Review
Biochemistry & Molecular Biology
Ava Nasrolahi, Fatemeh Javaherforooshzadeh, Mohsen Jafarzadeh-Gharehziaaddin, Javad Mahmoudi, Khadijeh Dizaji Asl, Zahra Shabani
Summary: NTFs are considered as new and promising candidates for treating AD and AD-associated cognitive impairment, with potential to protect and treat neurodegenerative diseases.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Cell Biology
Daniel Hellenbrand, Clayton L. Haldeman, Jae-Sung Lee, Angela G. Gableman, Elena K. Dai, Stephen D. Ortmann, Jerrod C. Gotchy, Kierra K. Miller, Adrianna M. Doucas, Nicole C. Nowak, William L. Murphy, Amgad S. Hanna
Summary: The gold standard for treating peripheral nerve injuries with large nerve gaps is autologous nerve grafts. However, incorporating mineral coated microparticles (MCMs) to release growth factors like NGF and GDNF can significantly enhance axon growth and improve limb function in rats with nerve grafts.
NEURAL REGENERATION RESEARCH
(2021)
Review
Neurosciences
Wesley Stansberry, Brian Pierchala
Summary: The discovery of neurotrophins and their potential to save dying neurons in neurodegenerative diseases caused great excitement. Subsequent findings of the survival-promoting activity of BDNF, CNTF, and GDNF on motor neurons led to their proposed use in ALS. This review summarizes the literature on the role of NGF, BDNF, CNTF, and GDNF on spinal motor neuron development and physiology, as well as the preclinical studies and clinical trials evaluating their potential for ALS treatment.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Review
Neurosciences
Olesja Bondarenko, Mart Saarma
Summary: Neurotrophic factors (NTFs) are essential for neuronal development and survival but face challenges in delivery to the brain due to the blood-brain barrier. Nanoparticles (NPs) show promise in stabilizing and transporting NTFs across the BBB, offering a potential solution to systemic delivery.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Vincenzo Giuseppe Nicoletti, Krisztian Pajer, Damiano Calcagno, Gholam Pajenda, Antal Nogradi
Summary: Mature neurotrophic factors and their propeptides are crucial in regulating neuronal growth, survival, and recovery. Understanding the mechanisms of these factors offers potential for neuroregenerative medicine.
Article
Biochemistry & Molecular Biology
Maria S. Gavrish, Mark D. Urazov, Tatiana A. Mishchenko, Victoria D. Turubanova, Ekaterina A. Epifanova, Victoria G. Krut', Alexey A. Babaev, Maria V. Vedunova, Elena Mitroshina
Summary: The role of neurotrophic factors BDNF and GDNF in maintaining brain resistance to hypoxia and promoting recovery of neural networks is being actively studied. This study aimed to evaluate the effects of overexpressing BDNF and GDNF using viral vectors in modeling hypoxia. The results showed increased survival rate of mice under hypoxic conditions, indicating that overexpression of neurotrophic factors may be a potential neuroprotection method.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Asima Karim, M. Shahid Iqbal, Tahir Muhammad, Rizwan Qaisar
Summary: A biomarker to accurately predict muscle loss in Parkinson's disease (PD) patients has not yet been found. In this study, we evaluated the biomarkers of neuromuscular junction stability and found that levels of CAF22 were elevated while levels of BDNF and GDNF were reduced in PD patients. These biomarkers showed significant associations with muscle loss indicators. Combining these biomarkers into a cumulative risk score enhanced the diagnostic accuracy of muscle loss.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Rong-Wei Kou, Bing Xia, Rui Han, Zhi-Qing Li, Jun-Ren Yang, Xia Yin, Yu-Qi Gao, Jin-Ming Gao
Summary: This study identified 10 secondary metabolites, including a new lanostane triterpenoid named 2 alpha-hydroxy-inotodiol (2 alpha-HI), from the edible mushroom I. obliquus. The results showed that 2 alpha-HI exhibited remarkable neuroprotective activity against oxidative stress and apoptosis induced by H2O2 in SH-SY5Y cells, mediated by the Nrf2 and BDNF/TrkB/ERK/CREB signaling pathway. Additionally, the neuroprotective effects of 2 alpha-HI were preliminarily verified in zebrafish.
Article
Medicine, General & Internal
Teodora Yaneva-Sirakova, Latchezar Traykov, Kiril Karamfiloff, Ivo Petrov, Julieta Hristova, Dobrin Vassilev
Summary: Carotid stenting can affect the levels of neurotrophins, which are important for the survival, development, and function of neurons.
ANNALS OF MEDICINE
(2023)
Article
Neurosciences
Leili Mortazavi, Tristan J. Hynes, Chloe S. Chernoff, Shrishti Ramaiah, Hannah G. Brodie, Brittney Russell, Brett A. Hathaway, Sukhbir Kaur, Catharine A. Winstanley
Summary: Dopamine agonist therapies used to treat Parkinson's disease can exacerbate impulse control and gambling disorders, but the underlying mechanisms are unclear. Recent studies have found that adding win-paired cues to the rat gambling task increases risky decision-making and impulsivity via the dopamine system. Ropinirole treatment in male rats transiently increased motor impulsivity and choice of high-risk/high-reward options, especially during acquisition of the cued gambling task. The drug enhanced model-free learning and suppressed the activity of dopaminergic midbrain neurons, leading to perpetuated risky choice.
