期刊
JOURNAL OF THE NEUROLOGICAL SCIENCES
卷 311, 期 1-2, 页码 32-36出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jns.2011.08.041
关键词
Vitamin D; Multiple sclerosis; Gene-environment interactions
资金
- National Council for Science and Technology (CONACyT, Mexico)
- Multiple Sclerosis Society of Great Britain and Northern Ireland
- Multiple Sclerosis Society of Canada Scientific Research Foundation
Vitamin D has been studied for over a century and its functions related to calcium homeostasis are well established. Over the last 30 years or so it has become increasingly clear that it has a wider role in physiology and, importantly, also in disease. Vitamin D deficiency has been linked to multiple sclerosis (MS); however the molecular mechanisms of this association were poorly understood. Recent technological advances have provided major insights as to how vitamin D may exert its role, particularly through the actions of the vitamin D receptor (VDR). In this review we aim to highlight the importance of the interaction between vitamin D and MS associated genes which provide a biological basis for the association between vitamin D and MS risk. (C) 2011 Elsevier B.V. All rights reserved.
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