Article
Multidisciplinary Sciences
Tess Dierckx, Sam Vanherle, Mansour Haidar, Elien Grajchen, Fleur Mingneau, Pascal Gervois, Esther Wolfs, Dany Bylemans, Arnout Voet, Tien Nguyen, Ibrahim Hamad, Markus Kleinewietfeld, Jeroen F. J. Bogie, Jerome J. A. Hendriks
Summary: This study reveals the reasons for the failure of remyelination, including the overly inflammatory microenvironment and the intrinsic inability of oligodendrocyte precursor cells to differentiate. The study also shows that phloretin can significantly promote remyelination by acting on the nuclear receptor peroxisome proliferator-activated receptor gamma to promote the maturation of oligodendrocyte precursor cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Neurosciences
Morgan W. Psenicka, Brandon C. Smith, Rachel A. Tinkey, Jessica L. Williams
Summary: Neurodegenerative diseases often involve inflammation, and multiple sclerosis (MS) is a complex interplay between inflammation and neurodegeneration. Oligodendrocyte precursor cells (OPCs) play an active role in promoting neuroinflammation and neurodegeneration in MS, in addition to being a target of autoimmune pathology.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Yizi Zhu, Mingzhu Chen, Yubo Zhang, Mei Han
Summary: This study found that stemazole can enhance the survival rate and clone formation of oligodendrocyte precursor cells (OPCs) and decrease cell apoptosis. In addition, in vivo experiments showed that stemazole promotes the recovery of motor dysfunction and repair of myelin sheaths. These findings suggest that stemazole may be a potential therapeutic agent for demyelinating diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ulises Gomez-Pinedo, Jordi A. Matias-Guiu, Maria Soledad Benito-Martin, Lidia Moreno-Jimenez, Inmaculada Sanclemente-Alaman, Belen Selma-Calvo, Sara Perez-Suarez, Francisco Sancho-Bielsa, Alejandro Canales-Aguirre, Juan Carlos Mateos-Diaz, Mercedes A. Hernandez-Sapiens, Edwin E. Reza-Zaldivar, Doddy Denise Ojeda-Hernandez, Lucia Vidorreta-Ballesteros, Paloma Montero-Escribano, Jorge Matias-Guiu
Summary: The study demonstrated that delivering HOG cells through the nasal route resulted in preferential migration to niches of OPCs in the CNS, potentially contributing to remyelination.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Omri Zveik, Nina Fainstein, Ariel Rechtman, Nitzan Haham, Tal Ganz, Iris Lavon, Livnat Brill, Adi Vaknin-Dembinsky
Summary: Oligodendrocyte progenitor cells play a role in both remyelination and immune response in the central nervous system. CSF from patients with progressive MS impairs differentiation of OPCs and reduces immune functions.
Article
Biochemistry & Molecular Biology
Feng-Yi Yang, Li-Hsin Huang, Meng-Ting Wu, Zih-Yun Pan
Summary: This study explored the effects of low-intensity pulsed ultrasound (LIPUS) on remyelination and resident cells in a demyelination model. The results showed that LIPUS can significantly increase myelin basic protein (MBP) expression, inhibit glial cell activation, enhance mature oligodendrocyte density, and promote brain-derived neurotrophic factor (BDNF) expression at the lesion site. In addition, LIPUS treatment resulted in the presence of a heterogeneous population of microglia with various morphologies in the demyelination lesion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Marisa A. Jeffries, Lauren E. McLane, Luipa Khandker, Marie L. Mather, Angelina V. Evangelou, Divyangi Kantak, Jennifer N. Bourne, Wendy B. Macklin, Teresa L. Wood
Summary: This study investigated the role of mTOR signaling in oligodendrocyte lineage during remyelination. The results showed that mTOR is required for metabolic function in cuprizone-demyelinated adult brain, influencing myelin production efficiency and myelin thickness during the repair process. Loss of mTOR in OPCs did not affect remyelination efficiency after other types of lesions, suggesting a specific function in cuprizone-induced demyelination.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Clinical Neurology
Vanja Tepavcevi, Catherine Lubetzki
Summary: The failure of remyelination in multiple sclerosis (MS) is often characterized by low oligodendrocyte progenitor cell density. Stimulating this process may be crucial for achieving myelin regeneration.
Review
Neurosciences
Davin Packer, Emily. E. E. Fresenko, Em. P. P. Harrington
Summary: Significant progress has been made in understanding the biology of remyelination and its potential as a therapeutic strategy for preventing neurodegeneration and disability in multiple sclerosis (MS). Different animal models have been used to study oligodendroglial responses and remyelination, each with its own mechanisms of demyelination, involvement of inflammatory cells, neurodegeneration, and capacity for remyelination. It is important to investigate remyelination in the context of aging and an inflammatory environment for potential translation to progressive MS. This review discusses the assessment of remyelination in mouse models of demyelination, the differences and advantages of these models, emerging therapeutic strategies, and current clinical trials promoting remyelination.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Neurosciences
Tal Ganz, Omri Zveik, Nina Fainstein, Marva Lachish, Ariel Rechtman, Lihi Sofer, Livnat Brill, Tamir Ben-Hur, Adi Vaknin-Dembinsky
Summary: Pushing OPC into differentiation program may help overcome remyelination failure, but creating a permissive environment for OPC activation, migration, and differentiation is also crucial.
