Article
Clinical Neurology
Dejan Georgiev, Marusa Mencinger, Robert Rajnar, Polona Music, Mitja Benedicic, Dusan Flisar, Roman Bosnjak, Jan Mehrkens, Zvezdan Pirtosek, Kai Boetzel, Maja Trost
Summary: A four-year longitudinal study found that bilateral stimulation of the subthalamic nucleus has beneficial effects on non-motor symptoms in patients with advanced Parkinson's disease, but may not be effective in all domains. Further research with larger cohorts and longer follow-up is needed to better understand the long-term effects of this treatment.
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Neurosciences
Francesco Bove, Danilo Genovese, Martina Petracca, Tommaso Tufo, Danila Pisani, Maria Rita Lo Monaco, Anna Rita Bentivoglio, Paolo Calabresi, Carla Piano
Summary: This study aimed to assess the incidence rate and risk factors for sialorrhea in long-term follow-up of patients with advanced Parkinson's disease. The findings indicate that deep brain stimulation (DBS) does not increase the risk of developing sialorrhea.
NPJ PARKINSONS DISEASE
(2022)
Article
Clinical Neurology
Nico Golfre Andreasi, Luigi Michele Romito, Roberta Telese, Roberto Cilia, Antonio Emanuele Elia, Alessio Novelli, Giovanni Tringali, Giuseppe Messina, Vincenzo Levi, Grazia Devigili, Sara Rinaldo, Angelo Amato Franzini, Roberto Eleopra
Summary: STN-DBS has a long-lasting effect on motor complications in both male and female PD patients, but there may be slight differences in certain aspects that require further investigation.
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Bowen Chang, Chen Ni, Jiaming Mei, Chi Xiong, Peng Chen, Manli Jiang, Chaoshi Niu
Summary: This study investigated the relationship between uric acid levels and improvement of motor symptoms in patients with Parkinson's disease after subthalamic nucleus deep brain stimulation. The results showed a non-linear correlation between uric acid levels and motor symptom improvement.
NEUROLOGICAL SCIENCES
(2023)
Article
Neurosciences
Matteo Conti, Alessandro Stefani, Roberta Bovenzi, Rocco Cerroni, Elena Garasto, Fabio Placidi, Claudio Liguori, Tommaso Schirinzi, Nicola B. Mercuri, Mariangela Pierantozzi
Summary: In this study, the short-term effects of subthalamic nucleus deep-brain stimulation (STN-DBS) on beta-band cortical functional connectivity (FC) were investigated in Parkinson's disease (PD) patients. The results showed that PD patients exhibited widespread cortical hyperconnectivity in beta bands, and STN-DBS could acutely reduce beta FC primarily in cortical regions involved in basal ganglia-cortical circuits.
Article
Clinical Neurology
Thomas Koeglsperger, Jan H. Mehrkens, Kai Boetzel
Summary: The study investigated subthalamic beta band peak amplitudes in a Parkinson's disease patient over time using a novel neurostimulator. A double-peaked beta activity was found on both sides, with stimulation and physical activity resulting in decreased beta band amplitude and a previously unrecognized peak at 13 Hz in the right hemisphere. These findings support further research on distinct peaks in the beta band as potential closed-loop biomarkers.
ACTA NEUROCHIRURGICA
(2021)
Article
Behavioral Sciences
Ganhua Luo, Xinchong Shi, LuLu Jiang, Lei Wu, Chang Yi, Wenbiao Xian, Yanmei Liu, Fuhua Wen, Hao Qian, Jie Chen, Xiaoli Fu, Jinlong Liu, Xiangsong Zhang, Ling Chen
Summary: Parkinson's disease is a neurodegenerative disorder affecting millions of people worldwide. Deep brain stimulation surgery has been shown to improve motor symptoms, depression, and quality of life in PD patients. However, it does not prevent the decrease of dopamine transporter in striatal areas.
BRAIN AND BEHAVIOR
(2023)
Article
Clinical Neurology
Asra Askari, Brandon J. Zhu, Xiru Lyu, Kelvin L. Chou, Parag G. Patil
Summary: The study found that STN DBS has differential effects on rigidity in upper and lower extremities in patients with Parkinson's disease. However, there was no significant difference in tremor or bradykinesia between the upper and lower extremities. Even though there were slight differences in the maximal-effect loci for stimulation between the upper and lower extremities, they were not statistically resolved.
PARKINSONISM & RELATED DISORDERS
(2022)
Article
Clinical Neurology
Mylene Meyer, Sophie Colnat-Coulbois, Solene Frismand, Pierre Vidailhet, Pierre-Michel Llorca, Elisabeth Spitz, Raymund Schwan
Summary: The study found that while there was no overall increase in social adjustment scores, patients with Parkinson's disease eligible for neurosurgery should undergo preoperative psychosocial therapy to define their expectations and help them in psychological restructuring. This type of therapy could be complementary to psychoeducation, helping to prevent postoperative disappointment and social maladjustment.
