Article
Clinical Neurology
S. R. M. Bus, M. C. Broers, I. M. Lucke, C. Bunschoten, G. G. A. van Lieverloo, M. E. Adrichem, R. van Veen, L. Wieske, H. F. Lingsma, H. S. Goedee, W. L. van der Pol, I. N. van Schaik, P. A. Van Doorn, B. C. Jacobs, F. Eftimov
Summary: This study assessed the clinical outcome in treatment-naive patients with CIDP, finding that most patients showed improvement after treatment, but over half of the patients remained untreated at 1 year, with around one-third in remission. Differences between treatment groups did not reach statistical significance, and residual symptoms and deficits were common across all treatments.
JOURNAL OF NEUROLOGY
(2022)
Article
Medicine, Research & Experimental
S. R. M. Bus, L. Zambreanu, A. Abbas, Y. A. Rajabally, R. D. M. Hadden, R. J. de Haan, C. A. J. M. de Borgie, M. P. Lunn, I. N. van Schaik, F. Eftimov
Summary: This study aims to investigate the long-term remission effects of combined IVIg and corticosteroid treatment on CIDP patients, as well as the potential impact on reducing healthcare costs and improving patient quality of life.
Article
Clinical Neurology
Anna Kostera-Pruszczyk, Anna Potulska-Chromik, Malgorzata Lukawska, Marta Lipowska, Dorota Hoffman-Zacharska, Beata Olchowik, Magdalena Figlerowicz, Karolina Kanabus, Edyta Rosiak
Summary: Childhood CIDP can manifest in atypical forms in over 50% of cases, including distal, pure motor, or pure sensory variants. While most children have a good prognosis, long-term treatment may be necessary for some patients.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Charline Benoit, Juliette Svahn, Rabab Debs, Christophe Vandendries, Timothee Lenglet, Julie Zyss, Thierry Maisonobe, Karine Viala
Summary: Focal chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) can be categorized into focal demyelinating plexus neuropathy and monomelic sensori-motor or motor involvement of peripheral nerves. Patients with focal plexus neuropathy have a better prognosis compared to those with monomelic involvement of peripheral nerves.
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM
(2021)
Article
Clinical Neurology
Colin Anderson-Smits, Mary E. E. Ritchey, Zhongwen Huang, Shailesh Chavan, Nizar Souayah, Hakan Ay, J. Bradley Layton
Summary: Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a rare disease where the immune system attacks the nerves. Intravenous immunoglobulin (IVIG) is recommended as one of the first-line treatments for CIDP. This study aimed to gather information on the day-to-day use of IVIG by patients with CIDP.
NEUROLOGY AND THERAPY
(2023)
Article
Immunology
Soudeh Ghafouri-Fard, Bashdar Mahmud Hussen, Fwad Nicknafs, Naghme Nazer, Arezou Sayad, Mohammad Taheri
Summary: The study demonstrated down-regulation of PIAS genes in peripheral blood of patients with inflammatory demyelinating polyradiculoneuropathy, which could accurately distinguish between patients and healthy individuals, suggesting their potential as biomarkers.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Jianian Hu, Chongbo Zhao, Jie Lin
Summary: This article systematically lists potential therapeutic strategies targeting different components of the immune system for chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), discusses the importance of immunopathology in CIDP, and mentions ongoing clinical trials.
AUTOIMMUNITY REVIEWS
(2022)
Article
Clinical Neurology
Giuseppe Liberatore, Alberto De Lorenzo, Claudia Giannotta, Fiore Manganelli, Massimiliano Filosto, Giuseppe Cosentino, Dario Cocito, Chiara Briani, Andrea Cortese, Raffaella Fazio, Giuseppe Lauria, Angelo Maurizio Clerici, Tiziana Rosso, Girolama Alessandra Marfia, Giovanni Antonini, Guido Cavaletti, Marinella Carpo, Pietro Emiliano Doneddu, Emanuele Spina, Stefano Cotti Piccinelli, Erdita Peci, Luis Querol, Eduardo Nobile-Orazio
Summary: This study investigated the occurrence and clinical features of anti-nerve autoantibodies in Italian patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). The results showed that anti-neurofascin155 and anti-contactin1 antibodies were associated with specific clinical symptoms, while anti-ganglioside antibodies were related to a progressive course.
