Article
Clinical Neurology
Elisa Visani, Ferruccio Panzica, Roberto Eleopra, Davide Rossi Sebastiano, Paola Lanteri, Grazia Devigili, Sara Dotta, Sara Rinaldo, Silvana Franceschetti
Summary: This study evaluates the effects of MRgFUS treatment on drug-resistant essential tremor by assessing cortico-muscular coherence and the out-strength among cortical areas. The results suggest that in patients who respond well to MRgFUS, the cortico-muscular coherence increases in the motor-area of the treated hemisphere immediately after the treatment, while the reorganization of cortico-muscular coherence and cortico-cortical out-strength towards the cortical motor area occurs with a delay.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Geriatrics & Gerontology
Richard Agren, Amar Awad, Patric Blomstedt, Anders Fytagoridis
Summary: Comparison of cerebellar lobule volumes between ET patients and HCs using automated segmentation revealed smaller volumes in ET patients, opposing the hypothesis of localized atrophy in cerebellar motor areas in ET. However, the possibility of cerebellar pathophysiology in ET was not ruled out. Further prospective investigations using alternative neuroimaging modalities may help elucidate the pathophysiology of ET and guide diagnostic and therapeutic approaches.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Neurosciences
Jan Kujala, Sasu Makela, Pauliina Ojala, Jukka Hyona, Riitta Salmelin
Summary: Large-scale integration of information across cortical structures is crucial for supporting human cognitive processing. During naturalistic reading, reading tasks are associated with widespread increases in cortico-cortical coherence and facilitate directed neural interactions across a wide range of frequencies.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Chloe C. Casagrande, Brandon J. Lew, Brittany K. Taylor, Mikki Schantell, Jennifer O'Neill, Pamela E. May, Susan Swindells, Tony W. Wilson
Summary: The study found that both HIV-infected individuals and controls exhibit similar somatosensory gating, but there are differences in the strength of spontaneous cortical activity in the left postcentral gyrus. Interestingly, HIV-infected individuals also showed a significant reduction in cortical thickness within the same tissue. Further analysis indicated that this reduction was significantly correlated with CD4 nadir levels and mediated the relationship between HIV infection and spontaneous cortical activity in the left postcentral gyrus.
HUMAN BRAIN MAPPING
(2021)
Article
Clinical Neurology
Nahid Zokaei, Andrew J. Quinn, Michele T. Hu, Masud Husain, Freek van Ede, Anna Christina Nobre
Summary: The study found a significant reduction in beta cortico-muscular coherence in individuals with Parkinson's disease, which was closely related to motor symptoms. This highlights cortico-muscular coherence as a potential neural marker of Parkinson's disease pathology, with implications for monitoring disease progression and evaluating the efficacy of new treatments.
BRAIN COMMUNICATIONS
(2021)
Article
Neurosciences
Patti Nijhuis, Peter E. Keller, Sylvie Nozaradan, Manuel Varlet
Summary: Research shows that the synchronization between cortical and muscular activity in the beta frequency band becomes time-locked to taps executed in synchrony with visual and auditory stimuli, highlighting the critical role of beta band neural oscillations in cortical-muscular coupling underlying sensorimotor synchronisation.
Article
Neurosciences
Jin Hua Zheng, Wen Hua Sun, Jian Jun Ma, Zhi Dong Wang, Qing Qing Chang, Lin Rui Dong, Xiao Xue Shi, Ming Jian Li, Qi Gu, Si Yuan Chen, Dong Sheng Li
Summary: The PIGD and TD motor subtypes of Parkinson's disease have different clinical manifestations. This study found that PIGD patients had smaller gray matter volume in the medial frontal gyrus, which was negatively correlated with the severity of PIGD symptoms. Additionally, PIGD patients showed stronger functional connectivity between the right superior frontal gyrus and other brain regions. These findings help explain the clinical differences between the two motor subtypes of PD.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
S. Franceschetti, E. Visani, D. Rossi Sebastiano, D. Duran, T. Granata, R. Solazzi, G. Varotto, L. Canafoglia, F. Panzica
Summary: The study found that Perampanel can reduce the severity of action myoclonus by decreasing cortico-muscular coherence and restoring the leadership of cortical regions. This highlights mechanisms suitable for treating myoclonus and emphasizes the role of reduced local synchronization and better control of distant synaptic effects.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Clinical Neurology
Bo Wang, Haotian Wang, Zhidong Cen, Jiachen Yuan, Dehao Yang, Xinhui Chen, Fei Xie, Lebo Wang, Sheng Wu, Zhiyuan Ouyang, Yu-Feng Zang, Wei Luo
Summary: This study investigated white matter structural changes in patients with familial cortical myoclonic tremor with epilepsy (FCMTE) and their relationship with clinical and electrophysiological features. The results showed widespread reductions in white matter values in FCMTE patients, including in the commissural, projection, and association fibers. Increased white matter volume was found in the right cerebellum and sagittal stratum, while decreased values were detected in the sagittal stratum. Furthermore, there was a positive correlation between the volume of the right cerebellum and somatosensory-evoked potential amplitude.