Review
Neurosciences
Karina Maciak, Angela Dziedzic, Joanna Saluk
Summary: Remyelination depends on the repair of damaged myelin sheaths, involving microglia cells, oligodendrocyte precursor cells (OPCs), and mature oligodendrocytes. Short, noncoding RNA molecules, microRNAs (miRNAs), are believed to play a crucial role in the remyelination process by regulating gene expression. Various delivery systems, including extracellular vesicles, hold promise as an efficient and non-invasive way for providing miRNAs to stimulate remyelination.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Cell Biology
Haritha L. Desu, Placido Illiano, James S. Choi, Maureen C. Ascona, Han Gao, Jae K. Lee, Roberta Brambilla
Summary: The study reveals that neuroinflammation in multiple sclerosis leads to a shift in oligodendrocyte precursor cells (OPCs) towards an immunomodulatory phenotype, reducing their remyelination capacity and impairing their repair function. Furthermore, enhancing TNFR2 activation could be an effective strategy to restore OPC reparative capacity.
Article
Immunology
Peter Goettle, Janos Groh, Laura Reiche, Joel Gruchot, Nicole Rychlik, Luisa Werner, Iria Samper Agrelo, Rainer Akkermann, Annika Zink, Alessandro Prigione, Hans-Peter Hartung, Rudolf Martini, Patrick Kuery
Summary: This study demonstrates that teriflunomide modulates oligodendroglial precursor cell homeostasis and promotes myelin repair in the cuprizone mediated de-/remyelination model. Teriflunomide treatment accelerates the generation of oligodendrocytes and restoration of myelin sheaths, and restores mitochondrial integrity within oligodendroglial cells. These findings highlight the importance of de novo pyrimidine synthesis inhibition and mitochondrial homeostasis in successful myelin repair and axonal protection.
JOURNAL OF NEUROINFLAMMATION
(2023)
Review
Cell Biology
Federica Cherchi, Anna Maria Pugliese, Elisabetta Coppi
Summary: Oligodendrocyte-formed myelin sheaths facilitate fast synaptic transmission in the brain, but their degeneration can lead to demyelinating diseases. Remyelination relies on the differentiation of oligodendrocyte progenitor cells into mature oligodendrocytes, with the neuromodulator adenosine and its receptors playing crucial roles in this process. The review highlights the potential therapeutic targets in demyelinating pathologies like multiple sclerosis by targeting adenosine receptor ligands.
NEURAL REGENERATION RESEARCH
(2021)
Article
Plant Sciences
Li Liu, Manjing Li, Qingwu Liu, Lina Yang, Lisong Sun, Yuxuan Guo, Yujie Li, Ying Chen, Xiaoxin Zhu, Qi Li
Summary: This study found that ginsenoside Rg1 (Rg1) promotes differentiation of oligodendrocyte precursor cells (OPCs) and myelin regeneration, showing promising therapeutic significance for functional recovery in neurodegenerative diseases such as multiple sclerosis.
Article
Microbiology
Xin Zhu, Anshan Shan, Zhi Ma, Wei Xu, Jiajun Wang, Shuli Chou, Baojing Cheng
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2015)
Article
Behavioral Sciences
Angela Allen, Claude Messier
BEHAVIOURAL BRAIN RESEARCH
(2013)
Article
Behavioral Sciences
Taylor Hatchard, Jaimee J. Ting, Claude Messier
BEHAVIOURAL BRAIN RESEARCH
(2014)
Article
Cell Biology
Darren J. Yip, Chelsea P. Corcoran, Matias Alvarez-Saavedra, Adriana DeMaria, Stephen Rennick, Alan J. Mears, Michael A. Rudnicki, Claude Messier, David J. Picketts
DEVELOPMENTAL CELL
(2012)
Article
Developmental Biology
Federica De Angelis, Antonietta Bernardo, Valerio Magnaghi, Luisa Minghetti, Ada Maria Tata
DEVELOPMENTAL NEUROBIOLOGY
(2012)
Article
Neurosciences
Andra M. Smith, Claude Messier
FRONTIERS IN HUMAN NEUROSCIENCE
(2014)
Article
Geriatrics & Gerontology
Delyana Miller, Michle Gagnon, Vincent Talbot, Claude Messier
JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES
(2013)
Review
Geriatrics & Gerontology
Delyana I. Miller, Vanessa Taler, Patrick S. R. Davidson, Claude Messier
NEUROBIOLOGY OF AGING
(2012)
Article
Neurosciences
Reno M. Gandhi, Cary S. Kogan, Claude Messier, Lindsey S. MacLeod
Review
Neurosciences
J. J. Boulanger, C. Messier
Article
Health Care Sciences & Services
Delyana Ivanova Miller, France Aube, Vincent Talbot, Michele Gagnon, Claude Messier
TELEMEDICINE AND E-HEALTH
(2014)
Article
Neurosciences
Reno M. Gandhi, Cary S. Kogan, Claude Messier
FRONTIERS IN CELLULAR NEUROSCIENCE
(2014)
Article
Neurosciences
Alexandria Beland-Millar, Masaki Takimoto, Taku Hamada, Claude Messier
Article
Behavioral Sciences
Jenna J. Boulanger, Claude Messier
BEHAVIOURAL BRAIN RESEARCH
(2017)
Article
Psychology, Educational
Delyana I. Miller, Patrick S. R. Davidson, Dwayne Schindler, Claude Messier
JOURNAL OF PSYCHOEDUCATIONAL ASSESSMENT
(2013)