WORLD NEUROSURGERY
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Julio B. Guimaraes, Renan N. Chemin, Flavia F. Araujo, Thomas M. Link, Flavio D. Silva, Alexandre Bitar, Marcelo A. C. Nico, Alipio G. O. Filho
Summary: Meniscal root tears can have significant effects on meniscal biomechanics and kinematics, potentially leading to the development of knee osteoarthritis. Arthroscopic techniques have been developed to repair these tears and restore normal joint movement, with the aim of delaying the onset of osteoarthritis. Familiarity with diagnostic criteria and surgical techniques is important for radiologists in reporting preoperative and postoperative MRI findings accurately.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2022)
Article
Psychiatry
Ilse M. J. Kant, Jeroen de Bresser, Simone J. T. van Montfort, Henri J. M. M. Mutsaerts, Theo D. Witkamp, Marc Buijsrogge, Claudia Spies, Jeroen Hendrikse, Arjen J. C. Slooter
Summary: The study aimed to investigate the neural substrate of postoperative delirium by examining the association between preoperative brain MRI features and the occurrence of delirium after major surgery. While preoperative cortical brain infarcts and more complex white matter hyperintensity shape showed potential associations with postoperative delirium, brain volumes, white matter hyperintensity volume, and cerebral perfusion were not found to be associated with delirium occurrence.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2021)
Article
Geriatrics & Gerontology
Ilse M. J. Kant, Arjen J. C. Slooter, Myriam Jaarsma-Coes, Simone J. T. van Montfort, Theo D. Witkamp, Wietze Pasma, Jeroen Hendrikse, Jeroen de Bresser
Summary: This study identified different MRI brain phenotypes in older patients undergoing major elective surgery, and found that individuals with multi-burden pathology are at higher risk of developing postoperative delirium. Understanding these MRI brain phenotypes can provide insights into the structural correlates of predisposition to postoperative delirium.
NEUROBIOLOGY OF AGING
(2021)
Article
Biochemistry & Molecular Biology
Giulia Di Rauso, Francesco Cavallieri, Isabella Campanini, Annalisa Gessani, Valentina Fioravanti, Alberto Feletti, Benedetta Damiano, Sara Scaltriti, Elisa Bardi, Maria Giulia Corni, Francesca Antonelli, Vittorio Rispoli, Francesca Cavalleri, Maria Angela Molinari, Sara Contardi, Elisa Menozzi, Annette Puzzolante, Jessica Rossi, Stefano Meletti, Giuseppe Biagini, Giacomo Pavesi, Valerie Fraix, Mirco Lusuardi, Alessandro Fraternali, Annibale Versari, Carla Budriesi, Elena Moro, Andrea Merlo, Franco Valzania
Summary: This study evaluated the long-term effects of STN-DBS on freezing of gait (FOG) in advanced Parkinson's Disease (PD). The results showed that FOG significantly improved in the on-stimulation/off-medication condition compared to the off-stimulation/off-medication condition, highlighting the possible beneficial long-term effects of STN-DBS on FOG.
Review
Clinical Neurology
Jingya Miao, Mohamed Tantawi, Victoria Koa, Ashley B. Zhang, Veronica Zhang, Ashwini Sharan, Chengyuan Wu, Caio M. Matias
Summary: fMRI can be used in patients with PD-DBS to study the effects of stimulation on brain networks and the mechanism of action. Although further validation of safety and advances in imaging techniques are needed, fMRI may play an increasingly important role in improving clinical care and providing individualized treatment.
FRONTIERS IN NEUROLOGY
(2022)
Article
Computer Science, Artificial Intelligence
Xinchun Cui, Yubang Xu, Yue Lou, Qinghua Sheng, Miao Cai, Liying Zhuang, Gang Sheng, Jiahu Yang, Jinxing Liu, Yue Feng, Xiaoli Liu
Summary: In this study, a FResnet18 model is proposed to classify MRI images of PD and HC by fusing image texture features with deep features. The results show that the model can successfully differentiate between PD and HC with high accuracy, and it outperforms existing approaches.
INTERNATIONAL JOURNAL OF INTELLIGENT SYSTEMS
(2022)
Review
Clinical Neurology
Ji-Hyun Choi, Chaewon Shin, Han-Joon Kim, Beomseok Jeon
Summary: This review examined the placebo response in patients with degenerative cerebellar ataxias (CAs). The findings showed varying degrees of improvement in objective ataxia scales in the placebo groups. The study highlights the importance of considering placebo response in designing, analyzing, and interpreting clinical trials and in clinical practice for CA patients.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Hui-Jun Yang, Han-Joon Kim, Yu Jin Jung, Dallah Yoo, Ji-Hyun Choi, Jin Hee Im, Beomseok Jeon
Summary: This study conducted a data-driven subgroups analysis of patients with early multiple system atrophy (MSA) using latent class analysis (LCA). The results identified at least three different subgroups in early MSA. This is the first identification of disease subtypes in early MSA based on data, revealing heterogeneity within MSA-P and MSA-C subtypes.
