Article
Engineering, Biomedical
Ulrike Sprengel, Patrick Saalfeld, Janneck Stahl, Sarah Mittenentzwei, Moritz Drittel, Benjamin Behrendt, Naoki Kaneko, Daniel Behme, Philipp Berg, Bernhard Preim, Sylvia Saalfeld
Summary: The presented immersive VR application allows for virtual embolization and interactive blood flow visualization in the immersive virtual reality environment, supporting treatment planning and education in clinical practice.
INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY
(2021)
Article
Clinical Neurology
Kevin Agyemang, Samantha Lorena Paganelli, Jeanine de Oliveira Silva, Dimitriy Korotkov, Adam Bryce, Juan Carlos Ahumada Vizcaino, Jose Mayo Elo Mikue, Guilherme Salemi Riechelmann, Rony Gomes Rodriguez, Manuel Moreno Hernandez, Jose Maria de Campos Filho, Hugo Leonardo Doria-Netto, Raphael Wuo-Silva, Feres Chaddad-Neto
Summary: Brainstem AVMs, comprising 2% to 7% of all brain AVMs, have a worse prognosis due to a higher proportion of hemorrhage. Surgery, despite its associated poor outcomes, is favored by some due to concerns over latency and potential risks of other treatment options. This case demonstrates that in experienced hands, complete resection of brainstem AVMs can be achieved with a combination of selective embolization, neurophysiological monitoring, and microsurgical techniques.
OPERATIVE NEUROSURGERY
(2023)
Article
Clinical Neurology
Virginia Rojas-Nieves, Cristian Rosa-Carrasquillo, Allan Reyes-Sullivan, Marie Roman, Caleb E. Feliciano-Valls, Hector M. Torres-Perez, Pamela Fernandez, Maria J. Crespo
Summary: Hemorrhage from ruptured brain arteriovenous malformations (AVMs) is a major cause of morbidity and mortality. Current treatment involves endovascular embolization with adenosine-induced hypotension. This case report describes the successful intracranial AVM embolization in an adenosine-resistant patient using concomitant administration of nitroglycerin.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Saminderjit Kular, George Tse, Bhavya Pahwa, Tony Goddard, Nayyar Saleem, Sanjoy Nagaraja, Richard Dyde, Tufail Patankar
Summary: The Scepter Mini (SM) is a small dual-lumen micro-balloon that can enhance the safety and efficacy of trans-ophthalmic embolization of anterior cranial fossa (ACF) dural arteriovenous fistulas (dAVFs). In this study, all patients treated with the SM balloon showed complete occlusion of the ACF dAVF without any immediate complications. The MB is a valuable adjunctive tool in protecting the retinal and posterior ciliary arteries against unwanted reflux of the liquid embolic agent.
Article
Clinical Neurology
Kevin Yeboah, Mary-Ann Fares, Paul Hansen, Albert J. Yoo
Summary: This case report presents a patient with a mixed pial-dural arterial venous malformation (AVM) that was effectively treated with a sequential transarterial and trans-cortical venous embolization.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Mohammed Nadeem, Keyur Shah, Mehul Modi, Harsh Deora, G. Bhanumathi, A. R. Prabhuraj, Arivazhagan Arimappamagan, K. V. L. Narasinga Rao, Sampath Somanna, Dwarakanath Srinivas, B. Jeeva
Summary: Gamma Knife radiosurgery (GKRS) has been evaluated as a treatment for partially embolized arteriovenous malformations (AVMs). The study found that complete AVM obliteration was achieved in 60% of patients who underwent GKRS after partial embolization, with an average final obliteration rate of 79% after the combined treatment. This suggests that embolization followed by GKRS is a valid management option for selected complicated AVMs.
Review
Clinical Neurology
Mohamed E. El-Abtah, Jordan C. Petitt, Ahmed Kashkoush, Rebecca Achey, Mark D. Bain, Nina Z. Moore
Summary: Endovascular treatment options for AVM-associated intracranial aneurysms are limited, mainly consisting of aneurysmal coil embolization or parent vessel sacrifice. The choice of embolization strategy depends on factors such as AVM angioarchitecture, rupture status, and adjunct AVM treatments.
WORLD NEUROSURGERY
(2022)
Article
Clinical Neurology
V. Hellstern, P. Bhogal, M. Aguilar Perez, M. Alfter, A. Kemmling, E. Henkes, O. Ganslandt, H. Henkes
Summary: The study focused on the use of adenosine induced cardiac standstill as an adjunct to endovascular embolization of brain AVMs, involving 47 patients with low mortality and risk of permanent neurological deficits. Post-embolization angiographic follow-up revealed that most patients had no residual shunt.
