Article
Medicine, General & Internal
Panagiotis Plomaritis, Aikaterini Theodorou, Vasiliki Michalaki, Maria-Ioanna Stefanou, Lina Palaiodimou, Georgia Papagiannopoulou, Vasiliki Kotsali-Peteinelli, Marianna Bregianni, Elissavet Andreadou, Georgios P. Paraskevas, Sotirios Giannopoulos, Georgios Tsivgoulis, Anastasios Bonakis
Summary: The study aimed to evaluate the prevalence and severity of PLMS in acute stroke patients, and to clarify the association between PLMS and coexisting SDB. The results showed that PLMS were common and mostly severe in acute stroke patients, and had a significant impact on stroke outcomes. Therefore, early detection and treatment of PLMS are important for stroke patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Davide Sparasci, Raffaele Ferri, Anna Castelnovo, Silvia Miano, Kosuke Tanioka, Naoko Tachibana, Chiara Carelli, Gianna Riccitelli, Giulio Disanto, Chiara Zecca, Claudio Gobbi, Mauro Manconi
Summary: Restless legs syndrome (RLS) is highly frequent in patients with multiple sclerosis (MS), with a comparable frequency of periodic limb movements during sleep (PLMS) to the general population. The low percentage of patients with RLS having a high PLMS index, together with the absence of correlation between RLS and clinical and polysomnography parameters, indicates the existence of a distinct symptomatic form of RLS in MS.
Review
Behavioral Sciences
Lucas Lima Najar, Rachel Alencar de Castro Araujo Pastor, Nancy Foldvary-Schaefer, Marleide da Mota Gomes
Summary: The study found no significant difference in PLMS frequency between patients with epilepsy and controls, but existing studies did not adjust for potential confounders. Therefore, further research is needed to explore the common occurrence of sleep disturbances in patients with epilepsy.
EPILEPSY & BEHAVIOR
(2021)
Article
Clinical Neurology
Jacob L. Edelson, Logan D. Schneider, David Amar, Andreas Brink-Kjaer, Katie L. Cederberg, Zoltan Kutalik, Erika W. Hagen, Paul E. Peppard, Priscila Farias Tempaku, Sergio Tufik, Daniel S. Evans, Katie Stone, Greg Tranah, Brian Cade, Susan Redline, Jose Haba-Rubio, Raphael Heinzer, Pedro Marques-Vidal, Peter Vollenweider, Juliane Winkelmann, James Zou, Emmanuel Mignot
Summary: A genome-wide association study discovered two genetic loci that were significantly associated with periodic limb movements in sleep. These movements were found to be genetically correlated with restless leg syndrome, insomnia, and risk of stroke, but not with iron deficiency. Causal effect of restless leg syndrome on periodic limb movements in sleep was identified through analysis.
Article
Clinical Neurology
Andras Szentkiralyi, Marco Hermesdorf, Benedikt Sundermann, Maria Czira, Henning Teismann, Niklas Wulms, Heike Minnerup, Peter Young, Klaus Berger
Summary: This study aims to investigate the association between periodic limb movements in sleep (PLMS) and brain morphology. Through polysomnography and MRI scans in 189 participants, it was found that PLMS was significantly associated with reduced volumes of the hippocampus and amygdala.
Review
Clinical Neurology
Narat Srivali, Charat Thongprayoon, Supawit Tangpanithandee, Pajaree Krisanapan, Michael A. Mao, Andrey Zinchuk, Brain B. Koo, Wisit Cheungpasitporn
Summary: Through a systematic review and meta-analysis of observational studies, an association between periodic limb movements during sleep (PLMS) and hypertension was found. The pooled risk ratio of hypertension in patients with PLMS was 1.26 (95% CI, 1.12-1.41). Further prospective or interventional studies are needed to confirm this association.
Article
Clinical Neurology
Nicola Andrea Marchi, Arton Peci, Jose Haba-Rubio, Geoffroy Solelhac, Virginie Bayon, Mathieu Berger, Peter Vollenweider, Pedro Marques-Vidal, Armin von Gunten, Marie-Pierre Francoise Strippoli, Martin Preisig, Bogdan Draganski, Raphael Heinzer
Summary: This cross-sectional study found no significant association between periodic leg movements and cognitive functioning among community-dwelling older adults. However, further studies are needed to clarify the relationship between periodic leg movements and cognitive functioning, as there is a lack of data in this field.