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Marina Romozzi, Giulia Bisogni, Mario Sabatelli, Marco Luigetti
Summary: This study demonstrated that in selected cases it is possible to successfully stop chronic IVIg treatment, even in patients who have been treated for several years.
NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Pietro E. Doneddu, Marta Ruiz, Elisa Bianchi, Giuseppe Liberatore, Fiore Manganelli, Dario Cocito, Giuseppe Cosentino, Luana Benedetti, Girola A. Marfia, Massimiliano Filosto, Chiara Briani, Claudia Giannotta, Eduardo Nobile-Orazio
Summary: A diagnostic score was developed to distinguish anti-MAG neuropathy from CIDP and was applied to patients with atypical anti-MAG neuropathy. The score allowed an accurate discrimination between the two groups and may help in selecting proper treatment for patients with anti-MAG antibodies.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Merel C. Broers, Carina Bunschoten, Judith Drenthen, Tiago A. O. Beck, Esther Brusse, Hester F. Lingsma, Jeffrey A. Allen, Richard A. Lewis, Pieter A. van Doorn, Bart C. Jacobs
Summary: This study reveals a common occurrence of over- and underdiagnosis of CIDP, with diagnostic pitfalls such as lack of attention to proximal muscle weakness, insufficient recognition of clinical atypical phenotypes, overreliance on CSF protein levels, and failure to exclude other causes of polyneuropathy.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Cell Biology
Christoph Hudemann, Jochen Hoffmann, Enno Schmidt, Michael Hertl, Ruediger Eming
Summary: Pemphigus vulgaris (PV) is a potentially lethal autoimmune bullous skin disorder caused by IgG autoantibodies against desmoglein 3 (Dsg3) and Dsg1. High-dose intravenous immunoglobulins (IVIgs) have been used as an effective and safe treatment for severe, therapy-refractory PV. In a mouse model for PV, IVIg treatment resulted in alterations of T- and B-cell populations, indicating a tolerance-associated polarization in lymphatic tissue. These findings suggest that the clinical efficacy of IVIg in PV may be mediated by these distinct alterations of T- and B-cell populations.
Article
Clinical Neurology
Malek Mansour, Amine Rachdi, Nesrine Baradai, Amel Kacem, Ines Bedoui, Ridha Mrissa
Summary: CIDP is a rare and polymorphic disorder, and our study is the first in Tunisia and the Maghreb countries to include the largest series of patients. The results were similar to the literature, with good outcomes expected for CIDP patients after treatment.
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Thomas Grueter, Jeremias Motte, Yesim Bulut, Anna Kordes, Diamantis Athanasopoulos, Miriam Fels, Christiane Schneider-Gold, Ralf Gold, Anna Lena Fisse, Kalliopi Pitarokoili
Summary: The study found that axonal damage variables are strongly correlated with clinical disability in patients with CIDP. Typical CIDP and atypical CIDP variants have distinct electrophysiological characteristics.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Merel C. Broers, Marcel Wilde, Hester F. Lingsma, Johan Lei, Katia M. C. Verhamme, Bart C. Jacobs
Summary: In this study, background rates of CIDP in the Netherlands were assessed using a population-based cohort study. The overall incidence and prevalence rates of CIDP were determined, with higher rates observed in men and in individuals aged 50 years or older. Additionally, comorbidities such as diabetes mellitus and other autoimmune diseases were found in a portion of CIDP cases. These findings are important for monitoring changes in CIDP frequency, identifying potential risk factors, and estimating the social and economic burden of the disease.
