Article
Radiology, Nuclear Medicine & Medical Imaging
Maria da Graca Morais Martin, Vitor Ribeiro Paes, Ellison Fernando Cardoso, Carlos Eduardo Borges Passos Neto, Cristina Takami Kanamura, Claudia da Costa Leite, Maria Concepcion Garcia Otaduy, Renata Aparecida de Almeida Monteiro, Thais Mauad, Luiz Fernando Ferraz da Silva, Luiz Henrique Martins Castro, Paulo Hilario Nascimento Saldiva, Marisa Dolhnikoff, Amaro Nunes Duarte-Neto
Summary: This study investigated brain abnormalities in deceased COVID-19 patients using minimally invasive autopsy. Imaging findings and histological analysis revealed various pathological changes in the brain, including infarcts, hemorrhages, and neuronal degeneration, suggesting the involvement of SARS-CoV-2 in brain damage.
INSIGHTS INTO IMAGING
(2022)
Article
Sport Sciences
Stanley Hughwa Hung, Mohamed Salah Khlif, Sharon Kramer, Emilio Werden, Laura J. Bird, Bruce C. V. Campbell, Amy Brodtmann
Summary: This study aimed to examine the association between poststroke physical activity (PA) and white matter hyperintensities (WMH) volume. The results showed that meeting PA guidelines was associated with lower WMH volume in univariable analysis. However, in multivariable analysis, meeting PA guidelines was not associated with WMH volume, while older age was associated with greater WMH volume.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Article
Multidisciplinary Sciences
Junyan Huo, Gan Zhang, Wenjing Wang, Wen Cao, Mengxia Wan, Tao Huang, Dongsheng Fan, Yu Fu
Summary: In this study, the bidirectional causal relationship between migraine and white matter lesions was explored using a two-sample mendelian randomization method. The analysis of a recent large-scale genome-wide association study data did not provide evidence for causality between white matter lesions and migraine.
SCIENTIFIC REPORTS
(2023)
Article
Psychiatry
Antonio Terracciano, Bertin Cenatus, Xianghe Zhu, Selin Karakose, Yannick Stephan, Sofia Marcolini, Peter P. De Deyn, Martina Luchetti, Angelina R. Sutin
Summary: Neuroticism is associated with white matter hyperintensities, which partly mediate the association between neuroticism and cognitive function. This finding suggests that white matter integrity is a potential neurobiological pathway underlying the relationship between neuroticism and cognitive health.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Multidisciplinary Sciences
Valery L. Visser, Henry Rusinek, Johannes Weickenmeier
Summary: Research suggests that periventricular white matter hyperintensities may be related to mechanical loading on the ventricular wall, potentially leading to pathology. There is currently no unified theory to explain the occurrence of periventricular white matter hyperintensities around the horns of the lateral ventricles.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Mark R. Etherton, Markus D. Schirmer, Maria Clara Zanon Zotin, Pamela M. Rist, Gregoire Boulouis, Arne Lauer, Ona Wu, Natalia S. Rost
Summary: The study found that white matter hyperintensity volume, age, pre-stroke disability, and normal-appearing white matter mean diffusivity were independently associated with increased PSMD. Additionally, the effect of age on functional outcomes was indirectly mediated by PSMD. Increased PSMD could serve as a putative radiographic marker of brain age for stroke outcomes prognostication.
INTERNATIONAL JOURNAL OF STROKE
(2022)
Article
Clinical Neurology
Veronika Vadinova, Aleksi J. Sihvonen, Kimberley L. Garden, Laura Ziraldo, Tracy Roxbury, Kate O'Brien, David A. Copland, Katie L. McMahon, Sonia L. E. Brownsett
Summary: This study investigated the relationship between premorbid WMH severity and longitudinal comprehension and production outcomes in aphasia. Severe WMH were found to contribute to impaired language comprehension but not production in individuals with aphasia. The findings highlight the importance of considering different language domains when studying predictors of aphasia recovery.
NEUROREHABILITATION AND NEURAL REPAIR
(2023)
Article
Cardiac & Cardiovascular Systems
Lingling Ding, Bo Hou, Jie Zang, Tong Su, Feng Feng, Zhaohui Zhu, Bin Peng
Summary: This study investigated the relationship between angiogenesis and WMH penumbra in patients with WMHs, and found evidence of angiogenesis occurring in the WMH penumbra. Further studies are needed to verify the effect of angiogenesis on WMH growth.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Neurosciences
Valentina Bordin, Ilaria Bertani, Irene Mattioli, Vaanathi Sundaresan, Paul McCarthy, Sana Suri, Eniko Zsoldos, Nicola Filippini, Abda Mahmood, Luca Melazzini, Maria Marcella Lagana, Giovanna Zamboni, Archana Singh-Manoux, Mika Kivimaki, Klaus P. Ebmeier, Giuseppe Baselli, Mark Jenkinson, Clare E. Mackay, Eugene P. Duff, Ludovica Griffanti
Summary: This study explores the harmonization of white matter hyperintensity (WMH) measures across two major studies of healthy elderly populations, using preprocessing strategies and multivariate regression to reduce dataset differences and provide highly calibrated results.
