimed to investigate the differences in epigenetic age and DNA methylome between CLZ-treated patients and those without psychopharmacological treatment. The results revealed that CLZ-treated patients had a lower epigenetic age compared to drug-naive patients, particularly in certain sex and age groups. Additionally, differential methylation sites were found between the two groups, and these sites were enriched in longevity-related genes.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Alejandra Padua-Bracho, Jose A. Velazquez-Aragon, Veronica Fragoso-Ontiveros, Paulina Maria Nunez-Martinez, Maria de la Luz Mejia Aguayo, Yuliana Sanchez-Contreras, Miguel Angel Ramirez-Otero, Marcela Angelica De la Fuente-Hernandez, Silvia Vidal-Millan, Talia Wegman-Ostrosky, Abraham Pedroza-Torres, Cristian Arriaga-Canon, Luis A. Herrera-Montalvo, Rosa Maria Alvarez-Gomez
Summary: This study describes the clinical and molecular spectrum of Lynch syndrome (LS) patients in Mexico. Among a cohort of patients, approximately 28% had variants in mismatch repair (MMR) genes, 30% had variants in non-MMR genes, and 42% had no genetic variants. The majority of variants were found in the MLH1 gene. Molecular and clinical characterization of LS patients in specific populations allows personalized follow-up and the development of public health policies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Rocio Morales-Barcenas, Yesennia Sanchez-Perez, Miguel Santibanez-Andrade, Yolanda Chirino, Ernesto Soto-Reyes, Claudia M. Garcia-Cuellar
Summary: This study demonstrates that exposure to PM10 enhances the activity of c-Jun, Jun B, and Fra-1, increases the expression of MMP-9, and promotes cell invasion in lung epithelial cells through the AhR pathway. Furthermore, the activity of Fos B and C-Fos is downregulated by PM10. These findings highlight the potentially toxic effects of the PM10 mixture in lung epithelial cells.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Oncology
Jose Alberto Carlos-Escalante, Sonia Iliana Mejia-Perez, Ernesto Soto-Reyes, Lissania Guerra-Calderas, Bernardo Cacho-Diaz, Karla Torres-Arciga, Michel Montalvo-Casimiro, Rodrigo Gonzalez-Barrios, Nancy Reynoso-Noveron, Miguel Ruiz-de la Cruz, Clara Estela Diaz-Velasquez, Silvia Vidal-Millan, Rosa Maria Alvarez-Gomez, Thalia Estefania Sanchez-Correa, Claudio Hiram Pech-Cervantes, Jose Antonio Soria-Lucio, Areli Perez-Castillo, Ana Maria Salazar, Cristian Arriaga-Canon, Felipe Vaca-Paniagua, Aliesha Gonzalez-Arenas, Patricia Ostrosky-Wegman, Alejandro Mohar-Betancourt, Luis A. Herrera, Teresa Corona, Talia Wegman-Ostrosky
Summary: This study investigates the molecular characteristics of astrocytomas in Mexican patients, focusing on AGT, MGMT, and TP53 somatic variants. The presence of AGT and MGMT variants, as well as MGMT promoter methylation, is associated with improved survival and response to chemotherapy. Notably, AGT variants are found exclusively in women, revealing molecular differences between genders in astrocytoma. Further research is needed to validate these findings.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Review
Cell Biology
Aylin Del Moral-Morales, Marisol Salgado-Albarran, Yesennia Sanchez-Perez, Nina Kerstin Wenke, Jan Baumbach, Ernesto Soto-Reyes
Summary: Architectural proteins such as CTCF are crucial for chromatin organization and gene expression control. CTCF functions as a key player in maintaining complex chromatin structure due to its ability to bind various sequences. However, the exact mechanisms of its versatility are still not fully understood. This review focuses on CTCF's interactions with other epigenetic molecules, including histone and DNA demethylases, as well as long non-coding RNAs that recruit CTCF. Understanding the partners of CTCF is essential for unraveling chromatin regulation and investigating the finely-tuned role of CTCF as a master regulator of chromatin.