JOURNAL OF NEUROSCIENCE
(2023)
Review
Geriatrics & Gerontology
Piniel Alphayo Kambey, Kouminin Kanwore, Abiola Abdulrahman Ayanlaja, Iqra Nadeem, YinZhen Du, Wokuheleza Buberwa, WenYa Liu, Dianshuai Gao
Summary: Parkinson's disease is a common neurodegenerative disorder with unknown etiology, making it challenging to develop effective therapies. Glial cell line-derived neurotrophic factor (GDNF) has shown promise in preclinical studies but has yielded equivocal clinical results. Recent research suggests that the failure of GDNF in clinical trials may be due to a deficiency in nuclear receptor-related factor 1 (Nurr1), which presents a potential therapeutic target for PD.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Yiyuan Xia, Zhi-Hao Wang, Pai Liu, Laura Edgington-Mitchell, Xia Liu, Xiao-Chuan Wang, Keqiang Ye
Summary: Neurotrophins such as BDNF promote neuronal survival and synaptic plasticity by activating tropomyosin receptor kinases. Reduced levels of BDNF and its receptor TrkB in Alzheimer's disease contribute to cognitive decline. The research shows that the TrkB receptor phosphorylates APP, reducing amyloid-beta production, but this process is disrupted by delta-secretase cleavage in AD.
MOLECULAR PSYCHIATRY
(2021)
Review
Pharmacology & Pharmacy
Anastasiia O. Sosnovtseva, Olga V. Stepanova, Aleksei A. Stepanenko, Anastasia D. Voronova, Andrey V. Chadin, Marat P. Valikhov, Vladimir P. Chekhonin
Summary: The regeneration of nerve tissue after spinal cord injury is a complex and poorly understood process. Medication and surgery are not very effective treatments for patients with spinal cord injuries. Gene therapy, particularly using recombinant adenoviruses as vectors, has gained popularity as a potential approach for treatment. This review discusses the advantages, limitations, and prospects of adenovectors in spinal cord injury therapy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Clinical Neurology
Sara C. Staubo, Ole Martin Fuskevag, Mathias Toft, Ingeborg H. Lie, Kirsti M. J. Alvik, Pal Jostad, Stein H. Tingvoll, Hallvard Lilleng, Kristina Rosqvist, Elisabet Storset, Per Odin, Espen Dietrichs, Erik Sveberg Dietrichs
Summary: The study suggests that the occurrence of impulse control disorders (ICDs) among patients using ropinirole is dependent on serum concentration and drug exposure, while the use of pramipexole may inherently increase ICD risk.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Maria Chiara De Nardo, Carla Petrella, Maria Di Chiara, Chiara Di Mario, Giorgia Deli, Elisa Travaglia, Laura Baldini, Alessia Russo, Pasquale Parisi, Marco Fiore, Gianluca Terrin
Summary: The present study investigated the relationship between nutritional intake and the serum levels of NGF and BDNF in preterm newborns. The results showed that enteral nutrition was positively correlated with NGF and BDNF levels, while parenteral nutrition was negatively correlated with them.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Masato Kinboshi, Takahiro Mukai, Yuki Nagao, Yusuke Matsuba, Yoshimi Tsuji, Shiho Tanaka, Kentaro Tokudome, Saki Shimizu, Hidefumi Ito, Akio Ikeda, Atsushi Inanobe, Yoshihisa Kurachi, Seiji Inoue, Yukihiro Ohno
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2017)
Article
Biochemistry & Molecular Biology
Ryoichi Shirai, Fumiyasu Hirano, Naoki Ohkura, Kiyoshi Ikeda, Seiji Inoue
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2009)
Article
Biochemistry & Molecular Biology
Kohshi Kinkawa, Ryoichi Shirai, Shin Watanabe, Michihisa Toriba, Kyozo Hayashi, Kiyoshi Ikeda, Seiji Inoue
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2010)
Article
Biochemistry & Molecular Biology
Masanori Nishida, Masataka Okamoto, Ai Ohno, Kohji Okumura, Kyozo Hayashi, Kiyoshi Ikeda, Seiji Inoue
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
(2010)
Article
Biochemistry & Molecular Biology
Ryoichi Shirai, Rikiya Gotou, Fumiyasu Hirano, Kiyoshi Ikeda, Seiji Inoue
JOURNAL OF BIOLOGICAL CHEMISTRY
(2010)
Article
Pharmacology & Pharmacy
Akiko Shimada, Naoki Ohkura, Kyozo Hayashi, Yuji Samejima, Tamotsu Omori-Satoh, Seiji Inoue, Kiyoshi Ikeda
Article
Pharmacology & Pharmacy
Ryoichi Shirai, Michihisa Toriba, Kyozo Hayashi, Kiyoshi Ikeda, Seiji Inoue
Article
Pharmacology & Pharmacy
Shimon Lecht, Hadar Arien-Zakay, Yoav Wagenstein, Seiji Inoue, Cezary Marcinkiewicz, Peter I. Lelkes, Philip Lazarovici
VASCULAR PHARMACOLOGY
(2010)
Article
Cell Biology
Atsushi Furukawa, Kouzou Kita, Misao Toyomoto, Shinobu Fujii, Seiji Inoue, Kyozo Hayashi, Kiyoshi Ikeda
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2007)
Article
Biochemistry & Molecular Biology
K Okumura, A Ohno, M Nishida, K Hayashi, K Ikeda, S Inoue
JOURNAL OF BIOLOGICAL CHEMISTRY
(2005)
Article
Neurosciences
M Toyomoto, S Inoue, K Ohta, S Kuno, M Ohta, K Hayashi, K Ikeda
NEUROSCIENCE LETTERS
(2005)
Article
Biochemistry & Molecular Biology
M Toyomoto, M Ohta, K Okumura, H Yano, K Matsumoto, S Inoue, K Hayashi, K Ikeda
Article
Biochemistry & Molecular Biology
K Okumura, S Inoue, K Ikeda, K Hayashi
Article
Biochemistry & Molecular Biology
K Okumura, S Inoue, K Ikeda, K Hayashi
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2002)