Article
Pediatrics
Jeffrey D. Graham, Emily Bremer, Barbara Fenesi, John Cairney
Summary: Research demonstrates that short-term classroom-based physical activity breaks have positive effects on executive functioning and psychological states in children. Additionally, levels of aerobic and musculoskeletal fitness moderate these effects.
FRONTIERS IN PEDIATRICS
(2021)
Review
Psychiatry
Maryam Sorkhou, Rachel H. Bedder, Tony P. George
Summary: This systematic review examined the evidence for adverse behavioral sequalae of cannabis in healthy individuals, finding that factors such as frequency of use, THC content, age of onset, and cumulative exposure can contribute to negative outcomes. The strongest evidence was found for the impact of cannabis on psychosis and psychosocial functioning, highlighting the importance of understanding vulnerability to these adverse effects in order to prevent and treat problematic cannabis use.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Behavioral Sciences
Laura N. Pulido, Jose A. Pochapski, Adam Sugi, Julie Y. Esaki, Joao L. Stresser, William N. Sanchez, Gabriel Baltazar, David Levcik, Romulo Fuentes, Claudio Da Cunha
Summary: This study tested the effects of methylphenidate on a spatial memory task and found that it may act more as a motivational enhancer rather than a cognitive enhancer.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Mattia Ferraiolo, Emmanuel Hermans
Summary: L-DOPA and dopamine agonists are key therapeutic options for managing the motor symptoms of Parkinson's disease. Despite similarities in their mechanism of action, pramipexole, ropinirole, and rotigotine have distinct clinical profiles possibly due to differences in their pharmacological properties. This review aims to explore the properties of these dopamine agonists from both clinical and molecular perspectives, providing a unified framework for interpretation.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Neurosciences
Laura Lopez-Cruz, Benjamin U. Phillips, Jonathan M. Hailwood, Lisa M. Saksida, Christopher J. Heath, Timothy J. Bussey
Summary: Effort-based decision-making is impaired in multiple psychopathologies, leading to significant impacts on patients' daily life. The current decision-making tests in rodents are limited by confounding factors such as delayed reinforcement and off-target cognitive demands. This study introduced a novel touchscreen task that minimizes these variables, providing advantages over conventional decision-making tasks.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Neurosciences
Heather E. Soder, Jessica A. Cooper, Paula Lopez-Gamundi, Jennifer K. Hoots, Cecilia Nunez, Victoria M. Lawlor, Scott D. Lane, Michael T. Treadway, Margaret C. Wardle
Summary: The study aimed to investigate the effects of different doses of d-amphetamine on effort for reward and reward learning in healthy volunteers. The results indicated that d-amphetamine increased willingness to exert effort, particularly at low to intermediate expected values of reward, due to decreased effort discounting. Baseline effort and working memory also moderated this effect, with d-amphetamine increasing effort more in individuals with lower working memory and lower baseline effort.
NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Clinical Neurology
Mathieu Di Miceli, Adesina Omoloye, Benjamin Gronier
Summary: This study demonstrated that the combination of methylphenidate and a dopamine D-2 receptor antagonist has long-lasting effects on midbrain dopamine neurons, mediated by glutamatergic-dependent mechanisms.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Article
Neurosciences
Vanessa Era, Matteo Candidi, Rachele Pezzetta, Claudia Pulcini, Sara D'Antonio, Silvia Zabberoni, Antonella Peppe, Alberto Costa, Sara Taglieri, Giovanni Augusto Carlesimo, Salvatore Maria Aglioti
Summary: Studies suggest that the dopaminergic system supports individual flexible behavior. Parkinson's Disease (PD) patients performed better and found interactions more enjoyable when their dopaminergic system was functioning properly. This indicates the key role of the dopaminergic system in the flexible adaptation of one's own actions to a partner's during motor interactions.
SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
(2023)
Article
Neurosciences
Lin Zhang, Deirdre M. McCarthy, Karen L. Eskow Jaunarajs, Joseph Biederman, Thomas J. Spencer, Pradeep G. Bhide
Summary: The study indicates that the KOR antagonist norbinaltorphimine (norBNI) and methylphenidate can improve attention and working memory in the PNE mouse model by increasing dopamine and noradrenaline release.
Review
Medicine, General & Internal
Yan Wang, De-Qi Jiang, Cheng-Shu Lu, Ming-Xing Li, Li-Lin Jiang
Summary: The study found that the combination therapy of pramipexole and levodopa is more clinically effective in treating Parkinson's disease compared to levodopa monotherapy. Additionally, the combination therapy also showed a better safety profile in reducing adverse events in Parkinson's disease patients.
Article
Nutrition & Dietetics
Philippa A. Jackson, Charlotte Kenney, Joanne Forster, Ellen F. Smith, Rian Elcoate, Bethany Spittlehouse, Jodee Johnson, David O. Kennedy
Summary: This study investigated the effects of low and moderate doses of coffeeberry extract on cognition and mood. The results showed that 100 mg of coffeeberry extract resulted in increased mental fatigue and decreased accuracy on a task of sustained attention. However, no significant effects were found with 300 mg of coffeeberry extract. Therefore, low to moderate doses of coffeeberry extract do not have a beneficial effect on mood, mental and physical energy levels, or cognition.
Article
Clinical Neurology
Marieke A. G. Martens, Nina Dalton, Jessica Scaife, Catherine J. Harmer, Paul J. Harrison, Elizabeth M. Tunbridge
Summary: Our study found that COMT has little or no effect on emotional processing or mood in healthy adult men, which contradicts some neuroimaging studies. However, novel COMT inhibitors for treating cognitive dysfunction are unlikely to have acute off target effects on emotional behaviors.
JOURNAL OF PSYCHOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Dong-Xin Wang, Ying Yang, Xiao-Song Huang, Jia-Yu Tang, Xi Zhang, Hong-Xing Huang, Bin Zhou, Bo Liu, Hui-Qiong Xiao, Xiao-Hui Li, Ping Yang, Shu-Cheng Zou, Kun Liu, Xiao-Ye Wang, Xiao-Song Li
Summary: Pramipexole alleviates neuronal injury by activating BNIP3-mediated mitophagy and reducing miR-96 in MPP+-induced cells.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Elon D. Wallert, Elsmarieke van de Giessen, Remco J. J. Knol, Martijn Beudel, Rob M. A. de Bie, Jan Booij
Summary: Imaging of dopaminergic transmission plays a crucial role in the diagnosis and research of neurodegenerative disorders. It provides high diagnostic accuracy in detecting nigrostriatal degeneration in diseases such as Parkinson's disease and dementia with Lewy bodies. Additionally, it helps in studying the preclinical and premotor phases of these disorders and examining different subtypes of Parkinson's disease. Imaging also aids in understanding the neuronal substrates of impulse control disorders and measuring endogenous dopamine release in the treatment of Parkinson's disease.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Neurosciences
Hannah V. Oakes, David McWethy, Shannon Ketchem, Lily Tran, Kaitlyn Phillips, Laura Oakley, Richard J. Smeyne, Brooks B. Pond
Summary: The study found that female mice are more sensitive to MPTP, and chronic exposure to MPH leads to the depletion of the antioxidant GSH. Further research suggests that estrogen may increase neuronal sensitivity to MPTP.
NEUROTOXICITY RESEARCH
(2021)