CLINICAL NEURORADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ujjwal Gorsi, Akash Bansal, Sreedhara B. Chaluvashetty, Anupam Lal, Naveen Kalra, Mandeep Kang, Vanita Suri, Manavjit Singh Sandhu
Summary: This hospital-based study retrospectively analyzed 44 females with uncommon causes of pregnancy related haemorrhage who underwent uterine artery embolization. The study found that interventional radiology techniques achieved a technical success rate of 97.7% and a clinical success rate of 95.4% with no major complications.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Editorial Material
Surgery
Michael J. Zobel, Willieford Moses, Ashley Walther, Donuta Nowicki, Lori Howell, Joseph Miller, Chadi Zeinati, Dean M. Anselmo
Summary: This case report highlights the critical importance of a multidisciplinary approach in managing life-threatening complications in patients with capillary malformation-arteriovenous malformation syndrome.
JOURNAL OF VASCULAR SURGERY-VENOUS AND LYMPHATIC DISORDERS
(2021)
Article
Clinical Neurology
Mark D. Johnson, Brittany Staarmann, Mario Zuccarello
Summary: Treating cerebral AVMs involves balancing risk and natural history of the lesion. Individual AVM characteristics such as size and location can affect the risk of hemorrhage. Advancements in treatment strategies and technology have led to decreased morbidity associated with lesion obliteration.
WORLD NEUROSURGERY
(2022)
Article
Clinical Neurology
Christian Paul Stracke, Wolfram Schwindt, Lukas Meyer, Jens Fiehler, Rene Chapot
Summary: This study reports two cases of symptomatic spinal AVMs treated with a transvenous approach using the retrograde pressure cooker technique. The transvenous embolization with liquid embolics may offer advantages in treating certain spinal AVMs, and no clinical complications occurred in these cases.
Article
Cardiac & Cardiovascular Systems
Vanessa F. Schmidt, Max Masthoff, Richard Brill, Peter B. Sporns, Michael Koehler, Victor Schulze-Zachau, Martin Takes, Denis Ehrl, Daniel Puhr-Westerheide, Wolfgang G. Kunz, Mwivano Dunstan Shemwetta, Eric M. Mbuguje, Azza A. Naif, Abizer Sarkar, Jens Ricke, Max Seidensticker, Walter A. Wohlgemuth, Moritz Wildgruber
Summary: The study evaluated the safety and effectiveness of image-guided embolotherapy for extracranial arteriovenous malformations (AVMs) primarily affecting the face. The results showed that image-guided embolotherapy is safe and effective for treating extracranial AVMs of the face.
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
(2022)
Article
Surgery
Xueqiang Fan, Jianbin Zhang, Peng Liu, Zhidong Ye
Summary: This study retrospectively reports the experience of treating hand arteriovenous malformations (AVMs) with embolo/sclerotherapy, which is effective and safe. The post-operative arterial-dominant outflow vein pressure index (AVI) significantly increased, suggesting its potential value in predicting recurrence.
FRONTIERS IN SURGERY
(2023)
Article
Clinical Neurology
Xiangyu Meng, Hongwei He, Peng Liu, Dezhi Gao, Yu Chen, Shibin Sun, Ali Liu, Youxiang Li, Hengwei Jin
Summary: The RBAS scale can be used to predict the obliteration of brain arteriovenous malformations in patients undergoing combined endovascular embolization and gamma knife surgery treatment. Patients with an RBAS >1.5 are more suitable for gamma knife surgery rather than the combined treatment.
FRONTIERS IN NEUROLOGY
(2021)
Review
Clinical Neurology
Theodosios Stamatopoulos, Evangelos Anagnostou, Sotirios Plakas, Konstantinos Papachristou, Panagiotis Lagos, Apostolos Samelis, Shahram Derakhshani, Aristotelis Mitsos
Summary: Carotid cavernous fistulas (CCFs) are rare vascular abnormalities that are often caused by head trauma or aneurysmal rupture. This study reviewed 38 cases of CCF treated with flow diversion devices (FDDs), showing a high success rate of clinical improvement and long-term angiographic occlusion. However, further research with multi-center prospective trials is needed to confirm these findings.