Article
Clinical Neurology
Shuyu Sun, Xianchao Zhao, Jiafeng Ren, Jinxiang Cheng, Junying Zhou, Changjun Su
Summary: This study investigated the objective sleep characteristics and risk factors among PD patients with and without RLS. The findings showed that RLS prevalence among PD patients was 28.0%, with PD-RLS patients exhibiting poorer sleep quality and disrupted sleep architecture. Motor symptoms severity in PD was significantly linked to sleep quality in both PD-RLS and PD-NRLS patients, with periodic limb movements during sleep being a key risk factor for sleep quality in PD patients with RLS.
FRONTIERS IN NEUROLOGY
(2021)
Article
Critical Care Medicine
L. J. Delaney, E. Litton, K. L. Melehan, H. -C. C. Huang, V. Lopez, F. Van Haren
Summary: This study investigated the feasibility and reliability of using actigraphy for sleep monitoring in intensive care unit patients. Results showed that actigraphy had a moderate level of agreement with polysomnography in distinguishing between sleep and wakeful states, especially among non-ventilated patients. The study suggests that actigraphy may be a reasonable alternative to measure sleep in intensive care settings.
Article
Clinical Neurology
Sang-Ahm Lee, Soo Jeong Kim, So Young Lee, Hyo Jae Kim
Summary: The prevalence of PLMS in patients with OSA was 14.1%, and it was positively associated with older age, male gender, and obesity. PLMS had a negative correlation with the physical and mental component summary scores of the health survey, but not with Beck Depression Inventory scores after controlling for confounding variables.
SLEEP AND BREATHING
(2022)
Article
Geriatrics & Gerontology
Yu Zhang, Zi En Zhang, De Shi, Yi Zhao, Lihong Huang, Yanxin Zhao, Hui Wang, Jing Zhao, Feng Wang, Chaorong Zhao, Shan Gao, Wenshi Wei, Dongya Huang, Zhen Guo Liu
Summary: The study found that Parkinson's disease patients commonly experience off-states in the morning, which may impact their quality of life, with severity worsening as the disease progresses. Additionally, nocturnal sleep problems may partially mediate the relationship between morning off-states and quality of life.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Review
Respiratory System
Panagis Drakatos, Michelle Olaithe, Dhun Verma, Katarina Ilic, Diana Cash, Yaqoot Fatima, Sean Higgins, Allan H. Young, K. Ray Chaudhuri, Joerg Steier, Timothy Skinner, Romola Bucks, Ivana Rosenzweig
Summary: This paper evaluates the evidence for separable underlying patho-mechanisms of periodic limb movements (PLMs) to separable PLM motor patterns and phenotypes in order to elucidate potential new treatment modalities. Significant sleep fragmentation due to PLMD can lead to functional impairment, including hyperactivity in children and poor concentration in adults. Associations between PLM phenotypes and major neurologic and psychiatric disorders remain controversial, and further investigation into divergent biological pathways may lead to important new treatment modalities.
JOURNAL OF THORACIC DISEASE
(2021)
Article
Multidisciplinary Sciences
J. Perrier, M. Duivon, P. Clochon, S. Rehel, F. Doidy, J. M. Grellard, C. Segura-Djezzar, J. Geffrelot, G. Emile, D. Allouache, C. Levy, S. Polvent, F. Viader, F. Eustache, F. Joly, B. Giffard
Summary: Sleep disturbance is common among breast cancer survivors, with differences in sleep structure compared to healthy controls, including increased awakenings, decreased Delta power during sleep deepening and recovery, increased Alpha and Beta power related to arousal during deep sleep, and decreased Theta power related to emotional regulation during dream sleep.
SCIENTIFIC REPORTS
(2022)
Review
Clinical Neurology
Ioanna Kouri, Mithri R. Junna, Melissa C. Lipford
Summary: This article provides summaries of restless legs syndrome (RLS), periodic limb movements of sleep, and periodic limb movement disorder. RLS is a common sleep disorder that affects 5% to 15% of the general population. RLS can occur in childhood and its prevalence increases with age. It can be caused by various factors such as iron deficiency, chronic renal failure, peripheral neuropathy, and certain medications. Treatment options include pharmacologic agents and nonpharmacologic therapies. Periodic limb movements of sleep often accompany RLS but can also occur independently. The clinical significance of these movements is still debated. Periodic limb movement disorder is a distinct sleep disorder that occurs in individuals without RLS and is diagnosed by exclusion.