Article
Neurosciences
Wasim Khan, Mohamed Salah Khlif, Remika Mito, Thijs Dhollander, Amy Brodtmann
Summary: Advanced diffusion MRI was used to assess microstructural properties of normal-appearing white matter (NAWM) before it converted to white matter hyperintensities (WMHs) in ischemic stroke. The study found that NAWM converting to WMHs already exhibited changes in tissue compositions, with lower white matter-like and increased fluid-like and gray matter-like properties compared to persistent NAWM. Furthermore, the microstructural compositions were related to overall WMH burden, indicating greater fluid-like properties in NAWM vulnerable to WMH development.
Article
Computer Science, Artificial Intelligence
Vaanathi Sundaresan, Giovanna Zamboni, Peter M. Rothwell, Mark Jenkinson, Ludovica Griffanti
Summary: In this study, an ensemble triplanar network was proposed for automated segmentation of white matter hyperintensities on brain MR images, resulting in accurate segmentation by incorporating anatomical information in loss functions. Evaluation on multiple datasets showed robust performance in both deep and periventricular regions, outperforming existing methods and comparable to top deep learning methods.
MEDICAL IMAGE ANALYSIS
(2021)
Article
Neuroimaging
Corey J. Bolton, Omair A. Khan, Elizabeth E. Moore, Kimberly R. Pechman, L. Taylor Davis, Dandan Liu, Bennett A. Landman, Katherine A. Gifford, Timothy J. Hohman, Angela L. Jefferson
Summary: Functional independence is an important predictor of quality of life in aging. This study found that smaller baseline grey matter volumes, particularly in regions commonly affected by Alzheimer's disease, and greater baseline white matter hyperintensities were associated with faster functional decline over a mean 5-year follow-up. These effects were stronger in participants at increased risk of AD, particularly those who carried the APOE ε4 allele.
NEUROIMAGE-CLINICAL
(2023)
Article
Neurosciences
Michele Porcu, Luigi Cocco, Sirio Cocozza, Giuseppe Pontillo, Annunziata Operamolla, Giovanni Defazio, Jasjit S. Suri, Arturo Brunetti, Luca Saba
Summary: The study found statistically significant correlations between white matter hyperintensities (WMH) and cognitive test scores, as well as an association between total WMH burden (tWMHb) and reduced neural activity in various brain regions, particularly the prefrontal cortex, precuneus, and cerebellar crus I/II. This suggests that WMH burden is linked to impairments in neurocognitive function among healthy individuals.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Cardiac & Cardiovascular Systems
Adam de Havenon, Nethra R. R. Parasuram, Anna L. L. Crawford, Mercy H. H. Mazurek, Isha R. R. Chavva, Vineetha Yadlapalli, Juan E. E. Iglesias, Matthew S. S. Rosen, Guido J. J. Falcone, Seyedmehdi Payabvash, Gordon Sze, Richa Sharma, Steven J. J. Schiff, Basmah Safdar, Charles Wira, William T. T. Kimberly, Kevin N. N. Sheth
Summary: This study found that portable magnetic resonance imaging (pMRI) could successfully identify white matter hyperintensity (WMH) in the brain and be used in unconventional settings. The results suggest that pMRI may have a potential role in reducing disparities in neuroimaging.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Geriatrics & Gerontology
Emanuel M. Boutzoukas, Andrew O'Shea, Alejandro Albizu, Nicole D. Evangelista, Hanna K. Hausman, Jessica N. Kraft, Emily J. Van Etten, Pradyumna K. Bharadwaj, Samantha G. Smith, Hyun Song, Eric C. Porges, Alex Hishaw, Steven T. DeKosky, Samuel S. Wu, Michael Marsiske, Gene E. Alexander, Ronald Cohen, Adam J. Woods
Summary: The decline of frontal lobe structures is faster in older adults and is associated with poorer executive function. Research on the effects of frontal lobe white matter hyperintensities (WMH) on executive function in normal aging is relatively limited. The study shows that the location and pattern of frontal WMH may be important for understanding age-related differences in cognitive functions.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Geriatrics & Gerontology
Jorge J. Llibre-Guerra, Yan Li, Isabel Elaine Allen, Juan C. Llibre-Guerra, Ana M. Rodriguez Salgado, Ana Ibis Penalver, Arianna Almirall Sanchez, Jennifer S. Yokoyama, Lea Grinberg, Victor Valcour, Bruce L. Miller, Juan J. Llibre-Rodriguez
Summary: This study examines the effects of self-identified race and genetic admixture on dementia prevalence and cognitive performance. The results show no independent association between self-identified race and African ancestry proportion with dementia prevalence and cognitive performance. This suggests that observed differences in dementia prevalence among diverse populations may be primarily influenced by social determinants of health.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Engineering, Biomedical
Andre Fonseca, Camila Sardeto Deolindo, Taisa Miranda, Edgard Morya, Edson Amaro Jr, Birajara Soares Machado
Summary: This study introduces an unsupervised data segmentation method based on time series complexity and in the cluster-weighted representation, which accurately predicts brain signal changes. The method is suitable for short signals, able to detect changes in rhythmic oscillations, and does not have strict modeling conditions.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2022)
Review
Surgery
Andressa Cristina Sposato Louzada, Marcelo Fiorelli Alexandrino da Silva, Maria Fernanda Cassino Portugal, Nickolas Stabellini, Antonio Eduardo Zerati, Edson Amaro, Marcelo Passos Teivelis, Nelson Wolosker
Summary: The study evaluated abdominal aortic aneurysm repair rates, trends, costs, and in-hospital mortality in the Brazilian Public Health System covering over 160 million people. The findings showed a low and decreasing rate of repairs, with a predominance of emergency and endovascular repairs associated with lower mortality.
