Article
Pharmacology & Pharmacy
Mani Ordoubadi, Florence K. A. Gregson, Hui Wang, Mark Nicholas, Sandra Gracin, David Lechuga-Ballesteros, Jonathan P. Reid, Warren H. Finlay, Reinhard Vehring
Summary: The study extensively investigated the particle formation of L-leucine through three experimental methods and theory, providing insights into predicting the properties of spray-dried particles. The research enhanced the understanding of the particle formation process and proposed a model for predicting the properties of spray-dried particles.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Engineering, Chemical
Xiaoqian Ma, Shen Yan, Shengyu Zhang, Quanyi Yin, Xiaodong Chen, Winston Duo Wu
Summary: This study aimed to investigate the impact of component size and solubility on the surface composition of uniform two-component particles fabricated by a micro-fluidic spray dryer. Results showed different enrichment degrees of components on the particle surfaces, and discussed the potential formation mechanism and effects of surface composition on particle wettability, providing new guidance for manufacturing functional spray dried powders with various components.
Article
Engineering, Chemical
Aijun Di, Shengyu Zhang, Xuan Liu, Zhenbo Tong, Siping Sun, Zengchao Tang, Xiao Dong Chen, Winston Duo Wu
Summary: This study developed microparticles with improved solubility and antioxidant activity using resveratrol as a model drug. Chitosan played a key role in adjusting drug release behavior and enhancing mucoadhesion properties.
Article
Engineering, Chemical
Priscila Dayane de Freitas Santos, Larissa do Val Siqueira, Carmen Cecilia Tadini, Carmen Silvia Favaro-Trindade
Summary: The application of biopolymers and feasible technologies is crucial for large-scale food package production and reducing plastic pollution. This study aimed to incorporate tucuma oil (TO) and TO microparticles into cassava starch sheets and evaluate their effect on physical, optical, and mechanical properties. The sheets enriched with TO and microparticles presented yellow color and higher opacity compared to the control. The presence of large microparticles caused discontinuity of the sheet structure and decreased mechanical strength.
Article
Food Science & Technology
Maria Isabel Landim Neves, Mayara de Souza Queiros, Rodolfo Lazaro Soares Viriato, Ana Paula Badan Ribeiro, Mirna Lucia Gigante
Summary: This study investigated the stability of LMP made with AMF and FHSBO during storage at different temperatures, finding that storage temperature and lipid base influenced the polymorphic form of LMP, and an increase in FHSBO concentration can enhance polymorphic stability.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Mani Ordoubadi, Florence K. A. Gregson, Hui Wang, Nicholas B. Carrigy, Mark Nicholas, Sandra Gracin, David Lechuga-Ballesteros, Jonathan P. Reid, Warren H. Finlay, Reinhard Vehring
Summary: The study investigated the formation of trileucine-containing spray-dried microparticles for pulmonary delivery. It was found that adding a small amount of trileucine could significantly lower particle densities, and particle morphology and surface composition varied with different trileucine concentrations.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Chemistry, Applied
Alberto Baldelli, Diana Yumeng Liang, Yigong Guo, Anubhav Pratap-Singh
Summary: Iron fortification through spray-dried microparticles can alleviate iron deficiency. The optimal formulation consists of equal weight percentages of iron compound, bulk material, and wall material, resulting in small particle size and high bioavailability. Encapsulation of iron gluconate reduces toxicity, while encapsulated iron fumarate decreases absorption.
FOOD HYDROCOLLOIDS
(2023)
Article
Chemistry, Multidisciplinary
Marie Mettler, Adrien Dewandre, Nikolay Tumanov, Johan Wouters, Jean Septavaux
Summary: This work extends the application scope of microfluidic-based crystallization methods by introducing solid microcapsules, and demonstrates the potential of this method for compound characterization.
CHEMICAL COMMUNICATIONS
(2023)
Article
Pharmacology & Pharmacy
Anna Lechanteur, Eva Gresse, Luisa Orozco, Erwan Plougonven, Angelique Leonard, Nicolas Vandewalle, Geoffroy Lumay, Brigitte Evrard
Summary: Particle engineering technologies can be used to produce new inhaled powders with improved lung deposition. By optimizing the production process and powder composition, higher fine particle fractions can be achieved.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Tingting Li, Bo Wan, Rajan Jog, Antonio Costa, Diane J. Burgess
Summary: This study utilized a central composite design approach to investigate the sensitivity of yield and particle size of spray-dried pectin microparticles towards different input parameters. By optimizing the spray drying conditions, a maximum yield was achieved with relatively consistent particle size range. The yield prediction model was validated using octreotide acetate as a representative peptide, showing changes in surface roughness and melting enthalpy of pectin microparticles.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Engineering, Chemical
I. D. Perez-Landa, I. Bonilla-Landa, J. L. Monribot-Villanueva, M. Ramirez-Vazquez, R. Lasa, W. Ramos-Torres, J. L. Olivares-Romero, F. Barrera-Mendez
Summary: This study developed a photoprotective system for intake administration using chitosan and sodium lignosulfonate as encapsulating materials for the photosensitive spinosad. In vitro release studies showed high stability to photodegradation and appropriate insecticide release rate for the developed bioinsecticide carrier system.