INTERVENTIONAL NEURORADIOLOGY
(2022)
Review
Clinical Neurology
Andreas Karamitros, Theodosis Kalamatianos, George Stranjalis, Evangelos Anagnostou
Summary: Neurovascular compression syndromes (NVCS) occur when a cranial nerve is mechanically irritated by a vascular structure in direct contact with it, resulting in corresponding symptoms. Vestibular paroxysmia is an example of NVCS caused by neurovascular contact between the eighth cranial nerve and a blood vessel. Understanding the unique anatomy of the vestibulocochlear nerve is crucial for studying this syndrome, and imaging techniques play a significant role in demonstrating clinically relevant cases. Based on the reviewed literature, the 3D CISS MRI sequence appears to be the most effective imaging technique for visualizing neurovascular compression of the eighth cranial nerve.
JOURNAL OF NEURORADIOLOGY
(2022)
Article
Clinical Neurology
Dimitrios Tzanetakos, John S. Tzartos, Aigli G. Vakrakou, Marianthi Breza, Georgios Velonakis, Panos Stathopoulos, Eirini Pantou, Ioannis Markakis, Dimitra Papadimitriou, Efstratios Karavasilis, Panagiotis Toulas, Maria-Eleptheria Evangelopoulos, Georgios Koutsis, Maria Anagnostouli, Leonidas Stefanis, Costantinos Kilidireas
Summary: In this study, we used MRI to evaluate cortical and leptomeningeal involvement in MOGAD and RRMS patients. We found that MOGAD patients had significantly fewer cortical lesions compared to RRMS patients, with a slightly higher prevalence of intracortical-subpial lesions in MOGAD. Additionally, leptomeningeal contrast enhancement was observed in some MOGAD patients, which was associated with a higher number of cortical lesions.
MULTIPLE SCLEROSIS JOURNAL
(2022)
Article
Clinical Neurology
Athena Zachou, Danai Palaiologou, Emmanouil Kanavakis, Evangelos Anagnostou
Summary: This study reported a case of a boy with cervical dystonia who was diagnosed with SCA 29 based on the identification of an ITPR1 gene variant through genetic sequencing.
BRAIN & DEVELOPMENT
(2022)
Letter
Clinical Neurology
E. Anagnostou, D. Karathanasis, M. E. Evangelopoulos
Summary: This article reports a 32-year-old woman with relapsing-remitting multiple sclerosis and incomplete remission of right optic neuritis who presented with a unique neuro-ophthalmologic abnormality characterized by spontaneous, pendular, vertical movement of the right eye consistent with the Heimann-Bielschowsky phenomenon. This rare form of dissociated nystagmus is likely to reflect the coexistence of an asymmetric conduction delay in the optic nerve and a strategic network disruption in brainstem gaze holding centres.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Article
Neurosciences
Maria-Eleftheria Evangelopoulos, Georgios Koutsis, Fotini Boufidou, Manolis Markianos
Summary: Cholesterol levels may be associated with disease characteristics in multiple sclerosis, particularly with demyelination and immune response. This study found lower levels of plasma and cerebrospinal fluid cholesterol in patients with multiple sclerosis. Patients with positive oligoclonal bands had even lower cerebrospinal fluid cholesterol levels, which may be related to disease progression and enhanced humoral immune response.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Genetics & Heredity
Minas Tzagournissakis, Emmanouil Foukarakis, Dimitrios Samonakis, Miltiadis Tsilimbaris, Kleita Michaelidou, Lambros Mathioudakis, Anastasios Marinis, Emmanouil Giannakoudakis, Cleanthe Spanaki, Irene Skoula, Sofia Erimaki, Georgios Amoiridis, Georgios Koutsis, Sofia Koukouraki, Kostas Stylianou, Andreas Plaitakis, Panayiotis D. Mitsias, Ioannis Zaganas
Summary: Our study revealed that the prevalence of hATTR in Crete is one of the world's highest. Three different pathogenic TTR variants causing distinct clinical phenotypes were identified in this relatively small population pool.