WORLD JOURNAL OF SURGERY
(2022)
Article
Clinical Neurology
Jessica Borges Kroth, Benjamim Handfas, Glaucia Rodrigues, Francisco Zepeda, Marco Aurelio Oliveira, Danny J. J. Wang, Raymundo Machado de Azevedo Neto, Gisele Sampaio Silva, Edson Amaro, Isaac Olubunmi Sorinola, Adriana Bastos Conforto
Summary: This study aims to compare the effects of RPSS on upper limb motor performance and learning in stroke patients at different stages, as well as investigate its impact on brain perfusion, functional imaging activation, and GABA levels. The results will inform future clinical trials on tailoring RPSS for patients who are more likely to benefit from this intervention.
FRONTIERS IN NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Michel Satya Naslavsky, Claudia K. Suemoto, Luciano Abreu Brito, Marilia Oliveira Scliar, Renata Eloah Ferretti-Rebustini, Roberta Diehl Rodriguez, Renata E. P. Leite, Nathalia Matta Araujo, Victor Borda, Eduardo Tarazona-Santos, Wilson Jacob-Filho, Carlos Pasqualucci, Ricardo Nitrini, Kristine Yaffe, Mayana Zatz, Lea T. Grinberg
Summary: Dementia is more common in Blacks than in Whites, possibly due to a combination of environmental and biological factors. Interestingly, studies have shown a lower risk of dementia associated with APOE epsilon 4 in individuals of African ancestry. However, the underlying biological factors are not well understood. This study found that African ancestry was associated with a lower burden of neuropathology, but in individuals with severe neuropathology, it was associated with worse clinical symptoms of dementia.
MOLECULAR PSYCHIATRY
(2022)
Article
Neurosciences
Thiago Pereira Rodrigues, Mariana Athaniel Silva Rodrigues, Leonardo Favi Bocca, Feres Eduardo Chaddad Neto, Sergio Cavalheiro, Edson Amaro Junior, Gisele Sampaio Silva, Italo Capraro Suriano, Ricardo Silva Centeno
Summary: The aim of this study was to evaluate the course of brain edema in patients with malignant middle cerebral artery infarction treated with decompressive craniectomy (DC) using hemispheric volumetric measurements. The results showed that the peak of cerebral edema occurred on the 7th day after stroke symptoms onset. Further studies evaluating therapies for brain edema, even after DC, should be investigated.
ARQUIVOS DE NEURO-PSIQUIATRIA
(2023)
Article
Behavioral Sciences
Joao Ricardo Sato, Claudinei Eduardo Biazoli, Ana Paula Arantes Bueno, Arthur Caye, Pedro Mario Pan, Marcos Santoro, Jessica Honorato-Mauer, Giovanni Abrahao Salum, Marcelo Queiroz Hoexter, Rodrigo Affonseca Bressan, Andrea Parolin Jackowski, Euripedes Constantino Miguel, Sintia Belangero, Luis Augusto Rohde
Summary: Neuroimaging studies suggest that brain development mechanisms may explain some ADHD symptoms. However, the mechanisms by which genetic factors influence brain development in relation to ADHD remain largely unknown. This study aimed to investigate the associations between an ADHD polygenic risk score and brain network functioning. The findings suggest correlations between the ADHD polygenic risk score and the segregation of cingulo-opercular networks and the default mode network, supporting the role of attentional networks and DMN in attention processes. However, these associations were not found at follow-up.