Article
Engineering, Chemical
Chao Shang, Zhangxiong Wu, Winston Duo Wu, Xiao Dong Chen
Summary: Binder-free zeolite microspheres with hierarchical porosities were prepared by combining spray-drying encapsulation and steaming transformation. The morphology, structure, and crystallinity of the resulted zeolites can be controlled by adjusting the water/gel mass ratio and SAC time. The zeolite microspheres possess surface buckled morphologies, uniform large particle sizes, hierarchical porosities, good mechanic strength, and intrinsic strong acid sites, demonstrating enhanced catalytic activity and stability in acid catalytic aldol condensation.
CHEMICAL ENGINEERING SCIENCE
(2021)
Article
Pharmacology & Pharmacy
Paraskevi Kyriaki Monou, Eleftherios G. Andriotis, Nikolaos Bouropoulos, Emmanuel Panteris, Melpomeni Akrivou, Ioannis S. Vizirianakis, Zeeshan Ahmad, Dimitrios G. Fatouros
Summary: In this study, a multi-component system for pulmonary delivery was developed, including engineered microparticles and investigation of two active pharmaceutical ingredients. All formulations exhibited satisfactory performance and drug release. Physicochemical properties evaluation showed appropriate morphology and aerodynamic performance of the microparticles, with release of the active ingredients monitored in simulated lung fluid.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Carlos Rodriguez-Nogales, Joke Meeus, Gaby Thonus, Sam Corveleyn, Eric Allemann, Olivier Jordan
Summary: Nano- and micro-technologies offer a solution for drugs with low solubility, improving their chances of success in pre-clinical and clinical stages. This study presents a unique design approach using drug nanocrystals loaded in extended release polymeric microparticles for local treatment of osteoarthritis. The results demonstrate the successful development of a formulation with high drug encapsulation rates, allowing for continuous and controlled drug release over four months.
Article
Pharmacology & Pharmacy
Ana Juric Simcic, Iva Erak, Biserka Cetina Cizmek, Anita Hafner, Jelena Filipovic-Grcic
Summary: The aim of this study was to investigate the relationship between the composition of the W/O emulsion used in the spray-drying process and the quality of the dry polymer particles obtained. It was found that emulsions containing Poloxamer (R) 407 and sorbitan monooleate released the drug rapidly, while emulsions without additives or with chitosan released the drug slowly.
Article
Engineering, Chemical
Ri Zhang, Shasha Zhang, Mengyan Ding
Summary: A thin liquid film method is proposed to evaluate sand erosion in annular flow. This method considers the direct interaction between the liquid film and gas core, as well as the entrainment and deposition of droplets. The erosion rate is calculated by considering the effects of liquid entrainment and particle velocity decay. The method is fully verified by comparing with experimental data.
Article
Engineering, Chemical
Yu Suo, Xianheng Su, Wenyuan He, Xiaofei Fu, Zhejun Pan
Summary: This research investigates the mechanical properties of sandstone-shale composite through orthogonal experimental method and discrete element simulation. The results show that different lithologies and thickness ratios can affect the strength and fracture mode of the composite rock samples.
Article
Engineering, Chemical
Maurizio Troiano, Andrea El Hassanin, Roberto Solimene, Alessia Teresa Silvestri, Fabrizio Scala, Antonino Squillace, Piero Salatino
Summary: This study investigates the potential of Fluidized Bed Finishing (FBF) for square flat AlSi10Mg specimens manufactured via Laser-Powder Bed Fusion (L-PBF) additive manufacturing technology. The results show that good finishing can be achieved using rotation-assisted tests, with a maximum reduction of surface roughness by 67%. Steel particles are found to be the most effective bed material.
Review
Engineering, Chemical
Ningbo Song, Wanzhong Yin, Jin Yao
Summary: Seawater's dissolved salts and minerals have various effects on the flotation process, including influencing the characteristics and behavior of flotation factors, as well as affecting the surface of sulfide minerals. In most cases, seawater has adverse effects on the flotation of sulfide minerals, but these effects can be mitigated by adjusting the reagents.
Article
Engineering, Chemical
Kaiqiao Wu, Shuxian Jiang, Victor Francia, Marc-Olivier Coppens
Summary: In rectangular and cylindrical annular fluidized beds, pulsating gas flow can create regular bubble patterns, overcoming challenges seen in conventional units. This study provides new opportunities for modularization of fluidized bed operations.
Article
Engineering, Chemical
Shuo Li, Huili Zhang, Jan Baeyens, Miao Yang, Zehao Li, Yimin Deng
Summary: The paper assesses the behavior of cohesive Geldart C-type particles when fluidized by air with the aid of vibration. It determines that mechanical vibration is a simple and effective method to improve the fluidity of cohesive particles during fluidization.
