Review
Clinical Neurology
Viktoria Papp, Melinda Magyari, Orhan Aktas, Thomas Berger, Simon A. Broadley, Philippe Cabre, Anu Jacob, Jun-ichi Kira, Maria Isabel Leite, Romain Marignier, Katsuichi Miyamoto, Jacqueline Palace, Albert Saiz, Maria Sepulveda, Olafur Sveinsson, Zsolt Illes
Summary: The systematic review of worldwide prevalence, incidence, and demographic characteristics of NMOSD highlighted variations among different geographic areas and ethnicities, with prominent female predominance in adults and peak incidence and prevalence in middle-aged adults. African ethnicity had the highest incidence and prevalence of NMOSD, whereas White ethnicity had the lowest, suggesting the need for further epidemiologic studies to investigate genetic effects and etiologic factors.
Article
Clinical Neurology
Ren Wei, Xiaolu Xu, Yunyun Duan, Ningnannan Zhang, Jie Sun, Haiqing Li, Yuxin Li, Yongmei Li, Chun Zeng, Xuemei Han, Fuqing Zhou, Muhua Huang, Runzhi Li, Zhizheng Zhuo, Frederik Barkhof, James H. Cole, Yaou Liu
Summary: This study evaluated the clinical significance of deep learning-derived brain age prediction in NMOSD and RRMS. The results showed that both NMOSD and RRMS patients had a significantly higher brain age gap compared to healthy controls. The brain age gap was associated with baseline disability score, advanced brain volume loss, and disease duration. Additionally, the brain age gap predicted the worsening of disability status in both NMOSD and RRMS patients.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Medicine, Research & Experimental
Yuping Yang, Junle Li, Ting Li, Zhen Li, Zhizheng Zhuo, Xuemei Han, Yunyun Duan, Guanmei Cao, Fenglian Zheng, Decai Tian, Xinli Wang, Xinghu Zhang, Kuncheng Li, Fuqing Zhou, Muhua Huang, Yuxin Li, Haiqing Li, Yongmei Li, Chun Zeng, Ningnannan Zhang, Jie Sun, Chunshui Yu, Fudong Shi, Umer Asgher, Nils Muhlert, Yaou Liu, Jinhui Wang
Summary: This study investigated the impact of multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) on the cerebellar connectome. The findings showed both shared and specific alterations in the connectome between MS and NMOSD, with MS patients exhibiting increased morphological connectivity within the cerebellar secondary motor module and NMOSD patients showing increased connectivity between the cerebellar primary motor module and cerebral motor- and sensory-related areas. Additionally, both diseases had decreased functional connectivity between cerebellar motor modules and cerebral association cortices.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Medicine, General & Internal
Dean M. Wingerchuk, Claudia F. Lucchinetti
Summary: Neuromyelitis Optica and its spectrum is a relapsing demyelinating disorder of the central nervous system, encompassing six syndromes and associated with aquaporin-4 autoantibodies. Effective treatment is able to prevent relapses.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Medicine, General & Internal
Dean M. Wingerchuk, Claudia F. Lucchinetti
Summary: Neuromyelitis Optica, previously known as Devic's disease, is a relapsing demyelinating disorder of the central nervous system that encompasses six syndromes and is associated with aquaporin-4 autoantibodies. Effective treatment is crucial in preventing relapses.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Medicine, Research & Experimental
Jing Huang, Bowen Xin, Xiuying Wang, Zhigang Qi, Huiqing Dong, Kuncheng Li, Yun Zhou, Jie Lu
Summary: This study evaluated the value of quantitative radiomic features extracted from brain white matter lesions for differential diagnosis of MS and NMO, and established an MM-RF model with high accuracy in both training and independent testing. Age, sex, and EDSS were found to have mild correlations with radiomic features.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Clinical Neurology
Laura Cacciaguerra, Antonio Carotenuto, Elisabetta Pagani, Damiano Mistri, Marta Radaelli, Vittorio Martinelli, Massimo Filippi, Maria A. Rocca
Summary: The study found that patients with neuromyelitis optica spectrum disorder have abnormal enlargement and impaired water diffusion in the perivascular space (PVS), which is associated with brain atrophy, deep grey matter atrophy, and poorer cognitive performance.
