期刊
ACTA CIRURGICA BRASILEIRA
卷 30, 期 12, 页码 824-830出版社
ACTA CIRURGICA BRASILEIRA
DOI: 10.1590/S0102-865020150120000006
关键词
Kidney/physiopathology; Acute Kidney Injury/pathology; Proteinuria; Renal Veins; Models, Animal; Rats
类别
PURPOSE: To compare renal dysfunction after right nephrectomy and ligation of the right renal vein with preservation of kidney. METHODS: Animals' weight, pH, density, protein in urine and histological samples of the kidneys were evaluated. Fifteen female rats (Wistar) were divided into three groups. In the control group, right renal vein dissections were performed. In the second group, the right nephrectomy was performed. In the third group, the right renal vein was ligated and the kidney was preserved. Urine samples were taken before, three and seven days after the procedure. On the seventh postoperative day the kidneys were removed to histopathological study. Analysis by Student's t test was performed. RESULTS: weight loss, alterations of urine pH (p<0.05), in specific gravity, proteinuria (p<0.05) were found in groups 2 and 3; hemorrhagic infarction and edema were found after ligation of the right renal vein; changes in the left kidney were also observed on the seventh day. CONCLUSIONS: Unilateral nephrectomy and ligation of the right renal vein produced early changes in glomerular filtration, being more intense in group 3. The contralateral kidney preserved failed to properly maintain renal function in both situations.
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