JOURNAL OF CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Neurosciences
Angela Ann Joseph, Anupama Gupta, Nandita Hazari, Mani Kalaivani, Ravindra Mohan Pandey, Rajesh Sagar, Manju Mehta, Garima Shukla
Summary: The aim of this study was to examine sleep disturbances in children with ADHD compared to their typically developing peers after controlling for moderating variables. The results showed that children with ADHD had higher rates of sleep disturbances and disorders compared to the control group.
Article
Gerontology
Ryan Van Patten, Tanya T. Nguyen, Zanjbeel Mahmood, Ellen E. Lee, Rebecca E. Daly, Barton W. Palmer, Tsung-Chin Wu, Xin Tu, Dilip V. Jeste, Elizabeth W. Twamley
Summary: The study found that subjective cognitive complaints are associated with negative health characteristics such as poor sleep and high body mass index, as well as lower levels of positive factors like happiness and wisdom. Psychological correlates of SCCs are as significant as physical correlates, highlighting the importance of mental health in evaluating SCCs. Age does not moderate the relationship between SCCs and physical/mental health.
INTERNATIONAL JOURNAL OF AGING & HUMAN DEVELOPMENT
(2022)
Article
Psychology, Clinical
Barton W. Palmer, Catherine Shir, Hang Chang, Mallory Mulvaney, Joshua M. H. Hall, I-Wei Shu, Hua Jin, James B. Lohr
Summary: Post-Traumatic Stress Disorder (PTSD) is associated with an increased risk of metabolic syndrome (MetS), independent of antipsychotic medication. Attention should be given to managing metabolic risk factors in patients with PTSD.
INTERNATIONAL JOURNAL OF MENTAL HEALTH
(2023)
Article
Psychology, Clinical
Michael L. Thomas, Barton W. Palmer, Ellen E. Lee, Jinyuan Liu, Rebecca Daly, Xin M. Tu, Dilip V. Jeste
Summary: The study aimed to create a 7-item abbreviated version of the SD-WISE, formed by selecting one item from each of the seven subscales. The results indicated that the combination of these 7 items showed acceptable unidimensional model fit and good reliability. This abbreviated version, SD-WISE-7, demonstrated high correlation with the original 28-item scale and maintained a similar pattern of correlations with demographic and validity variables.
INTERNATIONAL PSYCHOGERIATRICS
(2022)
Article
Ethics
Laura B. Dunn, Jane P. Kim, Maryam Rostami, Sangeeta Mondal, Katie Ryan, Asees Waraich, Laura Weiss Roberts, Barton W. Palmer
Summary: The study found that the At Risk group was more willing to participate in neuromodulation trials compared to the Comparison group, and reported higher levels of feeling lucky regarding the research protocols. Further research is needed to explore the full range of potential influences on research participation.
JOURNAL OF EMPIRICAL RESEARCH ON HUMAN RESEARCH ETHICS
(2022)
Article
Oncology
Sonia Ancoli-Israel, Lianqi Liu, Loki Natarajan, Michelle Rissling, Ariel B. Neikrug, Shawn D. Youngstedt, Paul J. Mills, Georgia R. Sadler, Joel E. Dimsdale, Barbara A. Parker, Barton W. Palmer
Summary: Objective cognitive performance improved in women with breast cancer (WBC) from pre- to post-chemotherapy to one year later, while matched-controls showed consistent improvement throughout all time points. WBC reported significantly worse cognitive function compared to controls. Poorer neuropsychological functioning in WBC was predicted by inconsistent circadian activity rhythms, poor sleep quality, longer nap times, and cognitive complaints. Worse subjective cognition was predicted by lower sleep quality, higher fatigue, and depressed mood. Interventions targeting sleep, circadian rhythms, and fatigue may benefit cognitive function in WBC.
SUPPORTIVE CARE IN CANCER
(2022)
Correction
Psychology, Clinical
Michael L. Thomas, Barton W. Palmer, Ellen E. Lee, Jinyuan Liu, Rebecca Daly, Xin M. Tu, Dilip V. Jeste
INTERNATIONAL PSYCHOGERIATRICS
(2022)
Article
Information Science & Library Science
Manoj A. Thomas, Yan Li, Allen S. Lee
Summary: This article proposes a procedure for generalizing an information systems artifact from one setting to another, emphasizing the practical significance of design science research in solving problems and creating artifacts that work in new settings.