ANNALS OF NEUROLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Woojun Kim, Hyeong-Geol Shin, Hyebin Lee, Dohoon Park, Junghwa Kang, Yoonho Nam, Jongho Lee, Jinhee Jang
Summary: This study evaluated the characteristics of brain lesions in multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) using chi-separation imaging. The findings showed that MS lesions exhibited a higher proportion of hypodiamagnetic lesions compared to NMOSD lesions, suggesting that this feature can be used to differentiate between the two diseases.
Review
Clinical Neurology
Rosa Cortese, Antonio Giorgio, Gianmarco Severa, Nicola De Stefano
Summary: Several MRI measures have been developed to capture the complexity of pathological processes in MS brains, providing specific information on tissue damage and aiding in treatment decisions. However, understanding the underlying pathologic mechanisms in MS progression and repair, as well as the lack of sensitive outcome measures for progressive phases, presents a challenge in developing effective treatments. MRI biomarkers play a crucial role in monitoring disease activity and treatment response in MS and other demyelinating diseases, but their role in diseases like NMOSD and MOGAD is still marginal.
FRONTIERS IN NEUROLOGY
(2021)
Article
Multidisciplinary Sciences
Jin Myoung Seok, Wanzee Cho, Yeon Hak Chung, Hyunjin Ju, Sung Tae Kim, Joon-Kyung Seong, Ju-Hong Min
Summary: In this study, a deep learning model was developed to differentiate between multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) using brain MRI data. The model achieved an accuracy of 76.1%, with a sensitivity of 77.3% and a specificity of 74.8%. The application of Grad-CAM revealed that white matter lesions were the major classifier. This compact model could be helpful in the clinical diagnosis of MS and NMOSD.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
George Tackley, Yazhuo Kong, Rachel Minne, Silvia Messina, Anderson Winkler, Ana Cavey, Rosie Everett, Gabriele C. DeLuca, Andrew Weir, Matthew Craner, Irene Tracey, Jacqueline Palace, Charlotte J. Stagg, Uzay Emir
Summary: This study characterized the metabolite profiles of brain lesions in MS and AQP4Ab-NMOSD patients using an optimized MRS methodology, revealing some under-explored subtleties in MRS profiles, such as the absence of myo-Inositol concentration differences in AQP4Ab-NMOSD brain lesions versus NAWM and the potential influence of NAAG differences between lesions and normal appearing white matter in MS.
Article
Clinical Neurology
Juan Zhang, Mei-Jiao Chen, Gui-Xian Zhao, Hong-Fu Li, Lei Wu, Yong-Feng Xu, Yajin Liao, Zengqiang Yuan, Zhi-Ying Wu
Summary: The study explored the association between PRRC2A variants and susceptibility to NMOSD and MS in the Han Chinese population. Certain PRRC2A variants were found to alter susceptibility to AQP4(+)NMOSD and MS, with specific genotypes increasing the risk. Additionally, haplotypes and gene expression levels associated with these variants were identified, suggesting potential implications for personalized therapeutic approaches in these disease entities.
JOURNAL OF NEUROLOGY
(2021)
Article
Neurosciences
Eun Bin Cho, Se Young Jung, Jin-Hyung Jung, Yohwan Yeo, Hee Jin Kim, Kyungdo Han, Dong Wook Shin, Ju-Hong Min
Summary: A population-based study in South Korea found that patients with multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) have an increased risk of developing dementia, with MS patients having a higher risk compared to NMOSD patients.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Clinical Neurology
Romina Mariano, Silvia Messina, Adriana Roca-Fernandez, Maria Leite, Yazhuo Kong, Jacqueline A. Palace
Summary: Spinal cord involvement is a key feature of multiple sclerosis, neuromyelitis optica with AQP4 antibodies, and MOG-antibody disease. Quantitative spinal cord MRI was used in a cross-sectional study to differentiate these conditions, showing significant damage in AQP4-antibody disease and multiple sclerosis, while MOG-antibody disease had a predominant central grey matter component. The study also found that relapsing MOG-antibody disease is a more severe phenotype and applied various analyses to discriminate between different diseases.
Article
Medicine, General & Internal
Yiqun Wu, Mo Yang, Pei Gao, Zijing Wang, Junhui Wu, Jiating Wang, Quangang Xu, Huanfen Zhou, Tao Wu, Weiping Wu, Shihui Wei, Yong-Hua Hu
Summary: This study estimated the incidence of neuromyelitis optica spectrum disorders (NMOSDs) in Chinese adults and investigated their relationship with latitude. The results showed a higher incidence rate in females and differences in incidence based on age and gender. This suggests the involvement of genetic, hormonal, and other factors in the pathophysiology of NMOSDs.