Article
Behavioral Sciences
Ana Ovsenik, Matej Podbregar, Nikola Lakic, Martin Bresar, Pavle Boskoski, Ivan Verdenik, Andrej Fabjan
Summary: This study aims to evaluate neurovascular coupling in patients with aortic stenosis (AS) using Transcranial Doppler ultrasonography. The results show that patients with AS have higher relative blood flow velocity changes, indicating dysregulation of neurovascular coupling, which could be a contributing factor to cognitive decline.
BRAIN AND BEHAVIOR
(2023)
Article
Endocrinology & Metabolism
Joel S. Burma, Rowan K. Van Roessel, Ibukunoluwa K. Oni, Jeff F. Dunn, Jonathan D. Smirl
Summary: When quantifying neurovascular coupling (NVC) with transcranial Doppler ultrasound (TCD), completing a minimum of five trials is necessary to ensure the validity and reliability of NVC metrics.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Endocrinology & Metabolism
Jodie L. Koep, Bert Bond, Alan R. Barker, Stefanie L. Ruediger, Faith K. Pizzey, Jeff S. Coombes, Tom G. Bailey
Summary: This study aimed to investigate the effects of age and sex on neurovascular coupling (NVC). The results showed a negative relationship between NVC and age in females, while no relationship was found in males. These findings highlight the importance of considering sex-dependent effects of aging when studying cerebrovascular regulation.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Geriatrics & Gerontology
Ana Monteiro, Pedro Castro, Gilberto Pereira, Carmen Ferreira, Farzaneh Sorond, Andrew Milstead, James P. Higgins, Jorge Polonia, Elsa Azevedo
Summary: The study found signs of impaired NVC in hypertensive patients, especially with lower cerebral blood flow velocity increment during visual stimulation, suggesting that hypertensive diabetic patients may have more severe cerebrovascular abnormalities. White matter disease burden did not predict worse NVC, and future research should continue to evaluate the potential of NVC assessment as an early marker for CSVD.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Neurosciences
Anas Rashid, Enrica Laura Santarcangelo, Silvestro Roatta
Summary: This study investigated the relationship between hypnotizability and posterior cerebral artery flow velocity, and found that individuals with higher hypnotizability have lower metabolic demand when facing visual stimulation.
Article
Engineering, Biomedical
Kannaphob Ladthavorlaphatt, Farhaana B. S. Surti, Lucy C. Beishon, Ronney B. Panerai, Thompson G. Robinson
Summary: A similar pattern of cerebral blood velocity (CBv) response has been observed for neurovascular coupling (NVC) assessment with cognitive tasks of varying complexity and duration. This study found that the main contributions to CBv responses were arterial blood pressure (BP) and resistance area product (VRAP), while metabolic demands were also a factor. Further studies are needed to explore different paradigms and their effects on neurovascular coupling.
MEDICAL ENGINEERING & PHYSICS
(2022)
Article
Neurosciences
Yi Yuan, Qianqian Wu, Xingran Wang, Mengyang Liu, Jiaqing Yan, Hui Ji
Summary: Previous studies have shown that transcranial ultrasound stimulation (TUS) can modulate cerebral hemodynamics, neural activity, and neurovascular coupling in resting samples, as well as inhibit neural activity in task samples. However, the effects of TUS on cerebral blood oxygenation and neurovascular coupling in task samples are still unclear.
Article
Obstetrics & Gynecology
Marta M. Martinez-Martinez, Jorge Fernandez-Travieso, Nieves Gomez Munoz, Beatriz Varela Mezquita, Maria Luisa Almarcha-Menargues, Ambrosio Miralles Martinez
Summary: Patients with preeclampsia showed significantly higher intracranial artery mean velocities at diagnosis and within the first week postpartum, which normalized by day 30. Vasoconstriction was present in about one-third of preeclampsia cases, but mostly mild and asymptomatic. Severe preeclampsia was associated with vasoconstriction development.
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH
(2021)
Article
Physiology
Joel S. Burma, Selina Rattana, Nathan E. Johnson, Jonathan D. Smirl
Summary: Previous research has shown that cerebrovascular regulation varies across the cardiac cycle, with greater regulation during systole. This study examined these findings in relation to neurovascular coupling metrics and biological sex. The results showed higher cerebral blood velocity and total activation during systole, but a greater relative increase in cerebral blood velocity during diastole. Women had higher resting cerebral blood velocity and greater diastolic cerebrovascular conductance. Differences between sexes were not significant for systolic measures or NVC response metrics. This study highlights the importance of considering the cardiac cycle and biological sex in studies of cerebrovascular regulation and neurovascular coupling.
JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Review
Neurosciences
Patrick J. Drew
Summary: In the brain, increases in neural activity lead to changes in local blood flow through neurovascular coupling. However, the traditional explanation that increased blood flow supplies the metabolic needs of active neurons is inconsistent with a large body of evidence. Neurovascular coupling is irregular or absent in many brain regions and states, and increased respiration can improve brain oxygenation without changes in blood flow. Simulation studies suggest that low blood flow areas are inevitable due to the brain's vascular architecture and cannot be eliminated by functional hyperemia. This article discusses potential alternative functions of neurovascular coupling such as supplying oxygen for neuromodulator synthesis, regulating brain temperature, signaling to neurons, optimizing cerebral vascular structure, accommodating non-Newtonian blood flow, and driving cerebrospinal fluid circulation.
TRENDS IN NEUROSCIENCES
(2022)
Article
Clinical Neurology
Nicola Merli, Marina Padroni, Cristiano Azzini, Andrea Bernardoni, Carla Marcialis, Valeria Tugnoli, Vincenzo Inchingolo, Maura Pugliatti
Summary: This article presents a case of reversible cerebral vasoconstriction syndrome (RCVS), which is characterized by severe headache, possible acute neurological symptoms, segmental constriction of cerebral arteries, and spontaneous resolution within 3 months. The article highlights the role of transcranial color-coded Doppler (TCCD) imaging in the early detection and monitoring of cerebrovascular diseases.
NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Mausaminben Hathidara, Nidhi H. Patel, Alan Flores, Yosdely Cabrera, Frank Cabrera, Sebastian Koch
Summary: The study found that TCD is useful in detecting vasospasm and monitoring the temporal evolution of RCVS. The number of vessels with abnormal velocities gradually increases, peaks between 13 and 14 days after symptom onset, and normalizes at 60 days.
JOURNAL OF NEUROIMAGING
(2022)
Article
Neurosciences
Xiaoshuai Li, Ning Xu, Chihang Dai, Xuxu Meng, Xiaoyu Qiu, Heyu Ding, Rong Zeng, Han Lv, Pengfei Zhao, Zhenghan Yang, Shusheng Gong, Zhenchang Wang
Summary: This study found altered cerebral blood flow and regional homogeneity in pulsatile tinnitus patients, indicating abnormal neurovascular coupling in these patients. These findings provide new information for understanding the neuropathological mechanisms underlying pulsatile tinnitus.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Clinical Neurology
Mersedeh Bahr-Hosseini, Marom Bikson
Summary: The vascular response to transcranial electrical stimulation (tES) involves both primary and secondary phenomena mediated by four cellular elements, with the nature of the response depending on vessel anatomy and physiology. Further research is needed to explore the mechanisms underlying the vascular response and its impact on neural activity in healthy and pathological conditions.
Review
Biology
Mitsuhiro Fukuda, Alexander J. Poplawsky, Seong-Gi Kim
Summary: High-resolution functional magnetic resonance imaging (fMRI) is gaining popularity due to the availability of ultra-high magnetic fields, but the accuracy of detecting the true location of neuronal activity using increased spatial resolutions remains debatable.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
Tamas Arokszallasi, Eszter Balogh, Laszlo Csiba, Istvan Fekete, Klara Fekete, Laszlo Olah
Article
Acoustics
Eszter Balogh, Tamas Arokszallasi, Laszlo Csiba, Laszlo Olah
JOURNAL OF CLINICAL ULTRASOUND
(2019)
Article
Peripheral Vascular Disease
Katalin Reka Czuriga-Kovacs, Csilla Cecilia Szekeres, Zoltan Bajko, Krisztina Csapo, Laszlo Olah, Maria Tunde Magyar, Sandor Molnar, Daniel Czuriga, Laszlo Kardos, Andrea Bojtor Buraine, Daniel Bereczki, Pal Soltesz, Laszlo Csiba
JOURNAL OF CLINICAL HYPERTENSION
(2019)
Article
Clinical Neurology
Eszter Balogh, Tamas arokszallasi, Katalin Kortefai, Veronika eva Nagy, Laszlo Csiba, Laszlo Olah
Summary: The study found that a BAC close to the legal limit for driving in some European countries inhibits neuronal activity and causes dilation of cerebral arterioles. This cerebral vasodilation may explain the decrease in cerebral vasoreactivity and could contribute to the disturbance of visually evoked flow response after alcohol consumption.
NEUROLOGICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Istvan Szegedi, Rita Orban-Kalmandi, Attila Nagy, Ferenc Sarkady, Nikolett Vasas, Mate Sik, Levente Istvan Lanczi, Ervin Berenyi, Laszlo Olah, Alexandra Crisan, Laszlo Csiba, Zsuzsa Bagoly
Summary: This study aimed to investigate the association between clot burden score (CBS) and hemostasis parameters, and evaluate their impact on thrombolysis outcomes. The results showed that CBS is a significant independent predictor of thrombolysis outcomes.
Article
Clinical Neurology
Lilla Hudak, Attila Csaba Nagy, Sarolta Molnar, Gabor Mehes, Katalin Erzsebet Nagy, Laszlo Olah, Laszlo Csiba
Summary: The incidence of clinical autopsies is declining worldwide, which is unfavorable as there can be discrepancies between clinical and pathological diagnostic findings that may have an impact on treatment or outcome. This study focused on the differences in diagnostic findings between clinical and pathological assessments in patients who had a stroke.
STROKE AND VASCULAR NEUROLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Edina Gabriella Szekely, Rita Orban-Kalmandi, Istvan Szegedi, Eva Katona, Barbara Barath, Katalin Reka Czuriga-Kovacs, Linda Loczi, Nikolett Vasas, Istvan Fekete, Klara Fekete, Ervin Berenyi, Laszlo Olah, Laszlo Csiba, Zsuzsa Bagoly
Summary: This study investigated the levels of alpha 2-plasmin inhibitor (alpha 2-PI) during thrombolysis in acute ischemic stroke (AIS) patients and found that low levels were associated with stroke severity and poor long-term outcomes.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Editorial Material
Acoustics
Laszlo Olah, Marton Olah
Summary: Computed tomography and magnetic resonance imaging are commonly used diagnostic tools in neurosurgery, but intraoperative ultrasound is valuable for real-time imaging of intracranial pathologic processes, control of surgical procedures, assistance in drain or catheter placement, and assessment of residual tumor or hematoma volume during neurosurgical interventions.
JOURNAL OF CLINICAL ULTRASOUND
(2023)
Article
Medicine, General & Internal
Klaudia Borbely, Hanna Balogh, Ilona Blanka Kardos, Daniele Mariastefano Fontanini, Laszlo Olah, Ervin Berenyi, Pal Maurovich-Horvat
Summary: CADASIL is a hereditary vascular disorder inherited in an autosomal dominant manner, with characteristic MRI lesions including symmetric and bilateral white matter periventricular hyperintensities, lacunar infarcts, and cerebral microbleeds.
Meeting Abstract
Clinical Neurology
L. Csiba, A. Nagy, S. Molnar, G. Mehes, K. Nagy, L. Olah, L. Hudak
INTERNATIONAL JOURNAL OF STROKE
(2022)
Meeting Abstract
Clinical Neurology
L. Hudak, A. C. Nagy, G. Mehes, S. Molnar, K. Nagy, L. Olah, L. Csiba
INTERNATIONAL JOURNAL OF STROKE
(2020)
Review
Neurosciences
T. Arokszallasi, L. Olah
NEUROSONOLOGY AND CEREBRAL HEMODYNAMICS
(2018)
Meeting Abstract
Clinical Neurology
E. Balogh, T. Arokszallasi, S. Viski, L. Csiba, L. Olah
EUROPEAN JOURNAL OF NEUROLOGY
(2018)
Review
Critical Care Medicine
Sandor Viski, Laszlo Olah
JOURNAL OF CRITICAL CARE MEDICINE
(2017)
Meeting Abstract
Clinical Neurology
L. Olah, M. Orosz, K. R. Czuriga-Kovacs, S. Viski, L. Csiba
INTERNATIONAL JOURNAL OF STROKE
(2017)