NEUROLOGY-GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Georgios K. Papadimas, Constantinos Papadopoulos, Kyriaki Kekou, Chrisoula Kartanou, Athina Kladi, Evangelia Nitsa, Christalena Sofocleous, Evangelia Tsanou, Ioannis Sarmas, Stefania Kaninia, Elisabeth Chroni, Georgios Tsivgoulis, Vasilios Kimiskidis, Marianthi Arnaoutoglou, Leonidas Stefanis, Marios Panas, Georgios Koutsis, Georgia Karadima, Joanne Traeger-Synodinos
Summary: This study retrospectively analyzed the medical records of 561 Greek patients with myotonic dystrophies. The findings show similarities in clinical and genetic characteristics between these patients and those from other regions. Muscle weakness is the first symptom in both types of myotonic dystrophies, while multisystemic involvement and cataracts are common manifestations. The study highlights the importance of specialized neuromuscular centers that can provide genetic counseling and a multidisciplinary approach.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Chrisoula Kartanou, Maria Seferiadi, Stella Pomoni, Constantin Potagas, Chrystalena Sofocleous, Joanne Traeger-Synodinos, Leonidas Stefanis, Marios Panas, Georgios Koutsis, Georgia Karadima
Summary: This study investigates the frequency, genotypic and phenotypic profile of FXTAS in two cohorts of Greek patients with late-onset movement disorders and suggests that FXTAS is an important, albeit rare, cause of late-onset movement disorders. It highlights the importance of FMR1 genetic testing in the diagnosis of late-onset movement disorders.
PARKINSONISM & RELATED DISORDERS
(2023)
Letter
Clinical Neurology
Evangelos Anagnostou, Georgios Armenis, Athina Zachou, Ioanna Kouzi
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Zoi Kontogeorgiou, Chrisoula Kartanou, Michail Rentzos, Panagiotis Kokotis, Evangelos Anagnostou, Thomas Zambelis, Elisabeth Chroni, Argyris Dinopoulos, Marios Panas, Georgios Koutsis, Georgia Karadima
Summary: By screening 60 patients with CMT2, dHMN, or HSN in the Greek population, 20 pathogenic or likely pathogenic variants were identified, highlighting the genetic and phenotypic variability of axonal CMT. The diagnostic yield of the customized gene panel in this study compares favorably with other European populations, contributing to the characterization of pathogenic variants related to axonal neuropathies.
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM
(2023)
Article
Clinical Neurology
Stephanie Efthymiou, Luiz E. E. Novis, Georgios Koutsis, Chrysoula Koniari, Reza Maroofian, Valentina Turchetti, Georgios Velonakis, Luiz F. F. Vasconcellos, Salmo Raskin, Varunvenkat M. M. Srinivasan, Alistair T. T. Pagnamenta, Yaramanchanahalli B. B. Arun, Uddhava V. V. Kinhal, Vykuntaraju K. K. Gowda, Helio A. G. Teive, Henry Houlden
Summary: Bi-allelic variants in PRDX3 are associated with early onset slowly progressive cerebellar ataxia, with hyperkinetic and hypokinetic features, cerebellar atrophy, and occasional involvement of olivary and brainstem. We describe a simplex case with a reported variant and two additional cases with novel variants, expanding the phenotypic spectrum of the disease. SCAR32 should be considered in the differential diagnosis of sporadic or recessive childhood and adolescent-onset pure and complex cerebellar ataxia.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Clinical Neurology
Luca Porcu, Mario Fichera, Lorenzo Nanetti, Eliana Rulli, Paola Giunti, Michael H. Parkinson, Alexandra Durr, Claire Ewenczyk, Sylvia Boesch, Wolfgang Nachbauer, Elisabetta Indelicato, Thomas Klopstock, Claudia Stendel, Francisco Javier Rodriguez de Rivera, Ludger Schoels, Zofia Fleszar, Ilaria Giordano, Claire Didszun, Anna Castaldo, Myriam Rai, Thomas Klockgether, Massimo Pandolfo, Joerg B. Schulz, Kathrin Reetz, Caterina Mariotti, EFACTS Study Grp
Summary: This study analyzed the longitudinal changes of SARA scores in 502 patients with Friedreich ataxia over a 4-year period and found significant variability in the speed of score progression. The gait item had the highest annual progression rate.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ioannis Panagiotopoulos, Efstathios Papatheodorou, Aris Anastasakis, Eustathios Kastritis, Polyxeni Gourzi, Zoi Kontogeorgiou, Georgios Koutsis, Georgia Karadima, Maria Koutelou
Summary: This case emphasizes the importance of considering amyloidosis as a differential diagnosis for non-specific symptoms and the need for early diagnosis and management of ATTR-CA.
HELLENIC JOURNAL OF NUCLEAR MEDICINE
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
Zoi Kontogeorgiou, Chrisoula Kartanou, Chrisanthi Tsirligkani, Evangelos Anagnostou, Michail Rentzos, Georgia Karadima, Georgios Koutsis
EUROPEAN JOURNAL OF HUMAN GENETICS
(2022)