期刊
JOURNAL OF THE NEUROLOGICAL SCIENCES
卷 307, 期 1-2, 页码 34-40出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jns.2011.05.025
关键词
Amyotrophic lateral sclerosis; Behavioral changes; Apathy; The Frontal System Behavior Scale (FrSBe); Voxel-based morphometry; Diffusion tensor imaging
资金
- Ministry of Health, Labor and Welfare, Japan
Background: Amyotrophic lateral sclerosis (ALS) is a multisystem disorder with impairment of frontotemporal functions such as cognition and behavior, but the behavioral changes associated with ALS are not well defined. Methods: Twenty-one consecutive patients with sporadic ALS and 21 control subjects participated in the study. The Frontal System Behavior Scale (FrSBe) was used to assess behavioral change. Voxel-based morphometry (VBM) and voxel-based analysis of diffusion tensor images (DTI) were performed to explore the associations of brain degeneration with behavior. All patients were evaluated before the notification of ALS. Results: FrSBe scores of ALS patients before notification were significantly increased compared to those of control subjects. Moreover, the FrSBe Apathy score of ALS patients significantly changed from pre- to post-illness (P<0.001). The severity of apathy was significantly correlated with atrophy in the prefrontal cortex, especially in the orbitofrontal (P=0.006) and dorsolateral prefrontal (P=0.006) cortices in VBM, and in the right frontal gyrus (P<0.001) in DTI. Conclusions: ALS patients exhibited apathy during the early course of the illness, the severity of which was significantly associated with frontal lobe involvement. These findings support the view that a continuum exits between ALS and frontotemporal dementia. (C) 2011 Elsevier B.V. All rights reserved.
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