Article
Engineering, Chemical
Zhenfei Feng, Qingyuan Zhang, Shanpan Liang, Zhenzhou Li, Fangwen Guo, Jinxin Zhang, Ding Yuan
Summary: A new micro/mini-channel heat sink (MCHS) with a combined structure of longitudinal and transverse vortex generators is designed, using Al2O3 nanofluid as the working medium. The study explores the effects of transverse vortex generator shape and longitudinal vortex generator angle on the hydraulic and thermal characteristics, comprehensive performance, entropy generation, and exergy efficiency. The results show that the triangular transverse vortex generator improves the comprehensive performance and exergy efficiency. Combined with the longitudinal vortex generator, the MCHS achieves the best comprehensive performance, entropy generation, and exergy efficiency when the Reynolds number is 742.
Article
Engineering, Chemical
Kostas Giannis, Christoph Thon, Guoqing Yang, Arno Kwade, Carsten Schilde
Summary: This study presents a 3D convolutional neural network (3D-CNN) methodology for generating realistic 3D models of particles. The method trains on 2D projections of particle images to predict their 3D shapes, and evaluates the accuracy of the predictions using Fourier shape descriptors (FSDs). This methodology has wide applications in particle shape analysis.
Article
Engineering, Chemical
Zheng-qing Zhou, Lu-jia Chai, Yu-long Zhang, Ya-bin Wang, Ze-chen Du, Tian-yi Wang, Yu-zhe Liu
Summary: The dynamic oxidation and shell-breaking processes of aluminum nanoparticles (ANPs) during heating were studied using in situ transmission electron microscopy. The results revealed that the changes in shell thickness can be divided into three stages, and the active aluminum content of ANP decreased before shell-breaking.
Article
Engineering, Chemical
Fulei Chen, Huaqing Ma, Zihan Liu, Lianyong Zhou, Yongzhi Zhao
Summary: A particle breakage model based on the particle replacement scheme, using the polyhedral model to describe particles, is proposed in this work to accurately describe the breakage of a large number of particles. Additionally, a fast-cutting algorithm is proposed to reproduce the size distribution of progeny particles determined by the breakage model. The validation and simulation results show satisfactory accuracy, efficiency, and stability of the algorithm.
Review
Engineering, Chemical
Matteo Errigo, Christopher Windows-Yule, Massimiliano Materazzi, Dominik Werner, Paola Lettieri
Summary: Gas-solid fluidized-bed systems have advantages in terms of chemical reaction efficiency and temperature control, making them widely used in industrial applications. However, the design, scale-up, and optimization of these complex units are limited by the lack of deep physical understanding. Non-invasive and non-intrusive diagnostic techniques provide a way for researchers to study these systems without affecting the flow field or directly contacting the medium under study.
Article
Engineering, Chemical
Saeed Fateh, Mohammad Behshad Shafii, Mohammad Najafi, Cyrus Aghanajafi
Summary: Applying a magnetic field to ferrofluids alters their flow characteristics and enhances heat transfer. Through visualization and quantitative investigation, it is found that the magnetic field influences the flow patterns and velocity profiles, improving fluid mixing and vorticity magnitude.
Article
Engineering, Chemical
Lei Gao, Bingbing Wei, Xiaochuan Hu, Zaifeng Yao, Yiwen Fang, Xuejian Gao
Summary: In this study, a numerical model of sand triaxial test was established using discrete element software PFC3D, and an indoor triaxial test was conducted to calibrate the numerical model. The influence of microscopic parameters on the macroscopic mechanical response of sand was analyzed. The results showed that the friction coefficient had the greatest impact on the peak strength and residual strength of the sand's stress-strain curve, and it was positively correlated. The normal tangential stiffness ratio was negatively correlated, while the porosity and boundary flexibility stiffness had minimal influence on it.
Article
Engineering, Chemical
Xuan Liu, Jie Gong, Kai Jiang, Xiaojuan Lai, Yu Tian, Kang Zhang
Summary: This study aimed to improve the performance of lignite coal water slurries (CWSs) by synthesizing a series of three-arm amphiphilic block copolymers. By controlling the relative molecular weight, hydrophilic/hydrophobic ratio, and ionic group content, the apparent viscosity of CWSs was significantly reduced and the static stability was improved. Thermogravimetric testing and XPS analysis were conducted to reveal the mechanism behind the improved performance.
Article
Engineering, Chemical
Lanka Dinushke Weerasiri, Daniel Fabijanic, Subrat Das
Summary: Fluidization at low pressure offers significant benefits for the fine chemical industry. This study investigates the behavior of bubbles and bed expansion under low pressure conditions. It is found that lower pressure leads to larger bubbles, increased bubble quantity, and higher aspect ratio. The predictability is affected by the inhomogeneous fluidization, but low pressure fluidization can generate similar bubble sizes with lower fluidizing mass compared to atmospheric pressure.