PARKINSONISM & RELATED DISORDERS
(2022)
Article
Clinical Neurology
Jung Hwan Shin, Kyung Ah Woo, Chan Young Lee, Seung Ho Jeon, Han-Joon Kim, Beomseok Jeon
Summary: This study developed an automated and objective tool to evaluate postural abnormalities in PD patients, using a deep learning-based pose-estimation algorithm. The results showed that the automatically measured postural abnormalities were in excellent agreement with manual labeling methods.
JOURNAL OF MOVEMENT DISORDERS
(2022)
Letter
Clinical Neurology
Hee Jin Chang, Ryul Kim, Minchae Kim, Jangsup Moon, Man Jin Kim, Han-Joon Kim
JOURNAL OF MOVEMENT DISORDERS
(2022)
Letter
Clinical Neurology
Jae Young Joo, Jihoon G. Yoon, Seoungbok Lee, Jangsup Moon, Han-Joon Kim
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Hee Jin Chang, Han-Joon Kim, Kyung Ah Woo, Jung Hwan Shin, Ki-Young Jung
Summary: This study evaluated the effect of CPAP on the quality of life in patients with MSA and their caregivers. The results showed that CPAP treatment had a beneficial effect on sleep complaints and QoL of the patients and improved caregivers' QoL.
SLEEP AND BREATHING
(2023)
Editorial Material
Clinical Neurology
Kyung Ah Woo, Han-Joon Kim, Beomseok Jeon
JOURNAL OF MOVEMENT DISORDERS
(2023)
Letter
Clinical Neurology
Hyoshin Son, Jihoon G. Yoon, Man Jin Kim, Jangsup Moon, Han-Joon Kim
JOURNAL OF MOVEMENT DISORDERS
(2023)
Letter
Clinical Neurology
Jae Young Joo, Hee Jin Chang, Kyung Ah Woo, Han Sang Lee, Han-Joon Kim
PARKINSONISM & RELATED DISORDERS
(2023)
Letter
Clinical Neurology
Chaewon Shin, Seong-Ik Kim, Sung-Hye Park, Jung Hwan Shin, Chan Young Lee, Han-Joon Kim, Hyuk-Joon Lee, Seong-Ho Kong, Yun-Suhk Suh, Han-Kwang Yang, Beomseok Jeon
JOURNAL OF MOVEMENT DISORDERS
(2023)
Letter
Clinical Neurology
Sangmin Park, Jung Hwan Shin, Seung Ho Jeon, Chan Young Lee, Han-Joon Kim, Beomseok Jeon
JOURNAL OF MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Hee Jin Chang, Jiae Kim, Jae Young Joo, Han-Joon Kim
Summary: This study aimed to evaluate the feasibility and efficacy of online video-call speech therapy for patients with Parkinson's disease. By comparing two groups of patients who received online speech therapy and in-person therapy, it was found that online video-call therapy was as effective as traditional therapy in improving speech difficulties and was feasible.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Clinical Neurology
Chan Young Lee, Hyesook Kim, Han-Joon Kim, Jung Hwan Shin, Hee Jin Chang, Kyung Ah Woo, Ki-Young Jung, Oran Kwon, Beomseok Jeon
Summary: The study found no significant association between diet quality and the probability of developing Parkinson's disease and its risk or prodromal markers in patients with isolated rapid eye movement (REM) sleep behavior disorder (iRBD). However, in patients under the age of 70, legume consumption was negatively correlated with the probability of developing Parkinson's disease, and patients with fewer prodromal markers had significantly higher legume consumption.
PARKINSONISM & RELATED DISORDERS
(2023)
Letter
Clinical Neurology
Hee Jin Chang, Kyung Ah Woo, Han-Joon Kim, Beomseok Jeon
JOURNAL OF CLINICAL NEUROLOGY
(2023)
Article
Clinical Neurology
Jung-Ick Byun, Kwang Su Cha, Minah Kim, Woo-Jin Lee, Han Sang Lee, Jun-Sang Sunwoo, Jung-Won Shin, Tae-Joon Kim, Jin-Sun Jun, Han-Joon Kim, Won Chul Shin, Carlos H. Schenck, Sang Kun Lee, Ki-Young Jung
Summary: This study suggests that cortical cholinergic activity may be impaired in iRBD patients, and functional connectivity between the nucleus basalis of Meynert and posterior regions may play a central role in the cognitive function of these patients.
JOURNAL OF CLINICAL NEUROLOGY
(2022)