INFORMATION SYSTEMS RESEARCH
(2022)
Article
Geriatrics & Gerontology
Dilip V. Jeste, Danielle K. Glorioso, Colin A. Depp, Ellen E. Lee, Rebecca E. Daly, Dylan J. Jester, Barton W. Palmer, Brent T. Mausbach
Summary: Objective: This study tested a new remotely-administered manualized resilience- and wisdom-focused behavioral intervention to reduce perceived stress and loneliness in older adults. The results support the feasibility, acceptability, and possible efficacy of this intervention.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2023)
Article
Geriatrics & Gerontology
Dylan J. Jester, Barton W. Palmer, Michael L. Thomas, Lauren L. Brown, Lize Tibirica, Dilip V. Jeste, Todd Gilmer
Summary: The impact of years of education on cognitive decline varies by race and ethnicity due to historical and current inequities in educational quality. This study found that, regardless of educational attainment, Black and Latinx adults had lower cognitive scores compared to White adults. Higher-educated White adults received the greatest protection from cognitive decline, followed by Latinx adults and then Black adults.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Review
Psychiatry
Dylan J. Jester, Michael L. Thomas, Emily T. Sturm, Philip D. Harvey, Matcheri Keshavan, Beshaun J. Davis, Shekhar Saxena, Rajesh Tampi, Heather Leutwyler, Michael T. Compton, Barton W. Palmer, Dilip Jeste
Summary: Social determinants of health (SDoHs) have a significant impact on the health of individuals with schizophrenia-spectrum psychotic disorders (SSPDs), with risk factors including childhood abuse, parental psychopathology, parental communication problems, bullying, and low socioeconomic status in urban areas. Racial/ethnic discrimination and social fragmentation are also associated with the prevalence and symptoms of psychosis. Homeless populations and seriously mentally ill individuals are more likely to experience food insecurity. Further research is needed to understand the positive factors and develop interventions to reduce the adverse health impacts of SDoHs.
SCHIZOPHRENIA BULLETIN
(2023)
Review
Psychiatry
Emily T. Sturm, Michael L. Thomas, Anastasia G. Sares, Subodh Dave, David Baron, Michael T. Compton, Barton W. Palmer, Dylan J. Jester, Dilip Jeste
Summary: Social determinants of health impact the development and course of schizophrenia-spectrum psychotic disorders. There is a lack of published scholarly reviews on the psychometric properties and pragmatic utility of assessing social determinants of health among individuals with these disorders. This study aimed to review and evaluate the assessment measures for social determinants of health. The findings suggest that while some assessments show promise, there is a need for the development and validation of brief screening measures suitable for clinical application, as well as the use of novel assessment tools and sophisticated psychometric evaluations.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Psychiatry
Arren Ramsey, Tushara Govind, Jeffrey A. Lam, Barton W. Palmer, Dilip V. Jeste, Ellen E. Lee
Summary: This study examined the association between compassion and physical health outcomes in individuals with schizophrenia. The results showed that individuals with schizophrenia had lower levels of compassion towards themselves and others and worse physical health compared to non-psychiatric subjects. Higher levels of self-compassion were associated with better physical health outcomes. Therefore, this study is important for understanding the physical health of individuals with schizophrenia.
SCHIZOPHRENIA RESEARCH
(2023)
Article
Psychology, Clinical
Lize Tibirica, Dylan J. Jester, Jordan N. Kohn, Allison P. Williams, Linda K. Mcevoy, Barton W. Palmer
Summary: This study examined the association between perceived discrimination and the risk of cognitive impairment with no dementia (CIND) and Alzheimer's disease and related dementias (ADRD) among Latinx adults. The results showed that neither everyday discrimination nor nativity status on their own had a statistically significant association with CIND/ADRD. However, non-US-born Latinx adults who reported no discrimination had a 42% lower risk of CIND/ADRD than US-born adults.
INTERNATIONAL PSYCHOGERIATRICS
(2023)
Article
Psychiatry
Concepcion Barrio, Dahlia Fuentes, Lize Tibirica, Mercedes Hernandez, Paula Helu-Brown, Shahrokh Golshan, Barton W. Palmer
Summary: Latinxs are underrepresented in mental health research, possibly due to complexities in the research consent process, including language preferences. This study examined determinants of comprehension of research consent procedures and found that health and research literacy may be targets for reducing disparities in consent comprehension.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Geriatrics & Gerontology
Anne Malaktaris, Ariel J. Lang, Pollyanna Casmar, Selena Baca, Samantha Hurst, Dilip V. Jeste, Barton W. Palmer
Summary: This pilot study suggests that compassion meditation training is feasible and potentially beneficial in improving well-being among community-dwelling older adults. Further research is needed to confirm the efficacy of CM training in this population.
CLINICAL GERONTOLOGIST
(2022)