Article
Clinical Neurology
Silvana Franceschetti, Elisa Visani, Ferruccio Panzica, Antonietta Coppola, Pasquale Striano, Laura Canafoglia
Summary: This study aimed to identify suitable measures to explain the different severity of Familial Adult Myoclonic Epilepsy (FAME) compared to Progressive Myoclonic Epilepsy (PMEs) and detect the signature of the distinctive brain networks. The results showed that FAME2 patients had better localized CMC and increased betweenness-centrality (BC) compared to EPM1 patients, which played a role in improving and spreading myoclonus. Additionally, the brain network impairments were more severe in FAME2 patients.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Neurosciences
Alexandrine Morand, Shailendra Segobin, Gregory Lecouvey, Julie Gonneaud, Francis Eustache, Geraldine Rauchs, Beatrice Desgranges
Summary: This study found that older participants had lower gray matter volumes in several brain areas, but these did not correlate with TBPM performance. On the other hand, a decline in white matter integrity was correlated with TBPM performance, indicating a disconnection process that occurs in aging and contributes to cognitive decline.
Article
Biology
Shi-Chun Bao, Kenry W. C. Leung, Kai-Yu Tong
Summary: NMES was found to improve cortico-muscular interaction between the ipsilesional brain and paretic lower limbs, indicating potential applications of EEG-EMG in post-stroke motor rehabilitation.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Multidisciplinary Sciences
Qing Wang, Meshal Aljassar, Nikhil Bhagwat, Yashar Zeighami, Alan C. Evans, Alain Dagher, G. Bruce Pike, Abbas F. Sadikot, Jean-Baptiste Poline
Summary: This study analyzed the structural differences in the cerebellum in ET using a large dataset and found that the results varied with different methods, suggesting that the current estimation of cerebellar involvement in ET may be overemphasized in MRI studies. It highlights the importance of methods sensitivity analysis on results interpretation.
SCIENTIFIC REPORTS
(2023)
Article
Neuroimaging
Thomas A. W. Bolton, Dimitri Van De Ville, Jean Regis, Tatiana Witjas, Nadine Girard, Marc Levivier, Constantin Tuleasca
Summary: In this study, the morphometric underpinnings of variability in essential tremor (ET) were explored. It was found that ET patients had higher variance in surface area in the left lingual and caudal anterior cingulate cortices, and lower variance in mean curvature in the right superior temporal cortex, pars triangularis, left supramarginal gyrus, and bilateral paracentral gyrus. The study also identified clinical characteristics associated with the heterogeneity of ET, such as head tremor and impairments in daily life activities.
NEUROIMAGE-CLINICAL
(2023)
Article
Neurosciences
Saroj Bista, Amina Coffey, Antonio Fasano, Teresa Buxo, Matthew Mitchell, Eileen Rose Giglia, Stefan Dukic, Mark Heverin, Muthuraman Muthuraman, Richard G. Carson, Madeleine Lowery, Orla Hardiman, Lara McManus, Bahman Nasseroleslami
Summary: Primary lateral sclerosis (PLS) is characterized by the degeneration of upper motor neurons (UMNs) in the primary motor area (M1). This study used cortico-muscular coherence (CMC) to examine the oscillatory drives between cortical regions and muscles during a motor task in PLS. The findings showed atypical engagement of both contralateral and ipsilateral M1 during motor activity in PLS, indicating pathogenic and adaptive/compensatory alterations in neural activity.