GENES BRAIN AND BEHAVIOR
(2023)
Article
Biology
Felipe C. Ribeiro, Danielle Cozachenco, Luana Heimfarth, Juliana T. S. Fortuna, Guilherme B. de Freitas, Jorge M. de Sousa, Soniza V. Alves-Leon, Renata E. P. Leite, Claudia K. Suemoto, Lea T. Grinberg, Fernanda G. De Felice, Mychael V. Lourenco, Sergio T. Ferreira
Summary: Multiple research models suggest that the function and synaptic localization of proteasomes, intracellular machineries involved in protein degradation, are impaired in the brains affected by Alzheimer's disease.
COMMUNICATIONS BIOLOGY
(2023)
Article
Nursing
Elaine Cristina Lopes da Rocha, Kayo Henrique Jardel Feitosa Sousa, Paola Alves de Oliveira Lucchesi, Magda Guimaraes de Araujo Faria, Marcos Alencar Abaide Balbinotti, Flavio Rebustini, Renata Eloah de Lucena Ferretti-Rebustini, Cristiane Helena Gallasch
Summary: This study aimed to cross-culturally adapt and assess the content validity evidence of the Cognitive Symptom Checklist-Work-21 in the Brazilian context. The final version, named "Lista de verificacao de sintomas cognitivos relacionados ao trabalho -22 itens", showed strong evidence of content validity and good linguistic equivalence in the Brazilian context.
REVISTA BRASILEIRA DE ENFERMAGEM
(2023)
Article
Medicine, General & Internal
Nelson Wolosker, Andressa Cristina Sposato Louzada, Felipe Soares Oliveira Portela, Marcelo Fiorelli Alexandrino da Silva, Guilherme de Paula Pinto Schettino, Lucas Hernandes Correa, Edson Amaro Junior, Marcelo Passos Teivelis
Summary: This study evaluated outcomes of vascular surgeries in the public health system and proposed strategies to improve public vascular care, including mandatory reporting of key complications, screening for specific conditions, and the use of telemedicine and specialized centers.
EINSTEIN-SAO PAULO
(2023)
Article
Medicine, General & Internal
Marcelo Fiorelli Alexandrino da Silva, Andressa Cristina Sposato Louzada, Marcelo Passos Teivelis, Dafne Braga Diamante Leiderman, Maria Fernanda Cassino Portugal, Nickolas Stabellini, Edson Amaro Junior, Nelson Wolosker
Summary: This study evaluated the epidemiology of varicose vein stripping in Brazil's largest city, Sao Paulo. The majority of patients treated were female adults. Over the course of 11 years, a total of 66,577 varicose vein surgeries were performed, with an increasing trend over the years.
REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
(2022)
Article
Medicine, General & Internal
Guilherme de Carvalho Campos Neto, Edson Amaro Junior, Eduardo Weltman, Suzana Maria Fleury Malheiros, Bruna Leticia Ferrari, Taise Vitor, Marycel Rosa Felisa Figols de Barboza, Rosemeire Pereira Bezerra, Lilian Yuri Itaya Yamaga, Jairo Wagner, Ronaldo Hueb Baroni
Summary: No significant difference in somatostatin analog uptake was found between meningiomas treated with radiation therapy and those that had not been treated.
EINSTEIN-SAO PAULO
(2022)
Article
Medicine, General & Internal
Alexandre Maiera Anacleto, Marcia Maria Morales, Marcelo Passos Teivelis, Marcelo Fiorelli Alexandrino da Silva, Maria Fernanda Cassino Portugal, Nickolas Stabellini, Claudia Szlejf, Edson Amaro Junior, Nelson Wolosker
Summary: This study analyzed public data from patients who underwent open repair surgeries for aortic thoracoabdominal aneurysms and type B dissections. The results showed that hospitals with higher surgical volumes had better outcomes, and mortality rates did not differ significantly between elective and emergency cases. The findings suggest the importance of establishing specialized referral centers.
EINSTEIN-SAO PAULO
(2022)
Article
Neurosciences
Edson Amaro Junior
Summary: This article describes the major advances in artificial intelligence and Big Data applied to neurology, focusing on neurosciences based on medical images. It also discusses Real-World Data (RWD) and analytics related to large volumes of information, as well as some of the most relevant scientific initiatives at the time of writing.
ARQUIVOS DE NEURO-PSIQUIATRIA
(2022)
Article
Nursing
Renata Eloah de Lucena Ferretti-Rebustini, Juliana Nery de Souza-Talarico, Jack Roberto Silva Fhon, Sherry A. Greenberg
Summary: Population aging poses challenges to healthcare systems, necessitating gerontological advanced practice nurses (GAPN) to address specific and complex care needs of older adults. In advanced practice, comprehensive geriatric assessment is crucial for implementing care plans.
REVISTA DA ESCOLA DE ENFERMAGEM DA USP
(2022)