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM
(2022)
Article
Clinical Neurology
G. G. A. van Lieverloo, S. Peric, P. E. Doneddu, F. Gallia, A. Nikolic, L. Wieske, C. Verhamme, I. N. van Schalk, E. Nobile-Orazio, I Basta, F. Eftimov
JOURNAL OF NEUROLOGY
(2018)
Letter
Clinical Neurology
Diego Franciotta, Matteo Gastaldi, Elisabetta Zardini, Eduardo Nobile-Orazio
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM
(2018)
Editorial Material
Clinical Neurology
Eduardo Nobile-Orazio
Article
Clinical Neurology
Richard Hughes, Marinos C. Dalakas, Ingemar Merkies, Norman Latov, Jean-Marc Leger, Eduardo Nobile-Orazio, Gen Sobue, Angela Genge, David Cornblath, Martin Merschhemke, Carolyn Marie Ervin, Catherine Agoropoulou, Hans-Peter Hartung
Article
Medical Laboratory Technology
Diego Franciotta, Matteo Gastaldi, Tiziana Biagioli, Luana Benedetti, Claudia Giannotta, Roberta Bedin, Elisabetta Zardini, Eduardo Nobile-Orazio
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2018)
Article
Clinical Neurology
Pietro Emiliano Doneddu, Daniele Mandia, Francesco Gentile, Francesca Gallia, Giuseppe Liberatore, Fabrizia Terenghi, Marta Ruiz, Eduardo Nobile-Orazio
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM
(2020)
Review
Clinical Neurology
P. De Sanctis, P. E. Doneddu, L. Vigano, C. Selmi, E. Nobile-Orazio
EUROPEAN JOURNAL OF NEUROLOGY
(2020)
Letter
Clinical Neurology
P. E. Doneddu, P. De Sanctis, L. Vigano, C. Selmi, F. Gentile, E. Nobile-Orazio
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Eduardo Nobile-Orazio, Sonia Pujol, Fabrice Kasiborski, Rabye Ouaja, Gilles Della Corte, Robert Bonek, Dario Cocito, Angelo Schenone
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM
(2020)
Editorial Material
Clinical Neurology
Giuseppe Liberatore, Tiziana De Santis, Pietro Emiliano Doneddu, Francesco Gentile, Alberto Albanese, Eduardo Nobile-Orazio
Review
Clinical Neurology
Pietro E. Doneddu, Emanuele Spina, Chiara Briani, Gian Maria Fabrizi, Fiore Manganelli, Eduardo Nobile-Orazio
Summary: Recommendations for COVID-19 vaccination in patients with inflammatory neuropathies were developed based on the best evidence and expert opinion, as prior data on the safety and efficacy of vaccines in this population are limited. Further research is needed to assess the safety and efficacy of vaccination in patients with inflammatory neuropathies and other immune conditions.
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM
(2021)
Article
Clinical Neurology
Francesco Gentile, Fabrizia Terenghi, Pietro Emiliano Doneddu, Alberto De Lorenzo, Claudia Giannotta, Andrea Giordano, Rita Mazza, Andrea Nozza, Eduardo Nobile-Orazio
Summary: Regular assessment of serum VEGF levels is useful in monitoring the progression of POEMS syndrome. Normalized sVEGF levels are associated with prolonged relapse-free survival and better clinical improvement. After remission, 6-month sVEGF monitoring is a sensitive predictor of clinical relapse.
NEUROLOGICAL SCIENCES
(2023)
Meeting Abstract
Clinical Neurology
Y. A. Rajabally, A. Fowle, E. Nobile-Orazio, J. -M. Leger, P. A. van Doorn, A. Uncini, P. van Den Bergh
EUROPEAN JOURNAL OF NEUROLOGY
(2018)
Meeting Abstract
Clinical Neurology
E. Nobile-Orazio, D. Cocito, Lauria G. Pinter, R. Fazio, E. Marchioni, C. Briani, A. Schenone, L. Santoro
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM
(2018)
Meeting Abstract
Clinical Neurology
P. Doneddu, D. Mandia, F. Gallia, E. Nobile-Orazio
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM
(2018)